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Journal Articles

Remodeling the bone marrow tumor microenvironment with CART cell therapy to overcome resistance in multiple myeloma

Free
Jennifer Feigin, Omar Gutierrez Ruiz, Carli Stewart, Brooke Kimball, Kun Yun, Mehrdad Hefazi Torghabeh, Claudia Manriquez Roman, Wannakorn Khopanlert, Ismail Can, Long Mai, Truc Huynh, Sophia Goldberg, Sara Foote, Grace DeFranco, Olivia Sirpilla, Dominic Skeele, Ateka Saleh, Hong Xia, Matthew Schellenberg, Yi Lin, Diane Jelinek, P. Leif Bergsagel, Elizabeth Siegler, R. Leo Sakemura, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 1028.
https://doi.org/10.1182/blood-2025-1028
Published: 2025
Journal Articles

Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks

Free
Mehrdad Hefazi Torghabeh, R. Leo Sakemura, Hong Xia, Brooke Kimball, Long Mai, Claudia Manriquez Roman, Afshin Shameli, Olivia Sirpilla, Carli Stewart, Taro Hitosugi, Grace DeFranco, Jennifer Feigin, Shuwen Zhang, Truc Huynh, Ismail Can, Abhishek Mangaonkar, Kun Yun, Ateka Saleh, Lionel Kankeu Fonkoua, Yoh Yamaguchi, Sara Foote, Sophia Goldberg, Omar Gutierrez Ruiz, Elizabeth Siegler, Bruce Blazar, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 587.
https://doi.org/10.1182/blood-2025-587
Published: 2025
Journal Articles

Live imaging of human xenogeneic CART cells in a clinical trial of companion dogs with lymphoma

Free
Elizabeth Siegler, Alex Abel, Wesley Wierson, Truc Huynh, Carli Stewart, Long Mai, Brooke Kimball, Jennifer Feigin, Kun Yun, Claudia Manriquez Roman, Ismail Can, Omar Gutierrez Ruiz, Hong Xia, Ekene Ogbodo, Olivia Sirpilla, Grace DeFranco, Sophia Goldberg, Ateka Saleh, Sara Foote, Dominic Skeele, Yoh Yamaguchi, Lionel Kankeu Fonkoua, Mehrdad Hefazi Torghabeh, R. Leo Sakemura, Jeffrey Bryan, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 4105.
https://doi.org/10.1182/blood-2025-4105
Published: 2025
Journal Articles

Ibrutinib enhances 41BB-costimulated CART19 function and persistence through immune reprogramming: Insights from the phase 3 ECOG-ACRIN E1912 clinical Trial

Free
Truc Huynh, Victoria Wang, Jennifer Feigin, Elizabeth Siegler, Brooke Kimball, Carli Stewart, Kun Yun, Long Mai, Claudia Manriquez Roman, Hong Xia, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Olivia Sirpilla, Grace DeFranco, Sophia Goldberg, Ateka Saleh, Dominic Skeele, Sara Foote, Yoh Yamaguchi, Lionel Kankeu Fonkoua, Mehrdad Hefazi Torghabeh, Sameer Parikh, Vitoria Cantinho Pereira, Paul Buckley, Alan Ramsay, Tait Shanafelt, Neil Kay, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 2101.
https://doi.org/10.1182/blood-2025-2101
Published: 2025
Journal Articles

Tumor-derived microRNA-125a impairs CART cell function and predicts treatment failure in B cell malignancies

Free
Olivia Sirpilla, Ismail Can, Kun Yun, Grace DeFranco, Carli Stewart, Truc Huynh, Elizabeth Siegler, Brooke Kimball, Long Mai, Claudia Manriquez Roman, Jennifer Feigin, Omar Gutierrez Ruiz, Neil Kay, Lindsey Roeker, Yucai Wang, Patrick Johnston, Yi Lin, Stephen Ansell, Paul Hampel, Sameer Parikh, Esteban Braggio, R. Leo Sakemura, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 2321.
https://doi.org/10.1182/blood-2025-2321
Published: 2025
Journal Articles

Targeting CSF1R to overcome myeloid cell suppression in CART therapy

Free
Grace DeFranco, Kun Yun, Claudia Manriquez Roman, Jennifer Feigin, Samuel Olivier, Mehrdad Hefazi Torghabeh, Carli Stewart, Brooke Kimball, Elizabeth Siegler, Truc Huynh, Justyna Gleba, Matthew Pawlush, Andrew Zakko, Michael Redig, Skyeler Klinge, Long Mai, Aylin Alasonyalilar Demirer, James Miller, Erin Miller, R. Leo Sakemura, Ismail Can, Olivia Sirpilla, Omar Gutierrez Ruiz, Dominic Skeele, Sophia Goldberg, Sara Foote, Ateka Saleh, Hong Xia, Ekene Ogbodo, Yushi Qiu, Robert Smallridge, Abba Zubair, Han Tun, John Copland, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 5883.
https://doi.org/10.1182/blood-2025-5883
Published: 2025
Journal Articles

IL-4 epigenetically reprograms CART19-28ζ cells to drive dysfunction

Free
Carli Stewart, Mehrdad Hefazi Torghabeh, Makena Rodriguez, Grace DeFranco, Sara Foote, Brooke Kimball, Long Mai, Truc Huynh, Elizabeth Siegler, Jennifer Feigin, Kun Yun, Dominic Skeele, Sophia Goldberg, Ateka Saleh, Olivia Sirpilla, Ismail Can, Hong Xia, Omar Gutierrez Ruiz, Ekene Ogbodo, Sameer Parikh, Esteban Braggio, Neil Kay, R. Leo Sakemura, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 2338.
https://doi.org/10.1182/blood-2025-2338
Published: 2025
Journal Articles

