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Koji Izutsu
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Journal Articles

Pirtobrutinib in Richter Transformation: Updated Efficacy and Safety Results with 18-Month Median Survival Follow-up from the Phase 1/2 BRUIN Study

William G. Wierda, Nirav N. Shah, Chan Yoon Cheah, David Lewis, Marc S. Hoffmann, Catherine C. Coombs, Nicole Lamanna, Shuo Ma, Deepa Jagadeesh, Talha Munir, Yucai Wang, Toby A. Eyre, Joanna M. Rhodes, Matthew McKinney, Ewa Lech-Maranda, Constantine S. Tam, Wojciech Jurczak, Koji Izutsu, Alvaro J. Alencar, Manish Patel, John F. Seymour, Jennifer A. Woyach, Lindsey E. Roeker, Philip A. Thompson, Paolo Abada, Caleb Ho, Narasimha Marella, Chunxiao Wang, Amy S. Ruppert, Binoj Chandrasekharan Nair, Hui Liu, Donald E. Tsai, Paolo Ghia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1737.
https://doi.org/10.1182/blood-2023-181108
Published: 2023
Journal Articles

Impact of Mogamulizumab-Containing Chemotherapy on HBV Reactivation in Patients with T-Cell Lymphoma: A Multicenter Retrospective Observational Study (PROACTIVE-MOGA)

Kisato Nosaka, Shigeru Kusumoto, Yoshitaka Imaizumi, Hiroya Hashimoto, Junya Makiyama, Makoto Yoshimitsu, Takeharu Kato, Hidenori Sasaki, Youko Suehiro, Ki-Ryang Koh, Toyotaka Kawamata, Toshikazu Miyakawa, Yoshifusa Takatsuka, Takayuki Sato, Yuko Shirouchi, Koji Kato, Koji Izutsu, Tohru Murayama, Takehiro Higashi, Hiromi Iwasaki, Satoru Kosugi, Hitoji Uchiyama, Kunihiro Tsukasaki, Yusuke Yamashita, Fumiya Ogasawara, Emiko Sakaida, Takero Shindo, Kimikazu Yakushijin, Keiichi Akizuki, Ken-ichiro Etoh, Noriaki Kawano, Tetsuyuki Igarashi, Noriko Fukuhara, Nobuhiko Nakamura, Isao Yoshida, Nobuaki Nakano, Tomoharu Yoshizumi, Masashi Mizokami
Journal: Blood
Blood (2023) 142 (Supplement 1): 6192.
https://doi.org/10.1182/blood-2023-185878
Published: 2023
Journal Articles

Efficacy and Safety of Valemetostat Monotherapy in Patients with Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results of the Phase 2 VALENTINE-PTCL01 Study

Steven M. Horwitz, Koji Izutsu, Neha Mehta-Shah, Raul Cordoba, Stefan K. Barta, Emmanuel Bachy, Giuseppe Gritti, Eric Jacobsen, Shigeru Kusumoto, Yann Guillermin, Anca Prica, Dok Hyun Yoon, Eva Domingo Domenech, Jie Wang, Jin Seok Kim, Kate Cwynarski, Marjolein van der Poel, Ai Inoue, Jin Jin, Sutan Wu, Keiko Nakajima, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 302.
https://doi.org/10.1182/blood-2023-179304
Published: 2023
Journal Articles

Patient-Reported Outcomes (PROs) Among Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Receiving Pirtobrutinib: Analysis from the BRUIN Phase 1/2 Study

Catherine C. Coombs, Jennifer A. Woyach, Jennifer R. Brown, Paolo Ghia, Lindsey E. Roeker, Krish Patel, Toby A. Eyre, Constantine S. Tam, John F. Seymour, Nirav N. Shah, Ian W. Flinn, Chan Y. Cheah, Shuo Ma, Joanna M. Rhodes, Koji Izutsu, Wojciech Jurczak, William G. Wierda, Angely Loubert, Nalin Payakachat, Lisa M. Hess, Paolo Abada, Nicole Lamanna
Journal: Blood
Blood (2023) 142 (Supplement 1): 6535.
https://doi.org/10.1182/blood-2023-186145
Published: 2023
Journal Articles

