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Sergio Amadori
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Journal Articles

Correlation of Baseline Gene Mutations With Quizartinib Efficacy in Patients With FLT3 -ITD-Positive Newly Diagnosed Acute Myeloid Leukemia in the Phase 3 QuANTUM-First Trial

Mark J. Levis, Pau Montesinos, Hee-Je Kim, Radovan Vrhovac, Elzbieta Patkowska, Pavel Zak, Po-Nan Wang, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Alexander E. Perl, Mitsuhiro Yazawa, Jaime E. Connolly Rohrbach, Venkat Thodima, Ken C. N. Chang, Li Liu, Karima Imadalou, Akash Nahar, Kristy Burns, Harry P. Erba
Journal: Blood
Blood (2024) 144 (Supplement 1): 848.
https://doi.org/10.1182/blood-2024-203303
Published: 2024
Journal Articles

10 Year Follow-up of CALGB 10603/Ratify: Midostaurin Versus Placebo Plus Intensive Chemotherapy in Newly Diagnosed FLT3 Mutant Acute Myeloid Leukemia Patients Aged 18-60 Years

Richard M Stone, Jun Yin, Sumithra J Mandrekar, Axel Benner, Maral Saadati, Ilene A. Galinsky, Ben L. Sanford, Rebecca Teske, Susan M. Geyer, Thomas Prior, Sergio Amadori, Frederick R. Appelbaum, Joseph Brandwein, Konstanze Döhner, Gerhard Ehninger, Arnold Ganser, Rebecca B. Klisovic, Jürgen Krauter, Guido Marcucci, Bruno Medeiros, Dietger W. Niederwieser, Miguel A. Sanz, Richard F. Schlenk, Hubert Serve, Jorge Sierra, Martin S. Tallman, Andrew H Wei, Theo J.M. de Witte, Christian Thiede, Hartmut Döhner, Richard A. Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 218.
https://doi.org/10.1182/blood-2024-201058
Published: 2024
Journal Articles

Quantum-First: Effects of Quizartinib (Q) on RFS, OS, CIR, and MRD in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication-Positive ( FLT3 -ITD+) Acute Myeloid Leukemia (AML) Who Received Continuation (CONT) Therapy (tx)

Mark J. Levis, Harry Erba, Pau Montesinos, Elzbieta Patkowska, Jorge E. Cortes, Herve Dombret, Alexander E. Perl, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Li Liu, Yasser M. Mostafa Kamel, Karima Imadalou, Abderrahmane Laadem, Mikkael A. Sekeres, Kristy Burns
Journal: Blood
Blood (2024) 144 (Supplement 1): 2890.
https://doi.org/10.1182/blood-2024-207305
Published: 2024
Journal Articles

Quantum-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed through Induction (IND) and Consolidation (CONS) Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (nd) FLT3 -ITD+ AML Patients (pts)

Alexander Perl, Harry P. Erba, Pau Montesinos, Radovan Vrhovac, Elzbieta Patkowska, Heeje Kim, Pavel Zak, Po-Nan Wang, Jaime E Rohrbach, Ken C N Chang, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F Schlenk, Mark J. Levis
Journal: Blood
Blood (2023) 142 (Supplement 1): 832.
https://doi.org/10.1182/blood-2023-186785
Published: 2023
Journal Articles

Impact of Allogeneic Hematopoietic Cell Transplantation in First Complete Remission in Addition to FLT3 Inhibition with Quizartinib in Acute Myeloid Leukemia with FLT3 -Internal Tandem Duplication: Results from the Quantum-First Trial

Richard F. Schlenk, Pau Montesinos, Antonio Romero-Aguilar, Radovan Vrhovac, Elżbieta Patkowska, Hee-Je Kim, Pavel Zak, Po-Nan Wang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Aziz Benzohra, Arnaud Lesegretain, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Alexander E. Perl, Mark J. Levis, Harry P. Erba
Journal: Blood
Blood (2022) 140 (Supplement 1): 2130–2132.
https://doi.org/10.1182/blood-2022-169011
Published: 2022
Journal Articles

Quantum-First Trial: FLT3 -ITD-Specific MRD Clearance Is Associated with Improved Overall Survival

Mark J. Levis, Harry P. Erba, Pau Montesinos, Radovan Vrhovac, Elzbieta Patkowska, Heeje Kim, Pavel Zak, Po-Nan Wang, Jaime E. Connolly Rohrbach, Ken CN Chang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Arnaud Lesegretain, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Alexander Perl
Journal: Blood
Blood (2022) 140 (Supplement 1): 546–548.
https://doi.org/10.1182/blood-2022-162739
Published: 2022
Journal Articles

