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Journal Articles

Pirtobrutinib in post-cbtki CLL/SLL: Final update from the Phase 1/2 BRUIN study with more than 5 years follow-up

Free
William Wierda, Jennifer Brown, Paolo Ghia, Lindsey Roeker, Krish Patel, Toby Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine Tam, John Seymour, Benoit Tessoulin, Nirav Shah, Chaitra Ujjani, Bita Fakhri, Catherine Coombs, Ian Flinn, Manish Patel, Sunita Dwivedy Nasta, Jonathon Cohen, Alvaro Alencar, Chan Cheah, Shuo Ma, Joanna Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Österborg, Koji Izutsu, Noriko Fukuhara, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Wojciech Jurczak, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 2115.
https://doi.org/10.1182/blood-2025-2115
Published: 2025
Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL): Final update from the Phase 1/2 BRUIN study

Free
Michael Wang, Jonathon Cohen, Nirav Shah, Wojciech Jurczak, Pier Luigi Zinzani, Chan Cheah, Chaitra Ujjani, Youngil Koh, Won Seog Kim, Sunita Dwivedy Nasta, Ian Flinn, Benoit Tessoulin, Shuo Ma, Alvaro Alencar, David Lewis, Jennifer Woyach, Kami Maddocks, Krish Patel, Yucai Wang, Joanna Rhodes, Constantine Tam, John Seymour, Hirokazu Nagai, Julie Vose, Bita Fakhri, Marc Hoffmann, Francisco Hernandez-Ilizaliturri, Andrew Zelenetz, Anita Kumar, Talha Munir, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Lindsey Roeker, Toby Eyre
Journal: Blood
Blood (2025) 146 (Supplement 1): 665.
https://doi.org/10.1182/blood-2025-665
Published: 2025
Journal Articles

Evaluation of ventoclax initiation prophylaxis and monitoring outcomes at each dose level and time point in patients with chronic lymphocytic leukemia: A real-world experience

Free
Christopher Jensen, Mazyar Shadman, Andres Chang, Nicole Lamanna, Beenish Manzoor, Chaitra Ujjani, Deborah Stephens, Wendy Sinai, Brian Hill, Jennifer Brown, Hande Tuncer, Matthew S Davids, Toby Eyre, Nicolas Martinez-Calle, Lori Leslie, Lindsey Roeker, Paul Barr, Nnadozie Emechebe, Alan Skarbnik, Bita Fakhri, Meghan Thompson, Joanna Rhodes, Isabelle Fleury, Frederick Lansigan, Robson Lima, Zhu Cui, Michael Coyle, Samin Houshyar, Laurie Pearson, Irina Pivneva, Talissa Watson, Annie Guerin, Nilanjan Ghosh
Journal: Blood
Blood (2025) 146 (Supplement 1): 3885.
https://doi.org/10.1182/blood-2025-3885
Published: 2025
Journal Articles

The predictive value of mosaic chromosomal alterations for lymphoid malignancies varies by monoclonal B-cell lymphocytosis status

Free
Rosalie Griffin, Tait Shanafelt, Sameer Parikh, Nicholas Boddicker, Kari Rabe, Cristine Allmer, Aaron Norman, Yuan Yao, Bryan Vallejo, Stacey Lehman, Janet Olson, Yucai Wang, Lindsey Roeker, Paul Hampel, Esteban Braggio, Mrinal Patnaik, Celine Vachon, James Cerhan, Curtis Hanson, Susan Slager
Journal: Blood
Blood (2025) 146 (Supplement 1): 3545.
https://doi.org/10.1182/blood-2025-3545
Published: 2025
Journal Articles

Other cancers in patients with chronic lymphocytic leukemia/SMALL lymphocytic lymphoma

Free
Helen Ma, Kari Rabe, Edward Ratner, Samuel Kosydar, Roberta Santos Azevedo, Pankaj Gupta, Susan O'Brien, Paul Hampel, Lindsey Roeker, Yucai Wang, Susan Slager, Sameer Parikh, Alessandra Ferrajoli
Journal: Blood
Blood (2025) 146 (Supplement 1): 4529.
https://doi.org/10.1182/blood-2025-4529
Published: 2025
Journal Articles

Venetoclax-obinutuzumab in frontline and R/R CLL: Outcomes compared to age- and sex-matched general population