Survival and CNS Relapse in Patients with CD5-Positive Diffuse Large B-Cell Lymphoma: A Multi-Institutional Observational Study in Japan

Yuma Nato, Kana Miyazaki, Dai Maruyama, Hiroyuki Takahashi, Kazutaka Sunami, Satsuki Murakami, Eiju Negoro, Yuri Miyazawa, Ilseung Choi, Takahiro Okada, Nobuyuki Takayama, Naoto Tomita, Shuji Momose, Yuto Kaneda, Masahiro Yoshida, Hiroshi Gomyo, Kohtaro Toyama, Momoko Nishikori, Akio Saito, Junji Hiraga, Taro Masunari, Naoki Takahashi, Junya Makiyama, Tomotaka Suzuki, Hiroko Tsunemine, Jun Takizawa, Takeharu Kato, Yasufumi Masaki, Noriko Fukuhara, Masataka Okamoto, Isao Tawara, Naoko Asano, Koichi Ohshima, Koji Izutsu, Koji Kato, Ritsuro Suzuki, Motoko Yamaguchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1762.
https://doi.org/10.1182/blood-2023-174647
Published: 2023
Journal Articles

TRANSCEND FL: Phase 2 Study Primary Analysis of Lisocabtagene Maraleucel as Second-Line Therapy in Patients with High-Risk Relapsed or Refractory Follicular Lymphoma

Franck Morschhauser, Saurabh Dahiya, M. Lia Palomba, Alejandro Martin Garcia-Sancho, Juan Luis Reguera, John Kuruvilla, Ulrich Jaeger, Guillaume Cartron, Koji Izutsu, Martin Dreyling, Brad S. Kahl, Herve Ghesquieres, Kirit Ardeshna, Hideki Goto, Anna Maria Barbui, Jeremy S. Abramson, Peter Borchmann, Isabelle Fleury, Stephan Mielke, Alan Skarbnik, Sven de Vos, Manali Kamdar, Reem Karmali, Andreas Viardot, Thalia Farazi, Omotayo Fasan, James Lymp, Min Vedal, Rina Nishii, Ariel Avilion, Jessica Papuga, Loretta J. Nastoupil
Journal: Blood
Blood (2023) 142 (Supplement 1): 602.
https://doi.org/10.1182/blood-2023-179474
Published: 2023
Journal Articles

Valemetostat for Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results from a Phase 1 Trial

Eric Jacobsen, Dai Maruyama, Pierluigi Porcu, Kensei Tobinai, Pamela B. Allen, Kenji Ishitsuka, Kunihiro Tsukasaki, Shigeru Kusumoto, Francine M. Foss, Nobuhiko Yamauchi, Satoko Morishima, Yoshitaka Imaizumi, Koji Izutsu, Tatyana Feldman, Toyotaka Kawamata, Yasuyuki Kakurai, Hideyuki Yamauchi, Noha Biserna, Ai Inoue, Shinji Tsutsumi, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 303.
https://doi.org/10.1182/blood-2023-172512
Published: 2023
Journal Articles

Valemetostat for Relapsed or Refractory B-Cell Lymphomas: Primary Results from a Phase 1 Trial

Koji Izutsu, Kenji Ishitsuka, Dai Maruyama, Kunihiro Tsukasaki, Shigeru Kusumoto, Yasuyuki Kakurai, Hideyuki Yamauchi, Ai Inoue, Masaya Tachibana, Shinji Tsutsumi, Kensei Tobinai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1731.
https://doi.org/10.1182/blood-2023-179301
Published: 2023
Journal Articles

Pirtobrutinib in Post-cBTKi CLL/SLL: ~30 Months Follow-up and Subgroup Analysis With/Without Prior BCL2i from the Phase 1/2 BRUIN Study

