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Journal Articles

CAR T cells and time-limited ibrutinib as treatment for relapsed/refractory mantle cell lymphoma: the phase 2 TARMAC study

Clinical Trials & Observations
Adrian Minson, Nada Hamad, Chan Y. Cheah, Constantine Tam, Piers Blombery, David Westerman, David Ritchie, Huw Morgan, Nicholas Holzwart, Stephen Lade, Mary Ann Anderson, Amit Khot, John F. Seymour, Molly Robertson, Imogen Caldwell, Georgina Ryland, Javad Saghebi, Zahra Sabahi, Jing Xie, Rachel Koldej, Michael Dickinson
Journal: Blood
Blood (2024) 143 (8): 673–684.
https://doi.org/10.1182/blood.2023021306
Published: 2024
Includes: Supplemental data
Journal Articles

Changes in Bcl-2 members after ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL

Marco V. Haselager, Karoline Kielbassa, Johanna ter Burg, Danique J. C. Bax, Stacey M. Fernandes, Jannie Borst, Constantine Tam, Francesco Forconi, Giorgia Chiodin, Jennifer R. Brown, Julie Dubois, Arnon P. Kater, Eric Eldering
Journal: Blood
Blood (2020) 136 (25): 2918–2926.
https://doi.org/10.1182/blood.2019004326
Published: 2020
Includes: Supplemental data
Journal Articles

Long-Term Follow-up of Ibrutinib Treatment for Rituximab-Refractory Waldenström's Macroglobulinemia: Final Analysis of the Open-Label Substudy of the Phase 3 iNNOVATE TM Trial

Judith Trotman, FRACP, Christian Buske, MD, Alessandra Tedeschi, MD, Jeffrey V. Matous, MD, David MacDonald, MD, Constantine Tam, MBBS, Olivier Tournilhac, MD PhD, Shuo Ma, MD PhD, Steven P. Treon, MD PhD, Albert Oriol, Jerry Ping, PhD, Eva M. Briso, PhD, Israel Arango-Hisijara, MD, Meletios A. Dimopoulos, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–39.
https://doi.org/10.1182/blood-2020-133916
Published: 2020
Journal Articles

Sustained Disease Control for Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma: An Updated Analysis of Juliet, a Global Pivotal Phase 2 Trial of Tisagenlecleucel

Stephen J. Schuster, MD, Michael R. Bishop, MD, Constantine Tam, MD PhD, Peter Borchmann, MD, Ulrich Jaeger, MD, Edmund K. Waller, MD, Harald Holte, MD PhD, Joseph P. McGuirk, DO, Samantha Jaglowski, MDMPH, Kensei Tobinai, MD PhD, Charalambos Andreadis, MD MSCE, Isabelle Fleury, Stephan Mielke, MD, Takanori Teshima, Jason R. Westin, MD, Veronika Bachanova, MD PhD, Stephen Ronan Foley, MD FRCPC, P Joy Ho, MBBS(Syd) DPhil(Oxon) FRACP FRCPA FFSc(RCPA), John M. Magenau, MD, Nina D. Wagner-Johnston, MD, Koji Kato, MD PhD, Marie Jose Kersten, MD PhD, Koen Van Besien, MD PhD, Jufen Chu, PhD, Aline Jary, MS, Özlem Anak, MD, Gilles Salles, MD PhD, Richard Thomas T. Maziarz, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1684.
https://doi.org/10.1182/blood-2018-99-115252
Published: 2018
Journal Articles

Bing Neel Syndrome: Retrospective Australasian Experience of a Rare Treatable Complication of Waldenström Macroglobulinaemia/ Lymphoplasmacytic Lymphoma

Dipti Talaulikar, PhD FRACP, FRCPA, MBBS, Tara Cochrane, MBBS, John Gibson, Nada Hamad, MBBS, BSc, MSc, Phoebe Joy Ho, MBBS DPhil FRACP FRCPA, Samar Issa, FRACP, Kwok Fiona, Jun Hee Lim, PhD, David Simpson, MBChB, FRACP, FRCPA, Constantine Tam, MD PhD, Jorge J. Castillo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5325.
https://doi.org/10.1182/blood-2018-99-113969
Published: 2018
Journal Articles