Impact of Gender on Molecular AML Subclasses - a Harmony Alliance Study

Tommaso Matteuzzi, Daniele Dall'Olio, Eric Sträng, Alessandra Merlotti, Javier Martinez Elicegui, Axel Benner, Maral Saadati, Julia Krzykalla, Caroline A. Heckman, Ana Heredia Casanoves, Jurjen Versluis, María Abáigar, Alberto Hernandez-Sanchez, Laura Jamilis, Peter JM Valk, Klaus H. Metzeler, Rosa Ayala, Joaquin Martinez Lopez, Herve Dombret, Pau Montesinos, Jorge Sierra, Claude Preudomme, Frederick Damm, Ken I Mills, Raúl Azibeiro Melchor, Jiří Mayer, Christian Thiede, Maria Teresa Voso, Sergio Amadori, Guillermo Sanz, Frederico Calado, Konstanze Döhner, Verena I Gaidzik, Michael Heuser, Torsten Haferlach, Marta Sobas, Amin T. Turki, Dirk Reinhardt, Rubén Villoria Medina, Michel van Speybroeck, Renate Schulze-Rath, Jesús M Hernández Rivas, Brian J.P Huntly, Hartmut Döhner, Gert J. Ossenkoppele, Castellani Gastone, Lars Bullinger
Journal: Blood
Blood (2021) 138 (Supplement 1): 3438.
https://doi.org/10.1182/blood-2021-152215
Published: 2021
Journal Articles

Results of the 6-Year Follow-up of the Gimema AML1310 Trial: A Risk-Adapted, MRD-Directed Therapy for Young Adults with Newly Diagnosed Acute Myeloid Leukemia

Adriano Venditti, Alfonso Piciocchi, Raffaele Palmieri, Valentina Arena, Anna Candoni, Valeria Calafiore, Lorella MA Melillo, Roberto Cairoli, Paolo De Fabritiis, Gabriella Storti, Prassede Salutari, Francesco Lanza, Giovanni Martinelli, Mario Luppi, Saveria Capria, Luca Maurillo, Maria Ilaria Del Principe, Giovangiacinto Paterno, Elisa Buzzatti, Maria Teresa Voso, Tiziana Ottone, Maria irno Consalvo, Paola Fazi, Marco Vignetti, William Arcese, Sergio Amadori, Francesco Buccisano
Journal: Blood
Blood (2021) 138 (Supplement 1): 2359.
https://doi.org/10.1182/blood-2021-147200
Published: 2021
Journal Articles

Harmony Alliance Provides a Machine Learning Researching Tool to Predict the Risk of Relapse after First Remission in AML Patients Treated without Allogeneic Haematopoietic Stem Cell Transplantation

Marta Sobas, Javier Martinez Elicegui, Angela Villaverde Ramiro, Teresa González, Alberto Hernandez-Sanchez, Raúl Azibeiro Melchor, Axel Benner, Eric Sträng, Castellani Gastone, Caroline A. Heckman, Ana Heredia Casanoves, Jurjen Versluis, María Abáigar, Laura Jamilis, Peter JM Valk, Klaus H. Metzeler, Rosa Ayala, Joaquin Martinez Lopez, Hervé Dombret, Jorge Sierra, Claude Preudomme, Frederick Damm, Ken I Mills, Jiří Mayer, Christian Thiede, Maria Teresa Voso, Sergio Amadori, Guillermo Sanz, Frederico Calado, Konstanze Döhner, Verena I Gaidzik, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk Reinhardt, Rubén Villoria Medina, Michel Van Speybroeck, Renate Schulze-Rath, John E Butler, Brian J.P Huntly, Hartmut Dohner, Gert J. Ossenkoppele, Lars Bullinger, Jesus Maria Hernández-Rivas
Journal: Blood
Blood (2021) 138 (Supplement 1): 4041.
https://doi.org/10.1182/blood-2021-149521
Published: 2021
Journal Articles

Does RAD21 Co-Mutation Have a Role in DNMT3A Mutated AML? Results of Harmony Alliance AML Database

Raúl Azibeiro Melchor, Alberto Hernández Sánchez, Teresa González, Marta Sobas, Javier Martinez Elicegui, Angela Villaverde Ramiro, Axel Benner, Eric Sträng, Castellani Gastone, Caroline A. Heckman, Ana Heredia Casanoves, Jurjen Versluis, María Abáigar, Laura Jamilis, Peter JM Valk, Klaus H. Metzeler, Rosa Ayala, Herve Dombret, Jorge Sierra, Claude Preudomme, Frederick Damm, Ken I Mills, Jiří Mayer, Christian Thiede, Maria Teresa Voso, Sergio Amadori, Guillermo Sanz, Frederico Calado, Konstanze Döhner, Verena I Gaidzik, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk Reinhardt, Rubén Villoria Medina, Michel van Speybroeck, Renate Schulze-Rath, John E Butler, Brian J.P Huntly, Jesús M Hernández Rivas, Lars Bullinger, Hartmut Döhner, Gert J. Ossenkoppele
Journal: Blood
Blood (2021) 138 (Supplement 1): 608.
https://doi.org/10.1182/blood-2021-150766
Published: 2021
Journal Articles

