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Christopher R. Vakoc
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Journal Articles

Systematic Evaluation of GAPs and Gefs Identifies ARHGAP45 As a Targetable Leukemia-Specific Dependency

Pu Zhang, Zhendong Cao, Xiangyu Pan, Yuqiao Liu, Cynthia Castro, Won Jun Kim, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Sanam Shahid, Jasmine S. Um, Erin R. Burns, Bing-Yi Chen, Winson Cai, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Anthony F. Daniyan, Christopher R. Vakoc, Omar Abdel-Wahab, Junwei Shi
Journal: Blood
Blood (2024) 144 (Supplement 1): 950.
https://doi.org/10.1182/blood-2024-198954
Published: 2024
Journal Articles

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Yusuke Tarumoto, Shan Lin, Jinhua Wang, Joseph P. Milazzo, Yali Xu, Bin Lu, Zhaolin Yang, Yiliang Wei, Sofya Polyanskaya, Mark Wunderlich, Nathanael S. Gray, Kimberly Stegmaier, Christopher R. Vakoc
Journal: Blood
Blood (2020) 135 (1): 56–70.
https://doi.org/10.1182/blood.2019001576
Published: 2020
Includes: Supplemental data
Journal Articles

Enhancer dysfunction in leukemia

Anand S. Bhagwat, Bin Lu, Christopher R. Vakoc
Journal: Blood
Blood (2018) 131 (16): 1795–1804.
https://doi.org/10.1182/blood-2017-11-737379
Published: 2018
Journal Articles

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

Geoffrey M. Matthews, Parinaz Mehdipour, Leonie A. Cluse, Katrina J. Falkenberg, Eric Wang, Mareike Roth, Fabio Santoro, Eva Vidacs, Kym Stanley, Colin M. House, James R. Rusche, Christopher R. Vakoc, Johannes Zuber, Saverio Minucci, Ricky W. Johnstone
Journal: Blood
Blood (2015) 126 (21): 2392–2403.
https://doi.org/10.1182/blood-2015-03-632984
Published: 2015
Includes: Supplemental data
Journal Articles

Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms

Ghaith Wedeh, Emir Hadzijusufovic, DVM, Sabine Cerny-Reiterer, D.V.M, Harald Herrmann, M.D., Katharina Blatt, MSc, Ph.D., Gregor Eisenwort, M.D., Ph.D, Gregor Hoermann, M.D., Ph.D., Wolfgang R Sperr, M.D., Leonhard Müllauer, M.D., Christopher R. Vakoc, M.D., Ph.D., James E Bradner, MD, Hans-Peter Horny, MD, Michael Willmann, D.V.M., Johannes Zuber, MD, Michel Arock, PharmD, Ph.D, Peter Valent
Journal: Blood
Blood (2013) 122 (21): 3747.
https://doi.org/10.1182/blood.V122.21.3747.3747
Published: 2013
Journal Articles

MLL-Rearranged Leukemias Are Dependent On the Histone H2B Ubiquitin Ligase RNF20

Christopher R. Vakoc, M.D., Ph.D., Eric Wang, Shinpei Kawaoka
Journal: Blood
Blood (2012) 120 (21): 649.
https://doi.org/10.1182/blood.V120.21.649.649
Published: 2012
Journal Articles

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML,

Harald Herrmann, M.D., Katharina Blatt, M.Sc., Junwei Shi, Amy R. Rappaport, Karoline V. Gleixner, M.D., Sabine Cerny-Reiterer, D.V.M., Barbara Peter, D.V.M., Eric Wang, Wolfgang R. Sperr, M.D., James E. Bradner, MD, Scott W. Lowe, Ph.D., Christopher R. Vakoc, M.D., Ph.D., Johannes Zuber, M.D., Peter Valent, M.D.
Journal: Blood
Blood (2011) 118 (21): 3484.
https://doi.org/10.1182/blood.V118.21.3484.3484
Published: 2011
Journal Articles

