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Journal Articles

Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

Lynda Villagomez, Porsha Smith, Fengting Yan, Victor Chen, Shelby Sloan, John T. Patton, Mackenzie Long, Fiona Brown, Elshafa H. Ahmed, Natarajan Muthusamy, Vincenzo Coppola, Anjali Mishra, Kris Vaddi, Peggy Scherle, Rosa Lapalombella, Lapo Alinari, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6381–6382.
https://doi.org/10.1182/blood-2022-168160
Published: 2022
Journal Articles

PRMT5 Inhibition Alters Mitochondrial Dynamics in Mantle Cell Lymphoma Creating Vulnerability to BH3 Mimetic Compounds

Claire Hinterschied, Fiona Brown, Janani Ravikrishnan, JoBeth Helmig-Mason, Kaylee R. Harrison, Aneeq Yasin, Shelby Sloan, Mackenzie Long, Neha Bhagwat, Kris Vaddi, Peggy Scherle, Jennifer A. Woyach, Selina Chen-Kiang, Olivier Elemento, Jihye Paik, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3118–3119.
https://doi.org/10.1182/blood-2022-167712
Published: 2022
Journal Articles

PRMT5 Inhibition Potentiates Anti-Tumor Immune Targeting of EBV-Driven B Cell Lymphoproliferative Disease

Elshafa Hassan Ahmed, Christoph Weigel, Rachel Saadey, Eric Brooks, Taylor Cash, Charlene Mao, Aneeq Yasin, Alexa Wandke, Ethan Baiocchi, Anna Mozhenkova, Fiona Brown, Shelby Sloan, JoBeth Helmig-Mason, Kaylee Harrison, Kris Vaddi, Peggy Scherle, Neha Bhagwat, Wing Keung Chan, Olivier Elemento, Christopher E Mason, Christopher C. Oakes, Robert A. Baiocchi, Polina Shindiapina
Journal: Blood
Blood (2022) 140 (Supplement 1): 3116–3117.
https://doi.org/10.1182/blood-2022-167988
Published: 2022
Journal Articles

Acquired Resistance to PRMT5 Inhibition in Mantle Cell Lymphoma Is Associated with Compensatory Activation of Multiple Signaling Pathways

Mackenzie Long, Shirsha Koirala, Shelby Sloan, Fiona Brown, Sheetal Tallada, Claire Hinterschied, Kara Corps, JoBeth Helmig-Mason, Ji Hyun Chung, Peggy Scherle, Kris Vaddi, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E Mason, Lapo Alinari, Bradley W Blaser, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3103–3104.
https://doi.org/10.1182/blood-2022-164641
Published: 2022
Journal Articles

PRMT5 Inhibition Reduces Autoinflammation in a Murine Model of Secondary Hemophagocytic Lymphohistiocytosis

Polina Shindiapina, Rachel Saadey, Aneeq Yasin, Charlene Mao, Alexa Wandke, Elshafa Hassan Ahmed, Ethan Baiocchi, Kris Vaddi, Peggy Scherle, Fiona Brown, Anna Mozhenkova, Ikbale El Ayachi, Austin D. Schenk, Shelby Sloan, Kaylee Harrison, JoBeth Helmig-Mason, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 36–37.
https://doi.org/10.1182/blood-2022-170239
Published: 2022
Journal Articles

PRMT5 Inhibition Promotes FOXO1 Tumor Suppressor Activity to Drive a Pro-Apoptotic Program That Creates Vulnerability to Combination Treatment with Venetoclax in Mantle Cell Lymphoma

Fiona Brown, Inah Hwang, Shelby Sloan, Claire Hinterschied, JoBeth Helmig-Mason, Mackenzie Long, Youssef Youssef, Wing Keung Chan, Alexander Prouty, Ji Hyun Chung, Yang Zhang, Kris Vaddi, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Lalit Sehgal, Lapo Alinari, Peggy Scherle, Rosa Lapalombella, Jihye Paik, Robert Baiocchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 681.
https://doi.org/10.1182/blood-2021-153733
Published: 2021
Journal Articles

PRMT5 Inhibition Modulates E2F1 and P53 to Restore Cell Cycle Regulation and Drive DNA Damage Response in Ibrutinib-Resistant Mantle Cell Lymphoma

Shelby Sloan, Fiona Brown, Mackenzie Long, JoBeth Helmig-Mason, Stacey Beck, Ji Hyun Chung, Walter Hanel, Eric Brooks, Haley Klimazewski, Cem Meydan, Jonathan Foox, Daniel Butler, John C. Byrd, Rosa Lapalombella, Maurizio Di Liberto, Christopher Mason, Selina Chen-Kiang, Kris Vaddi, Peggy Scherle, Robert Baiocchi, Lapo Alinari
Journal: Blood
Blood (2021) 138 (Supplement 1): 787.
https://doi.org/10.1182/blood-2021-153992
Published: 2021
Journal Articles

PRMT5 Inhibition Drives Therapeutic Vulnerability to BCL-2 Inhibition with Venetoclax and Provides Rationale for Combination Therapy in Mantle Cell Lymphoma

Fiona Brown, BS, Yang Zhang, PhD, Claire Hinterschied, Alexander Prouty, BS, Shelby Sloan, BS, JoBeth Helmig-Mason, Msc, Ji Hyun Chung, PhD, Kris Vaddi, PhD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Lapo Alinari, MD PhD, Peggy Scherle, PhD, Rosa Lapalombella, PhD, Jihye Paik, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 302.
https://doi.org/10.1182/blood-2019-130797
Published: 2019
Journal Articles

Targeting PRMT5 to Circumvent Acquired Ibrutinib Resistance in Mantle Cell Lymphoma

Shelby Sloan, BS, Fiona Brown, BS, JI Hyun Chung, PhD, Alexander Prouty, BS, Esther Wheeler, BS, Bonnie K Harrington, DVM, PhD, Eric Brooks, BS, Ayse S Yilmaz, MS, Hatice G Ozer, PhD, John C. Byrd, MD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Rosa Lapalombella, PhD, Kris Vaddi, PhD, Peggy Scherle, PhD, Youssef Youssef, MD, Robert A Baiocchi, MD PhD, Lapo Alinari, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4065.
https://doi.org/10.1182/blood-2019-128998
Published: 2019
Journal Articles

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

JI Hyun Chung, PhD, Shelby Sloan, BS, Peggy Scherle, PhD, Kris Vaddi, PhD, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2777.
https://doi.org/10.1182/blood-2019-131020
Published: 2019
Journal Articles

Exploring PRMT5 As a Potential Therapeutic Target in Canine Lymphomas

Kyle Renaldo, DVM, MS, Shelby Sloan, BS, JiHyun Chung, PhD, Lindsay Courtney, BS, Konstantin Shilo, MD, William Kisseberth, DVM, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4182.
https://doi.org/10.1182/blood-2018-99-119115
Published: 2018
Journal Articles

BZLF1-DEC205 Fusion Protein Enhances EBV-Protective Immunity in a Spontaneous Model of EBV-Driven Lymphoproliferative Disease

Elshafa Hassan Ahmed, DVM, Eric Brooks, Shelby Sloan, BS, Sarah Schlotter, Frankie Jeney, Charlene Mao, Polina Shindiapina, MD PhD, Salma Shire, Claire Hale, Manjusri Das, Alexander Prouty, Michael A. Caligiuri, MD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 342.
https://doi.org/10.1182/blood-2018-99-117837
Published: 2018