Free
Lauren Pomerantz, Sameer Parikh, Kari Rabe, Paul Hampel, Lindsey Roeker, Saad Kenderian, Neil Kay, Rachel Bailen, Amber Koehler, Catherine Coddington, Amy Behnken, Jose Leis, Talal Hilal, Mazie Tsang, Ricardo Parrondo, Susan Schwager, Sara Achenbach, Cinthya Mendoza Zepeda, Min Shi, Curtis Hanson, Susan Slager, Esteban Braggio, Yucai Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3905.
https://doi.org/10.1182/blood-2025-3905
Published: 2025
Journal Articles

Updated results from a Phase II study of minimal residual disease-guided venetoclax + obinutuzumab for the initial treatment of fit patients with chronic lymphocytic leukemia

Free
Meghan Thompson, Anthony Mato, Andrew Zelenetz, Jae Park, Mark Geyer, Andriy Derkach, David Nemirovsky, Deborah Stephens, Catherine Coombs, Prioty Islam, Christopher Jensen, Lorenzo Falchi, Lia Palomba, Anita Kumar, Gilles Salles, Eytan Stein, Jennifer Lue, Lauren Nogan, Bejal Kikani, Ryan Sutterby, Thu Quynh Nguyen, Alexandra Allen, Sumathy Sudhir, Gail Panton, Victoria Duffy, Dianna Tyznar, Jamila Brutus, Tenzin Nyima, Anmol Shah, Dhara Soni, Michael Silvestrone, Monica Shah, Miranda Harris, Megha Karnam, Claire Hutzler, Kevin David, Aaron Goldberg, Stephen Fleming, Giovanni Diaz, Habib Hamidi, Bita Fakhri, Lindsey Roeker
Journal: Blood
Blood (2025) 146 (Supplement 1): 3902.
https://doi.org/10.1182/blood-2025-3902
Published: 2025
Journal Articles

Molecular and structural basis of pan-resistance to BTK targeting therapies via BTK A428D mutation

Free
Quinlan Sievers, Hao Lu, Allison Cool, Stefan Gajewski, Tim Kong, Mark Noviski, Emel Ficici, Ratul Mukerji, James Iuliano, Jordan Ye, Mateo Sanchez Garcia de los Rios, Hugo Bousquet, Sarah Whelan, May Tan, Chris Phelps, Xiaoli Mi, Jahan Rahman, Samantha Sekeres, Erica Lamkin, Eduardo Bravo, Mark Ewalt, Anthony Mato, Lindsey Roeker, Justin Taylor, Meghan Thompson, Gwenn Hansen, Omar Abdel-Wahab
Journal: Blood
Blood (2025) 146 (Supplement 1): 2102.
https://doi.org/10.1182/blood-2025-2102
Published: 2025
Journal Articles

Non-CLL-type MBL and chip are associated precursor conditions: Insights from Mayo Clinic's MBL screening cohort

Free
Yuan Yao, Tait Shanafelt, Sameer Parikh, Paul Hampel, Lindsey Roeker, Yucai Wang, Aaron Norman, Kari Rabe, Janet Olson, Rosalie Griffin, Soren Basnet, Dennis Robinson, Mingma Hoel, Bryan Vallejo, Alyssa Clay-Gilmour, Stacey Lehman, Mrinal Patnaik, Timothy Call, James Cerhan, Celine Vachon, Neil Kay, Esteban Braggio, Curtis Hanson, Nicholas Boddicker, Susan Slager
Journal: Blood
Blood (2025) 146 (Supplement 1): 128.
https://doi.org/10.1182/blood-2025-128
Published: 2025
Journal Articles

A Phase II multicenter study of minimal residual disease-guided, time-limited acalabrutinib + obinutuzumab for the initial treatment of chronic lymphocytic leukemia

Free
Meghan Thompson, Anthony Mato, Lia Palomba, Lori Leslie, Andriy Derkach, David Nemirovsky, Prioty Islam, Mark Geyer, Philip Caron, Aaron Goldberg, Anita Kumar, Alison Moskowitz, Jennifer Lue, Colette Owens, Gilles Salles, Eytan Stein, Raphael Steiner, Pallawi Torka, Lori Dahncke, Emily Ordona, Mashiyate Meem, Claire Hutzler, Miranda Harris, Monica Shah, Megha Karnam, Lauren Nogan, Caitlin Maloney, Anmol Shah, Tenzin Nyima, Colleen Dorsey, Kate Doyle, Jennifer Howgate-Klingaman, Jamila Brutus, Dianna Tyznar, Anna Lincke, Rick Wray, Tatyana Feldman, Andrew Zelenetz, Lindsey Roeker
Journal: Blood
Blood (2025) 146 (Supplement 1): 5676.
https://doi.org/10.1182/blood-2025-5676
Published: 2025
Journal Articles