The Effect of Btk Inhibitors on Haemostasis and Thrombosis

Gasim Dobie, PhD, Daniel Man-yuen Sze, PhD, Constantine Tam, MD PhD, Denise Jackson, BAppSc (MLS), FAIMS, PhD FFSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 1126.
https://doi.org/10.1182/blood-2018-99-109803
Published: 2018
Journal Articles

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax

Clinical Trials & Observations
Mary Ann Anderson, Constantine Tam, Thomas E. Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David C. S. Huang, John F. Seymour, Andrew W. Roberts
Journal: Blood
Blood (2017) 129 (25): 3362–3370.
https://doi.org/10.1182/blood-2017-01-763003
Published: 2017
Includes: Supplemental data
Journal Articles

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

Clinical Trials & Observations
Michael R. Grever, Omar Abdel-Wahab, Leslie A. Andritsos, Versha Banerji, Jacqueline Barrientos, James S. Blachly, Timothy G. Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D. Ho, James B. Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J. Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A. Parikh, Jae H. Park, Aaron Polliack, Graeme R. Quest, Kanti R. Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F. Seymour, Tamar Tadmor, Martin S. Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S. Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini
Journal: Blood
Blood (2017) 129 (5): 553–560.
https://doi.org/10.1182/blood-2016-01-689422
Published: 2017
Journal Articles

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

Mary Ann Anderson, Jing Deng, John F. Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R. Brown, David Westerman, Eric G. Si, Ian J. Majewski, David Segal, Sari L. Heitner Enschede, David C. S. Huang, Matthew S. Davids, Anthony Letai, Andrew W. Roberts
Journal: Blood
Blood (2016) 127 (25): 3215–3224.
https://doi.org/10.1182/blood-2016-01-688796
Published: 2016
Includes: Supplemental data
Journal Articles

Ibrutinib Therapy in Rituximab-Refractory Patients with Waldenström's Macroglobulinemia: Initial Results from an International, Multicenter, Open-Label Phase 3 Substudy (iNNOVATE TM )

Meletios A. Dimopoulos, MD, Judith Trotman, FRACP, Alessandra Tedeschi, MD, Jeffrey V. Matous, MD, David Macdonald, MD MSc, FRCPC, Constantine Tam, MBBS, MD, Oliver Tournilhac, MD, Shuo Ma, MD PhD, Albert Oriol, MDPhD, Leonard T. Heffner, MD, Chaim Shustik, MD, Ramón García-Sanz, MD PhD, Robert F. Cornell, Carlos Fernández de Larrea, MD PhD, Jorge J. Castillo, MD, Miquel Granell, MD, Marie-Christine Kyrtsonis, MD, Veronique Leblond, MD PhD, Argiris Symeonidis, MD PhD, Priyanka Singh, MS, Jianling Li, MS, Thorsten Graef, MD PhD, Elizabeth Bilotti, MSN, Steven Treon, MD PhD, Christian Buske, MD
Journal: Blood
Blood (2015) 126 (23): 2745.
https://doi.org/10.1182/blood.V126.23.2745.2745
Published: 2015
Journal Articles

Favorable Patient Survival after Failure of Venetoclax (ABT-199/ GDC-0199) Therapy for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

Constantine Tam, MBBS, MD, Mary Ann Anderson, MBBS, David S. Ritchie, MDPhD, E. Henry Januszewicz, MBBS, Dennis Carney, Andrew W. Roberts, MBBS, PhD, John F. Seymour, MBBS, PhD
Journal: Blood
Blood (2015) 126 (23): 2939.
https://doi.org/10.1182/blood.V126.23.2939.2939
Published: 2015
Journal Articles

The BTK Inhibitor, Bgb-3111, Is Safe, Tolerable, and Highly Active in Patients with Relapsed/ Refractory B-Cell Malignancies: Initial Report of a Phase 1 First-in-Human Trial

