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Denise Brennan
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Journal Articles

Evaluation of AZD0486, a Novel CD19xCD3 T-Cell Engager, in Relapsed/Refractory Diffuse Large B-Cell Lymphoma in an Ongoing First-in-Human Phase 1 Study: High Complete Responses Seen in CAR-T-Naive and CAR-T-Exposed Patients

Sameh Gaballa, Jing-Zhou Hou, Sumana Devata, Seok-Goo Cho, Ranjit Nair, Dok Hyun Yoon, Ryan Jacobs, Koji Izutsu, Don A. Stevens, Dai Maruyama, Constantine S. Tam, Yazeed Sawalha, Aravind Ramakrishnan, Matthew Matasar, Denise Brennan, Sue Zhu, Robin Lesley, Yasuhiro Oki, David Sermer, Tae Min Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 868.
https://doi.org/10.1182/blood-2024-193681
Published: 2024
Journal Articles

Escalating Doses of AZD0486, a Novel CD19xCD3 T-Cell Engager, Result in High Complete Remissions with Rapid Clearance of Minimal Residual Disease in Patients with Relapsed/Refractory Follicular Lymphoma

Jing-Zhou Hou, Ranjit Nair, Ryan Jacobs, Tae Min Kim, Seok-Goo Cho, Dai Maruyama, Sumana Devata, Yazeed Sawalha, Dok Hyun Yoon, Constantine S. Tam, Koji Izutsu, Matthew Matasar, Don A. Stevens, Aravind Ramakrishnan, Denise Brennan, Xu Zhu, Robin Lesley, Yasuhiro Oki, David Sermer, Sameh Gaballa
Journal: Blood
Blood (2024) 144 (Supplement 1): 341.
https://doi.org/10.1182/blood-2024-193589
Published: 2024
Journal Articles

Exposure-Response Analysis and Quantitative Systems Pharmacology Modeling for Optimal RP2D Selection of AZD0486 in Follicular Lymphoma Patients

Xu (Sue) Zhu, Damilola Olabode, Massimo Lai, Cesar Pichardo-Almarza, Kevin Smart, Denise Brennan, David Sermer, Robin Lesley
Journal: Blood
Blood (2024) 144 (Supplement 1): 2794.
https://doi.org/10.1182/blood-2024-197995
Published: 2024
Journal Articles

Double Step-up Dosing (2SUD) Regimen Mitigates Severe Icans and CRS While Maintaining High Efficacy in Subjects with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (NHL) Treated with AZD0486, a Novel CD19xCD3 T-Cell Engager (TCE): Updated Safety and Efficacy Data from the Ongoing First-in-Human (FIH) Phase 1 Trial

Sameh Gaballa, Ranjit Nair, Ryan W Jacobs, Sumana Devata, Seok-Goo Cho, Don A. Stevens, Dok Hyun Yoon, Nirav N. Shah, Denise Brennan, Jason Law, Robert Chen, David Sermer, Robin Lesley, Ben Buelow, Alessandra Forcina, Jing-Zhou Hou
Journal: Blood
Blood (2023) 142 (Supplement 1): 1662.
https://doi.org/10.1182/blood-2023-174668
Published: 2023