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Simone Filosto
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Journal Articles

Impact of Inflammation, Tumor and Product Attributes on Clinical Outcomes in Patients with Relapsed/Refractory Follicular Lymphoma Treated with Axicabtagene Ciloleucel

Soumya Poddar, Jiali Yan, Gayatri Tiwari, Darawan Rinchai, Wangshu Zhang, Justin Budka, Weixin Peng, Shruti Salunkhe, Madison Davis, Qinghua Song, Sara Beygi, Harry Miao, Mike Mattie, Rhine Shen, Caron A. Jacobson, Davide Bedognetti, Simone Filosto, Sattva S. Neelapu
Journal: Blood
Blood (2024) 144 (Supplement 1): 4368.
https://doi.org/10.1182/blood-2024-211139
Published: 2024
Journal Articles

In Vitro and In Vivo Characterization of Axicabtagene Ciloleucel Identifies Features Associated with Treatment Resistance in Patients, Including a Dysfunctional CD8+ T Cell State Characterized By Overexpression of GATA3 Transcript

Soumya Poddar, Gabriela Balderrama-Gutierrez, Chad M. Williams, Tan Trinh, Subing Cao, Sunanda Kumar, Quinn Walker, Madison Davis, Alessandro Calo, Stacey Valny, Sean C Yoder, Lei Huang, Justin Budka, Jenny J. Kim, Rhine Shen, Simone Filosto, Sophie Viaud, Jorge Andrade, Davide Bedognetti, Mike Mattie
Journal: Blood
Blood (2024) 144 (Supplement 1): 7159.
https://doi.org/10.1182/blood-2024-209570
Published: 2024
Journal Articles

Intrinsic Immunosuppressive Features of Monocytes Suppress CART19 through IL-1 Pathway Modulation in Mantle Cell Lymphoma

Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Shuwen Zhang, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 908.
https://doi.org/10.1182/blood-2024-205905
Published: 2024
Journal Articles

Axicabtagene ciloleucel vs standard of care in second-line large B-cell lymphoma: outcomes by metabolic tumor volume

Clinical Trials & Observations
Frederick L. Locke, Olalekan O. Oluwole, John Kuruvilla, Catherine Thieblemont, Franck Morschhauser, Gilles Salles, Steven P. Rowe, Saran Vardhanabhuti, Joshua Winters, Simone Filosto, Christina To, Paul Cheng, Marco Schupp, Ronald Korn, Marie José Kersten
Journal: Blood
Blood (2024) 143 (24): 2464–2473.
https://doi.org/10.1182/blood.2023021620
Published: 2024
Includes: Supplemental data
Journal Articles

Improved Overall Survival with Axicabtagene Ciloleucel Vs Standard of Care in Second-Line Large B-Cell Lymphoma Among the Elderly: A Subgroup Analysis of ZUMA-7

Marie José Kersten, Umar Farooq, Aaron P. Rapoport, Frederick L. Locke, Lori A. Leslie, Armin Ghobadi, David B. Miklos, Caron A. Jacobson, Javier L. Munoz, Patrick B Johnston, Samantha M. Jaglowski, Ian W. Flinn, Tom van Meerten, Miguel-Angel Perales, Peter Vandenberghe, Peter A. Riedell, Kathleen Dorritie, David Szwajcer, Dimitrios Tzachanis, Saran Vardhanabhuti, Linqiu Du, Simone Filosto, Shilpa A. Shahani, Christina To, Jason Westin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1761.
https://doi.org/10.1182/blood-2023-173873
Published: 2023
Journal Articles

Association of Metabolic Tumor Volume (MTV) and Clinical Outcomes in Second-Line (2L) Relapsed/Refractory (R/R) Large B-Cell Lymphoma (LBCL) Following Axicabtagene Ciloleucel (Axi-Cel) Versus Standard-of-Care (SOC) Therapy in ZUMA-7

Frederick L. Locke, Olalekan O. Oluwole, John Kuruvilla, Catherine Thieblemont, Franck Morschhauser, Gilles Salles, Steven P Rowe, Saran Vardhanabhuti, Simone Filosto, Christina To, Paul Cheng, Marco Schupp, Ronald Korn, Marie José Kersten
Journal: Blood
Blood (2022) 140 (Supplement 1): 638–640.
https://doi.org/10.1182/blood-2022-158492
Published: 2022
Journal Articles

Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19

Kun Yun, Reona Leo Sakemura, Michelle J. Cox, Truc Huynh, Claudia Manriquez-Roman, Olivia Sirpilla, Carli M. Stewart, James H. Girsch, Ekene J. Ogbodo, Ismail Can, Brooke Kimball, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 10263–10264.
https://doi.org/10.1182/blood-2022-164706
Published: 2022
Journal Articles

Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial

Carli M. Stewart, Michelle J. Cox, Reona Leo Sakemura, Ekene J. Ogbodo, Ismail Can, Claudia Manriquez-Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Truc Huynh, Elizabeth L. Siegler, Jenny J Kim, Mike Mattie, Nathalie Scholler, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 4536–4537.
https://doi.org/10.1182/blood-2022-160219
Published: 2022
Journal Articles

