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Neha Bhagwat
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Journal Articles

Discovery of first-in-class calr-targeted precision ADCs delivering a CDK9degrader payload for the treatment of calr-mutated MPNs

Free
Norman Fultang, Ashley Schwab, Sharayu Chandratre, Jake Karwoski, Grace Davis, Ian Johnson, Neha Bhagwat, Yue Zou, Arpita Mondal, Max Foroutan, Ryan Holmes, Chun Chen, Corey Basch, Andrew Buesking, Sang Hyun Lee, Diane Heiser, Andrew Combs, Peggy Scherle
Journal: Blood
Blood (2025) 146 (Supplement 1): 72.
https://doi.org/10.1182/blood-2025-72
Published: 2025
Journal Articles

Discovery and preclinical characterization of orally bioavailable JAK2V617F mutant selective JH2 inhibitors with disease modification potential in myeloproliferative neoplasms

Free
Neha Bhagwat, Duanya Liu, Xiaowei Wu, Alexander Grego, Amy Crossan, Andrew Moore, Arpita Mondal, Carly Bachner, Diego Elrio, Dani Roth, John Rose, Joseph Rager, Joy Cote, Kirsten Gallagher, Klare Bersch, Miles Cowart, Natalie Kurtz, Angelina DiBiaso, Maggie Sumerau, Olusola Osinubi, Min Wang, Sharayu Chandratre, Song Mei, Srijita Dhar, Stephanie Rodgers, Sushanta Ratna, Yann Loret, Yue Zou, Sandy Geeganage, Andrew Combs, Jean-Jacques Kiladjian, Stephane Giraudier, Peggy Scherle
Journal: Blood
Blood (2025) 146 (Supplement 1): 70.
https://doi.org/10.1182/blood-2025-70
Published: 2025
Journal Articles

PRMT5 is a therapeutic vulnerability in cutaneous T-cell lymphoma

Free
Nicole Peterman, Pushpa Lata, Christoph Weigel, Sydney Leon, Ian Hout, Wing Chan, Ronny Schmidt, Ha Tran, Youssef Youssef, Peggy Scherle, Neha Bhagwat, John Reneau, Catherine Chung, Jonathan Brammer, Ryan Wilcox, Lapo Alinari, Robert Baiocchi, Walter Hanel
Journal: Blood
Blood (2025) 146 (Supplement 1): 1529.
https://doi.org/10.1182/blood-2025-1529
Published: 2025
Journal Articles

Interferon Synergizes with Inhibition of Pro-Apoptotic Proteins to Reduce Leukemia Burden in PDX Models of ML-DS

Free
Sonali P Barwe, Neha Bhagwat, Anilkumar Gopalakrishnapillai
Journal: Blood
Blood (2024) 144 (Supplement 1): 4156.
https://doi.org/10.1182/blood-2024-209899
Published: 2024
Journal Articles

Targeting PRMT5 in Primary Hemophagocytic Lymphohistiocytosis: A Novel Therapeutic Approach Using a Perforin-Deficient Mouse Model

Free
Sheldon Steyn, Chia-Jo Chen, Rachel Saadey, Charlene Mao, Peggy A Scherle, Neha Bhagwat, Kris Vaddi, Eric Brooks, Robert Baiocchi, Michael B. Jordan, Polina Shindiapina
Journal: Blood
Blood (2024) 144 (Supplement 1): 809.
https://doi.org/10.1182/blood-2024-208866
Published: 2024
Journal Articles

Phase Ib Study of PRT543, an Oral Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Patients with Relapsed or Refractory, Splicing Factor-Mutant Myeloid Malignancies

Free
Jan Philipp Bewersdorf, Xiaoli Mi, Bin Lu, Andrew T. Kuykendall, David Sallman, Manish Patel, Don A. Stevens, Alexander Philipovskiy, Grerk Sutamtewagul, Lucia Masarova, Gina Keiffer, Amit Verma, Neha Bhagwat, Diane Heiser, Sunhee Ro, Wan-Jen Hong, Omar Abdel-Wahab, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 3215.
https://doi.org/10.1182/blood-2024-198495
Published: 2024
Journal Articles

