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Geoffrey M. Matthews
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Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Geoffrey M. Matthews, PhD, Sara Gandolfi, MD, Johanna Bruggentheis, Ricardo De Matos Simoes, PhD, Dennis L Buckley, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Hayley Poarch, James E. Bradner, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1062.
https://doi.org/10.1182/blood.V128.22.1062.1062
Published: 2016
Journal Articles

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Geoffrey M. Matthews, PhD, Ricardo De Matos Simoes, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Paul J. Hengeveld, B.Sc., Megan A. Bariteau, BSc, Brian Glassner, PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Sara Gandolfi, MD, Pallavi Awate, MSc, Huihui Tang, PhD, Franciska Vazquez, PhD, Aedin Culhane, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 119.
https://doi.org/10.1182/blood.V128.22.119.119
Published: 2016
Journal Articles

Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology

Ricardo De Matos Simoes, PhD, Geoffrey M. Matthews, PhD, Yiguo Hu, MD PhD, Brian Glassner, PhD, Megan A. Bariteau, BSc, Michal Sheffer, PhD, Ryosuke Shirasaki, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 486.
https://doi.org/10.1182/blood.V128.22.486.486
Published: 2016
Journal Articles

Systematic Evaluation of Preclinical Genetically Determined Vs. "Stochastic"/Transient Resistance to High-Dose Melphalan Treatment in Multiple Myeloma

Paul J. Hengeveld, B.Sc., Geoffrey M. Matthews, PhD, Yiguo Hu, MDPhD, Michal Sheffer, PhD, Megan A. Bariteau, BSc, Haley I. Poarch, Eugen Dhimolea, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2484.
https://doi.org/10.1182/blood.V126.23.2484.2484
Published: 2015
Journal Articles

Constitutive Vs. Stroma-Induced Kinase Dependencies in Myeloma Cells: Functional Mapping Using Small Molecule Inhibitors As Chemical Probes

Eugen Dhimolea, PhD, Emily King, Michal Sheffer, PhD, Yiguo Hu, MDPhD, Pallavi P. Awate, Subhashis Sarkar, PhD, Geoffrey M. Matthews, PhD, Megan Murnane, Megan A. Bariteau, BSc, Blake T. Aftab, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3709.
https://doi.org/10.1182/blood.V126.23.3709.3709
Published: 2015
Journal Articles

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

Geoffrey M. Matthews, Parinaz Mehdipour, Leonie A. Cluse, Katrina J. Falkenberg, Eric Wang, Mareike Roth, Fabio Santoro, Eva Vidacs, Kym Stanley, Colin M. House, James R. Rusche, Christopher R. Vakoc, Johannes Zuber, Saverio Minucci, Ricky W. Johnstone
Journal: Blood
Blood (2015) 126 (21): 2392–2403.
https://doi.org/10.1182/blood-2015-03-632984
Published: 2015
Includes: Supplemental data
Journal Articles

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

Fabio Santoro, Oronza A. Botrugno, Roberto Dal Zuffo, Isabella Pallavicini, Geoffrey M. Matthews, Leonie Cluse, Iros Barozzi, Silvia Senese, Lorenzo Fornasari, Simona Moretti, Lucia Altucci, Pier Giuseppe Pelicci, Susanna Chiocca, Ricky W. Johnstone, Saverio Minucci
Journal: Blood
Blood (2013) 121 (17): 3459–3468.
https://doi.org/10.1182/blood-2012-10-461988
Published: 2013
Includes: Supplemental data
Journal Articles

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

Stephen R. Mattarollo, Alison C. West, Kim Steegh, Helene Duret, Christophe Paget, Ben Martin, Geoffrey M. Matthews, Jake Shortt, Marta Chesi, P. Leif Bergsagel, Michael Bots, Johannes Zuber, Scott W. Lowe, Ricky W. Johnstone, Mark J. Smyth
Journal: Blood
Blood (2012) 120 (15): 3019–3029.
https://doi.org/10.1182/blood-2012-04-426643
Published: 2012
Includes: Supplemental data
Journal Articles

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

Marta Chesi, Geoffrey M. Matthews, Victoria M. Garbitt, Stephen E. Palmer, Jake Shortt, Marcus Lefebure, A. Keith Stewart, Ricky W. Johnstone, P. Leif Bergsagel
Journal: Blood
Blood (2012) 120 (2): 376–385.
https://doi.org/10.1182/blood-2012-02-412783
Published: 2012
Includes: Supplemental data
Journal Articles

N-Methyl-2-Pyrrolidone Is a Biologically Active Thalidomide Subunit with In Vivo anti-Myeloma Properties

Jake Shortt, FRACP, FRCPA, Andy Hsu, PhD, Geoffrey M Matthews, PhD, Marta Chesi, P.Leif Bergsagel, MD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Paul Neeson, PhD, David Ritchie, MBBS, FRACP, FRCPA, Ricky W Johnstone, PhD
Journal: Blood
Blood (2010) 116 (21): 4082.
https://doi.org/10.1182/blood.V116.21.4082.4082
Published: 2010