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Alex Kentsis
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Journal Articles

The Histone Acetyltransferase MOZ (KAT6A) Is a Molecular Dependency and Therapeutic Target in NUP98 -Rearranged Acute Myeloid Leukemia

Nicole L Michmerhuizen, Emily Heikamp, Masayuki Umeda, Ilaria Iacobucci, Bright Arthur, Danika Di Giacomo, Ryan Hiltenbrand, Sandi Radko-Juettner, Pablo Portola, Aurelie Claquin, Bappaditya Chandra, David W Baggett, Hongling Huang, Peipei Zhou, Lingyun Long, Hao Shi, Yu Sun, Evangelia K Papachristou, Chandra Sekhar Reddy Chilamakuri, Francisca N. de L. Vitorino, Joanna M Gongora, Clive S D'Santos, Benjamin A Garcia, Richard W Kriwacki, Hongbo Chi, Alex Kentsis, Scott A Armstrong, Jeffery M Klco, Charles G. Mullighan
Journal: Blood
Blood (2024) 144 (Supplement 1): 825.
https://doi.org/10.1182/blood-2024-210529
Published: 2024
Journal Articles

A Multi-Site Break through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib (Trial In Progress)

Ghayas C. Issa, Alexander J. Ambinder, Wenbin Xiao, Scott Manalis, Alex K Shalek, Lukasz P. Gondek, Alex Kentsis, Nicholas J. Short, Naval Daver, Jing Ning, Lianchun Xiao, Michael Hemann, Ken Chen, Keyur P. Patel, Pavan Bachireddy, Andrew A. Lane, Marina Konopleva, Omar Abdel-Wahab, Jeffrey J. Molldrem, Ross L Levine, Mark J. Levis, Richard M Stone, Michael Andreeff, Farhad Ravandi, Aaron D. Goldberg, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.2.
https://doi.org/10.1182/blood-2024-201582
Published: 2024
Journal Articles

Proteolytic Control and Therapeutic Targeting of Oncogenic Gene Expression in Acute Myeloid Leukemia

Masahiro Uni, Asher Preska Steinberg, Alicia Slavit, Sophia Rha, Shuyuan Cheng, Laura K. Schmalbrock, Jiayu Su, Jing Ma, Andrew McPherson, Charles G. Mullighan, Torsten Haferlach, Ilaria Iacobucci, Jeffery M Klco, Raul Rabadan, Alex Kentsis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4149.
https://doi.org/10.1182/blood-2024-200137
Published: 2024
Journal Articles

Targeting PERK Arm of Unfolded Protein Response Helps to Eliminate Therapy-Induced Residual Senescent-like Acute Myeloid Leukemia Cells

Gowri Poigaialwar, Sumiko Takao, Sovira Chaudhry, Laura K. Schmalbrock, Varun Gupta, Alex Kentsis, Julio A. Aguirre-Ghiso, Marina Konopleva, Maria S. Sosa, Anna Skwarska
Journal: Blood
Blood (2024) 144 (Supplement 1): 4137.
https://doi.org/10.1182/blood-2024-203451
Published: 2024
Journal Articles

A dual-receptor T-cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML

Tao Dao, Guangyan Xiong, Sung Soo Mun, Jeremy Meyerberg, Tatyana Korontsvit, Jingyi Xiang, Ziyou Cui, Aaron Y. Chang, Casey Jarvis, Winson Cai, Hanzhi Luo, Aspen Pierson, Anthony Daniyan, Sarah Yoo, Sumiko Takao, Michael Kharas, Alex Kentsis, Cheng Liu, David A. Scheinberg
Journal: Blood
Blood (2024) 143 (6): 507–521.
https://doi.org/10.1182/blood.2023021054
Published: 2024
Includes: Supplemental data
Journal Articles

The AP-1/ETS Transcription Factor Network Regulates Stem Cell Quiescence and Chemotherapy Resistance in Acute Myeloid Leukemia

Sumiko Takao, Victor Morell, Fiona C. Brown, Richard Koche, Alex Kentsis
Journal: Blood
Blood (2022) 140 (Supplement 1): 8682–8683.
https://doi.org/10.1182/blood-2022-165325
Published: 2022
Journal Articles

The menin-MLL1 interaction is a molecular dependency in NUP98 -rearranged AML

Emily B. Heikamp, Jill A. Henrich, Florian Perner, Eric M. Wong, Charles Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann, Sumiko Takao, Yaniv Kazansky, Yana Pikman, Gerard M. McGeehan, Edward A. Kolb, Alex Kentsis, Scott A. Armstrong
Journal: Blood
Blood (2022) 139 (6): 894–906.
https://doi.org/10.1182/blood.2021012806
Published: 2022
Includes: Supplemental data
Journal Articles

RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality

Florisela Herrejon Chavez, Paolo Cifani, Alli Pine, Karen L Chu, Ersilia Barin, Alexandra Schurer, Hanzhi Luo, Diu T.T. Nguyen, Alex Kentsis, Christina Leslie, Michael G Kharas, Ly P Vu
Journal: Blood
Blood (2021) 138 (Supplement 1): 296.
https://doi.org/10.1182/blood-2021-147575
Published: 2021
Journal Articles

Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance

Sumiko Takao, MD PhD, Richard Koche, PhD, Paolo Cifani, PhD, Zheng Ser, Alex Kentsis, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1318.
https://doi.org/10.1182/blood-2018-99-114433
Published: 2018
Journal Articles

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Mir Hossain, PhD, Falak Sher, PhD, Davide Seruggia, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Paolo Cifani, PhD, Laura Dassama, PhD, Claudio Macias-Trevino, BS, Matthew C. Canver, MD PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MD PhD, Alex Kentsis, MD PhD, Stuart H. Orkin, MD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2018-99-117043
Published: 2018
Journal Articles

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

Lauren Forbes, BS, MS, Krasnopolsky Isaac, BA, Gerard Minuesa Dinares, PhD, Michael G. Kharas, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1352.
https://doi.org/10.1182/blood-2018-99-118807
Published: 2018
Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
https://doi.org/10.1182/blood.V130.Suppl_1.286.286
Published: 2017
Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3945.
https://doi.org/10.1182/blood.V128.22.3945.3945
Published: 2016
Journal Articles

Comprehensive Genomic Profiling for Improved Diagnosis and Therapy of Pediatric Acute Leukemias

Rachel Kobos, MD, Jie He, PhD, Peter G Steinherz, MD, Kevin J. Curran, MD, Thomas M. Renaud, MD, Christopher Forlenza, MD, Farid Boulad, MD, Susan Prockop, MD, Kristina Marie Knapp, Michael Walsh, MD, Mikhail Roshal, MD PhD, Lu Wang, MD PhD, Elli Papaemmanuil, PhD, Ahmet Dogan, Shan Zhong, PhD, Sohail Balasubramanian, M.S., Michelle Nahas, PhD, Jo-Anne Vergilio, MD, Jeff Ross, MD, Phil Stephens, PhD, Tariq I Mughal, MD, Vincent A. Miller, MD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD, Alex Kentsis, MD PhD, Neerav N Shukla, MD
Journal: Blood
Blood (2016) 128 (22): 1605.
https://doi.org/10.1182/blood.V128.22.1605.1605
Published: 2016
Journal Articles

Ribosomal Protein Rpl22 Regulates Development and Transformation Via Altering RNA Processing

Minshi Wang, PhD, Zheng Ser, Shuyun Rao, PhD, Shawn Fahl, Yong Zhang, Suraj Peri, PhD, Alex Kentsis, MD PhD, David L Wiest, PhD
Journal: Blood
Blood (2016) 128 (22): 3878.
https://doi.org/10.1182/blood.V128.22.3878.3878
Published: 2016
Journal Articles

Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia

Takayuki Hoshii, PhD, Paolo Cifani, PhD, Tomoyoshi Nakadai, PhD, Zhaohui Feng, BM, BS, Chun-Hao Huang, PhD, Richard Koche, PhD, Christopher D Delaney, Chun-Wei David Chen, PhD, Scott W. Lowe, PhD, Robert Roeder, PhD, Alex Kentsis, MD PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 434.
https://doi.org/10.1182/blood.V128.22.434.434
Published: 2016
Journal Articles

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Fiona C Brown, PhD, Eric Still, Paolo Cifani, PhD, Casie Reed, Scott Ficarro, PhD, Jie He, PhD, Richard Koche, PhD, Patrick Bhola, PhD, Peter Romanienko, PhD, Willie Mark, PhD, Andrei V. Krivtsov, PhD, Anthony Letai, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Scott A. Armstrong, MD PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 436.
https://doi.org/10.1182/blood.V128.22.436.436
Published: 2016
Journal Articles

High Expression of Myocyte Enhancer Factor 2C ( MEF2C ) Is Associated with Adverse Risk Features and Poor Outcome in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

George S. Laszlo, PhD, Todd A. Alonzo, PhD, Chelsea J. Gudgeon, BS, Kimberly H. Harrington, BS, Alex Kentsis, MD PhD, Robert B. Gerbing, MA, Yi-Cheng Wang, MS, Rhonda E. Ries, MA, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD, Roland B. Walter, MD PhD MS
Journal: Blood
Blood (2015) 126 (23): 2570.
https://doi.org/10.1182/blood.V126.23.2570.2570
Published: 2015
Journal Articles

Functional Proteomics of Regulatory and Epigenetic Signaling in Normal and Malignant Hematopoiesis

Paolo Cifani, PhD, Mojdeh Shakiba, Fiona Brown, PhD, Avantika Dhabaria, PhD, Daniel E. Bauer, MD, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4972.
https://doi.org/10.1182/blood.V126.23.4972.4972
Published: 2015
Journal Articles

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Fiona Brown, PhD, Eric Still, Paolo Cifani, PhD, Scott Ficarro, PhD, Gayle Pouliot, MD PhD, Esther Drill, PhD, Mithat Gonen, PhD, Jie He, PhD, Sohail Balasubramanian, M.S., Shan Zhong, PhD, Dean Pavlick, Bahar Yilmazel, Andrei V. Krivtsov, PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD, Steven M. Kornblau, MD, Richard M. Stone, MD, Guido Marcucci, MD, John C. Byrd, MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2015) 126 (23): 88.
https://doi.org/10.1182/blood.V126.23.88.88
Published: 2015