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Claudia D. Baldus
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Journal Articles

Chemotherapy or Stem Cell Transplantation in Adult High Risk Ph/BCR::ABL1-Negative ALL Patients with Early MRD Negativity: Results of the Randomized GMALL Trial 08/2013

Nicola Goekbuget, Folker Schneller, Kathrin Nachtkamp, Sr., Joachim Beck, Christoph Faul, Ralph Wäsch, Tobias Gaska, Lisa Heberling, Knut Wendelin, Thomas Kubin, Sonja Martin, Lino L. Teichmann, Veit L. Buecklein, Walter Fiedler, Christian Junghanss, Claudia D Baldus, Monika Brüggemann, Stefan Schwartz, Axel Benner, Nicholas Schreck, Lena Reiser, Hubert Serve, Andreas Viardot
Journal: Blood
Blood (2024) 144 (Supplement 1): 961.
https://doi.org/10.1182/blood-2024-199060
Published: 2024
Journal Articles

C/EBP Family Member Gene Fusions and Cooperating Genomic Events Define Two Distinct Molecular Sub-Groups in Adult B Precursor ALL

Björn-Thore Hansen, Thomas Beder, Sören Döhle, Wencke Walter, Malwine J Barz, Cecilia Bozzetti, Johanna Horns, Axel Künstner, Alina M. Hartmann, Sören Franzenburg, Michael Wittig, Barbara Ritter, Stefan Schwartz, Hauke Busch, Nikos Darzentas, Claudia Haferlach, Nicola Goekbuget, Monika Brüggemann, Claudia D Baldus, Lorenz Bastian
Journal: Blood
Blood (2024) 144 (Supplement 1): 1458.
https://doi.org/10.1182/blood-2024-211088
Published: 2024
Journal Articles

The Differential Impact of Secondary-Type Mutations in a Multinational Cohort of 5311 Intensively Treated Acute Myeloid Leukemia Patients

Jan-Niklas Eckardt, Marius Bill, Konstanze Döhner, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. H. Brummendorf, Utz Krug, Bernhard Wörmann, Hermann Einsele, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Johannes Schetelig, Jan Moritz Middeke, Lars Bullinger, Michael Heuser, Felicitas R Thol, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Mueller-Tidow, Barbora Weinbergerova, Jiri Mayer, Pierre-Yves Dumas, Sarah Bertoli, Eric Delabesse, Christian Récher, Arnaud Pigneux, Tobias Herold, Arnold Ganser, Hartmut Döhner, Martin Bornhäuser, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 2934.
https://doi.org/10.1182/blood-2024-201945
Published: 2024
Journal Articles

Integrateall, a Machine Learning Pipeline for Multi-Level Data Extraction from RNA-Seq Profiles Unravels Novel Drivers and Systematic Subtype Classification in B-Cell Precursor ALL

Nadine Wolgast, Thomas Beder, Mayukh Mondal, Wencke Walter, Stephan Hutter, Sonja Bendig, Jan Kässens, Björn-Thore Hansen, Katharina Iben, Barz Malwine, Martin Neumann, Nicola Goekbuget, Claudia Haferlach, Monika Brüggemann, Claudia D Baldus, Alina M. Hartmann, Lorenz Bastian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4213.
https://doi.org/10.1182/blood-2024-199557
Published: 2024
Journal Articles

Drug Sensitivity and Treatment Response Are Modulated By the Cell of Origin, the Underlying Gene Fusion, and Patient Age in KMT2A -Rearranged BCP-ALL

Alina M. Hartmann, Lorenz Bastian, Malwine J Barz, Eric Amelunxen, Johannes Haas, Lennart Lenk, Michaela Kotrova, Thomas Beder, Fabio D. Steffen, Kerstin K. Rauwolf, Nadine Wolgast, Patrick Ehm, Sonja Bendig, Julia Alten, Mayukh Mondal, Aeint-Steffen Ströh, Thomas Burmeister, Nicola Goekbuget, Beat Bornhauser, Jean-Pierre Bourquin, Monika Brüggemann, Martin Schrappe, Gunnar Cario, Claudia D Baldus
Journal: Blood
Blood (2024) 144 (Supplement 1): 318.
https://doi.org/10.1182/blood-2024-199017
Published: 2024
Journal Articles