Inhibition of c-Myc Expression and Function in Hematologic Malignancies

Ghayas C Issa, MD, Jake E Delmore, Michael R McKeown, Madeleine E Lemieux, Peter B Rahl, Hannah M. Jacobs, Efstathios Kastritis, MD, Timothy Gilpatrick, Ronald M Paranal, Jun Qi, Junwei Shi, Marta Chesi, Anna C. Schinzel, PhD, Christopher R. Vakoc, M.D., Ph.D., P.Leif Bergsagel, MD, Paul G. Richardson, MD, Richard Young, PhD, William C. Hahn, MD, PhD, Irene M. Ghobrial, MD, Kenneth C Anderson, MD, Andrew L. Kung, MD, PhD, Constantine S. Mitsiades, MD, PhD, James E Bradner, MD
Journal: Blood
Blood (2011) 118 (21): 1409.
https://doi.org/10.1182/blood.V118.21.1409.1409
Published: 2011
Journal Articles

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

Stella T. Chou, Eugene Khandros, L. Charles Bailey, Kim E. Nichols, Christopher R. Vakoc, Yu Yao, Zan Huang, John D. Crispino, Ross C. Hardison, Gerd A. Blobel, Mitchell J. Weiss
Journal: Blood
Blood (2009) 114 (5): 983–994.
https://doi.org/10.1182/blood-2009-03-207944
Published: 2009
Includes: Supplemental data
Journal Articles

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

Tamara Tripic, Wulan Deng, Yong Cheng, Ying Zhang, Christopher R. Vakoc, Gregory D. Gregory, Ross C. Hardison, Gerd A. Blobel
Journal: Blood
Blood (2009) 113 (10): 2191–2201.
https://doi.org/10.1182/blood-2008-07-169417
Published: 2009
Includes: Supplemental data
Journal Articles

GATA-1 Represses PU.1/ Sfpi-1 Gene Transcription in Erythro-Megakaryocytic Progenitors.

Stella T. Chou, MD, Charles L. Bailey, MD, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD, PhD, Christopher R. Vakoc, MD, PhD, Mitchell J. Weiss, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 1226.
https://doi.org/10.1182/blood.V110.11.1226.1226
Published: 2007
Journal Articles

Acetylation of GATA-1 is required for chromatin occupancy

Brief Report
Janine M. Lamonica, Christopher R. Vakoc, Gerd A. Blobel
Journal: Blood
Blood (2006) 108 (12): 3736–3738.
https://doi.org/10.1182/blood-2006-07-032847
Published: 2006
Includes: Supplemental data
Journal Articles

Acetylation of GATA-1 Is Required for Chromatin Occupancy.

Janine M. Lamonica, MA, Christopher R. Vakoc, PhD, Gerd A. Blobel, PhD, MD
Journal: Blood
Blood (2006) 108 (11): 1179.
https://doi.org/10.1182/blood.V108.11.1179.1179
Published: 2006
Journal Articles

Genomic Organization, Chromatin Structure, and Transcriptional Regulation of the Murine Alpha Hemoglobin Stabilizing Protein (AHSP) Gene.

Louis C. Dore, Christopher R. Vakoc, Gerd A. Blobel, MD, PhD, Ross C. Hardison, PhD, David M. Bodine, PhD, Patrick G. Gallagher, MD, Mitchell J. Weiss, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 3633.
https://doi.org/10.1182/blood.V106.11.3633.3633
Published: 2005
Journal Articles

Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin.

Christopher R. Vakoc, Sean A. Mandat, Ben A. Olenschock, Gerd A. Blobel, PhD
Journal: Blood
Blood (2005) 106 (11): 1734.
https://doi.org/10.1182/blood.V106.11.1734.1734
Published: 2005
Journal Articles

Global regulation of erythroid gene expression by transcription factor GATA-1

John J. Welch, Jason A. Watts, Christopher R. Vakoc, Yu Yao, Hao Wang, Ross C. Hardison, Gerd A. Blobel, Lewis A. Chodosh, Mitchell J. Weiss
Journal: Blood
Blood (2004) 104 (10): 3136–3147.
https://doi.org/10.1182/blood-2004-04-1603
Published: 2004