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Journal Articles

Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations

Hartmut Döhner, Courtney D. DiNardo, Frederick R. Appelbaum, Charles Craddock, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Andrew H. Wei, Bob Löwenberg
Journal: Blood
Blood (2024) 144 (21): 2169–2173.
https://doi.org/10.1182/blood.2024025409
Published: 2024
Journal Articles

Correlation of Baseline Gene Mutations With Quizartinib Efficacy in Patients With FLT3 -ITD-Positive Newly Diagnosed Acute Myeloid Leukemia in the Phase 3 QuANTUM-First Trial

Mark J. Levis, Pau Montesinos, Hee-Je Kim, Radovan Vrhovac, Elzbieta Patkowska, Pavel Zak, Po-Nan Wang, Jorge E. Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Alexander E. Perl, Mitsuhiro Yazawa, Jaime E. Connolly Rohrbach, Venkat Thodima, Ken C. N. Chang, Li Liu, Karima Imadalou, Akash Nahar, Kristy Burns, Harry P. Erba
Journal: Blood
Blood (2024) 144 (Supplement 1): 848.
https://doi.org/10.1182/blood-2024-203303
Published: 2024
Journal Articles

Handling of Allograft As an Intercurrent Event in Randomized Controlled Trials in Acute Leukemias: A Systematic Review

Roxane Couturier, Loic Vasseur, Nicolas Boissel, Hervé Dombret, Sylvie Chevret, Jérôme Lambert
Journal: Blood
Blood (2024) 144 (Supplement 1): 7449.
https://doi.org/10.1182/blood-2024-194149
Published: 2024
Journal Articles

Determinants of Isolated CNS Relapse in Adults with Philadelphia-Negative Acute Lymphoblastic Leukemia. from Graall-2005 to -2014 Trials

Nicolas Boissel, Emilie Lemasle, Sylvain Chantepie, Thibaut Leguay, Corentin Orvain, Françoise Huguet, Yosr Hicheri, Nathalie Dhédin, Patrice Chevallier, Marie Balsat, Sébastien Maury, Hunault-Berger Mathilde, Karin Bilger, Eolia Brissot, Sebastian Wittnebel, Julie Guerder, Sarah Bonnet, Pascal Turlure, Anne Huynh, Claire Bories, Michael Gregor, Natacha Mauz, Ahmad Aljijakli, Carlos Graux, Yves Chalandon, Norbert Ifrah, Vahid Asnafi, Emmanuelle Clappier, Véronique Lheritier, Hervé Dombret
Journal: Blood
Blood (2024) 144 (Supplement 1): 731.
https://doi.org/10.1182/blood-2024-198614
Published: 2024
Journal Articles

Sequential Intensified Conditioning Regimen Allogeneic Transplantation in Younger Adult Patients with Adverse-Risk Acute Myeloid Leukemia: A Multi-Center Prospective Study from the Acute Leukemia French Intergroup on Behalf of the Filo, ALFA, and SFGM-TC Study Groups

Regis Peffault de Latour, Edouard Forcade, Anne Huynh, Mathieu Leclerc, Stéphanie Nguyen Quoc, Patrice Ceballos, Jean-Baptiste Méar, Michael Loschi, Helene Labussiere-vallet, Jean-Henri Bourhis, Bruno Lioure, Ibrahim Yakoub-Agha, Jacques-Olivier Bay, Sylvie François, Claude-Éric Bulabois, Sylvain Chantepie, Marie-Thérèse Rubio, Patrice Chevallier, Anne Lise Mesnard, Delphine Lebon, Jean Valere Malfuson, Jérôme Cornillon, Etienne Daguindau, Pascal Turlure, Natacha Maillard, Alban Villate, Marie Robin, Nicole Raus, Jean-Yves Cahn, Arnaud Pigneux, Mathilde Hunault, Christian Recher, Hervé Dombret, Gerard Socie, Jean François Hamel, Raynier Devillier
Journal: Blood
Blood (2024) 144 (Supplement 1): 3483.
https://doi.org/10.1182/blood-2024-198603
Published: 2024
Journal Articles

Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study

Hervé Dombret, Alexandra Coelho, Laurène Fenwarth, Jean-Baptiste Micol, Lionel Ades, Thomas Cluzeau, Emmanuel Raffoux, Sylvain Chantepie, Pierre Arnautou, Mathieu Leclerc, Delphine Lebon, Thorsten Braun, Ollivier Legrand, Claire Bories, Céline Berthon, Juliette Lambert, Ahmad Aljijakli, Emilie Lemasle, Pascal Turlure, Benjamin Carpentier, Jamile Frayfer, Stephanie Haiat, Ambroise Marcais, Isabelle Plantier, Kevin-James Wattebled, Madalina Uzunov, Iona Vaida, Mael Heiblig, Lauris Gastaud, Laure Farnault, Dominique Penther, Nicole Raus, Renaud Buffet, Karine Celli-Lebras, Claude Preudhomme, Nicolas Duployez, Raphael Itzykson, Stephane De Botton
Journal: Blood
Blood (2024) 144 (Supplement 1): 2424.
https://doi.org/10.1182/blood-2024-207226
Published: 2024
Journal Articles

Secondary Genetic Alterations and Measurable Residual Disease in Core Binding Factor Acute Myeloid Leukemia - a Study from the Acute Leukemia French Intergroup

Loic Vasseur, Matthieu Duchmann, Nicolas Duployez, Emmanuel Raffoux, Celine Berthon, Mael Heiblig, Alexis Genthon, Thorsten Braun, Mathieu Leclerc, Delphine Lebon, Sylvain Chantepie, Jean-Baptiste Micol, Juliette Lambert, Christian Recher, Marie-Lorraine Chrétien, Thomas Cluzeau, Julien Vaidie, Jean-Valère Malfuson, Madalina Uzunov, Arnaud Pigneux, Pierre Peterlin, Sihem Tarfi, Pierre Hirsch, Dominique Penther, Eric Jourdan, Karine Celli-Lebras, Claude Preudhomme, Hervé Dombret, Jérôme Lambert, Nicolas Boissel, Raphael Itzykson
Journal: Blood
Blood (2024) 144 (Supplement 1): 227.
https://doi.org/10.1182/blood-2024-194060
Published: 2024
Journal Articles

Flow MRD Monitoring Combining Laip/Dfn and CD34+CD38- LSCs Is a Strong Predictor of Outcome in Adult AML Independently of the ELN-2022 Risk: First Results from the Multicentric Acute Leukemia French Intergroup MRD Flow Network

Adriana Plesa, Stéphanie Mathis, Florent Dumezy, Anne-Catherine Lhoumeau, Veronique Saada, Isabelle Arnoux, Jennifer Osman, Nicolas Chapuis, Franck Geneviève, Mikael Roussel, Delphine Manzoni, Anne Roggy, Remi Letestu, Veronique Harrivel, Elsa Bera, Jean Feuillard, Hélène Lapillonne, Richard Veyrat-Masson, Tatiana Raskovalova, Bouchra Badaoui, Valerie Bardet, Caroline Mayeur-Rousse, Francois Vergez, Jean Philippe Vial, Valerie Goncalves Monteiro, Frédéric Feger, Dominique Penther, Isabelle Luquet, Eric Delabesse, Nicolas Duployez, Karine Celli-Lebras, Mathilde Hunault, Raphael Itzykson, Arnaud Pigneux, Christian Récher, Hervé Dombret, Claude Preudhomme, Christophe Roumier
Journal: Blood
Blood (2024) 144 (Supplement 1): 226.
https://doi.org/10.1182/blood-2024-205457
Published: 2024
Journal Articles

Switch of Asparaginase Formulation Based on Antibody Monitoring in Adults with Philadelphia-Negative Adult Lymphoblastic Leukemia. Results of the Graall-2014 Trial

Marie Balsat, Corentin Orvain, Jean-François Benoist, Nicolas De Roux, Thibaut Leguay, Françoise Huguet, Patrice Chevallier, Cendrine Josson, Christine Bain-Wendlinger, Yosr Hicheri, Anne Thiebaut, Martine Escoffre-Barbe, Thomas Cluzeau, Florence Pasquier, Ana Berceanu, Florence Van Obbergh, Jamilé Frayfer, Gaëlle Guillerm, Victoria Cacheux, Isabelle Plantier, Laurence Sanhes, Chantal Himberlin, Jacques Vargaftig, Sabine Tricot, Yves Chalandon, Carlos Graux, Véronique Lheritier, Hervé Dombret, Hunault-Berger Mathilde, Nicolas Boissel
Journal: Blood
Blood (2024) 144 (Supplement 1): 1434.
https://doi.org/10.1182/blood-2024-199110
Published: 2024
Journal Articles