Age-Stratified Game-Theory-Informed Machine Learning of Molecular Alterations Unveils Prognostic Divergence in 3062 Pediatric and Adult Acute Myeloid Leukemia Patients

Jan-Niklas Eckardt, Waldemar Hahn, Rhonda E. Ries, Szymon Dariusz Chrost, Susann Winter, Sebastian Stasik, Christoph Röllig, Uwe Platzbecker, Carsten Müller-Tidow, Hubert Serve, Claudia D Baldus, Christoph Schliemann, Kerstin Schäfer-Eckart, Maher Hanoun, Martin Kaufmann, Andreas Burchert, Johannes Schetelig, Martin Bornhäuser, Markus Wolfien, Soheil Meshinchi, Christian Thiede, Jan Moritz Middeke
Journal: Blood
Blood (2024) 144 (Supplement 1): 2211.
https://doi.org/10.1182/blood-2024-198861
Published: 2024
Journal Articles

Clonal Dynamics of Leukemic and Clonal Hematopoiesis Mutations Predict Relapse in Single Cell MRD Analysis of AML in First Complete Remission

Enise Ceran, Anne Kathrin Merbach, Christian Rohde, Robert Durruthy-Durruthy, Adam Sciambi, Michelle Lotze, Gema Fuerte, Matteo Cattaneo, Ivan Lukic, Maxi Wass, Judith Schaffrath, Christoph Röllig, Richard F. Schlenk, Marina Scheller, Simone Kowoll, Jörg Steighardt, Bayram Edemir, Beatrice Ludwig-Kraus, Lutz P. Mueller, Sabine Edemir, Abi Vainstein-Haras, Ella Sorani, Irit Gliko Kabir, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia Wickenhauser, Claudia D Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhäuser, Carsten Müller-Tidow
Journal: Blood
Blood (2024) 144 (Supplement 1): 4337.
https://doi.org/10.1182/blood-2024-209953
Published: 2024
Journal Articles

Preclinical Development of a Novel Humanized and Fc-Engineered Antibody-Drug Conjugate for the Therapy of T-Cell Acute Lymphoblastic Leukemia

Steffen Krohn, Carina Lynn Gehlert, Dorothee Winterberg, Alexander Jochimsen, Ammelie Svea Boje, Natalie Baum, Claudia D Baldus, Monika Brüggemann, Gunnar Cario, Martin Schrappe, Lennart Lenk, Martin Gramatzki, Katja Klausz, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2024) 144 (Supplement 1): 4173.
https://doi.org/10.1182/blood-2024-207737
Published: 2024
Journal Articles

HLA-DR Expression on Leukemic Progenitor Cells before Allogeneic Hematopoietic Cell Transplantation Adds Prognostic Value in the Presence of MRD

Maximilian Alexander Rohnert, Jonas Schadt, Michael Kramer, Christoph Röllig, Johannes Schetelig, Friedrich Stölzel, Désirée Kunadt, Jan Moritz Middeke, Lars Thielecke, Friedemann Uschner, Ingmar Glauche, Christian Thiede, Martin Bornhaeuser, Uta Oelschlaegel, Malte von Bonin, Uwe Platzbecker, Claudia D Baldus, Hubert Serve, Carsten Mueller-Tidow
Journal: Blood
Blood (2024) 144 (Supplement 1): 2948.
https://doi.org/10.1182/blood-2024-194874
Published: 2024
Journal Articles

Data-Informed, Refined Immunophenotypic Classification of Adult T-Lineage Acute Lymphoblastic Leukemia

Stefan Habringer, Iva Todorova, Frederik Herzberg, Daniel Steiert, Arik Horne, Thomas Burmeister, Simon Haas, Ulrich Keller, Monika Brüggemann, Michaela Kotrova, Claudia D Baldus, Nicola Goekbuget, Martin Neumann, Stefan Schwartz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1460.
https://doi.org/10.1182/blood-2024-202301
Published: 2024
Journal Articles

Circulating Tumor DNA Kinetics at Day 14 after CAR T-Cell Therapy Identifies Patients with B-Cell Lymphoma at Risk for Early Treatment Failure

