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Jahan Rahman
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Journal Articles

DDX41-R525H mutation promotes dysplastic hematopoiesis via aberrant splicing of key regulators of HSC biology

Free
Rasika Venkataraman, Jahan Rahman, Takero Miyagawa, Cheryl Hsueh, Axia Song, Erica Arriaga-Gomez, Fu-Yen Chang, Elizabeth Bonner, Sayantani Sinha, Ettaib El Marabti, Nifemi Akinwande, Derek Stirewalt, Anthony Rongvaux, Omar Abdel-Wahab, Sebastian Fica, Stanley Lee
Journal: Blood
Blood (2025) 146 (Supplement 1): 677.
https://doi.org/10.1182/blood-2025-677
Published: 2025
Journal Articles

Integrated dissociated and spatial single-cell profiling reveals that HDAC inhibition restores anti-PD-1 sensitivity in Hodgkin lymphoma by disrupting monocyte-Hodgkin-reed-sternberg cell-driven immunosuppressive niches.

Free
Amira Marouf, Sneha Mitra, Robert Stuver, Nivetha Ganesan, Jahan Rahman, Alexander Boardman, Philip Caron, Tiffany Chang, Kevin David, Zachary Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Paul Hamlin, Francisco Hernandez-Ilizaliturri, Steven Horwitz, Andrew Intlekofer, William Johnson, Reem Karmali, Jennifer Lue, Anita Kumar, Efrat Luttwak, Neena Mahajan, Ariela Noy, Colette Owens, Lia Palomba, Heiko Schoder, David Sermer, Venkatraman Seshan, Raphael Steiner, Pallawi Torka, Andrew Zelenetz, Gottfried von Keudell, Gilles Salles, Christina Leslie, Alison Moskowitz, Santosha Vardhana
Journal: Blood
Blood (2025) 146 (Supplement 1): 150.
https://doi.org/10.1182/blood-2025-150
Published: 2025
Journal Articles

Cytotoxic CD8⁺ T cells are required for CD20xCD3 bispecific antibody-mediated tumor control in B-cell non-Hodgkin lymphomas

Free
Philipp Berning, Kazuya Fukasawa, Jahan Rahman, Ya-Hui Lin, Gilles Salles, Hans-Guido Wendel, Lorenzo Falchi, Santosha Vardhana
Journal: Blood
Blood (2025) 146 (Supplement 1): 556.
https://doi.org/10.1182/blood-2025-556
Published: 2025
Journal Articles

Molecular and structural basis of pan-resistance to BTK targeting therapies via BTK A428D mutation

Free
Quinlan Sievers, Hao Lu, Allison Cool, Stefan Gajewski, Tim Kong, Mark Noviski, Emel Ficici, Ratul Mukerji, James Iuliano, Jordan Ye, Mateo Sanchez Garcia de los Rios, Hugo Bousquet, Sarah Whelan, May Tan, Chris Phelps, Xiaoli Mi, Jahan Rahman, Samantha Sekeres, Erica Lamkin, Eduardo Bravo, Mark Ewalt, Anthony Mato, Lindsey Roeker, Justin Taylor, Meghan Thompson, Gwenn Hansen, Omar Abdel-Wahab
Journal: Blood
Blood (2025) 146 (Supplement 1): 2102.
https://doi.org/10.1182/blood-2025-2102
Published: 2025
Journal Articles

Development of CD371 shielded hematopoietic stem cell grafts for protection against AML-directed immunotherapies

Free
Satoshi Kaito, Karen Li, Xiaoli Mi, Cynthia Castro, Nina Fox, Alexander Lewis, Adriana Cuibus, Kenyon Weis, Erin Burns, Sarah Yoo, Jahan Rahman, Susan DeWolf, Anthony Daniyan, Omar Abdel-Wahab
Journal: Blood
Blood (2025) 146 (Supplement 1): 2309.
https://doi.org/10.1182/blood-2025-2309
Published: 2025
Journal Articles

Systematic Evaluation of GAPs and Gefs Identifies ARHGAP45 As a Targetable Leukemia-Specific Dependency

Free
Pu Zhang, Zhendong Cao, Xiangyu Pan, Yuqiao Liu, Cynthia Castro, Won Jun Kim, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Sanam Shahid, Jasmine S. Um, Erin R. Burns, Bing-Yi Chen, Winson Cai, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Anthony F. Daniyan, Christopher R. Vakoc, Omar Abdel-Wahab, Junwei Shi
Journal: Blood
Blood (2024) 144 (Supplement 1): 950.
https://doi.org/10.1182/blood-2024-198954
Published: 2024
Journal Articles

