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Christina Leslie
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Journal Articles

A Single-Cell Atlas of Classical Mantle Cell Lymphoma Reveals Paired Tumor-Immune Malignant States Correlating with Prognosis

Amira Marouf, Sneha Mitra, Irem Isgor, Ashlee Joseph, Jahan Rahman, Ya-Hui Lin, Meril Takizawa, Ronan Chaligne, Shenon Sethi, Ahmet Dogan, Sandrine Roulland, Gilles Salles, Christina Leslie, Anita Kumar, Santosha A. Vardhana
Journal: Blood
Blood (2024) 144 (Supplement 1): 234.
https://doi.org/10.1182/blood-2024-206805
Published: 2024
Journal Articles

Low CD117 Expression Identifies Hematopoietic Stem Cell Subsets with Enhanced Lymphoid Potential in Mice and Humans

Harold K Elias, Sneha Mitra, Brianna Gipson, Marina Burgos da Silva, Nicole Lee, Mohamed A.E. Ali, Simon Grassman, Anastasia Kousa, Susan DeWolf, Christopher Y. Park, Joseph Sun, Christina Leslie, Avinash Bhandoola, Marcel R.M. van den Brink
Journal: Blood
Blood (2023) 142 (Supplement 1): 3417.
https://doi.org/10.1182/blood-2023-190000
Published: 2023
Journal Articles

RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality

Florisela Herrejon Chavez, Paolo Cifani, Alli Pine, Karen L Chu, Ersilia Barin, Alexandra Schurer, Hanzhi Luo, Diu T.T. Nguyen, Alex Kentsis, Christina Leslie, Michael G Kharas, Ly P Vu
Journal: Blood
Blood (2021) 138 (Supplement 1): 296.
https://doi.org/10.1182/blood-2021-147575
Published: 2021
Journal Articles

Targeted Integration of a CAR at a Novel Genomic Safe Harbor Directs Potent Therapeutic Outcomes

Ashlesha Odak, MS, Han Yuan, PhD, Judith Feucht, MD, Jorge Mansilla - Soto, PhD, Justin Eyquem, PhD, Christina Leslie, PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28.
https://doi.org/10.1182/blood-2020-141967
Published: 2020
Journal Articles

Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

Diu T.T. Nguyen, DPhil, Camila Prieto, PhD, Zhaoqi Liu, PhD, Justin Wheat, Alexendar Perez, Saroj Gourkanti, BA, Timothy Chou, BS, Ersilia Barin, Arthur Chow, BS, James Taggart, BA, Katerina Hoskova, Meera Dhodapkar, Alexandra Schurer, BS, Trevor Stephen Barlowe, BA, Ly Vu, PhD, Christina Leslie, PhD, Ulrich G. Steidl, MDPhD, Raul Rabadan, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
https://doi.org/10.1182/blood-2020-142229
Published: 2020
Journal Articles

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

Sun-Mi Park, PhD, Hyunwoo Cho, PhD, Angela Thornton, PhD, Trevor Stephen Barlowe, BA, Timothy Chou, BS, Sagar Chhangawala, PhD, Lauren Fairchild, PhD, Arthur Chow, BA, James Taggart, BA, Alexander Schurer, BA, Antoine Gruet, Matthew Witkin, Jun Hyun Kim, Ethan Shevach, Andrei Krivstov, Scott A. Armstrong, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3881.
https://doi.org/10.1182/blood-2018-99-115034
Published: 2018
Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 883.
https://doi.org/10.1182/blood-2018-99-112543
Published: 2018
Journal Articles

The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells

Diu Nguyen, PhD, Yuheng Lu, PhD, Zi-ning Choo, Christopher Chin, Camila Prieto, BA, Saroj Gourkanti, BA, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 884.
https://doi.org/10.1182/blood-2018-99-118949
Published: 2018
Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Gerard Minuesa Dinares, PhD, Steven K. Albanese, BS, Arthur Chow, BA, Alexandra Schurer, BS, Sun Mi Park, PhD, Christina Z. Rotsides, PhD, James Taggart, BS, Andrea Rizzi, BS, Levi N. Naden, PhD, Timothy Chou, BS, Saroj Gourkanti, BA, Daniel Cappel, PhD, Maria C. Passarelli, BS, Lauren Fairchild, PhD, Carolina Adura, PhD, Joseph Fraser Glickman, MSPH, PhD, Jessica Schulman, Christopher Famulare, MS, Minal Patel, BA, Joseph K. Eibl, PhD, Gregory M. Ross, PhD, Derek Tan, PhD, Christina Leslie, PhD, Thijs Beuming, PhD, Yehuda Goldgur, PhD, John D. Chodera, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 428.
https://doi.org/10.1182/blood-2018-99-118745
Published: 2018
Journal Articles

