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Journal Articles

A dual-receptor T-cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML

Tao Dao, Guangyan Xiong, Sung Soo Mun, Jeremy Meyerberg, Tatyana Korontsvit, Jingyi Xiang, Ziyou Cui, Aaron Y. Chang, Casey Jarvis, Winson Cai, Hanzhi Luo, Aspen Pierson, Anthony Daniyan, Sarah Yoo, Sumiko Takao, Michael Kharas, Alex Kentsis, Cheng Liu, David A. Scheinberg

Blood (2024) 143 (6): 507–521.

https://doi.org/10.1182/blood.2023021054

Published: 2024

Includes: Supplemental data

Journal Articles

A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies

Martin G. Klatt, Tao Dao, Zhiyuan Yang, Jianying Liu, Sung Soo Mun, Megan M. Dacek, Hanzhi Luo, Thomas J. Gardner, Christopher Bourne, Leila Peraro, Zita E. H. Aretz, Tanya Korontsvit, Michael Lau, Michael G. Kharas, Cheng Liu, David A. Scheinberg

Blood (2022) 140 (8): 861–874.

https://doi.org/10.1182/blood.2021012882

Published: 2022

Includes: Supplemental data

Journal Articles

A TCR Mimic Antibody-Directed CAR T Cell Specific for Intracellular NDC80 Is Broadly Cancer Reactive and Displays High Activity Against Hematological Malignancies

Martin G. Klatt, MD, Zhiyuan Yang, PhD, Jianying Liu, PhD, Tatyana Korontsvit, MD, Sung Soo Mun, Leila Peraro, PhD, Thomas J. Gardner, PhD, Christopher Bourne, Megan M. Dacek, Tao Dao, MD PhD, Cheng Liu, PhD, David A. Scheinberg, MD PhD

Blood (2020) 136 (Supplement 1): 20–21.

https://doi.org/10.1182/blood-2020-140179

Published: 2020

Journal Articles

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-141168

Published: 2020

Journal Articles

Epigenetic Drug Treatment Induces Presentation of New Class of Non-Exonic, Cryptic Neoantigens in Acute Myeloid Leukemia Cells

Martin G. Klatt, MD, Sung S. Mun, Nicholas D. Socci, PhD, Tatyana Korontsvit, MD, Tao Dao, MD PhD, David A. Scheinberg, MD PhD

Blood (2018) 132 (Supplement 1): 2717.

https://doi.org/10.1182/blood-2018-99-113691

Published: 2018

Journal Articles

Identification of Cross-Reactive Targets of TCR-Based Therapeutic Agents within the Human Proteome

Ron S Gejman, BA, Tao Dao, MDPhD, David A. Scheinberg, MDPhD

Blood (2017) 130 (Supplement 1): 3188.

https://doi.org/10.1182/blood.V130.Suppl_1.3188.3188

Published: 2017

Journal Articles

A Therapeutic TCR Mimic Monoclonal Antibody for Intracellular PRAME Protein in Leukemias

Aaron Chang, Tao Dao, PhD, Andrew Scott, Leonid Dubrovsky, MD, Cheng Liu, PhD, David A. Scheinberg, MD PhD

Blood (2015) 126 (23): 2527.

https://doi.org/10.1182/blood.V126.23.2527.2527

Published: 2015

Journal Articles

Wilms´Tumor 1 Protein Is Highly Expressed on Malignant Plasma Cells and Provides a Novel Target for Immunotherapeutic Approaches

Guenther Koehne, MDPhD, Satyajit Kosuri, MD, Ekaterina Doubrovina, MD PhD, Tao Dao, PhD, Andrew Scott, Achim A Jungbluth, MD, Richard J O'Reilly, MD

Blood (2015) 126 (23): 98.

https://doi.org/10.1182/blood.V126.23.98.98

Published: 2015

Journal Articles

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers

Sarwish Rafiq, PhD, Tao Dao, MDPhD, Cheng Liu, PhD, David A. Scheinberg, MD PhD, Renier J Brentjens, MD PhD

Blood (2014) 124 (21): 2155.

https://doi.org/10.1182/blood.V124.21.2155.2155

Published: 2014

Journal Articles

A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL + leukemias

Leonid Dubrovsky, Dmitry Pankov, Elliott Joseph Brea, Tao Dao, Andrew Scott, Su Yan, Richard J O’Reilly, Cheng Liu, David A. Scheinberg

