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Nilotinib with or without cytarabine for Philadelphia-positive acute lymphoblastic leukemia

Clinical Trials & Observations
Yves Chalandon, Philippe Rousselot, Sylvie Chevret, Jean-Michel Cayuela, Rathana Kim, Françoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Céline Berthon, Yosr Hicheri, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Magalie Joris, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Sabine Blum, Michael Gregor, Marina Lafage-Pochitaloff, Julie Quessada, Véronique Lhéritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2024) 143 (23): 2363–2372.
https://doi.org/10.1182/blood.2023023502
Published: 2024
Includes: Supplemental data
Journal Articles

Frontline Consolidation with Nelarabine for Adults with High-Risk T-Cell Acute Lymphoblastic Leukemia. Results of the Graall-2014/T Atriall Phase 2 Study

Nicolas Boissel, Carlos Graux, Francoise Huguet, Florence Pasquier, Aurore Touzart, Thomas Cluzeau, Ludovic Lhermitte, Eric Delabesse, Patrice Chevallier, Mathilde Hunault, Cedric Pastoret, Sebastien Maury, Nathalie Grardel, Martine Escoffre Barbe, Pascal Turlure, Beat Schafer, Marie Balsat, Philippe Rousselot, Thibaut Leguay, Eric Jourdan, Delphine Pranger, Michael Gregor, Emilie Lemasle, Anne Marie Ronchetti, Ana Berceanu, Ingrid Lafon, Madalina Uzunov, Etienne Lengline, Norbert Ifrah, Yves Chalandon, Véronique Lhéritier, Vahid Asnafi, Herve Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 962.
https://doi.org/10.1182/blood-2023-177696
Published: 2023
Journal Articles

Comparison of Two Reduced Intensity Conditioning Regimens (Baltimore with Clofarabine vs Thiotepa-Busulfan-Fludarabine) in Adults Receiving Peripheral Blood Stem Cell Haploidentical Transplantation for Myeloid Malignancies: A Retrospective Study of the SFGM-TC

Maxime Jullien, Remy Dulery, Etienne Daguindau, Michael Loschi, Ali Bazarbachi, Hélène Labussière-Wallet, Anne Huynh, Marianne Schwarz, Amandine Charbonnier, Pascal Turlure, Sebastien Maury, Raynier Devillier, Jacques-Olivier Bay, Micha Srour, Patrice Ceballos, Nathalie Contentin, Stephanie Nguyen-Quoc, Tony Marchand, Marie Thérèse Rubio, Edouard Forcade, Jerome Cornillon, Sylvain Chantepie, Claude-Eric Bulabois, Alban Villate, Ambroise Marcais, Yves Chalandon, Natacha Maillard, Gaelle Guillerm, Karin Bilger, Yves Beguin, Alice Garnier, Pierre Peterlin, Amandine Le Bourgeois, Thierry Guillaume, Mohamad Mohty, Patrice Chevallier
Journal: Blood
Blood (2023) 142 (Supplement 1): 3530.
https://doi.org/10.1182/blood-2023-180581
Published: 2023
Journal Articles

Allogeneic Hematopoietic Cell Transplantation in the Elderly Results in Similar Survival with Matched Related or Unrelated and Haploidentical Donors: A Report from the Société Francophone De Greffe De Moelle Et De Thérapie Cellulaire (SFGM-TC)

Imran Ahmad, Samia Harbi, Raynier Devillier, Cristina Castilla-Llorente, Marie Robin, Micha Srour, Jacques-Olivier Bay, Patrice Ceballos, Stéphanie Nguyen-Quoc, Édouard Forcade, Claude-Éric Bulabois, Amandine Charbonnier, Pascal Turlure, Sylvain Chantepie, Sébastien Maury, Michael Loschi, Hélène Labussière-Wallet, Tony Marchand, Marianne Schwarz, Ambroise Marçais, Ana Berceanu, Étienne Daguindau, Patrice Chevallier, Anne Huynh, Mohamad Mohty, Remy Dulery, Johan Maertens, Xavier Poiré, Natacha Maillard, Marie-Thérèse Rubio, Gaëlle Guillerm, Yves Chalandon, Anne-Lise Ménard, Jérôme Cornillon
Journal: Blood
Blood (2023) 142 (Supplement 1): 3604.
https://doi.org/10.1182/blood-2023-184995
Published: 2023
Journal Articles

Oncogenetic-Driven Targeted Therapy for Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia : A French ALL-Target Observatory Report