Impact on Mental Health, Disease Management and Socioeconomic Modifications in Hematological Patients during COVID-19 Pandemia in Italy

Marianna De Muro, MD, Sergio Amadori, Nicolina Rita Ardu, Elisabetta Cerchiara, Paolo De Fabritiis, MD, Pasquale Niscola, MD PhD, Sabatino Dante, Valentina Schittone, Cristiano Tesei, Malgorzata Monika Trawinska, MD, Elisabetta Abruzzese, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–37.
https://doi.org/10.1182/blood-2020-141599
Published: 2020
Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Adriano Venditti, Alfonso Piciocchi, Anna Candoni, Lorella Melillo, Valeria Calafiore, Roberto Cairoli, Paolo de Fabritiis, Gabriella Storti, Prassede Salutari, Francesco Lanza, Giovanni Martinelli, Mario Luppi, Patrizio Mazza, Maria Paola Martelli, Antonio Cuneo, Francesco Albano, Francesco Fabbiano, Agostino Tafuri, Anna Chierichini, Alessia Tieghi, Nicola Stefano Fracchiolla, Debora Capelli, Robin Foà, Caterina Alati, Edoardo La Sala, Paola Fazi, Marco Vignetti, Luca Maurillo, Francesco Buccisano, Maria Ilaria Del Principe, Maria Irno-Consalvo, Tiziana Ottone, Serena Lavorgna, Maria Teresa Voso, Francesco Lo-Coco, William Arcese, Sergio Amadori
Journal: Blood
Blood (2019) 134 (12): 935–945.
https://doi.org/10.1182/blood.2018886960
Published: 2019
Includes: Supplemental data
Journal Articles

Clinical Relevance of NOTCH1 Mutations in Ibrutinib-Treated Chronic Lymphocytic Leukemia (CLL)

Giovanni Del Poeta, MD, Luca Laurenti, MD, Annalisa Chiarenza, MD PhD, Francesca Maria Rossi, PhD, Massimiliano Postorino, MD, Riccardo Bomben, PhD, Maria Ilaria Del Principe, MD, Enrico Santinelli, MD, Idanna Innocenti, MD PhD, Federico Pozzo, MSc, Erika Tissino, PhD, Annalisa Biagi, MD, Paolo de Fabritiis, MD, Maria Cantonetti, MD, Pietro Bulian, MD, Sergio Amadori, MD, Francesco Di Raimondo, MD, Antonella Zucchetto, Valter Gattei, MD, William Arcese
Journal: Blood
Blood (2018) 132 (Supplement 1): 4396.
https://doi.org/10.1182/blood-2018-99-113074
Published: 2018
Journal Articles

The Amount of Apoptosis Predicts Outcome in Ibrutinib-Treated Chronic Lymphocytic Leukemia (CLL)

Giovanni Del Poeta, MD, Massimiliano Postorino, MD, Federico Pozzo, PhD, Maria Ilaria Del Principe, MD, Enrico Santinelli, MD, Riccardo Bomben, PhD, Annalisa Biagi, MD, Francesco Buccisano, MD, Francesca Maria Rossi, PhD, Adriano Venditti, MD, Paolo de Fabritiis, MD, Maria Cantonetti, MD, Sergio Amadori, MD, Valter Gattei, MD, William Arcese
Journal: Blood
Blood (2018) 132 (Supplement 1): 4397.
https://doi.org/10.1182/blood-2018-99-113060
Published: 2018
Journal Articles

Prognostic Impact of Insertion Site in Acute Myeloid Leukemia (AML) with FLT3 Internal Tandem Duplication: Results from the Ratify Study (Alliance 10603)

Frank G. Rücker, MD, Ling Du, PhD, Tamara J. Blätte, MSc, Axel Benner, Julia Krzykalla, MSc, Insa Gathmann, Richard A. Larson, MD, Francesco Lo-Coco, MD, Sergio Amadori, MD, Thomas W Prior, MD, Joseph M. Brandwein, MD, Frederick R. Appelbaum, MD, Bruno C. Medeiros, MD, Martin S. Tallman, MD, Michelle Geddes, MD, Jorge Sierra, MD, Eva Tiecke, PhD, Celine Pallaud, PhD, Miguel A. Sanz, MD, Theo M de Witte, MD, Dietger Niederwieser, MD, Gerhard Ehninger, MD, Michael Heuser, MD, Arnold Ganser, MD, Lars Bullinger, MD, Clara D. Bloomfield, MD, Richard M. Stone, MD, Hartmut Döhner, MD, Christian Thiede, MD, Konstanze Dohner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 435.
https://doi.org/10.1182/blood-2018-99-116149
Published: 2018
Journal Articles

