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Journal Articles

Rbmx Regulates YTHDC1 Nuclear Condensates to Promote Nascent Transcription in Acute Myeloid Leukemia

Isaac Wakiro, Yue Huang, Xuejing Yang, Xueqin Xie, Hanzhi Luo, Kathryn Chang, Aspen Pierson, Emily Batchelor, Yuanming Cheng, Diu T.T. Nguyen, Zhaoqi Liu, Michael G. Kharas

Blood (2024) 144 (Supplement 1): 627.

https://doi.org/10.1182/blood-2024-211338

Published: 2024

Journal Articles

Selective Inhibition of the m 6 a RNA Reader, YTHDC1, As a Novel Therapeutic Strategy for MYC-Driven Acute Myeloid Leukemia

Blood (2024) 144 (Supplement 1): 2207.

https://doi.org/10.1182/blood-2024-207561

Published: 2024

Journal Articles

Uncovering the HOXA9 Translational Regulatory Complex That Promotes AML Leukemic Stem Cells

Xueqin Xie, Florisela Herrejon Chavez, Ilyes Baali, Eren L. Chu, Chiara Evans, Xuejing Yang, Wei Wei, Hanzhi Luo, Sun Mi Park, Kathryn Chang, Aspen Pierson, Grace Han, Emily Batchelor, Quaid D. Morris, Ly Vu, Diu T.T. Nguyen, Michael G. Kharas

Blood (2024) 144 (Supplement 1): 4106.

https://doi.org/10.1182/blood-2024-211477

Published: 2024

Journal Articles

m 6 a-Son-CCL5 Axis Controls HSC Fate and Inflammation

Hanzhi Luo, Mariela Cortés-López, Cyrus L. Tam, Michael Xiao, Isaac Wakiro, Karen L. Chu, Aspen Pierson, Mandy Chan, Kathryn Chang, Xuejing Yang, Grace Han, Erin Ahn, Quaid D. Morris, Dan A. Landau, Michael G. Kharas

Blood (2023) 142 (Supplement 1): 1297.

https://doi.org/10.1182/blood-2023-179552

Published: 2023

Journal Articles

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Nataly Cruz-Rodriguez, Andriana G. Kotini, Saul Carcamo, Malgorzata Olszewska, Elsa Bernard, Hanzhi Luo, Michael G Kharas, Dan Hasson, Eirini P. Papapetrou

Blood (2022) 140 (Supplement 1): 1996–1997.

https://doi.org/10.1182/blood-2022-165728

Published: 2022

Journal Articles

Fructose Treatment Targets Myeloid Leukemogenesis in IDH2 Mutants By Exhausting Alpha-Ketoglutarate Pools

Angela Maria Savino, Briana Turner, Sangmoo Jeong, Tanya Schild, Xuejing Yang, Hanzhi Luo, Rachel Chirayil, Quinlan Cullen, Mandy Chan, Grace Han, Kathryn Chang, Sudha Janaki Raman, Justin R Cross, Kayvan Keshari, Michael G Kharas

Blood (2022) 140 (Supplement 1): 2966–2967.

https://doi.org/10.1182/blood-2022-164626

Published: 2022

Journal Articles

Dual IKZF2 and CK1α Degrader Targets Acute Myeloid Leukemia Cells

Sun Mi Park, David Miyamoto, Grace Han, Mandy Chan, Nicole Curnutt, Nathan Tran, Anthony Velleca, Jun Hyun Kim, Alexandra Schurer, Kathryn Chang, Christina M Woo, Michael G Kharas

Blood (2022) 140 (Supplement 1): 675–676.

https://doi.org/10.1182/blood-2022-167678

Published: 2022

Journal Articles

A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies

Martin G. Klatt, Tao Dao, Zhiyuan Yang, Jianying Liu, Sung Soo Mun, Megan M. Dacek, Hanzhi Luo, Thomas J. Gardner, Christopher Bourne, Leila Peraro, Zita E. H. Aretz, Tanya Korontsvit, Michael Lau, Michael G. Kharas, Cheng Liu, David A. Scheinberg

Blood (2022) 140 (8): 861–874.

https://doi.org/10.1182/blood.2021012882

Published: 2022

Includes: Supplemental data

Journal Articles

RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality

Florisela Herrejon Chavez, Paolo Cifani, Alli Pine, Karen L Chu, Ersilia Barin, Alexandra Schurer, Hanzhi Luo, Diu T.T. Nguyen, Alex Kentsis, Christina Leslie, Michael G Kharas, Ly P Vu

Blood (2021) 138 (Supplement 1): 296.

https://doi.org/10.1182/blood-2021-147575

Published: 2021

Journal Articles

TP53 Mutations and RNA Binding Protein Musashi 2 Drive Resistance to PRMT5-Targeted Therapy in B-Cell Lymphoma

Ingrid Tatiana Erazo, Chiara M Evans, Daniel Zakheim, Karen L Chu, Olena Barbash, Alice Yunsi Refermat, Connie Lee Batlevi, Anas Younes, Michael G Kharas