Aurelie Cabannes-Hamy, Lucien Courtois, Marie Balsat, Mathieu Simonin, Françoise Huguet, Martine Escoffre-Barbe, Florence Pasquier, Caroline Bonmati, Pascal Turlure, Thomas Cluzeau, Delphine Lebon, Eve Gehlkopf, Eolia Brissot, Justine Decroocq, Patrice Chevallier, Sylvain Chantepie, Victoria Cacheux, Sebastien Maury, Safia Chebrek, Thibaut Leguay, Melody Fort, Natacha Mauz, Mathlide Lamarque, Hunault-Berger Mathilde, Stefan Wickenhauser, Jamilé Frayfer, Anne Banos, Emmanuelle Tavernier, Denis Caillot, Anne Marie Ronchetti, Celine Berthon, Etienne Lengline, Véronique Lhéritier, Hervé Dombret, Ambroise Marçais, Antoine Pinton, Guillaume P Andrieu, Nicolas Boissel, Ludovic Lhermitte, Vahid Asnafi, Philippe Rousselot
Journal: Blood
Blood (2023) 142 (Supplement 1): 518.
https://doi.org/10.1182/blood-2023-179192
Published: 2023
Journal Articles

FLT3 Ligand Kinetic Profile Predicts Response to Treatment and Event-Free Survival (EFS) in Adults with High-Risk MDS/CMML Receiving CPX-351: A GFM Study

Pierre Peterlin, Joëlle Gaschet, Pascal Turlure, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Ana Berceanu, Sophie Park, Marie Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa-Diaz, Louis Drevon, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli-Salazar, Maxime Jullien, Pierre Fenaux, Patrice Chevallier
Journal: Blood
Blood (2023) 142 (Supplement 1): 6469.
https://doi.org/10.1182/blood-2023-173741
Published: 2023
Journal Articles

Checkpoint Inhibitors and Allo-SCT in Hodgkin Lymphoma: A Matter of Time - a Study By the SFGM-TC

Eléonore Kaphan, François Bettega, David Michonneau, Mariela Catalina Montes De Oca, Nathalie Fegueux, Marie Robin, Ali Bazarbachi, Stéphanie Nguyen Quoc, David Beauvais, Edouard Forcade, Patrice Chevallier, Michael Loschi, Anne Huynh, Jacques-Olivier Bay, Marie Thérèse Rubio, Felipe Suarez, Xavier Poiré, Sylvie François, Déborah Desmier, Nathalie Contentin, Amandine Charbonnier, Jerome Cornillon, Sylvain Chantepie, Pascal Turlure, Claude-Eric Bulabois, Alban Villate
Journal: Blood
Blood (2023) 142 (Supplement 1): 4926.
https://doi.org/10.1182/blood-2023-184836
Published: 2023
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation for Elderly Acute Lymphoblastic Leukemia Patients: A Registry Study from the Société Francophone De Greffe De Moelle Et Thérapie Cellulaire (SFGM-TC)

Yves Chalandon, Raynier Devillier, Ariane Boumendil, Stéphanie Nguyen Quoc, Claude-Eric Bulabois, Patrice Ceballos, Eolia Brissot, Marie Thérèse Rubio, Hélène Labussière-Wallet, Johan Maertens, Patrice Chevallier, Natacha Maillard, Xavier Poiré, Cristina Castilla-Llorente, Prof. Yves Beguin, Jérôme Cornillon, Sebastien Maury, Tony Marchand, Etienne Daguindau, Jacques-Olivier Bay, Pascal Turlure, Amandine Charbonnier, Anne Menard, Karin Bilger, Gaelle Guillerm, Sylvie François, Ali Bazarbachi, Sylvain Chantepie, Philippe Lewalle, Sr., Ambroise Marcais, Michael Loschi, Malek Benakli, Paul Chauvet, Edouard Forcade, Anne Huynh, Marie Robin, Stavroula Masouridi-Levrat
Journal: Blood
Blood (2023) 142 (Supplement 1): 2235.
https://doi.org/10.1182/blood-2023-184383
Published: 2023
Journal Articles

Interim Results from Clevo: A Non-Interventional Cohort Study Investigating the Clonal Evolution of FMS-like Tyrosine Kinase 3 ( FLT3 ) Mutations during Disease Progression in Patients with Acute Myeloid Leukemia

Cristina Papayannidis, Blanca Boluda, Jonathan Canaani, Pascal Turlure, Ann De Becker, Anand Tandra, Dina Elsouda, Arnaud Houweling, Anil Upadhyay, Isabelle Wouters, Paresh Vyas
Journal: Blood
Blood (2022) 140 (Supplement 1): 11641–11643.
https://doi.org/10.1182/blood-2022-156296
Published: 2022
Journal Articles

Gilteritinib Activity in Refractory or Relapsed FLT3 -Mutated Acute Myeloid Leukemia Patients Previously Treated By Intensive Chemotherapy and Midostaurin: A Study from the French AML Intergroup ALFA/Filo

