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Priya Koppikar
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Journal Articles

Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms

Won Jun Kim, Edie I. Crosse, Emma De Neef, Inaki Etxeberria, Erich Sabio, Eric Wang, Jan Philipp Bewersdorf, Sydney X. Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H. Winick, Alexander M. Lewis, Robert Stanley, Susan Dewolf, Brigita Meskauskaite Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey J. Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony F. Daniyan, Benjamin D. Greenbaum, Christopher A. Klebanoff, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2024) 144 (Supplement 1): 343.
https://doi.org/10.1182/blood-2024-198639
Published: 2024
Journal Articles

A Public Neoantigen Produced By the SF3B1 K700E Mutation Is a Bona Fide T Cell Target in AML/MDS

Noah J Tubo, Duncheng Wang, Qiuming He, Yibin Chen, Ho Ngai, Yanqing Huang, Celine Kerros, Xizeng Mao, Shoudan Liang, Hong He, Gheath Alatrash, Priya Koppikar, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 6816.
https://doi.org/10.1182/blood-2023-190199
Published: 2023
Journal Articles

Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies

Tapan M. Kadia, Hagop Kantarjian, Gheath Alatrash, Anna Sergeeva, Hong He, Lisa St. John, Priya Koppikar, Celine Kerros, Karen Clise-Dwyer, Kathryn Ruissard, Abhishek Maiti, Courtney D. DiNardo, Elias Jabbour, Srdan Verstovsek, Naveen Pemmaraju, Nitin Jain, Ghayas C. Issa, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Aditi Shastri, Daniel R. Couriel, Maria Rhona Pinsoy, Sapna Parshottham, Richard E. Champlin, Jorge Cortes, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 1545.
https://doi.org/10.1182/blood-2023-189966
Published: 2023
Journal Articles

High-Throughput Identification of Graft-Vs-Leukemia TCRs in AML Patient Samples after Allogeneic Stem Cell Transplantation

Noah J Tubo, Duncheng Wang, Qiuming He, Yibin Chen, Ho Ngai, Yanqing Huang, Celine Kerros, Xizeng Mao, Shoudan Liang, Sachet Shukla, Arnau Peris Cuesta, Pavan Bachireddy, Julio Alcantara Montiel, Gheath Alatrash, Priya Koppikar, Jeffrey J. Molldrem
Journal: Blood
Blood (2023) 142 (Supplement 1): 7168.
https://doi.org/10.1182/blood-2023-190330
Published: 2023
Journal Articles

Characterization of Changes in the T-Cell Receptor Repertoire in Patients with Acute Myeloid Leukemia with Durable Remission Following Allogeneic Stem Cell Transplant

Ronald M. Paranal, MD, Hagop M. Kantarjian, MD, Alexandre Reuben, PhD, Celine Kerros, PhD, Priya Koppikar, PhD, Latasha Little, BS, Curtis Gumbs, Nicholas J. Short, MD, Jorge E. Cortes, MD, Elias Jabbour, MD, Jeffrey J. Molldrem, P. Andrew Futreal, PhD, Ghayas C. Issa, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5186.
https://doi.org/10.1182/blood-2019-129911
Published: 2019
Journal Articles

Evaluation of a FLT3 Bite® for Acute Myeloid Leukemia

Rebecca Goldstein, PhD, Anja Henn, Priya Koppikar, PhD, Ivonne Archibeque, BA, Brendon Frank, Mercedesz Balazs, Christoph Dahlhoff, PhD, Tobias Raum, PhD, Chi-Ming Li, PhD, Joachim Wahl, PhD, Dan Rock, Oliver Thomas, BSc, Christine Karbowski, PhD, Christina Krupka, PhD, Marion Subklewe, MD, Angela Coxon, PhD, Tara Chapman-Arvedson
Journal: Blood
Blood (2017) 130 (Supplement 1): 1354.
https://doi.org/10.1182/blood.V130.Suppl_1.1354.1354
Published: 2017
Journal Articles