Blood (2021) 138 (Supplement 1): 788.

https://doi.org/10.1182/blood-2021-151280

Published: 2021

Journal Articles

BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

Blood (2021) 138 (Supplement 1): 359.

https://doi.org/10.1182/blood-2021-149921

Published: 2021

Journal Articles

Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

Diu T.T. Nguyen, DPhil, Camila Prieto, PhD, Zhaoqi Liu, PhD, Justin Wheat, Alexendar Perez, Saroj Gourkanti, BA, Timothy Chou, BS, Ersilia Barin, Arthur Chow, BS, James Taggart, BA, Katerina Hoskova, Meera Dhodapkar, Alexandra Schurer, BS, Trevor Stephen Barlowe, BA, Ly Vu, PhD, Christina Leslie, PhD, Ulrich G. Steidl, MDPhD, Raul Rabadan, PhD, Michael G. Kharas, PhD

Blood (2020) 136 (Supplement 1): 15.

https://doi.org/10.1182/blood-2020-142229

Published: 2020

Journal Articles

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

Sun-Mi Park, PhD, Hyunwoo Cho, PhD, Angela Thornton, PhD, Trevor Stephen Barlowe, BA, Timothy Chou, BS, Sagar Chhangawala, PhD, Lauren Fairchild, PhD, Arthur Chow, BA, James Taggart, BA, Alexander Schurer, BA, Antoine Gruet, Matthew Witkin, Jun Hyun Kim, Ethan Shevach, Andrei Krivstov, Scott A. Armstrong, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 3881.

https://doi.org/10.1182/blood-2018-99-115034

Published: 2018

Journal Articles

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

Yuanming Cheng, PhD, Hanzhi Luo, PhD, Franco Izzo, PhD, Brian F Pickering, PhD, Ly P Vu, PhD, Alexandra Schurer, BS, Saroj Gourkanti, BA, Samie R. Jaffrey, MD PhD, Dan A. Landau, MD PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 327.

https://doi.org/10.1182/blood-2018-99-117191

Published: 2018

Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 883.

https://doi.org/10.1182/blood-2018-99-112543

Published: 2018

Journal Articles

The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells

Diu Nguyen, PhD, Yuheng Lu, PhD, Zi-ning Choo, Christopher Chin, Camila Prieto, BA, Saroj Gourkanti, BA, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 884.

https://doi.org/10.1182/blood-2018-99-118949

Published: 2018

Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 428.

https://doi.org/10.1182/blood-2018-99-118745

Published: 2018

Journal Articles

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

Lauren Forbes, BS, MS, Krasnopolsky Isaac, BA, Gerard Minuesa Dinares, PhD, Michael G. Kharas, PhD, Alex Kentsis, MD PhD

Blood (2018) 132 (Supplement 1): 1352.

https://doi.org/10.1182/blood-2018-99-118807

Published: 2018

Journal Articles

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

Josephine Wesely, PhD MSc, BSc, Andriana G. Kotini, PhD, Maria Georgomanoli, PhD, Hanzhi Luo, PhD, Han Yuan, Franco Izzo, PhD, Dan A. Landau, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD, Eirini P. Papapetrou, MD PhD

Blood (2018) 132 (Supplement 1): 772.

https://doi.org/10.1182/blood-2018-99-111506

Published: 2018

Journal Articles

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

Ly P Vu, PhD, Brian F Pickering, PhD, Yuanming Cheng, PhD, Zaccara Sara, PhD, Diu Nguyen, PhD, Gerard Minuesa, PhD, Timothy Chou, BS, Arthur Chow, BS, Matthew MacKay, Christopher Famulare, MS, Minal Patel, BA, Francine Garret-Bakelman, MD PhD, Ari Melnick, MD, Martin Carroll, MD, Christopher Mason, PhD, Samie R. Jaffrey, MD PhD, Michael G. Kharas, PhD

Blood (2017) 130 (Supplement 1): 791.

https://doi.org/10.1182/blood.V130.Suppl_1.791.791

Published: 2017

NARROW

Rbmx Regulates YTHDC1 Nuclear Condensates to Promote Nascent Transcription in Acute Myeloid Leukemia

Selective Inhibition of the m 6 a RNA Reader, YTHDC1, As a Novel Therapeutic Strategy for MYC-Driven Acute Myeloid Leukemia

Uncovering the HOXA9 Translational Regulatory Complex That Promotes AML Leukemic Stem Cells

m 6 a-Son-CCL5 Axis Controls HSC Fate and Inflammation

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Fructose Treatment Targets Myeloid Leukemogenesis in IDH2 Mutants By Exhausting Alpha-Ketoglutarate Pools

Dual IKZF2 and CK1α Degrader Targets Acute Myeloid Leukemia Cells

A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies

RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality

TP53 Mutations and RNA Binding Protein Musashi 2 Drive Resistance to PRMT5-Targeted Therapy in B-Cell Lymphoma

BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

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American Society of Hematology

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American Society of Hematology

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