Pirtobrutinib versus usual care for patients with richter transformation of chronic lymphocytic leukemia: Inverse probability of treatment weighting-based analysis of BRUIN trial and mayo observational cohort

Free
Yucai Wang, Kari Rabe, Paul Hampel, Lindsey Roeker, Jihao Zhou, Suheil Albert Atallah-Yunes, Susan Schwager, Min Shi, Curtis Hanson, Rebecca King, Cinthya Mendoza Zepeda, Saad Kenderian, Eli Muchtar, Neil Kay, Amber Koehler, Amy Behnken, Catherine Coddington, Susan Slager, Sameer Parikh
Journal: Blood
Blood (2025) 146 (Supplement 1): 5673.
https://doi.org/10.1182/blood-2025-5673
Published: 2025
Journal Articles

Progression of disease within 36 months (POD36) of starting first-line targeted therapy independently predicts poor overall survival in patients with chronic lymphocytic leukemia (CLL)

Free
Paul Hampel, Kari Rabe, Matthew Maurer, Yucai Wang, Saad Kenderian, Eli Muchtar, Lindsey Roeker, Jose Leis, Mazie Tsang, Talal Hilal, Ricardo Parrondo, Amber Koehler, Rachel Bailen, Catherine Coddington, Amy Behnken, Susan Schwager, Curtis Hanson, Esteban Braggio, Min Shi, Cinthya Mendoza, Susan Slager, Neil Kay, Sameer Parikh
Journal: Blood
Blood (2025) 146 (Supplement 1): 5667.
https://doi.org/10.1182/blood-2025-5667
Published: 2025
Journal Articles

Tumor-derived microRNA-125a impairs CART cell function and predicts treatment failure in B cell malignancies

Free
Olivia Sirpilla, Ismail Can, Kun Yun, Grace DeFranco, Carli Stewart, Truc Huynh, Elizabeth Siegler, Brooke Kimball, Long Mai, Claudia Manriquez Roman, Jennifer Feigin, Omar Gutierrez Ruiz, Neil Kay, Lindsey Roeker, Yucai Wang, Patrick Johnston, Yi Lin, Stephen Ansell, Paul Hampel, Sameer Parikh, Esteban Braggio, R. Leo Sakemura, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 2321.
https://doi.org/10.1182/blood-2025-2321
Published: 2025
Journal Articles

Phase 1/2 Studies of DZD8586, a Non-Covalent BBB Penetrant LYN/BTK Dual Inhibitor, in BTK Inhibitor Resistant Chronic Lymphocytic Leukemia (CLL) and Other B-Cell Non-Hodgkin Lymphoma (B-NHL)

Free
Yuqin Song, Keshu Zhou, Hongmei Jing, Geoffrey Chong, Jianqiu Wu, Wei Liu, Zengjun Li, Ming Jiang, Mei Lan, Kaiyang Ding, Guohui CUI, Tingyu Wang, Xutao Guo, Sujun Gao, Constantine S. Tam, Haiyan Yang, Fang Zhu, Wei Yang, Jian-Qing Mi, Liping Su, Ke Fang, Ziyi Liu, Lindsey Roeker, Chan Y. Cheah, Jianyong Li, Lu-Gui Qiu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3248.
https://doi.org/10.1182/blood-2024-197877
Published: 2024
Journal Articles

A Multi-Center Retrospective Study on Complex Karyotype in Patients with Richter Transformation Who Received No Chemoimmunotherapy for Their CLL

Free
Cecelia Miller, Ying Huang, John N. Allan, Seema A. Bhat, David A. Bond, Danielle M. Brander, John C. Byrd, Julio C. Chavez, Elise A. Chong, Alexey Danilov, Mark R Dowling, Kaitlyn M. Dvorak-Kornaus, Paul J. Hampel, Carrie I Ho, Prioty Islam, Nikita Malakhov, Matthew Matasar, Sarah Miller, Sameer A. Parikh, Kari G. Rabe, Joanna M. Rhodes, Lindsey Roeker, Kerry A. Rogers, Aditi Saha, Alan P Skarbnik, Hamish W Scott, Jake Schade, Mazyar Shadman, Geoffrey Shouse, Deborah M. Stephens, Meghan C. Thompson, Philip A. Thompson, Yucai Wang, Jennifer A. Woyach, Max Yano, Zulfa Omer, Adam S Kittai
Journal: Blood
Blood (2024) 144 (Supplement 1): 3245.
https://doi.org/10.1182/blood-2024-205668
Published: 2024
Journal Articles

Treatment Outcomes of Patients Treated with Venetoclax-Obinutuzumab Therapy Vs Btki Therapies in 1L CLL: An International Real-World Study