Constantine Tam, MBBS, MD, Andrew P Grigg, MBBS MD, Stephen Opat, MBBS, Matthew Ku, MBBS, Michael Gilbertson, MBBS, Mary Ann Anderson, MBBS, John F. Seymour, MBBS, PhD, David S. Ritchie, MDPhD, Carmen Dicorleto, Belinda Dimovski, Eric Hedrick, Jianxin Yang, Lai Wang, PhD, Lusong Luo, Ling Xue, Andrew W. Roberts, MBBS, PhD
Journal: Blood
Blood (2015) 126 (23): 832.
https://doi.org/10.1182/blood.V126.23.832.832
Published: 2015
Journal Articles

Outcome of Ibrutinib Treatment by Baseline Genetic Features in Patients with Relapsed or Refractory CLL/SLL with del17p in the Resonate-17 Study

Stephan Stilgenbauer, MD, Jeffrey A. Jones, MD MPH, Steven Coutre, MD, Anthony R. Mato, MD MSCE, Peter Hillmen, MB, ChB, PhD, Constantine Tam, MBBS, MD, Anders Osterborg, MD PhD, Tanya Siddiqi, MD, Michael J. Thirman, MD, Richard R. Furman, MD, Osman Ilhan, Michael Keating, MBBS, Timothy G. Call, MD, Jennifer R. Brown, MD PhD, Yunfeng Li, PhD, Karl Eckert, BA, Betty Y. Chang, PhD, Danelle F. James, MD MAS, Alvina D. Chu, MD, Michael Hallek, MD, Susan O'Brien, MD
Journal: Blood
Blood (2015) 126 (23): 833.
https://doi.org/10.1182/blood.V126.23.833.833
Published: 2015
Journal Articles

TIDEL-II: first-line use of imatinib in CML with early switch to nilotinib for failure to achieve time-dependent molecular targets

Clinical Trials & Observations
David T. Yeung, Michael P. Osborn, Deborah L. White, Susan Branford, Jodi Braley, Alan Herschtal, Michael Kornhauser, Samar Issa, Devendra K. Hiwase, Mark Hertzberg, Anthony P. Schwarer, Robin Filshie, Christopher K. Arthur, Yiu Lam Kwan, Judith Trotman, Cecily J. Forsyth, John Taper, David M. Ross, Jennifer Beresford, Constantine Tam, Anthony K. Mills, Andrew P. Grigg, Timothy P. Hughes
Journal: Blood
Blood (2015) 125 (6): 915–923.
https://doi.org/10.1182/blood-2014-07-590315
Published: 2015
Includes: Supplemental data
Journal Articles

Lack of durable disease control with chemotherapy for mycosis fungoides and Sézary syndrome: a comparative study of systemic therapy

Clinical Trials & Observations
Charlotte F. M. Hughes, Amit Khot, Christopher McCormack, Stephen Lade, David A. Westerman, Robert Twigger, Odette Buelens, Kate Newland, Constantine Tam, Michael Dickinson, Gail Ryan, David Ritchie, Colin Wood, H. Miles Prince
Journal: Blood
Blood (2015) 125 (1): 71–81.
https://doi.org/10.1182/blood-2014-07-588236
Published: 2015
Includes: Supplemental data
Journal Articles

Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions

Brief Report
Marie Levade, Elodie David, Cédric Garcia, Pierre-Alexandre Laurent, Sarah Cadot, Anne-Sophie Michallet, Jean-Claude Bordet, Constantine Tam, Pierre Sié, Loïc Ysebaert, Bernard Payrastre
Journal: Blood
Blood (2014) 124 (26): 3991–3995.
https://doi.org/10.1182/blood-2014-06-583294
Published: 2014
Includes: Multimedia, Supplemental data
Journal Articles