Comprehensive Molecular Profiling of FLT3 -Mutated Acute Myeloid Leukemia (AML) Patients Treated within the Ratify Trial (Alliance C10603)

Nikolaus Jahn, MD, Ekaterina Panina, MD, Lars Bullinger, MD, Anna Dolnik, PhD, Julia Herzig, PhD, Tamara J. Blätte, MSc, Axel Benner, Julia Krzykalla, MSc, Insa Gathmann, Richard A. Larson, MD, Francesco Lo-Coco, MD, Sergio Amadori, MD, Thomas W Prior, MD, Joseph M. Brandwein, MD, Frederick R. Appelbaum, MD, Bruno C. Medeiros, MD, Martin S. Tallman, MD, Eva Tiecke, PhD, Celine Pallaud, PhD, Gerhard Ehninger, MD, Michael Heuser, MD, Arnold Ganser, MD, Richard M. Stone, MD, Christian Thiede, MD, Hartmut Döhner, MD, Clara D. Bloomfield, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1534.
https://doi.org/10.1182/blood-2018-99-115842
Published: 2018
Journal Articles

Ratify (Alliance 10603): Prognostic Impact of FLT3 tyrosine Kinase Domain (TKD) and NPM1 Mutation Status in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) Treated with Midostaurin or Placebo Plus Standard Chemotherapy

Maria Teresa Voso, Richard A. Larson, MD, Thomas Prior, Guido Marcucci, Dan Jones, MD PhD, Jürgen Krauter, MD, Michael Heuser, MD, Serena Lavorgna, PhD, Josep Nomdedeu, MD PhD, Susan M. Geyer, PhD, Rebecca Klisovic, MD, Andrew H Wei, MBBS, PhD, Jorge Sierra, MD, Miguel A. Sanz, MD, Joseph M. Brandwein, MD FRCPC, Theo M de Witte, MD, Joop H. Jansen, Dietger Niederweiser, Frederick R. Appelbaum, MD, Bruno C. Medeiros, MD, Martin S. Tallman, MD, Richard F. Schlenk, MD, Arnold Ganser, MD, Sergio Amadori, MD, Yuan Cheng, PhD, Insa Gathmann, Eva Tiecke, PhD, Christian Thiede, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, Richard M. Stone, MD, Clara D. Bloomfield, MD, Francesco Lo-Coco, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2668.
https://doi.org/10.1182/blood-2018-99-114318
Published: 2018
Journal Articles

The Impact of Cytogenetic Clonality on Outcomes in Younger Acute Myeloid Leukemia Patients: Results on 1290 Patients Included in the EORTC/Gimema AML-10 and AML-12 Trials

Frederic Baron, Marian Stevens-Kroef, PhD, Michal Kicinski, Giovanna Meloni, Petra Muus, Jean-Pierre Marie, Constantijn J.M. Halkes, Xavier Thomas, MD, Radovan Vrhovac, MD PhD, Crescenza Pasciolla, Francois Lefrere, Sr., Simona Sica, Marco Mancini, Adriano Venditti, MD, Anne Hagemeijer, Heiko Becker, Joop H. Jansen, Sergio Amadori, MD, T. M. M de Witte, MD PhD, Roelof Willemze, Stefan Suciu
Journal: Blood
Blood (2017) 130 (Supplement 1): 1385.
https://doi.org/10.1182/blood.V130.Suppl_1.1385.1385
Published: 2017
Journal Articles

Impact of the Type of Anthracycline and of Allogeneic Stem Cell Transplantation in the Treatment of Younger Acute Myeloid Leukemia Patients: Long-Term Follow-up of the EORTC-Gimema AML-10 Trial

Frederic Baron, Fabio Efficace, PhD, Laura Cannella, Franco Mandelli, Petra Muus, Silvia Maria Trisolini, Constantijn J.M. Halkes, Paola Fazi, Marco Vignetti, Jean-Pierre Marie, Patrizia Chiusolo, Walter JFM Van Der Velden, Edoardo La Sala, Umberto Vitolo, Xavier Thomas, MD, Francois Lefrere, Sr., Francesco Di Raimondo, MD, Jean-Henri Bourhis, Giorgina Specchia, Jose E. Guimaraes, MD PhD, Bernardino Allione, Radovan Vrhovac, MD PhD, Felicetto Ferrara, Marian Stevens-Kroef, PhD, Roelof Willemze, Sergio Amadori, MD, Theo de Witte, Stefan Suciu
Journal: Blood
Blood (2017) 130 (Supplement 1): 3850.
https://doi.org/10.1182/blood.V130.Suppl_1.3850.3850
Published: 2017