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Richard F. Schlenk
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Journal Articles

Endothelial Dysfunction in Hematological Patients: Sublingual Microscopy, Hyperspectral Imaging, and Serum Endothelial Markers

Laura Simons, Muath Qadoura, Jule Buhl, Franziska Sunderer, Felix Korell, Ignatios Ikonomidis, Maximilian Dietrich, Silvia Seidlitz, Hans Vink, Lena Maier-Hein, Richard F. Schlenk, Carsten Müller-Tidow, Peter Dreger, Thomas Luft
Journal: Blood
Blood (2024) 144 (Supplement 1): 5519.
https://doi.org/10.1182/blood-2024-205216
Published: 2024
Journal Articles

Correlation of Baseline Gene Mutations With Quizartinib Efficacy in Patients With FLT3 -ITD-Positive Newly Diagnosed Acute Myeloid Leukemia in the Phase 3 QuANTUM-First Trial

Mark J. Levis, Pau Montesinos, Hee-Je Kim, Radovan Vrhovac, Elzbieta Patkowska, Pavel Zak, Po-Nan Wang, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Alexander E. Perl, Mitsuhiro Yazawa, Jaime E. Connolly Rohrbach, Venkat Thodima, Ken C. N. Chang, Li Liu, Karima Imadalou, Akash Nahar, Kristy Burns, Harry P. Erba
Journal: Blood
Blood (2024) 144 (Supplement 1): 848.
https://doi.org/10.1182/blood-2024-203303
Published: 2024
Journal Articles

Trial in Progress: A Randomized-Controlled Phase 2 Study Evaluating Venetoclax Plus Azacitidine Versus Intensive Chemotherapy in Adult Patients with Newly Diagnosed, NPM1 -Mutated AML - the SAL/AMLCG Vincent Trial

Lydia Kretschmer, Leo Ruhnke, Christoph Schliemann, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Christoph Schmid, Maher Hanoun, Tim Sauer, Klaus H Metzeler, Kerstin Schäfer-Eckart, Mathias Hänel, Martina Crysandt, Paul Jäger, Stefan W. Krause, Christine Dierks, Stefan Klein, Nadia Maguire, Lukas Peter Frenzel, Veit L. Buecklein, Frank Fiebig, Anna Harig, Christian Thiede, Moritz Middeke, Richard Dillon, Claudia D Baldus, Hubert Serve, Uwe Platzbecker, Karsten Spiekermann, Wolfgang Hiddemann, Martin Bornhäuser, Richard F. Schlenk, Carsten Müller-Tidow, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 1527.1.
https://doi.org/10.1182/blood-2024-198164
Published: 2024
Journal Articles

10 Year Follow-up of CALGB 10603/Ratify: Midostaurin Versus Placebo Plus Intensive Chemotherapy in Newly Diagnosed FLT3 Mutant Acute Myeloid Leukemia Patients Aged 18-60 Years

Richard M Stone, Jun Yin, Sumithra J Mandrekar, Axel Benner, Maral Saadati, Ilene A. Galinsky, Ben L. Sanford, Rebecca Teske, Susan M. Geyer, Thomas Prior, Sergio Amadori, Frederick R. Appelbaum, Joseph Brandwein, Konstanze Döhner, Gerhard Ehninger, Arnold Ganser, Rebecca B. Klisovic, Jürgen Krauter, Guido Marcucci, Bruno Medeiros, Dietger W. Niederwieser, Miguel A. Sanz, Richard F. Schlenk, Hubert Serve, Jorge Sierra, Martin S. Tallman, Andrew H Wei, Theo J.M. de Witte, Christian Thiede, Hartmut Döhner, Richard A. Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 218.
https://doi.org/10.1182/blood-2024-201058
Published: 2024
Journal Articles

Trial in Progress: The Phase 3, Randomized, Double-Blind, Placebo-Controlled QuANTUM-Wild Study of Quizartinib in Combination With Chemotherapy and as Single-Agent Maintenance in Newly Diagnosed, FLT3 -ITD-Negative Acute Myeloid Leukemia

Pau Montesinos, June-Won Cheong, Naval Daver, Amir T. Fathi, Mark J. Levis, Selina Luger, Toshihiro Miyamoto, Esther Natalie Oliva, Alexander E. Perl, Christian Récher, Richard F. Schlenk, Jianxiang Wang, Amer M. Zeidan, Li Liu, Yvonne Duong, Karima Imadalou, Karenza Alexis, Akash Nahar, Kristy Burns, Harry P. Erba
Journal: Blood
Blood (2024) 144 (Supplement 1): 1504.3.
https://doi.org/10.1182/blood-2024-205101
Published: 2024
Journal Articles