Jennifer A. Woyach, Jennifer R. Brown, Paolo Ghia, Lindsey E. Roeker, Krish Patel, Toby A. Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine S. Tam, John F. Seymour, Benoit Tessoulin, Nirav N. Shah, Chaitra S Ujjani, Bita Fakhri, Catherine C. Coombs, Ian W. Flinn, Manish Patel, Sunita D. Nasta, Jonathon B. Cohen, Alvaro J. Alencar, Chan Y. Cheah, Shuo Ma, Joanna M. Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Osterborg, Koji Izutsu, Donald E. Tsai, Paolo Abada, Minna Balbas, Jian Li, Amy S. Ruppert, Wojciech Jurczak, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 325.
https://doi.org/10.1182/blood-2023-185852
Published: 2023
Journal Articles

Patient-Reported Outcomes (PROs) from the Phase 2 TRANSCEND FL Study of Lisocabtagene Maraleucel (liso-cel) in Patients (pts) with Relapsed or Refractory Follicular Lymphoma (FL)

Guillaume Cartron, Alejandro Martin Garcia-Sancho, Juan Luis Reguera, Saurabh Dahiya, Shien Guo, Ling Shi, Laurie Eliason, Jinender Kumar, Thalia Farazi, Omotayo Fasan, Koji Izutsu
Journal: Blood
Blood (2023) 142 (Supplement 1): 668.
https://doi.org/10.1182/blood-2023-180175
Published: 2023
Journal Articles

Polatuzumab vedotin in previously untreated DLBCL: an Asia subpopulation analysis from the phase 3 POLARIX trial

Clinical Trials & Observations
Yuqin Song, Hervé Tilly, Shinya Rai, Huilai Zhang, Jie Jin, Hideki Goto, Yasuhito Terui, Ho-Jin Shin, Won Seog Kim, Junning Cao, Jifeng Feng, Hyeon Seok Eom, Tae Min Kim, Xavier Cheng-Hong Tsai, Jyh-Pyng Gau, Hideo Koh, Liling Zhang, Yongping Song, Yu Yang, Wei Li, He Huang, Kiyoshi Ando, Jeff P. Sharman, Laurie H. Sehn, Lilian Bu, Xin Wang, Yanwen Jiang, Jamie Hirata, Calvin Lee, Jun Zhu, Koji Izutsu
Journal: Blood
Blood (2023) 141 (16): 1971–1981.
https://doi.org/10.1182/blood.2022017734
Published: 2023
Includes: Supplemental data
Journal Articles

Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the phase 3 TRANSFORM study

Clinical Trials & Observations
Jeremy S. Abramson, Scott R. Solomon, Jon Arnason, Patrick B. Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew Lunning, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Ken Ogasawara, Manali Kamdar
Journal: Blood
Blood (2023) 141 (14): 1675–1684.
https://doi.org/10.1182/blood.2022018730
Published: 2023
Includes: Supplemental data
Journal Articles

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma

Clinical Trials & Observations
Koji Izutsu, Shinichi Makita, Kisato Nosaka, Makoto Yoshimitsu, Atae Utsunomiya, Shigeru Kusumoto, Satoko Morishima, Kunihiro Tsukasaki, Toyotaka Kawamata, Takaaki Ono, Shinya Rai, Hiroo Katsuya, Jun Ishikawa, Hironori Yamada, Kazunobu Kato, Masaya Tachibana, Yasuyuki Kakurai, Nobuaki Adachi, Kensei Tobinai, Kentaro Yonekura, Kenji Ishitsuka
Journal: Blood
Blood (2023) 141 (10): 1159–1168.
https://doi.org/10.1182/blood.2022016862
Published: 2023
Includes: Supplemental data
Journal Articles

Efficacy of Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed / Refractory Waldenström Macroglobulinemia: Results from the Phase 1/2 BRUIN Study

M.Lia Palomba, Manish R. Patel, Toby A. Eyre, Wojciech Jurczak, David John Lewis, Thomas Gastinne, Shuo Ma, Jonathon B. Cohen, Krish Patel, Jennifer R. Brown, Lydia Scarfò, Talha Munir, Ewa Lech-Marańda, Marc Hoffmann, Chaitra S. Ujjani, Bita Fakhri, Michael L. Wang, Koji Izutsu, Hirokazu Nagai, Constantine S. Tam, John F. Seymour, Joanna M. Rhodes, Julie M. Vose, Matthew McKinney, James N. Gerson, Minal A. Barve, Bryone J. Kuss, Youngil Koh, Wei Gao, Amy S. Ruppert, Richard A. Walgren, Donald E. Tsai, Binoj Nair, Katherine Bao, Anthony R. Mato, Chan Y. Cheah
Journal: Blood
Blood (2022) 140 (Supplement 1): 557–560.
https://doi.org/10.1182/blood-2022-159123
Published: 2022
Journal Articles