Selective SMARCA2 Degradation Promotes Leukemic Differentiation and Synergizes with CDK9 Inhibition to Potently Induce Death in Pre-Clinical Models of Acute Myeloid Leukemia

Free
Norman Fultang, Ashley M Schwab, Ian Johnson, Alexander Grego, Emma Filler, Carly Bachner, Jake Karwoski, Andrew Moore, Ashley Bartilomo, Anjana Agarwal, Olusola Peace Osinubi, Koichi Ito, Sarah Aminov, Srabani Sahu, Amit Verma, Peggy A Scherle, Neha Bhagwat, Diane Heiser
Journal: Blood
Blood (2024) 144 (Supplement 1): 2774.
https://doi.org/10.1182/blood-2024-208196
Published: 2024
Journal Articles

Targeting PRMT5-Mediated DNA Repair Pathway in Extra-Nodal NK/T-Cell Lymphoma (ENKTL)

Free
Youssef Youssef, Walter Hanel, Wing Chan, Fiona C. Brown, Claire Hinterschied, Jobeth Helmig-Mason, Neha Bhagwat, Kris Vaddi, Peggy A Scherle, Amin Noorani, Sr., Aharon G. Freud, Lapo Alinari, Christopher C. Oakes, Bethany L. Mundy-Bosse, Robert Baiocchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 5848.
https://doi.org/10.1182/blood-2024-201980
Published: 2024
Journal Articles

PRT2527, a Novel Highly Selective Cyclin-Dependent Kinase 9 (CDK9) Inhibitor, Has Potent Antitumor Activity in Combination with BTK and BCL2 Inhibition in Various Lymphoid Malignancies

Free
Norman Fultang, Ashley M Schwab, Sophia McAneny-Droz, Diane Heiser, Peggy A Scherle, Neha Bhagwat
Journal: Blood
Blood (2023) 142 (Supplement 1): 5783.
https://doi.org/10.1182/blood-2023-190093
Published: 2023
Journal Articles

PRMT5 Inhibition Alters Mitochondrial Dynamics in Mantle Cell Lymphoma Creating Vulnerability to BH3 Mimetic Compounds

Free
Claire Hinterschied, Fiona Brown, Janani Ravikrishnan, JoBeth Helmig-Mason, Kaylee R. Harrison, Aneeq Yasin, Shelby Sloan, Mackenzie Long, Neha Bhagwat, Kris Vaddi, Peggy Scherle, Jennifer A. Woyach, Selina Chen-Kiang, Olivier Elemento, Jihye Paik, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3118–3119.
https://doi.org/10.1182/blood-2022-167712
Published: 2022
Journal Articles

PRMT5 Inhibition Potentiates Anti-Tumor Immune Targeting of EBV-Driven B Cell Lymphoproliferative Disease

Free
Elshafa Hassan Ahmed, Christoph Weigel, Rachel Saadey, Eric Brooks, Taylor Cash, Charlene Mao, Aneeq Yasin, Alexa Wandke, Ethan Baiocchi, Anna Mozhenkova, Fiona Brown, Shelby Sloan, JoBeth Helmig-Mason, Kaylee Harrison, Kris Vaddi, Peggy Scherle, Neha Bhagwat, Wing Keung Chan, Olivier Elemento, Christopher E Mason, Christopher C. Oakes, Robert A. Baiocchi, Polina Shindiapina
Journal: Blood
Blood (2022) 140 (Supplement 1): 3116–3117.
https://doi.org/10.1182/blood-2022-167988
Published: 2022
Journal Articles

PRT2527, a Novel Highly Selective Cyclin-Dependent Kinase 9 (CDK9) Inhibitor, Has Potent Anti-Leukemic Activity in Preclinical Primary Models of Human B-ALL, T-ALL, and CLL

Free
Neha Bhagwat, Bruce Ruggeri, Yang Zhang, Yaron Mosesson, Clare Killick-Cole, Veena Jagannathan, Peggy Scherle
Journal: Blood
Blood (2022) 140 (Supplement 1): 505–506.
https://doi.org/10.1182/blood-2022-158998
Published: 2022
Journal Articles

