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Journal Articles

Isatuximab: surface strike, deep response in AL amyloidosis

Free
Clinical Trials & Observations
Eli Muchtar, Angela Dispenzieri
Journal: Blood
Blood (2025) 146 (21): 2495–2496.
https://doi.org/10.1182/blood.2025031062
Published: 2025
Journal Articles

Clinical course, predictors of development, and therapeutic response in multiple myeloma with central nervous system involvement

Free
Alexander Xiao, Saurabh Zanwar, Yi Lin, Prashant Kapoor, Nadine Abdallah, Moritz Binder, Francis Buadi, Angela Dispenzieri, David Dingli, Amie Fonder, Morie Gertz, Wilson Gonsalves, Suzanne Hayman, Yi Hwa, Miriam Hobbs, Taxiarchis Kourelis, Martha Lacy, Nelson Leung, Eli Muchtar, Mustaqeem Siddiqui, Melinda Tan, Rahma Warsame, Dragan Jevremovic, Robert Kyle, S. Vincent Rajkumar, Shaji Kumar
Journal: Blood
Blood (2025) 146 (Supplement 1): 2225.
https://doi.org/10.1182/blood-2025-2225
Published: 2025
Journal Articles

A new validated staging system for AL amyloidosis with stage IIIc defining an ultra-poor prognostic in systemic AL amyloidosis in the modern treatment era

Free
Jahanzaib Khwaja, Amy Kirkwood, Paolo Milani, Binoy Yohannan, Foteini Theodorakakou, Flores Weverling, Valeria Di Simone, Shaji Kumar, Sriram Ravichandran, Roberta Mussinelli, Ioannis Petropoulos, Oliver Cohen, Eli Muchtar, Kimon Stamatelopoulos, Julian Gillmore, Alexandros Briasoulis, Morie Gertz, Shameem Mahmood, Rahel Schwotzer, Monique Minnema, Angela Dispenzieri, Giovanni Palladini, Efstathios Kastritis, Ashutosh Wechalekar
Journal: Blood
Blood (2025) 146 (Supplement 1): 577.
https://doi.org/10.1182/blood-2025-577
Published: 2025
Journal Articles

Patterns of progression and clinical outcomes after first relapse in patients with primary plasma cell leukemia

Free
Daniel Packard, Shaji Kumar, Tamer Hellou, Prashant Kapoor, Angela Dispenzieri, Francis Buadi, David Dingli, Saurabh Zanwar, Dragan Jevremovic, Suzanne Hayman, Nelson Leung, Joselle Cook, Nadine Abdallah, Moritz Binder, Eli Muchtar, Rahma Warsame, Taxiarchis Kourelis, Ronald Go, Yi Hwa, Miriam Hobbs, Amie Fonder, Yi Lin, Morie Gertz, S. Vincent Rajkumar, Wilson Gonsalves
Journal: Blood
Blood (2025) 146 (Supplement 1): 1036.
https://doi.org/10.1182/blood-2025-1036
Published: 2025
Journal Articles

Clinical, anatomic, and histologic determinants of gastrointestinal disease burden and survival in systemic AL amyloidosis: A cohort study of 560 patients

Free
Max Steinhardt, Eli Muchtar, Taxiarchis Kourelis, Rahma Warsame, Michelle Mauermann, Francis Buadi, David Dingli, Nelson Leung, Joselle Cook, Ronald Go, Suzanne Hayman, Wilson Gonsalves, Prashant Kapoor, Saurabh Zanwar, Moritz Binder, Tamer Hellou, Melinda Tan, Amie Fonder, Miriam Hobbs, Nadine Abdallah, Yi Lin, Mustaqeem Siddiqui, Robert Kyle, Hermann Einsele, S. Vincent Rajkumar, Shaji Kumar, K. Martin Kortüm, Morie Gertz, Angela Dispenzieri
Journal: Blood
Blood (2025) 146 (Supplement 1): 3962.
https://doi.org/10.1182/blood-2025-3962
Published: 2025
Journal Articles

Cardiac complete response in AL amyloidosis: Phenotypic characteristics, functional recovery, and survival outcomes of 63 patients