Quantum-First: Effects of Quizartinib (Q) on RFS, OS, CIR, and MRD in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication-Positive ( FLT3 -ITD+) Acute Myeloid Leukemia (AML) Who Received Continuation (CONT) Therapy (tx)

Mark J. Levis, Harry Erba, Pau Montesinos, Elzbieta Patkowska, Jorge E. Cortes, Herve Dombret, Alexander E. Perl, Sergio Amadori, Jianxiang Wang, Richard F. Schlenk, Li Liu, Yasser M. Mostafa Kamel, Karima Imadalou, Abderrahmane Laadem, Mikkael A. Sekeres, Kristy Burns
Journal: Blood
Blood (2024) 144 (Supplement 1): 2890.
https://doi.org/10.1182/blood-2024-207305
Published: 2024
Journal Articles

Long Term Follow-up Data after Consolidation Therapy with Ponatinib in Combination with Cytarabine in Patients with FLT3 Mutated Acute Myeloid Leukemia in First Complete Remission

Thibaut Leguay, Laurène Fenwarth, Thomas Cluzeau, Anne Vekoff, Etienne Lengline, Juliette Lambert, Denis Caillot, Mathilde Hunault, Jean-Valère Malfuson, Sylvain Chantepie, Emmanuelle Tavernier, Berengere Gruson, José Fernandes, Pierre Peterlin, Melody Fort, Laure Morisset, Herve Dombret, Claude Preudhomme, Arnaud Pigneux, Philippe Rousselot
Journal: Blood
Blood (2024) 144 (Supplement 1): 2905.
https://doi.org/10.1182/blood-2024-209998
Published: 2024
Journal Articles

Cyclosporine Versus Cyclosporine Plus Mycophenolate Mofetil in Reduced Intensity Allogeneic Stem Cell Transplantation for Intermediate-Risk AML: A Multi-Center Randomized Study from the Acute Leukemia French Intergroup, on Behalf of the Filo, ALFA, and SFGM-TC Study Groups

Edouard Forcade, Raynier Devillier, Jean-François Hamel, Jean-Baptiste Méar, Claude-Éric Bulabois, Jean-Henri Bourhis, Sylvain Chantepie, Pascal Turlure, Patrice Chevallier, Patrice Ceballos, Bruno Lioure, Jacques-Olivier Bay, Jean Valere Malfuson, Stéphanie Nguyen-Quoc, Marianne Schwarz, Jérôme Cornillon, Michael Loschi, Mathieu Leclerc, Marie-Thérèse Rubio, Etienne Daguindau, Natacha Maillard, Amandine Charbonnier, Nathalie Contentin, Hélène Labussière-Wallet, Alban Villate, Ibrahim Yakoub-Agha, Arnaud Pigneux, Mathilde Hunault, Christian Recher, Hervé Dombret, Nicole Raus, Marie Robin, Jean-Yves Cahn, Gerard Socie, Anne Huynh, Régis Peffault De Latour
Journal: Blood
Blood (2024) 144 (Supplement 1): 4909.
https://doi.org/10.1182/blood-2024-203964
Published: 2024
Journal Articles

IL-1RAP Is a Targetable Surface Antigen in Relapsed/Refractoy AML

Mohamad Sabbah, Morgane Fontaine, Kim Pacchiardi, Alexis Delabrière, Stephane De Botton, Catherine Lonchamp, Renaud Buffet, Laure Farnault, Jean-Baptiste Micol, Typhaine Dumas-Rivero, Emmanuel Raffoux, Lionel Ades, Nicolas Boissel, Juliette Lambert, Kevin-James Wattebled, Matthieu Duchmann, Karine Celli-Lebras, Alexandra Coelho, Hervé Dombret, Edouard De Dreuzy, Marina Deschamps, Christophe Ferrand, Jens Hasskarl, Richard Sainson, Raphael Itzykson
Journal: Blood
Blood (2024) 144 (Supplement 1): 4311.
https://doi.org/10.1182/blood-2024-199673
Published: 2024
Journal Articles

