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Journal Articles

Development of synthetic introns for selective elimination of U2AF1 mutant MDS

Free
Qian Zhang, Kuan-Ting Lin, Christian Figueroa-Espada, Yuxi Ai, Salima Benbarche, Jeetayu Biswas, Robert Stanley, Cynthia Castro, Nina Fox, Sumit Rai, Matthew Walter, Timothy Graubert, Qing Feng, Rachel Darman, Daniel Heller, Robert Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2025) 146 (Supplement 1): 229.
https://doi.org/10.1182/blood-2025-229
Published: 2025
Journal Articles

Novel therapeutics for SF3B1 mutant cancers which exploit the missplicing of DCAF16

Free
Michal Sekrecki, Agata Sekrecka, Rohan Lattupally, Kenny Le, Xunhong Cao, Vicky Chen, Zhe Zhuang, Brendan Dwyer, Crystal Zhou, Charu Tiwari, Austin Gabel, Won Jun Kim, Robert Stanley, Salima Benbarche, Jose Pineda, Nathanael Gray, Tian Zhang, Peter Greenberg, Jason Gotlib, Gabriel Mannis, William Shomali, Giselle Salmasi, Tait Shanafelt, Capucine van Rechem, Xiaoyu Zhang, Bita Fakhri, Sydney Lu
Journal: Blood
Blood (2025) 146 (Supplement 1): 1474.
https://doi.org/10.1182/blood-2025-1474
Published: 2025
Journal Articles

DYRK1A controls CD47 endocytic degradation and leukemia immune surveillance

Free
Won Jun Kim, Alexander Arnuk, Jeetayu Biswas, Cuijuan Han, Nina Fox, Jacob Winick, Alexander Lewis, Kayla Koenig, Cynthia Castro, Abimbola Lawal, Robert Stanley, Joshua Weinreb, Zachary Zaroogian, Hui Liu, Zhuoning Li, Ileana Miranda, Anurag Sharma, Hilda Amalia Pasolli, Brian Eastman, Gopi Kumar Mittapalli, Chi-Ching Mak, Matthew Jarvis, Mara Monetti, Juan Osorio, Carine Bossard, Omar Abdel-Wahab, Eric Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 751.
https://doi.org/10.1182/blood-2025-751
Published: 2025
Journal Articles

Single-Cell Spatial Transcriptomics Identifies Lymphoid Aggregates with Location-Specific Alterations of Adaptive Immune Cells in Human MDS Bone Marrow

Free
Robert Stanley, Beatrice Zhang, Kimon V Argyropoulos, Brianna Gipson, Kenyon Weis, Alexander M. Lewis, Zoe Katsamakis, Karen Zhao, Catherine Snopkowski, Matthew Zatzman, Ning Fan, Ronan Chaligne, Umesh Bhanot, Mikhail Roshal, Ahmet Dogan, Benjamin D. Greenbaum, Eytan M. Stein, Marcel R.M. van den Brink, Omar Abdel-Wahab, Susan Dewolf
Journal: Blood
Blood (2024) 144 (Supplement 1): 817.
https://doi.org/10.1182/blood-2024-203714
Published: 2024
Journal Articles

Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms

Free
Won Jun Kim, Edie I. Crosse, Emma De Neef, Inaki Etxeberria, Erich Sabio, Eric Wang, Jan Philipp Bewersdorf, Sydney X. Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H. Winick, Alexander M. Lewis, Robert Stanley, Susan Dewolf, Brigita Meskauskaite Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey J. Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony F. Daniyan, Benjamin D. Greenbaum, Christopher A. Klebanoff, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2024) 144 (Supplement 1): 343.
https://doi.org/10.1182/blood-2024-198639
Published: 2024
Journal Articles

Synthetic Introns Identify the Novel RNA Splicing Factor GPATCH8 As Required for Mis-Splicing Induced By SF3B1 Mutations

Free
Salima Benbarche, Jose Maria Bello Pineda, Laura Baquero Galvis, Bo Liu, Jeetayu Biswas, Eric Wang, K. Ashley Lyttle, Alexander M. Lewis, Martina Sarchi, Sanjoy Mehta, Ralph Garippa, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Robert Stanley, Sergei Doulatov, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2023) 142 (Supplement 1): 3.
https://doi.org/10.1182/blood-2023-179848
Published: 2023
Journal Articles

