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Laura K. Schmalbrock
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Journal Articles

Proteolytic Control and Therapeutic Targeting of Oncogenic Gene Expression in Acute Myeloid Leukemia

Masahiro Uni, Asher Preska Steinberg, Alicia Slavit, Sophia Rha, Shuyuan Cheng, Laura K. Schmalbrock, Jiayu Su, Jing Ma, Andrew McPherson, Charles G. Mullighan, Torsten Haferlach, Ilaria Iacobucci, Jeffery M Klco, Raul Rabadan, Alex Kentsis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4149.
https://doi.org/10.1182/blood-2024-200137
Published: 2024
Journal Articles

Targeting PERK Arm of Unfolded Protein Response Helps to Eliminate Therapy-Induced Residual Senescent-like Acute Myeloid Leukemia Cells

Gowri Poigaialwar, Sumiko Takao, Sovira Chaudhry, Laura K. Schmalbrock, Varun Gupta, Alex Kentsis, Julio A. Aguirre-Ghiso, Marina Konopleva, Maria S. Sosa, Anna Skwarska
Journal: Blood
Blood (2024) 144 (Supplement 1): 4137.
https://doi.org/10.1182/blood-2024-203451
Published: 2024
Journal Articles

Combination Treatment of Venetoclax and Hypomethylating Agents (HMA) or Low-Dose Cytarabine (LDAC) for Patients with Acute Myeloid Leukemia (AML) - Real-World Data from Two German Academic Centers

Laura K. Schmalbrock, Krischan Braitsch, Paul Jung, Irmgard Bumeder, Philipp Kiewe, Jörg Westermann, Lars Bullinger, Ulrich Keller, Florian Bassermann, Jan Krönke, Kathrin Rieger, Katharina S. Goetze
Journal: Blood
Blood (2021) 138 (Supplement 1): 1257.
https://doi.org/10.1182/blood-2021-150943
Published: 2021
Journal Articles

Clonal evolution of acute myeloid leukemia with FLT3 -ITD mutation under treatment with midostaurin

Laura K. Schmalbrock, Anna Dolnik, Sibylle Cocciardi, Eric Sträng, Frauke Theis, Nikolaus Jahn, Ekaterina Panina, Tamara J. Blätte, Julia Herzig, Sabrina Skambraks, Frank G. Rücker, Verena I. Gaidzik, Peter Paschka, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Thomas Schroeder, Michael Lübbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Richard A. Larson, Arnold Ganser, Hendrik G. Stunnenberg, Saverio Minucci, Richard M. Stone, Clara D. Bloomfield, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
Journal: Blood
Blood (2021) 137 (22): 3093–3104.
https://doi.org/10.1182/blood.2020007626
Published: 2021
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing (NGS)-Based Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication ( FLT3 -ITD + AML) Treated with Additional Midostaurin

Julia K. Herzig, PhD, Frank G. Rücker, MD, Laura K. Schmalbrock, MD, Tamara J. Blätte, PhD, Daniela Weber, MSc, Sabrina Skambraks, Silke Kapp-Schwoerer, MD, Andrea Corbacioglu, PhD, Verena I Gaidzik, MD, Peter Paschka, MD, Ekaterina Panina, MD, Nikolaus Jahn, MD, Anika Schrade, PhD, Frauke Theis, MD, Sibylle Cocciardi, PhD, Walter Fiedler, MD, Helmut R. Salih, Gerald Wulf, MD, Hans Salwender, MD, Thomas Schroeder, Katharina S. Götze, Thomas Kindler, MD, Michael Luebbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Lars Bullinger, MD, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137568
Published: 2020
Journal Articles

Exome Sequencing of Relapsed Multiple Myeloma Combined with Pooled CRISPR/Cas9 Screens Identifies Gene Mutations Associated with Drug-Specific Resistance

Stephan Bohl, Laura K. Schmalbrock, MD, Imke Bauhuf, Anna Dolnik, Tamara J. Blätte, MSc, Stefanie Lindner, Dr., Tatjana Meyer, MSc, BSc, Sarah Knödler, Denise Miller, Miriam Kull, Christian Langer, MD, Hartmut Döhner, MD, Dirk Heckl, PhD, Lars Bullinger, Jan Krönke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 809.
https://doi.org/10.1182/blood-2019-131245
Published: 2019
Journal Articles

Assessment of the Genomic Landscape of Intermediate Risk Acute Myeloid Leukemia As Defined By 2010 ELN Risk Classification