ZUMA-19: A Phase 1/2 Study of Axicabtagene Ciloleucel Plus Lenzilumab in Patients With Relapsed or Refractory Large B-Cell Lymphoma

Olalekan O. Oluwole, Saad S. Kenderian, Parveen Shiraz, Reem Karmali, Ran Reshef, Philip L. McCarthy, Nilanjan Ghosh, Aleksandr Lazaryan, Simone Filosto, Soumya Poddar, Daqin Mao, Andrew Peng, Adrian Kilcoyne, Myrna Nahas, Sattva S. Neelapu
Journal: Blood
Blood (2022) 140 (Supplement 1): 10318–10320.
https://doi.org/10.1182/blood-2022-167688
Published: 2022
Journal Articles

A Pilot Study of Axicabtagene Ciloleucel (axi-cel) for the Treatment of Relapsed/Refractory Primary and Secondary Central Nervous System Lymphoma (CNSL)

Caron A. Jacobson, Caroline Falvey, Riemke Bouvier, Sarah Hogan, Elizabeth Kendricken, Julia Jones, Elizabeth Grimm, Robert A. Redd, Eudocia Q Lee, Luis Gonzalez Castro, Ugonma Chukwueke, Jose McFaline Figueroa, Austin I. Kim, Alexandra Torres, Linda Ramsdell, Leslie S. Kean, Ulrike Gerdemann, Alexandre Albanese, Paula Keskula, David Meredith, Lynette Sholl, Soumya Poddar, Madison Davis, Daquin Mao, Simone Filosto, Mike Mattie, Philippe Armand, Lakshmi Nayak
Journal: Blood
Blood (2022) 140 (Supplement 1): 1060–1061.
https://doi.org/10.1182/blood-2022-165256
Published: 2022
Journal Articles

Patients with Deleterious Germline Variants in STXBP2 Develop Toxicity after CAR-T Cell Therapy with Axicabtagene Ciloleucel

Mark B. Leick, Seunghun Han, Kathleen M.E. Gallagher, Harrison Silva, Grace Martin, Sabrina Camp, Hoyin Chu, Riaz Gillani, Michael C. Kann, Bryan D. Choi, Rebecca Larson, Merle Phillips, Tamina Kienka, Stefanie R. Bailey, Charlotte Graham, Christopher R. Reilly, Max Jan, Elba Gonzalez, Nora K. Horick, Justin Budka, Simone Filosto, Rhine R. Shen, Eliezer Van Allen, Saud H AlDubayan, Marcela V. Maus
Journal: Blood
Blood (2022) 140 (Supplement 1): 646–647.
https://doi.org/10.1182/blood-2022-166322
Published: 2022
Journal Articles

Primary Analysis of ZUMA-7: A Phase 3 Randomized Trial of Axicabtagene Ciloleucel (Axi-Cel) Versus Standard-of-Care Therapy in Patients with Relapsed/Refractory Large B-Cell Lymphoma

Frederick L. Locke, David B. Miklos, Caron Jacobson, Miguel-Angel Perales, Marie José Kersten, Olalekan O. Oluwole, Armin Ghobadi, Aaron P. Rapoport, Joseph P. McGuirk, John M. Pagel, Javier Muñoz, Umar Farooq, Tom Van Meerten, Patrick M. Reagan, Anna Sureda, Ian W. Flinn, Peter Vandenberghe, Kevin Song, Michael Dickinson, Monique C. Minnema, Peter A. Riedell, Lori A. Leslie, Sridhar Chaganti, Yin Yang, Simone Filosto, Marco Schupp, Christina To, Paul Cheng, Leo I. Gordon, Jason R. Westin
Journal: Blood
Blood (2021) 138 (Supplement 1): 2.
https://doi.org/10.1182/blood-2021-148039
Published: 2021
Journal Articles

TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma

Claudia Manriquez Roman, Michelle J. Cox, Reona Sakemura, Kun Yun, Mohamad M. Adada, Elizabeth L. Siegler, Olivia Sirpilla, Erin E. Tapper, Carli M. Stewart, Ekene J. Ogbodo, Ismail Can, Kendall J. Schick, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Wei Ding, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Gloria Olivier, Nathalie Scholler, Adrian Bot, Mike Mattie, Jenny J. Kim, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 901.
https://doi.org/10.1182/blood-2021-148591
Published: 2021
Journal Articles

A Phase II Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity

Matthew J. Frigault, Kathleen M.E. Gallagher, Marc Wehrli, Betsy Valles, Keagan Casey, Kevin Lindell, Michael Trailor, Hana Cho, Jami L. Brown, Nora K. Horick, Justin Chou, Rhine R. Shen, Simone Filosto, Adrian Bot, Marcela V. Maus
Journal: Blood
Blood (2021) 138 (Supplement 1): 2814.
https://doi.org/10.1182/blood-2021-146927
Published: 2021