Systematic Evaluation of AML-Associated Antigens Identifies Novel Anti-U5 snRNP200 Therapeutic Antibodies for the Treatment of AML

Free
Katherine Knorr, Caroline Erickson, Eric Wang, Jahan Rahman, Xiaoli Mi, Sydney Lu, Nina Fox, Alex Penson, Simon Hogg, Robert Stanley, Daichi Inoue, David Knorr, Jeffrey Ravetch, Omar Abdel-Wahab
Journal: Blood
Blood (2022) 140 (Supplement 1): 2247–2248.
https://doi.org/10.1182/blood-2022-158445
Published: 2022
Journal Articles

Modulation of RNA Splicing Enhances Response to BCL2 Inhibition in Acute Myeloid Leukemia

Free
Eric Wang, Jose Mario Bello Pineda, Jessie Bourcier, Maximilian Stahl, Alexander V Penson, Isaac Wakiro, Michael E Singer, Daniel Cui, Caroline Erickson, Katherine Knorr, Robert Stanley, Xufeng Chen, Elizabeth A. McMillan, Carine Bossard, Iannis Aifantis, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2021) 138 (Supplement 1): 507.
https://doi.org/10.1182/blood-2021-146373
Published: 2021
Journal Articles

PAK1 Is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome

Free
Robert Stanley, Ashley Pandolfi, M.Sc., Amit Verma, MD, Ulrich Steidl, MD PhD, Jonathan Chernoff, MD PhD, Yiting Yu, PhD, Jacqueline Boultwood
Journal: Blood
Blood (2014) 124 (21): 4614.
https://doi.org/10.1182/blood.V124.21.4614.4614
Published: 2014
Journal Articles

H2.0-Like Homeobox (HLX) Causes Pre-Leukemic Myeloid Expansion and Initiates AML In Cooperation With FLT3-ITD

Free
Ashley Pandolfi, M.Sc., Boris Bartholdy, Ph.D., Britta Will, PhD, Robert Stanley, Tihomira I Todorova, B.A., Christine McMahon, MD, Ulrich Steidl, MD PhD
Journal: Blood
Blood (2013) 122 (21): 4201.
https://doi.org/10.1182/blood.V122.21.4201.4201
Published: 2013
Journal Articles

H2.0-Like Homeobox (HLX) Induces Unlimited Clonogenicity, Blocks Differentiation, and Cooperates with FLT3-ITD in the Induction of Acute Myeloid Leukemia

Free
Ashley Pandolfi, M.Sc., Boris Bartholdy, Ph.D., Masahiro Kawahara, MD, Laura Barreyro, Britta Will, PhD, Robert Stanley, Roth Michael, MD, Ujunwa Cynthia Okoye-Okafor, M.Sc., Tihomira I Todorova, B.A., Maria E. Figueroa, MD, Ari Melnick, MD, Constantine S. Mitsiades, MD, PhD, Ulrich Steidl, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 651.
https://doi.org/10.1182/blood.V120.21.651.651
Published: 2012
Journal Articles

Parallel Transcriptional Analysis of Multiple Stem and Progenitor Populations Identifies Novel Commonly Dysregulated and Functionally Relevant Targets in AML

Free
Laura Barreyro, Britta Will, PhD, Boris Bartholdy, Ph.D., Li Zhou, PhD, Tihomira I Todorova, B.A., Robert Stanley, Susana Ben-Neriah, Cristina Montagna, PhD, Samir Parekh, MD, Andrea Pellagatti, PhD, Jacqueline Boultwood, PhD, Elisabeth Paietta, PhD, Rhett P Ketterling, MD, Larry D Cripe, MD, Hugo F Fernandez, MD, Peter L. Greenberg, MD, Jacob M Rowe, MD, Martin S. Tallman, MD, Christian Steidl, MD, Constantine S. Mitsiades, MD, PhD, Amit Verma, MD, Ulrich Steidl, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1875.
https://doi.org/10.1182/blood.V120.21.1875.1875
Published: 2012