Tim Versteegen, Philipp Nakov, Nikos Darzentas, Guranda Chitadze, Ingram Iaccarino, Wolfram Klapper, Natalie Schub, Monika Brüggemann, Friedrich Stoelzel, Claudia D Baldus, Christiane Pott, Mouhamad Khouja
Journal: Blood
Blood (2024) 144 (Supplement 1): 2959.
https://doi.org/10.1182/blood-2024-207721
Published: 2024
Journal Articles

Trial in Progress: A Randomized-Controlled Phase 2 Study Evaluating Venetoclax Plus Azacitidine Versus Intensive Chemotherapy in Adult Patients with Newly Diagnosed, NPM1 -Mutated AML - the SAL/AMLCG Vincent Trial

Lydia Kretschmer, Leo Ruhnke, Christoph Schliemann, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Christoph Schmid, Maher Hanoun, Tim Sauer, Klaus H Metzeler, Kerstin Schäfer-Eckart, Mathias Hänel, Martina Crysandt, Paul Jäger, Stefan W. Krause, Christine Dierks, Stefan Klein, Nadia Maguire, Lukas Peter Frenzel, Veit L. Buecklein, Frank Fiebig, Anna Harig, Christian Thiede, Moritz Middeke, Richard Dillon, Claudia D Baldus, Hubert Serve, Uwe Platzbecker, Karsten Spiekermann, Wolfgang Hiddemann, Martin Bornhäuser, Richard F. Schlenk, Carsten Müller-Tidow, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 1527.1.
https://doi.org/10.1182/blood-2024-198164
Published: 2024
Journal Articles

IDH2 Mutations from Clonal Hematopoiesis and Acquired IKZF1 Deletions Define a Novel B-ALL Subtype after Lenalidomide Therapy for Multiple Myeloma

Johanna Maria Horns, Thomas Beder, Malwine J Barz, Aeint-Steffen Ströh, Axel Künstner, Sonja Bendig, Guranda Chitadze, Cecilia Bozzetti, Nikos Darzentas, Katharina Iben, Michaela Kotrova, Martin Neumann, Wiebke Weßels, Hauke Busch, Lennart Lenk, Judith S. Hecker, Stefan Knop, Boris Böll, Johannes Duell, Walter Fiedler, Christoph Faul, Christoph Röllig, Bernd Spriewald, Björn Steffen, Maher Hanoun, Nicola Goekbuget, Claudia D Baldus, Lorenz Bastian, Monika Brüggemann
Journal: Blood
Blood (2024) 144 (Supplement 1): 631.
https://doi.org/10.1182/blood-2024-199601
Published: 2024
Journal Articles

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Binje Vick, Vindi Jurinovic, Lena Lagally, Kristina Kuhbandner, Lisa Latzko, Chiara Arnreich, Maja Rothenberg-Thurley, Gerulf Hänel, Amelie Muth, Annika Maria Dufour, Stephanie Schneider, Maya C. Andre, Claudia D Baldus, Martin P Carroll, Martin Ebinger, Katharina S. S. Götze, Pablo Menéndez, Jean-Emmanuel Sarry, Talía Velasco-Hernández, Michael von Bergwelt-Baildon, Klaus H Metzeler, Philipp A. Greif, Marion Subklewe, Sebastian Vosberg, Tobias Herold, Karsten Spiekermann, Irmela Jeremias
Journal: Blood
Blood (2024) 144 (Supplement 1): 6085.
https://doi.org/10.1182/blood-2024-198652
Published: 2024
Journal Articles

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

Emma Kroeze, Ingram Iaccarino, Michelle M. Kleisman, Mayukh Mondal, Thomas Beder, Mouhamad Khouja, Marc P. Höppner, Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Monika Brüggemann, Claudia D. Baldus, Gunnar Cario, Reno S. Bladergroen, Nathalie Garnier, Andishe Attarbaschi, Jaime Verdu-Amorós, Rosemary Sutton, Elizabeth Macintyre, Kenneth Scholten, Laura Arias Padilla, Birgit Burkhardt, Auke Beishuizen, Monique L. den Boer, Roland P. Kuiper, Jan L. C. Loeffen, Judith M. Boer, Wolfram Klapper
Journal: Blood
Blood (2024) 144 (1): 74–83.
https://doi.org/10.1182/blood.2024023938
Published: 2024
Includes: Supplemental data
Journal Articles

