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Journal Articles

Epichaperome Abundance Predicts Response to the Epichaperome Inhibitor, Puh-71, in Acute Myeloid Leukemia

Montreh Tavakkoli, MA,MD, Justin D. Kaner, MD, Sharma Sahil, PhD, Tony Taldone, PhD, Swathi Merugu, PhD, Gabriela Chiosis, PhD, Gail J. Roboz, MD, Monica L. Guzman, PhD

Blood (2019) 134 (Supplement_1): 5145.

https://doi.org/10.1182/blood-2019-125175

Published: 2019

Journal Articles

Harnessing the Epichaperome As a Therapeutic Approach in Multiple Myeloma

Eloisi Caldas Lopes, PhD, Tai Wang, PhD, David S Jayabalan, MSc, Tony Taldone, PhD, Jorge Monge, MD, Jorge Contreras, MD, Yip Winnie, Vicenta Trujillo, PhD, Panchal Palak, Nicholas Lombardi, Sharma Sahil, PhD, Digwal Chander, PhD, Morton Coleman, MD, Gabriela Chiosis, PhD, Ruben Niesvizky, MD, Monica L. Guzman, PhD

Blood (2019) 134 (Supplement_1): 4399.

https://doi.org/10.1182/blood-2019-125267

Published: 2019

Journal Articles

PTPN11 Mutated Acute Myeloid Leukemia (AML) Features an Abundant Epichaperome Network and Is Sensitive to the Epichaperome Inhibitor PU-H71

Justin D. Kaner, MD, Montreh Tavakkoli, MA,MD, Lisa Toudic, Brett M. Stevens, PhD, Craig T Jordan, PhD, Tony Taldone, PhD, Gabriela Chiosis, PhD, Ellen K. Ritchie, MD, Pinkal Desai, MDMPH, Michael B. Samuel, MD, Sangmin Lee, MD, Gail J. Roboz, MD, Monica L. Guzman, PhD

Blood (2019) 134 (Supplement_1): 3935.

https://doi.org/10.1182/blood-2019-128276

Published: 2019

Journal Articles

HSP90 Facilitates Oncogene-Induced Metabolic Reprogramming in B-Cell Lymphomas

Maria Nieves Calvo Vidal, PhD, Jan Krumsiek, PhD, Jayeshkumar Patel, MS, Shao Ning Yang, Jude M Phillip, DPhil, Rossella Marullo, MD PhD, Tony Taldone, PhD, Giorgio Inghirami, MD, Ari Melnick, MD, Gabriela Chiosis, PhD, Leandro Cerchietti, MD

Blood (2017) 130 (Supplement 1): 645.

https://doi.org/10.1182/blood.V130.Suppl_1.645.645

Published: 2017

Journal Articles

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

Blood (2016) 127 (7): 858–868.

https://doi.org/10.1182/blood-2015-05-645069

Published: 2016

Includes: Supplemental data

Journal Articles

A Hyperactive Signalosome Results in High Sensitivity to HSP90 Inhibitors in AML

Hongliang Zong, MD PhD, Tony Taldone, PhD, Gail J. Roboz, MD, Gabriela Chiosis, PhD, Monica L. Guzman, PhD

Blood (2015) 126 (23): 2567.

https://doi.org/10.1182/blood.V126.23.2567.2567

Published: 2015

Journal Articles

Targeting the Hsp90 Oncoproteome in Burkitt Lymphoma

Lisa Giulino Roth, MD, Herman van Besien, Anna Rodina, PhD, Tony Taldone, PhD, Hediye Erdjument-Bromage, PhD, Matthew J. Barth, MD, Gabriela Chiosis, PhD, Ethel Cesarman

Blood (2015) 126 (23): 592.

https://doi.org/10.1182/blood.V126.23.592.592

Published: 2015

Journal Articles

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Neha Bhagwat, Priya Koppikar, Matthew Keller, Sachie Marubayashi, Kaitlyn Shank, Raajit Rampal, Jun Qi, Maria Kleppe, Hardik J. Patel, Smit K. Shah, Tony Taldone, James E. Bradner, Gabriela Chiosis, Ross L. Levine

Blood (2014) 123 (13): 2075–2083.

https://doi.org/10.1182/blood-2014-01-547760

Published: 2014

Includes: Supplemental data

Journal Articles

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

Utthara Nayar, Pin Lu, Rebecca L. Goldstein, Jelena Vider, Gianna Ballon, Anna Rodina, Tony Taldone, Hediye Erdjument-Bromage, Max Chomet, Ronald Blasberg, Ari Melnick, Leandro Cerchietti, Gabriela Chiosis, Y. Lynn Wang, Ethel Cesarman

Blood (2013) 122 (16): 2837–2847.

https://doi.org/10.1182/blood-2013-01-479972

Published: 2013

Includes: Supplemental data

Journal Articles

Combination Therapy Using JAK2 and HSP90 Inhibitors Increased Efficacy in Myelofibrosis in Vivo