Pierre-Yves Dumas, Emmanuel Raffoux, Emilie Berard, Sarah Bertoli, Marie Anne Hospital, Mael Heiblig, Yohan Desbrosses, Caroline Bonmati, Cecile Pautas, Juliette Lambert, Corentin Orvain, Anne Banos, Florence Pasquier, Pierre Peterlin, Tony Marchand, Madalina Uzunov, Jamilé Frayfer, Pascal Turlure, Thomas Cluzeau, Eric Jourdan, Chantal Himberlin, Emmanuelle Tavernier, Alban Villate, Stéphanie Haiat, Marie-Lorraine Chretien, Martin Carre, Sylvain Chantepie, Iona Vaida, Mathieu Wemeau, Safia Chebrek, Gaëlle Guillerm, Romain Guieze, Houria Debarri, Eve Gehlkopf, Kamel Laribi, Ambroise Marçais, Alberto Santagostino, Marie C Bene, Ariane C Mineur, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2022) 140 (Supplement 1): 8996–8998.
https://doi.org/10.1182/blood-2022-159125
Published: 2022
Journal Articles

Molecular Response Analysis By High Throughput Sequencing in Higher Risk Myelodysplastic Syndrome (HR-MDS) Treated Intensively with CPX-351

Yannick Le Bris, Simon Bouzy, Audrey Ménard, Pascal Turlure, Patrice Chevallier, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Anna Berceanu, Sophie Park, Marie-Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa Diaz, Louis Devron, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli Salazar, Marie C Béné, Pierre Fenaux, Pierre Peterlin
Journal: Blood
Blood (2022) 140 (Supplement 1): 9821–9823.
https://doi.org/10.1182/blood-2022-162278
Published: 2022
Journal Articles

Prognostic Impact of Monoallelic Versus Biallelic TP53 Alterations in Intensively-Treated Adults AML Patients: A Retrospective Study from the ALFA Group

Laurène Fenwarth, Loïc Vasseur, Nicolas Duployez, Claude Gardin, Christine Terré, Juliette Lambert, Stéphane de Botton, Karine Celli-Lebras, Pascal Turlure, Thomas Cluzeau, Thorsten Braun, Xavier Thomas, Christian Recher, Sylvain Chantepie, Cécile Pautas, Hervé Dombret, Claude Preudhomme, Raphael Itzykson
Journal: Blood
Blood (2022) 140 (Supplement 1): 737–738.
https://doi.org/10.1182/blood-2022-163044
Published: 2022
Journal Articles

In Adults with Ph-Negative Acute Lymphoblastic Leukemia (ALL), Age-Adapted Chemotherapy Intensity and MRD-Driven Transplant Indication Significantly Reduces Treatment-Related Mortality (TRM) and Improves Overall Survival - Results from the Graall-2014 Trial

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Hunault-Berger Mathilde, Carlos Graux, Yves Chalandon, Eric Delabesse, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Cedric Pastoret, Martine Escoffre-Barbe, Florence Pasquier, Jean-Pierre Marolleau, Anne Thiebaut-Bertrand, Anne Huynh, Nathalie Dhedin, Emilie Lemasle, Caroline Bonmati, Sébastien Maury, Gaëlle Guillerm, Anna Berceanu, Urs Schanz, Thomas Cluzeau, Pascal Turlure, Philippe Rousselot, Bernard J.M. De Prijck, Nathalie Grardel, Marie C Bene, Marine Lafage, Norbert Ifrah, Veronique Lheritier, Vahid Asnafi, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2022) 140 (Supplement 1): 112–114.
https://doi.org/10.1182/blood-2022-157903
Published: 2022
Journal Articles

Single-Unit Transfusion Is Non Inferior to Double Unit Transfusion in Patients with Hematological Disorders Receiving Allogeneic or Autologous Bone Marrow Transplant or Induction Chemotherapy for Acute Leukemia: The 1versus2 Prospective Multicentric Randomized Clinical Trial

Sylvain Chantepie, Jean-Baptiste Mear, Anais R Briant, Jean-Pierre Vilque, Anne-Claire Gac, Stephane Cheze, Stephane Girault, Pascal Turlure, Jean-Pierre Marolleau, Delphine Lebon, Amandine Charbonnier, Fabrice Jardin, Pascal Lenain, Laure Peyro Saint Paul, Véronique Abonnet, Jean-Jacques Dutheil, Yannick Chene, Agnès Bazin, Oumedaly Reman, Jean-Jacques Parienti
Journal: Blood
Blood (2021) 138 (Supplement 1): 2141.
https://doi.org/10.1182/blood-2021-148270
Published: 2021
Journal Articles

Treatment-Free Remissions in Newly Diagnosed CP CML Patients Treated with the Combination of Nilotinib + Pegylated Interferon Alpha 2a Versus Nilotinib Alone in the National Phase III Petals Trial