A Single-Cell Atlas of Classical Mantle Cell Lymphoma Reveals Paired Tumor-Immune Malignant States Correlating with Prognosis

Free
Amira Marouf, Sneha Mitra, Irem Isgor, Ashlee Joseph, Jahan Rahman, Ya-Hui Lin, Meril Takizawa, Ronan Chaligne, Shenon Sethi, Ahmet Dogan, Sandrine Roulland, Gilles Salles, Christina Leslie, Anita Kumar, Santosha A. Vardhana
Journal: Blood
Blood (2024) 144 (Supplement 1): 234.
https://doi.org/10.1182/blood-2024-206805
Published: 2024
Journal Articles

Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms

Free
Won Jun Kim, Edie I. Crosse, Emma De Neef, Inaki Etxeberria, Erich Sabio, Eric Wang, Jan Philipp Bewersdorf, Sydney X. Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H. Winick, Alexander M. Lewis, Robert Stanley, Susan Dewolf, Brigita Meskauskaite Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey J. Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony F. Daniyan, Benjamin D. Greenbaum, Christopher A. Klebanoff, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2024) 144 (Supplement 1): 343.
https://doi.org/10.1182/blood-2024-198639
Published: 2024
Journal Articles

Ruxolitinib Promotes Clinical Responses in Large Granular Lymphocytic Leukemia Via Suppression of JAK/STAT-Dependent Inflammatory Cascades

Free
Alison Moskowitz, Jahan Rahman, Nivetha Ganesan, Kelly Hannigan, Katie Ksanznak, Hadassah Bitton, Ya-Hui Lin, Theresa Davey, Helen Hancock, Leslie Perez, Tayler Miller, Jamila Brutus, Ahmet Dogan, Mark Blaine Geyer, Eric Jacobsen, Anita Kumar, Jonathan Moreira, Jae H. Park, Meghan C. Thompson, Pallawi Torka, Andrew D. Zelenetz, Santosha A Vardhana, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 183.
https://doi.org/10.1182/blood-2023-181922
Published: 2023
Journal Articles

Distinct Patterns of CD4+ and CD8+ T-Cell Clonal Expansion Enable Broad Clinical Responses to Pembrolizumab + GVD in Patients with Relapsed Hodgkin Lymphoma

Free
Beatriz Wills, Jahan Rahman, Nivetha Ganesan, Gunjan L. Shah, Ariela Noy, Heiko Schoder, Joachim Yahalom, Anita Kumar, Lorenzo Falchi, Paul A. Hamlin, Maria Lia Palomba, William Johnson, Andrew M. Intlekofer, Philip Caron, Theresa Davey, Helen Hancock, Natasha Galasso, Brittney Munayirji, Ya Hui Lin, Alayna Santarosa, Ellie Casper, Georgio Pongas, Andrew D. Zelenetz, Craig H. Moskowitz, Gilles Salles, Santosha A Vardhana, Alison Moskowitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1623.
https://doi.org/10.1182/blood-2023-185083
Published: 2023
Journal Articles

Systematic Evaluation of AML-Associated Antigens Identifies Novel Anti-U5 snRNP200 Therapeutic Antibodies for the Treatment of AML

Free
Katherine Knorr, Caroline Erickson, Eric Wang, Jahan Rahman, Xiaoli Mi, Sydney Lu, Nina Fox, Alex Penson, Simon Hogg, Robert Stanley, Daichi Inoue, David Knorr, Jeffrey Ravetch, Omar Abdel-Wahab
Journal: Blood
Blood (2022) 140 (Supplement 1): 2247–2248.
https://doi.org/10.1182/blood-2022-158445
Published: 2022
Journal Articles

RAF-Independent MEK Mutations Drive Histiocytic Neoplasms In Vivo and Are Sensitive to Single-Agent ERK Inhibition in Patients

Free
Benjamin H Durham, Michael E Singer, Salima Benbarche, Caroline Erickson, Jahan Rahman, David B. Solit, Matthew Witkowski, Neal Rosen, Omar Abdel-Wahab, Eli L Diamond
Journal: Blood
Blood (2022) 140 (Supplement 1): 1098–1100.
https://doi.org/10.1182/blood-2022-163575
Published: 2022
Journal Articles

Development of Novel CAR Therapies for Diffuse Large B-Cell Lymphoma Using Genome-Wide Overexpression Screens

Free
Mat Legut, Zoran Gajic, Maria Guarino, Eleni Mimitou, Stephanie Hao, Jahan Rahman, Teresa Davoli, Peter Smibert, Catherine S. Diefenbach, Neville Sanjana
Journal: Blood
Blood (2021) 138 (Supplement 1): 1726.
https://doi.org/10.1182/blood-2021-148485
Published: 2021