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Ben Buelow
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Journal Articles

Double Step-up Dosing (2SUD) Regimen Mitigates Severe Icans and CRS While Maintaining High Efficacy in Subjects with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (NHL) Treated with AZD0486, a Novel CD19xCD3 T-Cell Engager (TCE): Updated Safety and Efficacy Data from the Ongoing First-in-Human (FIH) Phase 1 Trial

Sameh Gaballa, Ranjit Nair, Ryan W Jacobs, Sumana Devata, Seok-Goo Cho, Don A. Stevens, Dok Hyun Yoon, Nirav N. Shah, Denise Brennan, Jason Law, Robert Chen, David Sermer, Robin Lesley, Ben Buelow, Alessandra Forcina, Jing-Zhou Hou
Journal: Blood
Blood (2023) 142 (Supplement 1): 1662.
https://doi.org/10.1182/blood-2023-174668
Published: 2023
Journal Articles

Interim Results of the Phase 1 Study of Tnb-486, a Novel CD19xCD3 T-Cell Engager, in Patients with Relapsed/Refractory (R/R) B-NHL

Jing-Zhou Hou, Ryan Jacobs, Seok-Goo Cho, Sumana Devata, Sameh Gaballa, Dok Hyun Yoon, Don A. Stevens, Jin Seok Kim, Ben Buelow, Ranjit Nair
Journal: Blood
Blood (2022) 140 (Supplement 1): 1474–1475.
https://doi.org/10.1182/blood-2022-166385
Published: 2022
Journal Articles

A Phase 1 First-in-Human Study of Tnb-383B, a BCMA x CD3 Bispecific T-Cell Redirecting Antibody, in Patients with Relapsed/Refractory Multiple Myeloma

Shaji Kumar, Anita D'Souza, Nina Shah, Cesar Rodriguez, Peter M. Voorhees, Orlando F. Bueno, Ben Buelow, Kevin J. Freise, Susan Yue, Rajvineeth Kumar Pothacamury, Akshanth R. Polepally, Ravi Vij
Journal: Blood
Blood (2021) 138 (Supplement 1): 900.
https://doi.org/10.1182/blood-2021-150757
Published: 2021
Journal Articles

Initial Results of a Phase I Study of TNB-383B, a BCMA x CD3 Bispecific T-Cell Redirecting Antibody, in Relapsed/Refractory Multiple Myeloma

Cesar Rodriguez, MD, Anita D'Souza, MD MS, Nina Shah, MD, Peter M. Voorhees, MD, Ben Buelow, MD PhD, Ravi Vij, MBBS, Shaji K. Kumar, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-139893
Published: 2020
Journal Articles

TNB383B.0001: A Multicenter, Phase 1, Open-Label, Dose-Escalation Andexpansion Study of TNB-383B, a Bispecific Antibodytargeting BCMA in Subjects with Relapsed or Refractorymultiple Myeloma

Ben Buelow, MD PhD, Anita D'Souza, MBBS, Cesar Rodriguez, MD, Ravi Vij, MBBS, Rajneesh Nath, MD, Melinda Snyder, MS, Duy Pham, MBA, Ashwin Patel, PhD, Suhasini Iyer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1874.
https://doi.org/10.1182/blood-2019-123220
Published: 2019
Journal Articles

TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Harbani Malik, PhD, Ben Buelow, MD PhD, Udaya Rangaswamy, PhD, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, PhD, Shelley Force Aldred, Katherine Marie Harris, MD, Suhasini Iyer, PhD, Brett Jorgensen, PhD, Duy Pham, MBA, Kirthana Prabhakar, Ute Schellenberger, PhD, Harshad Ugamraj, Nathan Trinklein, PhD, Wim Van Schooten, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4070.
https://doi.org/10.1182/blood-2019-123226
Published: 2019
Journal Articles

T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma

Lekha Mikkilineni, MD, Elisabet E. Manasanch, MD, Norris Lam, BS, Danielle Vanasse, BS, Jennifer N. Brudno, MD, Irina Maric, MD MSci, Jeremy J. Rose, MS, Maryalice Stetler-Stevenson, MD PhD, Hao-Wei Wang, MD PhD, Constance M. Yuan, MD PhD, David F. Stroncek, MD, Jennifer Mann, CRNP, Micaela Ganadan, BSN, RN, Rashmika Patel, Nathan Trinklein, PhD, Ben Buelow, MD PhD, Ronald E. Gress, MD, James N. Kochenderfer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3230.
https://doi.org/10.1182/blood-2019-129088
Published: 2019
Journal Articles

A Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills Lymphoma Cells with Minimal Cytokine Secretion

Harbani Malik, PhD, Ben Buelow, MD PhD, Brian Avanzino, Aarti Balasubramani, Andrew Boudreau, Starlynn Clarke, PhD, Kevin Dang, Laura Davison, PhD, Shelley Force Aldred, Katherine Harris, PhD, Brett Jorgensen, PhD, Yuping Li, PhD, Harish Medlari, Keshav Narayan, Heather Ogana, Duy Pham, Kirthana Prabhakar, Udaya Rangaswamy, PhD, Preethi Sankaran, Ute Schellenberger, PhD, Harshad Ugamraj, Nathan Trinklein, PhD, Wim Van Schooten, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1671.
https://doi.org/10.1182/blood-2018-99-118913
Published: 2018
Journal Articles

Ex Vivo Assessment of Tnb-383B, a Bcma-Bispecific Antibody, Against Primary Tumor and Endogenous T Cells from Relapsing Multiple Myeloma Patients

David M. Foureau, PhD, Manisha Bhutani, MD, Myra Robinson, MS, Fei Guo, PhD, Duy Pham, Shelley Force Aldred, Ben Buelow, MD PhD, Katherine Rigby, Elise Tjaden, Marina Leonidas, Shebli Atrash, Ami P Ndiaye, NP, James Symanowski, PhD, Peter M. Voorhees, MD, Saad Z. Usmani, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1940.
https://doi.org/10.1182/blood-2018-99-118881
Published: 2018
Journal Articles

T Cells Expressing Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptors with Antigen Recognition Domains Made up of Only Single Human Heavy Chain Variable Domains Specifically Recognize Bcma and Eradicate Tumors in Mice

Norris Lam, BS, Leah Alabanza, PhD, Nathan Trinklein, PhD, Ben Buelow, MD PhD, James N. Kochenderfer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 504.
https://doi.org/10.1182/blood.V130.Suppl_1.504.504
Published: 2017
Journal Articles

T Cell Engagement without Cytokine Storm: A Novel Bcma x CD3 Antibody Killing Myeloma Cells with Minimal Cytokine Secretion

Ben Buelow, MD PhD, Duy Pham, Priya Choudhry, PhD, Kevin Dang, Payal Pratap, Starlynn Clarke, PhD, Katherine Harris, PhD, Brett Jorgensen, PhD, Shelley Force Aldred, Ute Schellenberger, PhD, Nina Shah, MD, Nathan Trinklein, PhD, Arun P. Wiita, MD PhD, Suhasini Iyer, PhD, Wim Van Schooten, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 501.
https://doi.org/10.1182/blood.V130.Suppl_1.501.501
Published: 2017