Free
Eli Muchtar, Susan Geyer, Angela Dispenzieri, Martha Grogan, Taxiarchis Kourelis, Francis Buadi, Prashant Kapoor, David Dingli, Wilson Gonsalves, Nelson Leung, Giampaolo Merlini, Julie Rosenthal, Melissa Lyle, Suzanne Hayman, Martha Lacy, Mustaqeem Siddiqui, Joselle Cook, Nadine Abdallah, Moritz Binder, Saurabh Zanwar, Yi Lin, Rahma Warsame, Robert Kyle, S. Vincent Rajkumar, Shaji Kumar, Morie Gertz
Journal: Blood
Blood (2025) 146 (Supplement 1): 3960.
https://doi.org/10.1182/blood-2025-3960
Published: 2025
Journal Articles

MAPK pathway-driven metabolic-inflammatory axis in AL amyloidosis

Free
Tal Zvida-Bloch, Eli Muchtar, Ifat Abramovich, Bella Agranovich, Mali Salmon-Divon, May Basood, Benjamin Bender, Adrian Duek, Merav Leiba, Moshe Gatt, Wilson Gonsalves, Angela Dispenzieri, Ofer Shpilberg, Oshrat Hershkovitz-Rokah
Journal: Blood
Blood (2025) 146 (Supplement 1): 5709.
https://doi.org/10.1182/blood-2025-5709
Published: 2025
Journal Articles

Cytogenetics-based clinical trajectories of patients with MRD negativity post autologous stem cell transplant for multiple myeloma

Free
Estefania Gauto Mariotti, Shaji Kumar, Wilson Gonsalves, Prashant Kapoor, Angela Dispenzieri, Francis Buadi, David Dingli, Dragan Jevremovic, Suzanne Hayman, Nelson Leung, Joselle Cook, Nadine Abdallah, Moritz Binder, Eli Muchtar, Rahma Warsame, Taxiarchis Kourelis, Ronald Go, Yi Hwa, Miriam Hobbs, Amie Fonder, Mustaqeem Siddiqui, Yi Lin, Robert Kyle, Morie Gertz, S. Vincent Rajkumar, Saurabh Zanwar
Journal: Blood
Blood (2025) 146 (Supplement 1): 362.
https://doi.org/10.1182/blood-2025-362
Published: 2025
Journal Articles

Disease characteristics, treatment patterns, and outcomes of AL amyloidosis patients with high-risk FISH cytogenetics

Free
Tamer Hellou, Estefania Gauto Mariotti, Ahmed Alnughmush, Daniel Packard, Max Steinhardt, Morie Gertz, Angela Dispenzieri, Dragan Jevremovic, Linda Baughn, Francis Buadi, David Dingli, Taxiarchis Kourelis, Saurabh Zanwar, Suzanne Hayman, Prashant Kapoor, Nelson Leung, Yi Hwa, Amie Fonder, Miriam Hobbs, Rahma Warsame, Joselle Cook, Moritz Binder, Nadine Abdallah, Yi Lin, Ronald Go, Mustaqeem Siddiqui, Robert Kyle, S. Vincent Rajkumar, Wilson Gonsalves, Shaji Kumar, Eli Muchtar
Journal: Blood
Blood (2025) 146 (Supplement 1): 5741.
https://doi.org/10.1182/blood-2025-5741
Published: 2025
Journal Articles

The SCOPE trial: A phase 2 Study of selinexor in combination with pomalidomide and dexamethasone for patients with relapsed and/or refractory multiple myeloma

Free
Prashant Kapoor, Morie Gertz, Paul DiZona, Eli Muchtar, Francis Buadi, Wilson Gonsalves, Miriam Hobbs, Amie Fonder, Yi Hwa, Taxiarchis Kourelis, David Dingli, Angela Dispenzieri, Joselle Cook, Suzanne Hayman, Moritz Binder, Nadine Abdallah, Mustaqeem Siddiqui, Rahma Warsame, S. Vincent Rajkumar, Betsy Knopf, Shaji Kumar
Journal: Blood
Blood (2025) 146 (Supplement 1): 2281.
https://doi.org/10.1182/blood-2025-2281
Published: 2025
Journal Articles

Real-world (RW) outcomes of newly diagnosed multiple myeloma (NDMM) patients (pts) treated with front-line daratumumab (dara), bortezomib (bor), lenalidomide (len) and dexamethasone (dex) (DVRd)