Franck E. Nicolini, Gabriel Etienne, Francoise Huguet, Agnès Guerci-Bresler, Aude Charbonnier, Martine Escoffre-Barbe, Viviane Dubruille, Hyacinthe Johnson-Ansah, Laurence Legros, Valerie Coiteux, Pascale Cony-Makhoul, Pascal Lenain, Lydia Roy, Philippe Rousselot, Denis Guyotat, Jean-Christophe Ianotto, Corentin Orvain, Eric Deconinck, Denis Caillot, Pascal Turlure, Stephane Courby, Philippe Quittet, Eric Hermet, Shanti Amé, Simona Lapusan, Stephane Morisset, Francois-Xavier Mahon, Delphine Rea, Stephanie Dulucq
Journal: Blood
Blood (2021) 138 (Supplement 1): 2553.
https://doi.org/10.1182/blood-2021-146412
Published: 2021
Journal Articles

CPX 351 As First Line Treatment in Higher Risk MDS. a Phase II Trial By the GFM

Pierre Peterlin, Pascal Turlure, Patrice Chevallier, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Anna Berceanu, Sophie Park, Marie Anne Hospital, Thomas Cluzeau, Jose Miguel Torregrosa Diaz, Louis Devron, Sylvie Chevret, Marie C Bene, Yannick Le Bris, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli-Salazar, Pierre Fenaux
Journal: Blood
Blood (2021) 138 (Supplement 1): 243.
https://doi.org/10.1182/blood-2021-145123
Published: 2021
Journal Articles

Replacing the Anthracycline By Gemtuzumab Ozogamicin in Older Patients with De Novo Standard-Risk Acute Myeloid Leukemia Treated Intensively - Results of the Randomized ALFA1401-Mylofrance 4 Study

Juliette Lambert, Jérôme Lambert, Emilie Lemasle, Magalie Joris, Sylvain Chantepie, Cecile Pautas, Xavier Thomas, Jean Valere Malfuson, Lauris Gastaud, Denis Caillot, Emmanuelle Tavernier, Pascal Turlure, Diana Carp, Celine Berthon, Olivier Legrand, Ambroise Marçais, Iona Vaida, Sarah Barbieux, Philippe Rousselot, Claude Gardin, Christine Terré, Nicolas Duployez, Claude Preudhomme, Karine Celli-Lebras, Sylvie Castaigne, Herve Dombret
Journal: Blood
Blood (2021) 138 (Supplement 1): 31.
https://doi.org/10.1182/blood-2021-145152
Published: 2021
Journal Articles

The Omission of High-Dose Cytarabine during Consolidation Therapy of Ph-Positive ALL Patients Treated with Nilotinib and Low-Intensity Chemotherapy Results in an Increased Risk of Relapses Despite Non-Inferior Levels of Late BCR-ABL1 MRD Response. First Results of the Randomized Graaph-2014 Study

Philippe Rousselot, Yves Chalandon, Sylvie Chevret, Jean-Michel Cayuela, Francoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Celine Berthon, Norbert Vey, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Jean Pierre Marolleau, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Olivier Spertini, Veronique Lheritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2021) 138 (Supplement 1): 512.
https://doi.org/10.1182/blood-2021-148843
Published: 2021
Journal Articles

Post-Transplant Cyclophosphamide in Acute Leukemia Patients Receiving More Than 5/10 HLA-Mismatched Allogeneic Stem Cell Transplantation: A Study on Behalf of the ALWP of the EBMT

Michele Wieczorek, Myriam Labopin, Luca Castagna, Eolia Brissot, Gerard Socié, Anna Maria Raiola, Emanuele Angelucci, Arancha Bermúdez, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Charles Crawley, Jean-Baptiste Mear, Maurizio Musso, Renato Fanin, Daniele Avenoso, Pascal Turlure, Cristina Tecchio, Jaime Sanz, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Journal: Blood
Blood (2021) 138 (Supplement 1): 3890.
https://doi.org/10.1182/blood-2021-151087
Published: 2021
Journal Articles

Prognostic significance of concurrent gene mutations in intensively treated patients with IDH -mutated AML: an ALFA study

CME Clinical Trials & Observations
Matthieu Duchmann, Jean-Baptiste Micol, Nicolas Duployez, Emmanuel Raffoux, Xavier Thomas, Jean-Pierre Marolleau, Thorsten Braun, Lionel Adès, Sylvain Chantepie, Emilie Lemasle, Céline Berthon, Jean-Valère Malfuson, Cécile Pautas, Juliette Lambert, Nicolas Boissel, Karine Celli-Lebras, Denis Caillot, Pascal Turlure, Norbert Vey, Arnaud Pigneux, Christian Recher, Christine Terré, Claude Gardin, Raphaël Itzykson, Claude Preudhomme, Hervé Dombret, Stéphane de Botton
Journal: Blood
Blood (2021) 137 (20): 2827–2837.
https://doi.org/10.1182/blood.2020010165
Published: 2021
Includes: Supplemental data