Free
Nicole Lamanna, Jennifer R. Brown, Chaitra S. Ujjani, Toby A. Eyre, Beenish Manzoor, Nilanjan Ghosh, Lindsey Roeker, Matthew S. Davids, Catherine C Coombs, Alan P Skarbnik, Brian T. Hill, Hande H. Tuncer, Lori A. Leslie, Joanna M. Rhodes, Isabelle Fleury, Paul M Barr, Nnadozie Emechebe, Nicolas Martinez-Calle, Christopher E. Jensen, Yun Choi, Dureshahwar Jawaid, Laurie K Pearson, Meghan C. Thompson, Steven E Marx, Wendy J. Sinai, Frederick Lansigan, Bita Fakhri, Deborah M. Stephens, Stephen J. Schuster, Michael Coyle, Irina Pivneva, Talissa Watson, Annie Guerin, Mazyar Shadman
Journal: Blood
Blood (2024) 144 (Supplement 1): 4625.
https://doi.org/10.1182/blood-2024-205223
Published: 2024
Journal Articles

Association Between Dose Reduction and Duration of Therapy in Patients Receiving Ibrutinib or Acalabrutinib for Chronic Lymphocytic Leukemia: A Medical Chart Review Study

Free
Mazyar Shadman, Lindsey Roeker, Javier Pinilla-Ibarz, Bhavini Srivastava, Sudeep Karve, Gabriel S. Krigsfeld, Erin Franceschini, Chadi Saifan, Siddharth Karanth, Ravi K. Goyal, Julien Rombi, Deborah M. Stephens
Journal: Blood
Blood (2024) 144 (Supplement 1): 3742.
https://doi.org/10.1182/blood-2024-205456
Published: 2024
Journal Articles

BRUIN CLL-321: Randomized Phase III Trial of Pirtobrutinib Versus Idelalisib Plus Rituximab (IdelaR) or Bendamustine Plus Rituximab (BR) in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Free
Jeff P. Sharman, Talha Munir, Sebastian Grosicki, Lindsey Roeker, John M. Burke, Christine I Chen, Norbert Grzasko, George Follows, Zoltán Mátrai, Alessandro Sanna, Shuhua Yi, Ru Feng, Vu Minh Hua, Jadwiga Holodja, Wojciech Jurczak, Matthias Ritgen, Lu-Gui Qiu, Francesc Bosch, Catherine C. Coombs, Katherine Bao, Vishalkumar Patel, Bin Liu, Livia Compte, Ananya Guntur, Ying (Denise) Wang, Marisa Hill, Ching Ching Leow, Paolo Ghia, Paul M Barr
Journal: Blood
Blood (2024) 144 (Supplement 1): 886.
https://doi.org/10.1182/blood-2024-198147
Published: 2024
Journal Articles

Minimal Residual Disease (MRD)-Adapted Duration of Front-Line Venetoclax and Obinutuzumab Treatment for Fit Patients with Chronic Lymphocytic Leukemia (CLL)

Free
Lindsey Roeker, Anthony R. Mato, Andrew D. Zelenetz, Jae H. Park, Mark Blaine Geyer, Andriy Derkach, David Nemirovsky, Prioty Islam, Lorenzo Falchi, Maria Lia Palomba, Anita Kumar, Gilles Salles, Jennifer Kimberly Lue, Aaron D. Goldberg, Deborah M. Stephens, Victoria Duffy, Gail Panton, Dianna Tyznar, Colleen Dorsey, Dhara Soni, Claire Hutzler, Lauren Nogan, Alexandra Allen, Tenzin Nyima, Thu Quynh Nguyen, Monica Shah, Tamotha R Cook, Jennifer Abillar-Wright, Jamila Brutus, Carissa Laudati, Bejal Kikani, Catherine C Coombs, Michael R. Silvestrone, Christopher E. Jensen, Bita Fakhri, Meghan C. Thompson
Journal: Blood
Blood (2024) 144 (Supplement 1): 1010.
https://doi.org/10.1182/blood-2024-203807
Published: 2024
Journal Articles

HMA/Ven Treatment Modifications and Associated Outcomes in IDH -Mutant AML

Free
Kuo-Kai Chin, Andriy Derkach, Christopher Famulare, Gaurav Gupta, Prabhakar Borge, Mark Blaine Geyer, Aaron D. Goldberg, Tamanna Haque, Jae H. Park, Lindsey Roeker, Martin S. Tallman, Maximilian Stahl, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 5962.
https://doi.org/10.1182/blood-2024-211733
Published: 2024