Free
Ricardo Parrondo, Ricardo de Menezes, Hanna Sledge, Kanika Yadav, Madhavi Nayyar, P. Leif Bergsagel, Rafael Fonseca, Prashant Kapoor, Francis Buadi, Morie Gertz, Angela Dispenzieri, Vivek Roy, Taimur Sher, Moritz Binder, Nadine Abdallah, Saurabh Chhabra, S. Vincent Rajkumar, Wilson Gonsalves, Joselle Cook, David Dingli, Yi Lin, Eli Muchtar, Caitlin Flott, Udit Yadav, Rahma Warsame, J Wiedmeier-Nutor, Taxiarchis Kourelis, Nelson Leung, Mustaqeem Siddiqui, Andre Fernandez, Shaji Kumar, Asher Chanan-Khan, Sikander Ailawadhi
Journal: Blood
Blood (2025) 146 (Supplement 1): 4585.
https://doi.org/10.1182/blood-2025-4585
Published: 2025
Journal Articles

Self-reported geriatric impairments and treatment toxicity in older patients with multiple myeloma - a single center prospective study

Free
Rosalyn Marar, Claire Yee, Anna Bodily, Tanya Wildes, Terri Menser, Megan Weivoda, Sarah Aug, Francis Buadi, Wilson Gonsalves, Prashant Kapoor, Angela Dispenzieri, Suzanne Hayman, Eli Muchtar, David Dingli, Joselle Cook, Saurabh Zanwar, Moritz Binder, Taxiarchis Kourelis, Morie Gertz, Rahma Warsame, Yi Lin, S. Vincent Rajkumar, Amylou Dueck, Shaji Kumar, Nadine Abdallah
Journal: Blood
Blood (2025) 146 (Supplement 1): 715.
https://doi.org/10.1182/blood-2025-715
Published: 2025
Journal Articles

Pirtobrutinib versus usual care for patients with richter transformation of chronic lymphocytic leukemia: Inverse probability of treatment weighting-based analysis of BRUIN trial and mayo observational cohort

Free
Yucai Wang, Kari Rabe, Paul Hampel, Lindsey Roeker, Jihao Zhou, Suheil Albert Atallah-Yunes, Susan Schwager, Min Shi, Curtis Hanson, Rebecca King, Cinthya Mendoza Zepeda, Saad Kenderian, Eli Muchtar, Neil Kay, Amber Koehler, Amy Behnken, Catherine Coddington, Susan Slager, Sameer Parikh
Journal: Blood
Blood (2025) 146 (Supplement 1): 5673.
https://doi.org/10.1182/blood-2025-5673
Published: 2025
Journal Articles

Progression of disease within 36 months (POD36) of starting first-line targeted therapy independently predicts poor overall survival in patients with chronic lymphocytic leukemia (CLL)

Free
Paul Hampel, Kari Rabe, Matthew Maurer, Yucai Wang, Saad Kenderian, Eli Muchtar, Lindsey Roeker, Jose Leis, Mazie Tsang, Talal Hilal, Ricardo Parrondo, Amber Koehler, Rachel Bailen, Catherine Coddington, Amy Behnken, Susan Schwager, Curtis Hanson, Esteban Braggio, Min Shi, Cinthya Mendoza, Susan Slager, Neil Kay, Sameer Parikh
Journal: Blood
Blood (2025) 146 (Supplement 1): 5667.
https://doi.org/10.1182/blood-2025-5667
Published: 2025
Journal Articles

Prognostic impact of cytogenetic abnormalities detected by FISH in AL amyloidosis with daratumumab-based frontline therapy

Free
Clinical Trials & Observations
Rajshekhar Chakraborty, Saurabh Zanwar, Ute Hegenbart, Divaya Bhutani, Morie A. Gertz, Angela Dispenzieri, Shaji Kumar, Anita D’Souza, Anannya Patwari, Andrew Cowan, GuiZhen Chen, Paolo Milani, Giovanni Palladini, Vaishali Sanchorawala, Geethika Bodanapu, Stefan O. Schönland, Suzanne Lentzsch, Eli Muchtar
Journal: Blood
Blood (2024) 144 (25): 2613–2624.
https://doi.org/10.1182/blood.2024025899
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes with Venetoclax-Based Treatment in Patients with Covalent Bruton Tyrosine Kinase Inhibitor (cBTKi)-Treated, Chemotherapy-Naïve Chronic Lymphocytic Leukemia (CLL): An International Retrospective Study