Lisocabtagene Maraleucel (liso-cel) Versus Standard of Care (SOC) with Salvage Chemotherapy Followed By Autologous Stem Cell Transplantation (ASCT) As Second-Line (2L) Treatment in Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL): Primary Analysis of the Randomized, Phase 3 Transform Study

Jeremy S. Abramson, Scott R. Solomon, Jon E. Arnason, Patrick B. Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew A. Lunning, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Manali Kamdar
Journal: Blood
Blood (2022) 140 (Supplement 1): 1581–1583.
https://doi.org/10.1182/blood-2022-159702
Published: 2022
Journal Articles

Duvelisib in Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma from the Phase 2 Primo Trial Expansion Phase: Impact of Prior Treatment and Expanded Safety Analysis

Eric D Jacobsen, Pier Luigi Zinzani, Jasmine Zain, Monica Mead, Carla Casulo, Giuseppe Gritti, Lauren C. Pinter-Brown, Koji Izutsu, Marci Daugherty, Jonathan E Brammer, Neha Mehta-Shah, Barbara Pro, Steven M. Horwitz
Journal: Blood
Blood (2022) 140 (Supplement 1): 9387–9389.
https://doi.org/10.1182/blood-2022-169432
Published: 2022
Journal Articles

Efficacy and Safety of Zanubrutinib in Japanese Patients with Mature B-Cell Malignancies

Takayuki Ishikawa, Masahiro Takeuchi, Kazuyuki Shimada, Kohmei Kubo, Takeshi Kondo, Katsuya Fujimoto, Tomoaki Fujisaki, Koji Nagafuji, Rika Sakai, Shingo Kurahashi, Tatsuro Jo, Kazutaka Sunami, Senji Kasahara, Tomonori Nakazato, Haiyi Guo, William Novotny, Chris Tankersley, Motohisa Takai, Hui Yao, Jinhua Zhong, Hongjie Zhu, Koji Izutsu
Journal: Blood
Blood (2022) 140 (Supplement 1): 3663–3665.
https://doi.org/10.1182/blood-2022-168696
Published: 2022
Journal Articles

Real-World Evidence for the Safety and Effectiveness of Tirabrutinib in 140 Japanese Patients with Recurrent or Refractory Primary Central Nervous System Lymphoma: Interim Report of Postmarketing Surveillance

Akira Kawasaki, Masaru Matsushita, Shingo Yoshida, Tanomu Matsukura, Koji Izutsu, Ryo Nishikawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 6685–6686.
https://doi.org/10.1182/blood-2022-156472
Published: 2022
Journal Articles

Preclinical Translational Research Suggests a Clinical Trial Strategy for a Novel MALT1 Inhibitor ONO-7018/CTX-177 Against Malignant Lymphomas

Daisuke Morishita, Akio Mizutani, Hiroko Yamakawa, Yasuyoshi Arikawa, Hirokazu Tozaki, Takuro Kameda, Ayako Kamiunten, Keisuke Kataoka, Akinori Yoda, Yotaro Ochi, Kotaro Shide, Koji Izutsu, Yosuke Minami, Kazuya Shimoda, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 8874–8875.
https://doi.org/10.1182/blood-2022-171019
Published: 2022
Journal Articles

Frequent Alterations of Driver Genes in Chromosome X and Their Clinical Relevance in Extranodal NK/T-Cell Lymphoma

Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Julie Bruneau, Manon Vavasseur, Michaël Dussiot, Isabelle Andre, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Christine Bole-Feysot, Patrick Nitschke, Bruno Tesson, Cécile Laurent, Thierry Jo Molina, Vahid Asnafi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Koichi Ohshima, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronne
Journal: Blood
Blood (2022) 140 (Supplement 1): 1737–1739.
https://doi.org/10.1182/blood-2022-159869
Published: 2022