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR :: ABL1 -positive ALL

Clinical Trials & Observations Brief Report
Lorenz Bastian, Thomas Beder, Malwine J. Barz, Sonja Bendig, Lorenz Bartsch, Wencke Walter, Nadine Wolgast, Björn Brändl, Christian Rohrandt, Björn-Thore Hansen, Alina M. Hartmann, Katharina Iben, Dennis Das Gupta, Miriam Denker, Johannes Zimmermann, Michael Wittig, Guranda Chitadze, Martin Neumann, Folker Schneller, Walter Fiedler, Björn Steffen, Matthias Stelljes, Christoph Faul, Stefan Schwartz, Franz-Josef Müller, Gunnar Cario, Lana Harder, Claudia Haferlach, Heike Pfeifer, Nicola Gökbuget, Monika Brüggemann, Claudia D. Baldus
Journal: Blood
Blood (2024) 143 (14): 1391–1398.
https://doi.org/10.1182/blood.2023021752
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular Subtypes in BCR::ABL1 -Positive ALL Are Defined By Cellular Origins and Cooperating Genomic Events

Lorenz Bastian, Thomas Beder, Malwine Barz, Sonja Bendig, Lorenz Bartsch, Wencke Walter, Nadine Wolgast, Björn Brändl, Christian Rohrandt, Björn-Thore Hansen, Alina M. Hartmann, Katharina Iben, Miriam Bultmann, Johannes Zimmermann, Michael Wittig, Guranda Chitadze, Martin Neumann, Folker Schneller, Walter Fiedler, Björn Steffen, Matthias Stelljes, Christoph Faul, Stefan Schwartz, Franz-Josef Müller, Gunnar Cario, Lana Harder, Claudia Haferlach, Heike Pfeifer, Nicola Goekbuget, Monika Brüggemann, Claudia D Baldus
Journal: Blood
Blood (2023) 142 (Supplement 1): 843.
https://doi.org/10.1182/blood-2023-187315
Published: 2023
Journal Articles

Secondary-Type Mutations Do Not Impact the Favorable Outcome of NPM1 -Mutated Acute Myeloid Leukemia Patients - Results from a Large Cohort of Intensively Treated Patients

Marius Bill, Jan-Niklas Eckardt, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Utz Krug, Bernhard Wörmann, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Hermann Einsele, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hanel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Leo Ruhnke, Johannes Schetelig, Jan Moritz Middeke, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Müller-Tidow, Martin Bornhäuser, Tobias Herold, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2023) 142 (Supplement 1): 721.
https://doi.org/10.1182/blood-2023-186160
Published: 2023
Journal Articles

Pseudoprogression As Adverse Event of Chimeric Antigen Receptor T Cell Therapy

Torsten Schroeder, Tjark Martens, Guranda Chitadze, Fatih Yalcin, Heiko Trautmann, Monika Brüggemann, Christine Heinen, Philipp Nakov, Anca Maria Albici, Nicolas Spath, Lukas Sprenger, Laura Jane Kramp, Matthias Ritgen, Dominique Wellnitz, Maciej Simon, Sebastian Lippross, Ingram Iaccarino, Wolfram Klapper, Lars Fransecky, Thomas Valerius, Natalie Schub, Christiane Pott, Claudia D Baldus, Friedrich Stoelzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 6935.
https://doi.org/10.1182/blood-2023-189047
Published: 2023
Journal Articles

Impact of KMT2A -PTD Mutational Subgroups on Outcome of AML Patients after Induction Therapy and Allogeneic Hematopoietic Cell Transplantation

Desiree Kunadt, Sven Zukunft, Klaus H Metzeler, Christoph Röllig, Christoph Schliemann, Jan Braess, Carsten Müller-Tidow, Alwin Kraemer, Sebastian Scholl, Inken Hilgendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Thomas Schroeder, Martin Kaufmann, Jan Moritz Middeke, Katja Sockel, Leo Ruhnke, Uwe Platzbecker, Hubert Serve, Matthias Stelljes, Claudia D Baldus, Andreas Neubauer, Johannes Schetelig, David Poitz, Christian Thiede, Martin Bornhäuser, Friedrich Stölzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 2236.
https://doi.org/10.1182/blood-2023-187273
Published: 2023