Quantum-First: Effects of Quizartinib (Q) on RFS, OS, CIR, and MRD in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication-Positive ( FLT3 -ITD+) Acute Myeloid Leukemia (AML) Who Received Continuation (CONT) Therapy (tx)

Mark J. Levis, Harry Erba, Pau Montesinos, Elzbieta Patkowska, Jorge E. Cortes, Herve Dombret, Alexander E. Perl, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Li Liu, Yasser M. Mostafa Kamel, Karima Imadalou, Abderrahmane Laadem, Mikkael A. Sekeres, Kristy Burns
Journal: Blood
Blood (2024) 144 (Supplement 1): 2890.
https://doi.org/10.1182/blood-2024-207305
Published: 2024
Journal Articles

Clonal Dynamics of Leukemic and Clonal Hematopoiesis Mutations Predict Relapse in Single Cell MRD Analysis of AML in First Complete Remission

Enise Ceran, Anne Kathrin Merbach, Christian Rohde, Robert Durruthy-Durruthy, Adam Sciambi, Michelle Lotze, Gema Fuerte, Matteo Cattaneo, Ivan Lukic, Maxi Wass, Judith Schaffrath, Christoph Röllig, Richard F. Schlenk, Marina Scheller, Simone Kowoll, Jörg Steighardt, Bayram Edemir, Beatrice Ludwig-Kraus, Lutz P. Mueller, Sabine Edemir, Abi Vainstein-Haras, Ella Sorani, Irit Gliko Kabir, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia Wickenhauser, Claudia D Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhäuser, Carsten Müller-Tidow
Journal: Blood
Blood (2024) 144 (Supplement 1): 4337.
https://doi.org/10.1182/blood-2024-209953
Published: 2024
Journal Articles

Quantum-First: Safety By Treatment Phase and By Age in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD) Positive Acute Myeloid Leukemia (AML)

Harry P. Erba, Herve Dombret, Alexander Perl, Tsvetomir Mitov, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Youngsook Choi, Mark J. Levis, Richard F Schlenk
Journal: Blood
Blood (2023) 142 (Supplement 1): 972.
https://doi.org/10.1182/blood-2023-186206
Published: 2023
Journal Articles

Kinetics of Complete Remission (CR) and CR Duration and Its Impact on Overall Survival (OS) and Event-Free Survival (EFS) in Quantum-First

Pau Montesinos, Alexander Perl, Mikkael A. Sekeres, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Richard F Schlenk, Harry P. Erba, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 4254.
https://doi.org/10.1182/blood-2023-187286
Published: 2023
Journal Articles

Quantum-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed through Induction (IND) and Consolidation (CONS) Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (nd) FLT3 -ITD+ AML Patients (pts)

Alexander Perl, Harry P. Erba, Pau Montesinos, Radovan Vrhovac, Elzbieta Patkowska, Heeje Kim, Pavel Zak, Po-Nan Wang, Jaime E Rohrbach, Ken C N Chang, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F Schlenk, Mark J. Levis
Journal: Blood
Blood (2023) 142 (Supplement 1): 832.
https://doi.org/10.1182/blood-2023-186785
Published: 2023
Journal Articles

Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1

Maike Janssen, Christina Schmidt, Peter-Martin Bruch, Maximilian F. Blank, Christian Rohde, Alexander Waclawiczek, Daniel Heid, Simon Renders, Stefanie Göllner, Lisa Vierbaum, Birgit Besenbeck, Sophie A. Herbst, Mareike Knoll, Carolin Kolb, Adriana Przybylla, Katharina Weidenauer, Anne Kathrin Ludwig, Margarete Fabre, Muxin Gu, Richard F. Schlenk, Friedrich Stölzel, Martin Bornhäuser, Christoph Röllig, Uwe Platzbecker, Claudia Baldus, Hubert Serve, Tim Sauer, Simon Raffel, Caroline Pabst, George Vassiliou, Binje Vick, Irmela Jeremias, Andreas Trumpp, Jeroen Krijgsveld, Carsten Müller-Tidow, Sascha Dietrich
Journal: Blood
Blood (2022) 140 (24): 2594–2610.
https://doi.org/10.1182/blood.2021014241
Published: 2022
Includes: Supplemental data
Journal Articles