Intrinsic Immunosuppressive Features of Monocytes Suppress CART19 through IL-1 Pathway Modulation in Mantle Cell Lymphoma

Free
Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Shuwen Zhang, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 908.
https://doi.org/10.1182/blood-2024-205905
Published: 2024
Journal Articles

Caspase-1 Inhibition Ameliorates CAR T-Cell Apoptosis and Tumor Cell Pyroptosis to Enhance the Efficacy and Safety of CAR T-Cell Therapy

Free
Wannakorn Khopanlert, Truc Huynh, Brooke L. Kimball, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Claudia Manriquez Roman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Long K. Mai, Hong Xia, Mehrdad Hefazi, Lionel Aurelien Kankeu Fonkoua, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian, R. Leo Sakemura
Journal: Blood
Blood (2024) 144 (Supplement 1): 907.
https://doi.org/10.1182/blood-2024-202661
Published: 2024
Journal Articles

Identification of T Cell Senescence As a Cell Fate Limiting the Antitumor Activity of 41BB-Costimulated CART Cells

Free
Ismail Can, R. Leo Sakemura, Olivia L. Sirpilla, Claudia Manriquez Roman, Carli M. Stewart, Kun Yun, Truc Huynh, Ekene Ogbodo, Lionel A Kankeu Fonkoua, Jennifer M. Feigin, Omar Gutierrez Ruiz, Long K. Mai, Hong Xia, Brooke L. Kimball, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, H. Atakan Ekiz, Berke Alkan, Fatih Sezer, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4808.
https://doi.org/10.1182/blood-2024-207818
Published: 2024
Journal Articles

Distinct Functional Impacts of Cytokine Receptor Blockade on CART Cells

Free
Kun Yun, Evandro Bezerra, R. Leo Sakemura, Emmanuel Contreras Guzman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, Jennifer M. Feigin, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 7166.
https://doi.org/10.1182/blood-2024-211119
Published: 2024
Journal Articles

Affinity of Anti-CD19 Antibodies Determines Subsequent CART19 Activation, Apoptosis and CRS in Preclinical Models

Free
R. Leo Sakemura, Claudia Manriquez Roman, Long K. Mai, Brooke L. Kimball, Truc Huynh, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Kun Yun, Carli M. Stewart, Omar Gutierrez Ruiz, Ismail Can, Ekene Ogbodo, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Jan Jaehrling, Kristina Ilieva, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2023) 142 (Supplement 1): 6796.
https://doi.org/10.1182/blood-2023-179408
Published: 2023
Journal Articles

Differential Susceptibility to Senescence in CART Cells Based on Co-Stimulatory Signaling

Free
Ismail Can, Reona Leo Sakemura, Claudia Manriquez-Roman, Olivia Sirpilla, Carli M. Stewart, Kun Yun, Michelle J. Cox, Truc Huynh, James H. Girsch, Ekene J. Ogbodo, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Justin C. Boysen, Elizabeth L. Siegler, Atakan Ekiz, Saad S. Kenderian, Neil E. Kay
Journal: Blood
Blood (2022) 140 (Supplement 1): 8600–8601.
https://doi.org/10.1182/blood-2022-163446
Published: 2022
Journal Articles

Targeting a Dominant Negative Splice Variant of TRAIL to Enhance CART Cell Functions

Free
Ismail Can, Sekar Natesampillai, Reona Leo Sakemura, Elizabeth L. Siegler, Claudia Manriquez-Roman, Shahrzad Jalali, Truc Huynh, Ashton Krogman, Mark Maynes, Andrew D. Badley, Saad S. Kenderian, Mehrdad Hefazi
Journal: Blood
Blood (2022) 140 (Supplement 1): 632–633.
https://doi.org/10.1182/blood-2022-163677
Published: 2022
Journal Articles

Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19

Free
Kun Yun, Reona Leo Sakemura, Michelle J. Cox, Truc Huynh, Claudia Manriquez-Roman, Olivia Sirpilla, Carli M. Stewart, James H. Girsch, Ekene J. Ogbodo, Ismail Can, Brooke Kimball, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 10263–10264.
https://doi.org/10.1182/blood-2022-164706
Published: 2022
Journal Articles

CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy

Free
Reona Leo Sakemura, Claudia Manriquez-Roman, Paulina Horvei, Michelle J. Cox, Truc Huynh, James H. Girsch, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Kristina Ilieva-Babinsky, Christian Augsberger, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 2362–2364.
https://doi.org/10.1182/blood-2022-158273
Published: 2022
Journal Articles

Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models

Free
Olivia Sirpilla, Reona Leo Sakemura, Mehrdad Hefazi, James H. Girsch, Truc Huynh, Michelle J. Cox, Kendall J. Schick, Claudia Manriquez-Roman, Ismail Can, Kun Yun, Carli M. Stewart, Ekene J. Ogbodo, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 1579–1580.
https://doi.org/10.1182/blood-2022-158872
Published: 2022
Journal Articles

Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial

Free
Carli M. Stewart, Michelle J. Cox, Reona Leo Sakemura, Ekene J. Ogbodo, Ismail Can, Claudia Manriquez-Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Truc Huynh, Elizabeth L. Siegler, Jenny J Kim, Mike Mattie, Nathalie Scholler, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 4536–4537.
https://doi.org/10.1182/blood-2022-160219
Published: 2022