Ekaterina Panina, MD, Frank G. Rücker, MD, Lars Bullinger, MD, Anna Dolnik, PhD, Julia Herzig, PhD, Tamara J. Blätte, MSc, Verena I. Gaidzik, MD, Peter Paschka, MD, Maria-Veronica Teleanu, MD, Nikolaus Jahn, MD, Laura K. Schmalbrock, MD, Daniela Weber, MSc, Lena Kubanek, Thomas Kindler, MD, Jörg Westermann, MD, Michael Lubbert, MD PhD, Helmut R. Salih, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 994.
https://doi.org/10.1182/blood-2018-99-114671
Published: 2018
Journal Articles

NGS-Based Monitoring of Measurable Residual Disease in FLT3 -ITD Positive Acute Myeloid Leukemia

Tamara J. Blätte, MSc, Laura K. Schmalbrock, MD, Sabrina Skambraks, Sibylle Cocciardi, MSc, Anna Dolnik, PhD, Konstanze Döhner, MD, Lars Bullinger, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2778.
https://doi.org/10.1182/blood-2018-99-113382
Published: 2018
Journal Articles

Whole Exome Sequencing Reveals High Genetic Diversity in Relapsed Multiple Myeloma

Laura K. Schmalbrock, MD, Stephan Bohl, MD, Anna Dolnik, PhD, Tamara J. Blätte, MSc, Maria-Veronica Teleanu, Miriam Kull, MD, Denise Miller, Lars Bullinger, MD, Christian Langer, MD, Jan Kronke
Journal: Blood
Blood (2017) 130 (Supplement 1): 4363.
https://doi.org/10.1182/blood.V130.Suppl_1.4363.4363
Published: 2017
Journal Articles

Clonal Evolution of FLT3 -ITD Positive AML in Patients Treated with Midostaurin in Combination with Chemotherapy within the Ratify (CALGB 10603) and AMLSG 16-10 Trials

Laura K. Schmalbrock, MD, Sibylle Cocciardi, MSc, Anna Dolnik, PhD, Mridul Agrawal, MDMSc, Frauke Theis, Nikolaus Jahn, MD, Tamara J. Blätte, MSc, Verena I. Gaidzik, MD, Peter Paschka, MD, Ekaterina Panina, MD, Walter Fiedler, MD, Helmut R. Salih, MD, Gerald Wulf, MD, Ulrich Germing, MD, Michael Lübbert, MD, Felicitas Thol, MD, Michael Heuser, MD, Richard A. Larson, MD, Arnold Ganser, MD, Richard F. Schlenk, MD, Richard M. Stone, MD, Hartmut Döhner, MD, Konstanze Döhner, MD, Lars Bullinger, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 182.
https://doi.org/10.1182/blood.V130.Suppl_1.182.182
Published: 2017
Journal Articles

Genetic Heterogeneity of t(8;21)(q22;q22.1) Acute Myeloid Leukemia Revealed By High-Throughput Targeted Sequencing

Nikolaus Jahn, MD, Mridul Agrawal, MDMSc, Anna Dolnik, PhD, Sibylle Cocciardi, MSc, Laura K. Schmalbrock, MD, Tamara J. Blätte, MSc, Verena I. Gaidzik, MD, Peter Paschka, MD, Daniela Weber, MSc, Ekaterina Panina, MD, Thomas Michael Schroeder, MD, Mohammed Amen Wattad, MD, Michael Pfreundschuh, Heinz A. Horst, MD PhD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Richard F. Schlenk, MD, Hartmut Döhner, MD, Lars Bullinger, MD, Konstanze Dohner, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2688.
https://doi.org/10.1182/blood.V130.Suppl_1.2688.2688
Published: 2017
Journal Articles

High Expression of the DNMT3A Embedded Pri- Mir -1301 Associates with Improved Outcome in Patients with Acute Myeloid Leukemia

Janine Häntschel, MSc, Madlen Jentzsch, MD, Juliane Grimm, Marius Bill, Stefanie Beinicke, MSc, Laura K. Schmalbrock, MD, Lynn Bonifacio, MD, Luba Schuhmann, Julia Schulz, Karoline Goldmann, Michael Cross, PhD, Georg-Nikolaus Franke, MD, Vladan Vucinic, Wolfram Pönisch, MD, Gerhard Behre, MD, Dietger Niederwieser, MD, Sebastian Schwind, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1203.
https://doi.org/10.1182/blood.V130.Suppl_1.1203.1203
Published: 2017