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Clinical Trials & Observations
Mathieu Simonin, Loïc Vasseur, Etienne Lengliné, Ludovic Lhermitte, Aurélie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie-Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stéphane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Arnaud Petit, Philippe Rousselot, Jérôme Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (15): 1570–1580.
https://doi.org/10.1182/blood.2023023754
Published: 2024
Includes: Supplemental data
Journal Articles

Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL

Estelle Balducci, Mathieu Simonin, Nicolas Duployez, Thomas Steimlé, Marie-Emilie Dourthe, Patrick Villarese, Stéphane Ducassou, Isabelle Arnoux, Jean-Michel Cayuela, Marie Balsat, Lucien Courtois, Guillaume Andrieu, Aurore Touzart, Françoise Huguet, Arnaud Petit, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Claude Preudhomme, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (9): 988–1000.
https://doi.org/10.1182/blood.2023022154
Published: 2024
Includes: Supplemental data
Journal Articles

Nilotinib with or without cytarabine for Philadelphia-positive acute lymphoblastic leukemia

Clinical Trials & Observations
Yves Chalandon, Philippe Rousselot, Sylvie Chevret, Jean-Michel Cayuela, Rathana Kim, Françoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Céline Berthon, Yosr Hicheri, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Magalie Joris, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Sabine Blum, Michael Gregor, Marina Lafage-Pochitaloff, Julie Quessada, Véronique Lhéritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2024) 143 (23): 2363–2372.
https://doi.org/10.1182/blood.2023023502
Published: 2024
Includes: Supplemental data
Journal Articles

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel

Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Hervé Dombret, Michael Doubek, Adele Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I. Marks, Giovanni Martinelli, Oliver Ottmann, Anita Rijneveld, Philippe Rousselot, Josep Ribera, Renato Bassan
Journal: Blood
Blood (2024) 143 (19): 1891–1902.
https://doi.org/10.1182/blood.2023020794
Published: 2024
Includes: Supplemental data
Journal Articles

Management of ALL in adults: 2024 ELN recommendations from a European expert panel

Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Hervé Dombret, Michael Doubek, Adele Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I. Marks, Giovanni Martinelli, Oliver Ottmann, Anita Rijneveld, Philippe Rousselot, Josep Ribera, Renato Bassan
Journal: Blood
Blood (2024) 143 (19): 1903–1930.
https://doi.org/10.1182/blood.2023023568
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic alterations and MRD refine risk assessment for KMT2A -rearranged B-cell precursor ALL in adults: a GRAALL study

Rathana Kim, Hugo Bergugnat, Cédric Pastoret, Florence Pasquier, Emmanuel Raffoux, Lise Larcher, Marie Passet, Nathalie Grardel, Eric Delabesse, Susanne Kubetzko, Aurélie Caye-Eude, Claus Meyer, Rolf Marschalek, Marine Lafage-Pochitaloff, Anne Thiebaut-Bertrand, Marie Balsat, Martine Escoffre-Barbe, Sabine Blum, Michael Baumann, Anne Banos, Nicole Straetmans, Maria-Pilar Gallego-Hernanz, Yves Chalandon, Carlos Graux, Jean Soulier, Thibaut Leguay, Mathilde Hunault, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2023) 142 (21): 1806–1817.
https://doi.org/10.1182/blood.2023021501
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax in Combination with Intermediate Doses of Cytarabine in Consolidation Phase for Acute Myeloid Leukemia Patients in First Complete Remission; Results of the Part 1 of the Phase 1/2 Multicentric Covenidac Study

Lauris Gastaud, Pierre Peterlin, Mathilde Hunault, Emmanuel Raffoux, Sarah Bertoli, Martin Carré, Cecile Pautas, Sylvain Chantepie, Juliette Lambert, Nicolas Duployez, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Vey, Arnaud Pigneux, Eric Delabesse, Claude Preudhomme, Adriana Plesa, Francois Vergez, Jean-François Hamel, Herve Dombret, Christian Recher
Journal: Blood
Blood (2023) 142 (Supplement 1): 4261.
https://doi.org/10.1182/blood-2023-173656
Published: 2023