Free
Paul J. Hampel, Kari G. Rabe, Romain Guieze, Yucai Wang, Emmanuelle Ferrant, Saad S. Kenderian, Marie Sarah Dilhuydy, Eli Muchtar, Anne-Sophie Michallet, Jose F. Leis, Luca Inchiappa, Mazie Tsang, Aline Clavert, Talal Hilal, Stephane Lepretre, Ricardo D. Parrondo, Emmanuelle Tchernonog, Amber Koehler, Lin Wang, Susan M. Schwager, Susan L. Slager, Neil E. Kay, Luc-Matthieu Fornecker, Sameer A. Parikh, Loic Ysebaert
Journal: Blood
Blood (2024) 144 (Supplement 1): 1856.
https://doi.org/10.1182/blood-2024-198200
Published: 2024
Journal Articles

Improved Survival with Daratumumab-Cybord Compared to Cybord As Frontline Therapy in Immunoglobulin Light Chain (AL) Amyloidosis

Free
Binoy Yohannan, Matthew James Rees, Morie A. Gertz, Angela Dispenzieri, Francis Buadi, David Dingli, Nelson Leung, Prashant Kapoor, Wilson I. Gonsalves, Taxiarchis Kourelis, Joselle Cook, Moritz Binder, Martha Lacy, Suzanne R Hayman, Yi Lin, Yi Lisa Hwa, Michelle G Rogers, Miriam Hobbs, Amie Fonder, Ronald S Go, Rahma M Warsame, Vincent Rajkumar, Shaji Kumar, Eli Muchtar
Journal: Blood
Blood (2024) 144 (Supplement 1): 2400.
https://doi.org/10.1182/blood-2024-209102
Published: 2024
Journal Articles

Initial Results of a Phase 1 First-in-Human Study of Cemsidomide (CFT7455), a Novel MonoDAC TM Degrader, with Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma

Free
Binod Dhakal, Andrew J. Yee, Paul G. Richardson, Sikander Ailawadhi, Saurabh Chhabra, Eli Muchtar, Jesús G. Berdeja, Shambavi Richard, Jeffrey V Matous, Urvi A. Shah, Mark A. Schroeder, Amro Ali, Leah Leahy, Riadh Lobbardi, Rong Chu, Eunju Hurh, Anthony S. Fiorino, Sagar Lonial
Journal: Blood
Blood (2024) 144 (Supplement 1): 3366.
https://doi.org/10.1182/blood-2024-204255
Published: 2024
Journal Articles

Targeting the PI3K/AKT Pathway and Fatty Acid Synthase in AL Amyloidosis: Mechanistic Insights and Therapeutic Implications

Free
Tal Zvida-Bloch, Eli Muchtar, Mali Salmon-Divon, Angela Dispenzieri, Benjamin Bender, Adrian Duek, Merav Leiba, Moshe E Gatt, Ofer Shpilberg, Oshrat Hershkovitz-Rokah
Journal: Blood
Blood (2024) 144 (Supplement 1): 3288.
https://doi.org/10.1182/blood-2024-206682
Published: 2024
Journal Articles

Trial in Progress: Phase II Study Evaluating Maintenance in Light Chain Amyloidosis (EMILIA)

Free
Aytaj Mammadzadeh, Madhu Nagaraj, Manraj Sra, Rafla Hassan, Gaby E Perez Burbano, Alissa Peterson, Morie A. Gertz, Angela Dispenzieri, Rafael Fonseca, Saurabh Chhabra, Erin J Wiedmeier-Nutor, Leif Bergsagel, Julie L Rosenthal, Amy Hart, Anna Jones, Prashant Kapoor, Francis Buadi, Nelson Leung, Wilson I. Gonsalves, Suzanne R Hayman, Taxiarchis Kourelis, Rahma M Warsame, Joselle Cook, Moritz Binder, Vincent Rajkumar, David Dingli, Shaji Kumar, Taimur Sher, Udit Yadav, Eli Muchtar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4685.1.
https://doi.org/10.1182/blood-2024-208457
Published: 2024