JAK1 As a Convergent Regulator of Hematopoietic Stem Cell Function and Stress Hematopoiesis

Maria Kleppe, PhD, Matthew H Spitzer, PhD, Sheng Li, PhD, Lauren Dong, M.S., Efthymia Papalexi, Corinne Hill, M.S, Sofie De Groote, M.S., Matthew Keller, M.S., Priya Koppikar, PhD, Franck Rapaport, PhD, Jorge Gandara, Christopher E. Mason, PhD, Garry P. Nolan, Prof, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2016) 128 (22): 722.
https://doi.org/10.1182/blood.V128.22.722.722
Published: 2016
Journal Articles

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

Brief Report
Nicole Kucine, Sachie Marubayashi, Neha Bhagwat, Efthymia Papalexi, Priya Koppikar, Marta Sanchez Martin, Lauren Dong, Marty S. Tallman, Elisabeth Paietta, Kai Wang, Jie He, Doron Lipson, Phil Stephens, Vince Miller, Jacob M. Rowe, Julie Teruya-Feldstein, Charles G. Mullighan, Adolfo A. Ferrando, Andrei Krivtsov, Scott Armstrong, Laura Leung, Stefan O. Ochiana, Gabriela Chiosis, Ross L. Levine, Maria Kleppe
Journal: Blood
Blood (2015) 126 (22): 2479–2483.
https://doi.org/10.1182/blood-2015-03-635821
Published: 2015
Includes: Supplemental data
Journal Articles

Mathematical Optimization of JAK Inhibitor Dose and Scheduling for MPN Patients

Kaitlyn R Shank, B.S., Priya Koppikar, PhD, Neha Bhagwat, PhD, Matthew D Keller, B.S., Franziska Michor, PhD, Ross L Levine, MD, Laura De Vargas Roditi, PhD
Journal: Blood
Blood (2014) 124 (21): 911.
https://doi.org/10.1182/blood.V124.21.911.911
Published: 2014
Journal Articles

Type II Inhibition of JAK2 with NVP-CHZ868 Reverses Type I JAK Inhibitor Persistence and Demonstrates Increased Efficacy in MPN Models

Sara C Meyer, MD PhD, Matthew D Keller, BS, Priya Koppikar, PhD, Olga A Guryanova, MD PhD, Maria Kleppe, PhD, Anna Sophia McKenney, MPH, William R Sellers, MD, Francesco Hofmann, PhD, Fabienne Baffert, Christoph Gaul, PhD, Thomas Radimerski, PhD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 160.
https://doi.org/10.1182/blood.V124.21.160.160
Published: 2014
Journal Articles

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Neha Bhagwat, Priya Koppikar, Matthew Keller, Sachie Marubayashi, Kaitlyn Shank, Raajit Rampal, Jun Qi, Maria Kleppe, Hardik J. Patel, Smit K. Shah, Tony Taldone, James E. Bradner, Gabriela Chiosis, Ross L. Levine
Journal: Blood
Blood (2014) 123 (13): 2075–2083.
https://doi.org/10.1182/blood-2014-01-547760
Published: 2014
Includes: Supplemental data
Journal Articles

Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms

Qiang Jeremy Wen, PhD, MD, Benjamin Goldenson, Sebastien Malinge, PhD, Brady L Stein, MD MHS, Terra L Lasho, MT, (ASCP), Lawrence Breyfogle, Rachael Schultz, Qiong Yang, Laure gilles-Gendre, Priya Koppikar, Omar Abdel-Wahab, MD, Benjamin L. Ebert, MD, PhD, Animesh Pardanani, MBBS, PhD, Sandeep Gurbuxani, MBBS, PhD, Ross L. Levine, MD, Ann Mullally, MD, Ayalew Tefferi, MD, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 109.
https://doi.org/10.1182/blood.V122.21.109.109
Published: 2013
Journal Articles