Hematologic and Immunologic Function and Patient Well-Being for the Phase III RESONATE TM Study of Ibrutinib Vs Ofatumumab in Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Jacqueline C. Barrientos, MD, Susan O'Brien, Jennifer R. Brown, MD PhD, Neil E. Kay, MD, Nishitha M. Reddy, MBBS, Steven Coutre, MD, Constantine Tam, MD, Stephen Mulligan, MBBS, MD FRACP, FRCPA, Ulrich Jaeger, MD, Steve Devereux, MD, Christopher Pocock, MD PhD, Tadeusz Robak, MD, Stephen J. Schuster, MD, Anna Schuh, MDPhD, Devinder Gill, MD, Adrian Bloor, PhD FRCPath, Claire Dearden, MD, Carol Moreno, MD, Gavin Cull, MBBS, DM, FRACP, FRCPA, Michael Hamblin, Jeffrey A. Jones, MD, Tanja Kierschniak, Karl Eckert, BA, Samuel Suzuki, MS, MBA, Emily Hsu, PhD, Danelle F. James, MD MAS, John C. Byrd, MD, Peter Hillmen, MB, ChB, PhD
Journal: Blood
Blood (2014) 124 (21): 4696.
https://doi.org/10.1182/blood.V124.21.4696.4696
Published: 2014
Journal Articles

Efficacy and Safety of Ibrutinib in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia with 17p Deletion: Results from the Phase II RESONATE™-17 Trial

Susan O'Brien, MD, Jeffrey A. Jones, MD, Steven Coutre, MD, Anthony R. Mato, MD, Peter Hillmen, MB, ChB, PhD, Constantine Tam, MD, Anders Osterborg, MD PhD, Tanya Siddiqi, MD, Michael J. Thirman, MD, Richard R. Furman, MD, Osman Ilhan, MD, Michael Keating, MBBS, Timothy G. Call, MD, Jennifer R. Brown, MD PhD, Michelle Stevens-Brogan, MS, Yunfeng Li, PhD, Maria Fardis, PhD MBA, Fong Clow, ScD, Danelle F. James, MD MAS, Alvina D. Chu, MD, Michael Hallek, MD, Stephan Stilgenbauer, MD
Journal: Blood
Blood (2014) 124 (21): 327.
https://doi.org/10.1182/blood.V124.21.327.327
Published: 2014
Journal Articles

Updated Efficacy Including Genetic and Clinical Subgroup Analysis and Overall Safety in the Phase 3 RESONATE TM Trial of Ibrutinib Versus Ofatumumab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Jennifer R. Brown, MD PhD, Peter Hillmen, MB, ChB, PhD, Susan O'Brien, MD, Jaqueline C. Barrientos, MD, Nishitha Reddy, MBBS, MScl, Steven Coutre, MD, Constantine Tam, MD, Stephen Mulligan, MBBS, MD FRACP, FRCPA, Ulrich Jaeger, MD, Paul M. Barr, MD, Richard R. Furman, MD, Thomas J. Kipps, MD, Florence Cymbalista, MD, Patrick Thornton, MD, Federico Caligaris-Cappio, MD, Julio Delgado, MD, Marco Montillo, MD, Sven DeVos, MD, Carol Moreno, MD, John Pagel, MD PhD, Jan A. Burger, MD PhD, Devon Chung, BS, Jennifer Lin, MA, MS, Linda Gau, MS, Betty Chang, PhD, Jesse McGreivy, MD, Danelle F. James, MD MAS, John C. Byrd, MD
Journal: Blood
Blood (2014) 124 (21): 3331.
https://doi.org/10.1182/blood.V124.21.3331.3331
Published: 2014
Journal Articles

Elucidation of Mild Bleeding Disorders Reported Under Ibrutinib (Imbruvica(R)) Therapy: Implications for Optimal Clinical Management

Loic Ysebaert, Marie Levade, PhD, Garcia Cedric, Anne-Sophie Michallet, MD PhD, Constantine Tam, MD, Sie Pierre, MDPhD, Bernard Payrastre
Journal: Blood
Blood (2014) 124 (21): 3296.
https://doi.org/10.1182/blood.V124.21.3296.3296
Published: 2014