Impact of Inotuzumb Ozogamicin on Outcome in Relapsed or Refractory Acute B-Lymphoblastic Leukemia Patients Prior to Allogeneic Hematopoietic Stem Cell Transplantation

Sabine Kayser, Chiara Sartor, Fabio Giglio, Alessandro Bruno, Jonathan Webster, Mark J. Levis, Richard F. Schlenk, Cristina Papayannidis
Journal: Blood
Blood (2022) 140 (Supplement 1): 8906–8907.
https://doi.org/10.1182/blood-2022-166193
Published: 2022
Journal Articles

Double-Blind, Placebo Controlled, Randomized, Multicenter, Phase II Study to Assess the Efficacy of the High Affinity CXCR4 Inhibitor BL-8040 As Addition to Consolidation Therapy in AML By the SAL and OSHO Leukemia Study Groups

Sonia Jaramillo Segura, Maxi Wass, Judith Schaffrath, Kathrin Rieger, Axel Nogai, Mathias Haenel, Regina Herbst, Friedrich Stoelzel, Christoph Röllig, Edgar Jost, Richard F. Schlenk, Richard Noppeney, Christian H. Brandts, Utz Krug, Katharina S. Goetze, Sebastian Buske, Axel Florschütz, Jörg Schubert, Bernhard Opitz, Martin Mohren, Eva Eßeling, Stephan von Witzendorff, Marion Subklewe, Martin Kaufmann, Norbert Frickhofen, Christian W Scholz, Kerstin Schäfer-Eckart, Volker Kunzmann, Martin Schmidt-Hieber, Herbert G. Sayer, Andreas Rank, Philipp Hemmati, Frank Schueler, Simone Kowoll, Marina Scheller, Jörg Steighardt, Bayram Edemir, Lutz Peter Mueller, Irit Gliko-Kabir, Beatrice Ludwig-Kraus, Sabine Edemir, Ella Sorani, Mascha Binder, Abi Vainstein, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhaeuser, Christian Junghanss, Carsten Mueller-Tidow
Journal: Blood
Blood (2022) 140 (Supplement 1): 3338–3340.
https://doi.org/10.1182/blood-2022-166748
Published: 2022
Journal Articles

Venetoclax-Based Salvage Therapy Improves Outcome in Relapsed/Refractory AML Patients Eligible for Intensive Treatment: A Propensity Score Matching Analysis

Julia M. Unglaub, Richard F. Schlenk, Maher Hanoun, H. Christian Reinhardt, Jan Moritz Middeke, Kerstin Schäfer-Eckart, Björn Steffen, Stefan W. Krause, Christoph Schliemann, Martin Kaufmann, Mathias Haenel, Edgar Jost, Martina Crysandt, Lars Fransecky, Hermann Einsele, Sabrina Kraus, Dirk Niemann, Andreas Neubauer, Ruth Seggewiss-Bernhardt, Sebastian Scholl, Stefan Klein, Christoph Schmid, Markus Schaich, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhaeuser, Hubert Serve, Christoph Röllig, Michael Kramer, Elena Katelari, Maike Janssen, Caroline Pabst, Thomas Luft, Peter Dreger, Carsten Müller-Tidow, Tim Sauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3317–3319.
https://doi.org/10.1182/blood-2022-167677
Published: 2022
Journal Articles

Macs - a Leukemic Stem Cell- Based Predictor of Clinical Response to Venetoclax and Other BH3 Mimetics for Acute Myeloid Leukemia

Simon Renders, Alexander Waclawiczek, Aino-Maija Leppä, Cecilia Reyneri, Barbara Betz, Karolin Stumpf, Maike Janssen, Julia M. Unglaub, Elisa Donato, Rabia Shahswar, Simon Raffel, Michael Heuser, Richard F. Schlenk, Michael Hundemer, Tim Sauer, Carsten Müller-Tidow, Andreas Trumpp
Journal: Blood
Blood (2022) 140 (Supplement 1): 2023–2024.
https://doi.org/10.1182/blood-2022-164831
Published: 2022
Journal Articles

Gemtuzumab Ozogamicin Plus Intensive Chemotherapy for Patients with NPM1 -Mutated Acute Myeloid Leukemia

Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Mohammad Wattad, Katharina Götze, Lars Fransecky, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Mark Ringhoffer, Richard Greil, Bernd Hertenstein, Jürgen Krauter, Uwe M. Martens, David Nachbaur, Maisun Abu Samra, Sigrid Machherndl-Spandl, Nadezda Basara, Claudia Leis, Anika Schrade, Silke Kapp-Schwoerer, Lars Bullinger, Felicitas R. Thol, Michael Heuser, Peter Paschka, Verena I. Gaidzik, Maral Saadati, Axel Benner, Richard F. Schlenk, Konstanze Döhner, Arnold Ganser
Journal: Blood
Blood (2022) 140 (Supplement 1): 2010–2013.
https://doi.org/10.1182/blood-2022-166084
Published: 2022
Journal Articles

Impact of Allogeneic Hematopoietic Cell Transplantation in First Complete Remission in Addition to FLT3 Inhibition with Quizartinib in Acute Myeloid Leukemia with FLT3 -Internal Tandem Duplication: Results from the Quantum-First Trial

Richard F. Schlenk, Pau Montesinos, Antonio Romero-Aguilar, Radovan Vrhovac, Elżbieta Patkowska, Hee-Je Kim, Pavel Zak, Po-Nan Wang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Aziz Benzohra, Arnaud Lesegretain, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Alexander E. Perl, Mark J. Levis, Harry P. Erba
Journal: Blood
Blood (2022) 140 (Supplement 1): 2130–2132.
https://doi.org/10.1182/blood-2022-169011
Published: 2022
Journal Articles

Quantum-First Trial: FLT3 -ITD-Specific MRD Clearance Is Associated with Improved Overall Survival

Mark J. Levis, Harry P. Erba, Pau Montesinos, Radovan Vrhovac, Elzbieta Patkowska, Heeje Kim, Pavel Zak, Po-Nan Wang, Jaime E. Connolly Rohrbach, Ken CN Chang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Arnaud Lesegretain, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Alexander Perl
Journal: Blood
Blood (2022) 140 (Supplement 1): 546–548.
https://doi.org/10.1182/blood-2022-162739
Published: 2022
Journal Articles

Characteristics and Outcome of Patients with Acute Myeloid Leukemia and Trisomy 4

Sabine Kayser, David Martínez-Cuadrón, Maher Hanoun, Friedrich Stölzel, Cristina Gil, H. Christian Reinhardt, Eliana Aguiar, Kerstin Schäfer-Eckart, Juan Miguel Bergua Burgues, Björn Steffen, Teresa Bernal, Stefan W. Krause, Rosalia Riaza, Christoph Schliemann, Jose Cervera, Martin Kaufmann, Laura Torres, Mathias Haenel, Evelyn Acuña-Cruz, Edgar Jost, Jesús Lorenzo Algarra, Martina Crysandt, Lars Fransecky, Javier Cornago Navascués, Sabrina Kraus, Joaquin Martinez-Lopez, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Ruth Seggewiss-Bernhardt, Sebastian Scholl, Stefan Klein, Christoph Schmid, Markus Schaich, Martin Schmidt-Hieber, Anthony D. Ho, Uwe Platzbecker, Claudia D. Baldus, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Hubert Serve, Mark Levis, Pau Montesinos, Christoph Röllig, Richard F. Schlenk
Journal: Blood
Blood (2021) 138 (Supplement 1): 1307.
https://doi.org/10.1182/blood-2021-150281
Published: 2021
Journal Articles

Venetoclax-Azacitidine As Salvage Therapy and Bridge to Allogeneic Cell Transplantation in Relapsed/Refractory AML Compared to Historical Data of the SAL Registry Study

Julia M. Unglaub, Richard F. Schlenk, Maher Hanoun, H. Christian Reinhardt, Jan Moritz Middeke, Kerstin Schäfer-Eckart, Björn Steffen, Stefan W. Krause, Christoph Schliemann, Martin Kaufmann, Mathias Haenel, Edgar Jost, Martina Crysandt, Lars Fransecky, Sabrina Kraus, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Ruth Seggewiss-Bernhardt, Sebastian Scholl, Stefan Klein, Christoph Schmid, Markus Schaich, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhäuser, Hubert Serve, Christoph Rollig, Michael Kramer, Elena Katelari, Maike Janssen, Caroline Pabst, Thomas Luft, Peter Dreger, Carsten Müller-Tidow, Tim Sauer
Journal: Blood
Blood (2021) 138 (Supplement 1): 4418.
https://doi.org/10.1182/blood-2021-151287
Published: 2021