Combination Therapy Using JAK2 and HSP90 Inhibitors Increased Efficacy in Myelofibrosis in Vivo

Ross L. Levine, Priya Koppikar, Sachie Marubayashi, Neha Bhagwat, Tony Taldone, PhD, Christopher Y. Park, MD, PhD, Gabriela Chiosis, PhD
Journal: Blood
Blood (2012) 120 (21): 805.
https://doi.org/10.1182/blood.V120.21.805.805
Published: 2012
Journal Articles

Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms

Qiang Jeremy Wen, MD, PhD, Benjamin Goldenson, Sebastien Malinge, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 64.
https://doi.org/10.1182/blood.V118.21.64.64
Published: 2011
Journal Articles

Janus Kinase-2 Inhibition Induces Durable Tolerance to Alloantigen by Dendritic Cell-Stimulated Human T Cells, Yet Preserves Immunity to Recall Antigen

Brian C. Betts, MD, Omar Abdel-Wahab, MD, Shane A Curran, PhD, Erin T St. Angelo, Priya Koppikar, Glenn Heller, PhD, Ross L Levine, MD, James W Young, MD
Journal: Blood
Blood (2011) 118 (21): 1903.
https://doi.org/10.1182/blood.V118.21.1903.1903
Published: 2011
Journal Articles

Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo,

Irum Khan, MBBS, Zan Huang, PhD, Qiang Jeremy Wen, MD, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 3862.
https://doi.org/10.1182/blood.V118.21.3862.3862
Published: 2011
Journal Articles

Heterodimeric JAK-STAT Activation As a Mechanism of Persistence to JAK2 Inhibitor Therapy

Neha Bhagwat, Priya Koppikar, Outi Kilpivaara, Taghi Manshouri, PhD, Mazhar Adli, Ann Mullally, MD, Omar Abdel-Wahab, MD, Laura Leung, Abby Weinstein, Sachie Marubayashi, Aviva Goel, Mithat Gonen, Zeev Estrov, Benjamin L. Ebert, MD, D.Phil, Gabriela Chiosis, PhD, Bradley Bernstein, Srdan Verstovsek, MD, PhD, Ross L Levine, MD
Journal: Blood
Blood (2011) 118 (21): 122.
https://doi.org/10.1182/blood.V118.21.122.122
Published: 2011
Journal Articles

Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell–stimulated T cells yet preserves immunity to recall antigen

Brian C. Betts, Omar Abdel-Wahab, Shane A. Curran, Erin T. St Angelo, Priya Koppikar, Glenn Heller, Ross L. Levine, James W. Young
Journal: Blood
Blood (2011) 118 (19): 5330–5339.
https://doi.org/10.1182/blood-2011-06-363408
Published: 2011
Includes: Supplemental data
Journal Articles

JAK2V617F-Mediated Phosphorylation of PRMT5 Down-Regulates Its Methyltransferase Activity and Promotes Myeloproliferation

Fan Liu, Xinyang Zhao, Fabiana Perna, Lan Wang, Priya Koppikar, Omar Abdel-Wahab, Ross L Levine, Hao Xue, Megan Hatlen, Silvia Menendez, Stephen D Nimer
Journal: Blood
Blood (2010) 116 (21): 794.
https://doi.org/10.1182/blood.V116.21.794.794
Published: 2010
Journal Articles

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis

Priya Koppikar, Omar Abdel-Wahab, Cyrus Hedvat, Sachie Marubayashi, Jay Patel, Aviva Goel, Nicole Kucine, Jeffrey R. Gardner, Andrew P. Combs, Kris Vaddi, Patrick J. Haley, Timothy C. Burn, Mark Rupar, Jacqueline F. Bromberg, Mark L. Heaney, Elisa de Stanchina, Jordan S. Fridman, Ross L. Levine
Journal: Blood
Blood (2010) 115 (14): 2919–2927.
https://doi.org/10.1182/blood-2009-04-218842
Published: 2010
Includes: Supplemental data