Blood (2014) 123 (21): 3296–3304.

https://doi.org/10.1182/blood-2014-01-549022

Published: 2014

Includes: Supplemental data

Journal Articles

A Bi-Specific T Cell Engaging Monoclonal Antibody (mAb) Derived From a TCR-Like Mab Specific For WT1/HLA-A0201 (ESK-BiTE) Shows a Potent Activity Against Human AML and Ph+ ALL In Mouse Models

Dmitry Pankov, MD, Tao Dao, MD, PhD, Yiyang Wang, Andrew Scott, Tatyana Korontsvit, MD, Victoria Zakhaleva, Nicholas Veomett, Michael Curcio, Ekaterina Doubrovina, MD, PhD, Richard J. O'Reilly, MD, Cheng Liu, PhD, David A. Scheinberg, MD, PhD

Blood (2013) 122 (21): 2521.

https://doi.org/10.1182/blood.V122.21.2521.2521

Published: 2013

Journal Articles

Therapeutic Efficacy and Cure Of Sensitive and T315I Pan-Resistant Human Ph+ Leukemia In Mice Using a TCR-Like Antibody To WT1/HLA-A0201 Alone, Or In Combination With Tyrosine Kinase Inhibitors

Leonid Dubrovsky, MD, Elliott Brea, Dmitry Pankov, MD, Nicholas Veomett, Tao Dao, MD/PhD, Su Yan, PhD, Cheng Liu, PhD, David A. Scheinberg, MD, PhD

Blood (2013) 122 (21): 855.

https://doi.org/10.1182/blood.V122.21.855.855

Published: 2013

Journal Articles

Native and Fc Enhanced Therapeutic Human Monoclonal Antibodies Targeting the Intracellular WT1 Oncogene Product in Leukemia.

Nicholas Veomett, Tao Dao, MD, PhD, Dmitry Pankov, MD, Su Yan, PhD, Richard J. O'Reilly, MD, Cheng Liu, PhD, David A. Scheinberg, MD, PhD

Blood (2012) 120 (21): 2599.

https://doi.org/10.1182/blood.V120.21.2599.2599

Published: 2012

Journal Articles

Phase II Trial of WT1 Analog Peptide Vaccine in Patients with Acute Myeloid Leukemia (AML) in Complete Remission (CR)

Todd L. Rosenblat, MD, Mark G. Frattini, MD, PhD, Suzanne M. Chanel, RN, Tao Dao, MD, PhD, Yvette Bernal, Joseph G. Jurcic, MD, Rhong Zhang, Pamela Simancek, Martin S Tallman, MD, David A. Scheinberg, MD, PhD, Peter G. Maslak, M.D.

Blood (2012) 120 (21): 3624.

https://doi.org/10.1182/blood.V120.21.3624.3624

Published: 2012

Journal Articles

A Cytotoxic Human Monoclonal Antibody Recognizing Cell Surface WT1 Peptide/HLA-A2 Complexes

David A. Scheinberg, MD, PhD, Tao Dao, MD, PhD, Su Yan, PhD, Liang Zhou, PhD, Tatyana Korontsvit, Victoriya Zakhaleva, Michael Curcio, Cheng Liu, PhD

Blood (2011) 118 (21): 1677.

https://doi.org/10.1182/blood.V118.21.1677.1677

Published: 2011

Journal Articles

Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia

Peter G. Maslak, Tao Dao, Lee M. Krug, Suzanne Chanel, Tatyana Korontsvit, Victoria Zakhaleva, Ronghua Zhang, Jedd D. Wolchok, Jianda Yuan, Javier Pinilla-Ibarz, Ellin Berman, Mark Weiss, Joseph Jurcic, Mark G. Frattini, David A. Scheinberg

Blood (2010) 116 (2): 171–179.

https://doi.org/10.1182/blood-2009-10-250993

Published: 2010

Journal Articles

Photo-Reactive and Non-Natural Amino Acid Epitopes of Human WT1 Enhance Immunogenicity and Allow Kinetic Study of Antigen Processing.