Ross L. Levine, Priya Koppikar, Sachie Marubayashi, Neha Bhagwat, Tony Taldone, PhD, Christopher Y. Park, MD, PhD, Gabriela Chiosis, PhD

Blood (2012) 120 (21): 805.

https://doi.org/10.1182/blood.V120.21.805.805

Published: 2012

Journal Articles

Anti-Apoptotic Bcl2 and Bcl-Xl Proteins Involved in Stroma-Induced Drug Tolerance to Hsp70 and Hsp90 Inhibitors in Leukemia and B-Cell Lymphoma

Eloisi Caldas Lopes, Fabian M Correa, Ling-Bo Shen, Jae-Hung Shieh, PhD, Tony Taldone, PhD, Gabriela Chiosis, PhD, Malcolm A.S. Moore, PhD

Blood (2012) 120 (21): 4900.

https://doi.org/10.1182/blood.V120.21.4900.4900

Published: 2012

Journal Articles

HSP70 Inhibitor, YK5, Ablates Blast, Progenitor and Stem Cell Populations in Primary Acute Myelogenous Leukemia Cells

Juan Felipe Rico, MD, Krishan K. Sharma, Yanlong Kang, PhD, Tony Taldone, PhD, Hardik Patel, Sarah Brennan, PhD, Hongliang Zong, MD, PhD, Michael W. Becker, MD, Gail J. Roboz, MD, Gabriela Chiosis, PhD, Monica L. Guzman, PhD

Blood (2011) 118 (21): 2493.

https://doi.org/10.1182/blood.V118.21.2493.2493

Published: 2011

Journal Articles

FLT3-ITD+ AML Blast, Progenitor and Stem Cell Populations Demonstrate Higher Sensitivity to the Hsp90 Inhibitor PU-H71,

Hongliang Zong, MD, PhD, Tony Taldone, PhD, James H. Ahn, Sarah Brennan, PhD, Jeanne P. De Leon, Michael W. Becker, MD, Gail J. Roboz, MD, Gabriela Chiosis, PhD, Monica L. Guzman, PhD

Blood (2011) 118 (21): 3500.

https://doi.org/10.1182/blood.V118.21.3500.3500

Published: 2011

Journal Articles

Determinants of Apoptotic Sensitivity to HSP90 Inhibition In Acute Myeloid Leukemia

Eloisi Caldas Lopes, Alexander Gozman, Tony Taldone, James Ahn, Sachie Marubayashi, Charles Rudin, Ross L Levine, Stephen Nimer, Gabriela Chiosis

Blood (2010) 116 (21): 2159.

https://doi.org/10.1182/blood.V116.21.2159.2159

Published: 2010

Journal Articles

Efficacy of the Novel Non-Quinone Based HSP-90 Inhibitor PU-H71 in JAK2V617F and MPLW515L-Induced Murine Models of Myeloproliferative Neoplasms.

Priya Koppikar, PhD, Sachie Marubayashi, Tony Taldone, Omar Abdel-Wahab, Nathan West, Alexander Gozman, James Ahn, Anna Rodina, Neha Bhagwat, Cyrus V. Hedvat, MD, PhD, James E. Bradner, MD, Gabriela Chiosis, Ross L. Levine, MD

Blood (2009) 114 (22): 3898.

https://doi.org/10.1182/blood.V114.22.3898.3898

Published: 2009

NARROW

Epichaperome Abundance Predicts Response to the Epichaperome Inhibitor, Puh-71, in Acute Myeloid Leukemia

Harnessing the Epichaperome As a Therapeutic Approach in Multiple Myeloma

PTPN11 Mutated Acute Myeloid Leukemia (AML) Features an Abundant Epichaperome Network and Is Sensitive to the Epichaperome Inhibitor PU-H71

HSP90 Facilitates Oncogene-Induced Metabolic Reprogramming in B-Cell Lymphomas

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

A Hyperactive Signalosome Results in High Sensitivity to HSP90 Inhibitors in AML

Targeting the Hsp90 Oncoproteome in Burkitt Lymphoma

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

Combination Therapy Using JAK2 and HSP90 Inhibitors Increased Efficacy in Myelofibrosis in Vivo

Anti-Apoptotic Bcl2 and Bcl-Xl Proteins Involved in Stroma-Induced Drug Tolerance to Hsp70 and Hsp90 Inhibitors in Leukemia and B-Cell Lymphoma

HSP70 Inhibitor, YK5, Ablates Blast, Progenitor and Stem Cell Populations in Primary Acute Myelogenous Leukemia Cells

FLT3-ITD+ AML Blast, Progenitor and Stem Cell Populations Demonstrate Higher Sensitivity to the Hsp90 Inhibitor PU-H71,

Determinants of Apoptotic Sensitivity to HSP90 Inhibition In Acute Myeloid Leukemia

Efficacy of the Novel Non-Quinone Based HSP-90 Inhibitor PU-H71 in JAK2V617F and MPLW515L-Induced Murine Models of Myeloproliferative Neoplasms.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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