A Phase 1 Dose Escalation Study of Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Patients with Myeloid Malignancies

Free
Manish R. Patel, Varun Monga, Shekeab Jauhari, Don Stevens, Lucia Masarova, Meredith McKean, David Mauro, John Viscusi, Peggy Scherle, Neha Bhagwat, Andrew Moore, William Sun, Rachel Chiaverelli, Eric Mintah, Rajneesh Nath, Eytan M. Stein, Neil Palmisiano, Grerk Sutamtewagul, Srdan Verstovsek
Journal: Blood
Blood (2021) 138 (Supplement 1): 2609.
https://doi.org/10.1182/blood-2021-150938
Published: 2021
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Free
Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

Free
Brief Report
Nicole Kucine, Sachie Marubayashi, Neha Bhagwat, Efthymia Papalexi, Priya Koppikar, Marta Sanchez Martin, Lauren Dong, Marty S. Tallman, Elisabeth Paietta, Kai Wang, Jie He, Doron Lipson, Phil Stephens, Vince Miller, Jacob M. Rowe, Julie Teruya-Feldstein, Charles G. Mullighan, Adolfo A. Ferrando, Andrei Krivtsov, Scott Armstrong, Laura Leung, Stefan O. Ochiana, Gabriela Chiosis, Ross L. Levine, Maria Kleppe
Journal: Blood
Blood (2015) 126 (22): 2479–2483.
https://doi.org/10.1182/blood-2015-03-635821
Published: 2015
Includes: Supplemental data
Journal Articles

Mathematical Optimization of JAK Inhibitor Dose and Scheduling for MPN Patients

Free
Kaitlyn R Shank, B.S., Priya Koppikar, PhD, Neha Bhagwat, PhD, Matthew D Keller, B.S., Franziska Michor, PhD, Ross L Levine, MD, Laura De Vargas Roditi, PhD
Journal: Blood
Blood (2014) 124 (21): 911.
https://doi.org/10.1182/blood.V124.21.911.911
Published: 2014
Journal Articles

Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis

Free
Brief Report
Sara C. Meyer, Matthew D. Keller, Brittany A. Woods, Lindsay M. LaFave, Lennart Bastian, Maria Kleppe, Neha Bhagwat, Sachie Marubayashi, Ross L. Levine
Journal: Blood
Blood (2014) 124 (14): 2280–2284.
https://doi.org/10.1182/blood-2014-03-560441
Published: 2014
Includes: Supplemental data
Journal Articles

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Free
Neha Bhagwat, Priya Koppikar, Matthew Keller, Sachie Marubayashi, Kaitlyn Shank, Raajit Rampal, Jun Qi, Maria Kleppe, Hardik J. Patel, Smit K. Shah, Tony Taldone, James E. Bradner, Gabriela Chiosis, Ross L. Levine
Journal: Blood
Blood (2014) 123 (13): 2075–2083.
https://doi.org/10.1182/blood-2014-01-547760
Published: 2014
Includes: Supplemental data
Journal Articles

Improved Efficacy Of Combination Of JAK2 and Hedgehog Inhibitors In Myelofibrosis

Free
Neha Bhagwat, B.S., Matthew D Keller, B.S., Raajit K. Rampal, M.D., Ph.D., Kaitlyn Shank, B.S., Elisa de Stanchina, PhD, Kristine Rose, PhD, Dereck Amakye, MD, Ross L. Levine, MD
Journal: Blood
Blood (2013) 122 (21): 666.
https://doi.org/10.1182/blood.V122.21.666.666
Published: 2013
Journal Articles

Combination Therapy Using JAK2 and HSP90 Inhibitors Increased Efficacy in Myelofibrosis in Vivo

Free
Ross L. Levine, Priya Koppikar, Sachie Marubayashi, Neha Bhagwat, Tony Taldone, PhD, Christopher Y. Park, MD, PhD, Gabriela Chiosis, PhD
Journal: Blood
Blood (2012) 120 (21): 805.
https://doi.org/10.1182/blood.V120.21.805.805
Published: 2012