Kurtis J. Haro, BS, Marta Gomez-Nunez, MD, Tao Dao, MD, PhD, Deming Chau, BS, Annie Won, BS, Sindy Escobar-Alvarez, BS, MS, Victoriya Zakhaleva, PhD, Tatyana Korontsvit, MD, David Gin, PhD, David A. Scheinberg, MD, PhD

Blood (2007) 110 (11): 2311.

https://doi.org/10.1182/blood.V110.11.2311.2311

Published: 2007

Journal Articles

Pilot Study of a Wilms Tumor Protein (WT1) Heteroclitic Peptide Vaccine in Patients with Myeloid and Thoracic Neoplasms.

Peter G. Maslak, MD, Lee Krug, MD, Suzanne Chanel, RN, Tao Dao, PhD, Leonard James, MD, PhD, Leslie Tyson, RN, Sara Bekele, BA, David A. Scheinberg, MD, PhD

Blood (2007) 110 (11): 903.

https://doi.org/10.1182/blood.V110.11.903.903

Published: 2007

Journal Articles

CD4+ Peptide Epitopes from the WT1 Oncoprotein Stimulate CD4+ and CD8+ T Cells That Recognize and Kill Leukemia and Solid Tumor Cells.

Rena J. May, PhD, Javier Pinilla, MD PhD, Tatyana Korontsvit, Victoriya Zakhaleva, Ronghua H. Zhang, Tao Dao, MD PhD, Peter Maslak, MD, David A. Scheinberg, MD PhD

Blood (2006) 108 (11): 3706.

https://doi.org/10.1182/blood.V108.11.3706.3706

Published: 2006

Journal Articles

Reliability of Computer Algorithm-Based Binding Predictions for the Identification of Leukemia Antigens.

Marta Gomez-Nunez, Javier Pinilla-Ibarz, Tao Dao, Tatyana Korontsvit, Victoriya Zakhaleva, Rena J. May, David A. Scheinberg

Blood (2005) 106 (11): 4483.

https://doi.org/10.1182/blood.V106.11.4483.4483

Published: 2005

NARROW

A dual-receptor T-cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML

A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies

A TCR Mimic Antibody-Directed CAR T Cell Specific for Intracellular NDC80 Is Broadly Cancer Reactive and Displays High Activity Against Hematological Malignancies

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Epigenetic Drug Treatment Induces Presentation of New Class of Non-Exonic, Cryptic Neoantigens in Acute Myeloid Leukemia Cells

Identification of Cross-Reactive Targets of TCR-Based Therapeutic Agents within the Human Proteome

A Therapeutic TCR Mimic Monoclonal Antibody for Intracellular PRAME Protein in Leukemias

Wilms´Tumor 1 Protein Is Highly Expressed on Malignant Plasma Cells and Provides a Novel Target for Immunotherapeutic Approaches

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers

A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL + leukemias

A Bi-Specific T Cell Engaging Monoclonal Antibody (mAb) Derived From a TCR-Like Mab Specific For WT1/HLA-A0201 (ESK-BiTE) Shows a Potent Activity Against Human AML and Ph+ ALL In Mouse Models

Therapeutic Efficacy and Cure Of Sensitive and T315I Pan-Resistant Human Ph+ Leukemia In Mice Using a TCR-Like Antibody To WT1/HLA-A0201 Alone, Or In Combination With Tyrosine Kinase Inhibitors

Native and Fc Enhanced Therapeutic Human Monoclonal Antibodies Targeting the Intracellular WT1 Oncogene Product in Leukemia.

Phase II Trial of WT1 Analog Peptide Vaccine in Patients with Acute Myeloid Leukemia (AML) in Complete Remission (CR)

A Cytotoxic Human Monoclonal Antibody Recognizing Cell Surface WT1 Peptide/HLA-A2 Complexes

Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia

Photo-Reactive and Non-Natural Amino Acid Epitopes of Human WT1 Enhance Immunogenicity and Allow Kinetic Study of Antigen Processing.

Pilot Study of a Wilms Tumor Protein (WT1) Heteroclitic Peptide Vaccine in Patients with Myeloid and Thoracic Neoplasms.

CD4+ Peptide Epitopes from the WT1 Oncoprotein Stimulate CD4+ and CD8+ T Cells That Recognize and Kill Leukemia and Solid Tumor Cells.

Reliability of Computer Algorithm-Based Binding Predictions for the Identification of Leukemia Antigens.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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