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

Josephine Wesely, PhD MSc, BSc, Andriana G. Kotini, PhD, Maria Georgomanoli, PhD, Hanzhi Luo, PhD, Han Yuan, Franco Izzo, PhD, Dan A. Landau, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD, Eirini P. Papapetrou, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 772.
https://doi.org/10.1182/blood-2018-99-111506
Published: 2018
Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Ly P. Vu, PhD, Camila Prieto, Elianna Amin, PhD, Gerard Minuesa, PhD, Sagar Chhangawala, Maria J Vidal, PhD, Andrei V. Krivtsov, PhD, Tim Chou, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Raquel P. Deering, Mithat Gonen, PhD, Maria E Figueroa, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Ari Melnick, MD, Ross L. Levine, MD, Fatima Al-Shahrour, PhD, Marcus Järås, Lisa Chu, Ralph Garippa, PhD, Christopher Lengner, PhD, Scott A. Armstrong, MD PhD, Glenn Cowley, PhD, David Root, PhD, John G Doench, PhD, Leandro Cerchietti, MD, Christina Leslie, PhD, Benjamin Ebert, Michael G. Kharas, PhD
Journal: Blood
Blood (2016) 128 (22): 739.
https://doi.org/10.1182/blood.V128.22.739.739
Published: 2016
Journal Articles

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Sun Mi Park, PhD, Mithat Gönen, PhD, Ly P. Vu, PhD, Gerard Minuesa, PhD, Patrick Tivnan, Trevor Barlowe, James Taggart, Yuheng Lu, Raquel P Deering, PhD, Nir Hacohen, PhD, Maria Figueroa, MD, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Ari M. Melnick, MD, Ross L. Levine, MD, Christina Leslie, PhD, Christopher J Lengner, PhD, Michael G Kharas, PhD
Journal: Blood
Blood (2014) 124 (21): 836.
https://doi.org/10.1182/blood.V124.21.836.836
Published: 2014
Journal Articles

Characterizing Transcriptional and Epigenetic Signatures Induced By FLT3-ITD Activation

Barbara Spitzer, MD, Olga A Guryanova, MD PhD, Omar Abdel-Wahab, MD, Nicole Kucine, MD, Mazhar Adli, PhD, Jason N. Berman, MD, Soheil Meshinchi, MD PhD, Bradley Bernstein, MD PhD, Raphael Pelossof, PhD, Christina Leslie, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2014) 124 (21): 2186.
https://doi.org/10.1182/blood.V124.21.2186.2186
Published: 2014
Journal Articles

Microrna Mediated Regulation of Hematopoietic Stem Cell Aging

Safak Yalcin, PhD, Mark Carty, Joseph Yusup Shin, Richard A Miller, PhD, Christina Leslie, PhD, Christopher Y. Park, MD PhD
Journal: Blood
Blood (2014) 124 (21): 602.
https://doi.org/10.1182/blood.V124.21.602.602
Published: 2014
Journal Articles

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL

Richard R. Furman, MD, Shuhua Cheng, PhD, Pin Lu, MD, PhD, Menu Setty, Alexandar Perez, Ailin Guo, MD, PhD, Joelle Racchumi, BS, Jiao Ma, PhD, Morton Coleman, MD, Kabaleeswaran Venkataraman, PhD, Guozhou Xu, PhD, Wei Chen, PhD, Hao Wu, PhD, Betty Y. Chang, PhD, Christina Leslie, PhD, Y. Lynn Wang, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4914.
https://doi.org/10.1182/blood.V122.21.4914.4914
Published: 2013
Journal Articles

Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells

Sun-Mi Park, Ph.D, Raquel P Deering, Yuheng Lu, Tivnan Patrick, Varun Shenoy, Steve Lianoglou, Ph.D, Fatima Al-Shahrour, Christina Leslie, Benjamin L. Ebert, MD, PhD, Christopher Lengner, George Q Daley, Michael G Kharas, PhD
Journal: Blood
Blood (2013) 122 (21): 468.
https://doi.org/10.1182/blood.V122.21.468.468
Published: 2013
Journal Articles

Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate.

Sun Mi Park, Ph.D, Raquel Deering, Yuheng Lu, Patrick Tivnan, Varun Shenoy, Steve Lianoglou, Ph.D, Fatima Al-Shahrour, PhD, Christina Leslie, PhD, Benjamin L. Ebert, MD, PhD, Christopher Lengner, Ph.D, George Q. Daley, MD, PhD, Michael G Kharas, PhD
Journal: Blood
Blood (2012) 120 (21): 2324.
https://doi.org/10.1182/blood.V120.21.2324.2324
Published: 2012
Journal Articles

Therapeutic Transgene Expression From Genomic Safe Harbors In Patient-Specific Induced Pluripotent Stem Cells

Eirini P Papapetrou, MD, PhD, Gabsang Lee, PhD, Nirav Malani, Manu Setty, Isabelle Riviere, PhD, Laxmi MS Tirunagari, Kyuichi Kadota, MD, Shoshannah L Roth, PhD, Patricia Giardina, MD, Agnes Viale, PhD, Christina Leslie, PhD, Frederic Bushman, PhD, Lorenz Studer, MD, Michel Sadelain, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 564.
https://doi.org/10.1182/blood.V116.21.564.564
Published: 2010
Journal Articles

MiR-28 Silencing In Germinal Center-Derived Lymphomas

Christof Schneider, MD, Roy L Maute, Pavel Sumazin, PhD, Manisha Brahmachary, PhD, Manu Setty, Laura Pasqualucci, MD, Angelo Rosolen, MD, Christina Leslie, PhD, Katia Basso, PhD, Riccardo Dalla-Favera, MD
Journal: Blood
Blood (2010) 116 (21): 703.
https://doi.org/10.1182/blood.V116.21.703.703
Published: 2010