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Journal Articles

Trial in progress: Phase II Study of (early) combination salvage therapy with venetoclax and intensified decitabine in relapsed/refractory AML (VenSwitch)

Lucas Mix, Jan Christian Schroeder, Osama Ahmad, Franziska Ginsberg, Andreas Riedel, David Soekler-Sanchez, Lennart Harland, Rebecca Froehlich, Jonas Schmidt, Nicolae Anghel, Peter Martus, Wichard Vogel, Britta Besemer, Wolfgang Bethge, Claudia Lengerke

Blood (2025) 146 (Supplement 1): 8253.

https://doi.org/10.1182/blood-2025-8253

Published: 2025

Journal Articles

PARP1 inhibition sensitizes AML to CD123 CAR-NK cells via immunophenotypic remodeling

Lea Kramer, Saskia Rudat, Shalini Ramachandran, Anna Stanger, Luca Hensen, Rimas Orentas, Congcong Zhang, Dominika Lukas, Fenja Gierschek, Evelyn Ullrich, Claudia Lengerke

Blood (2025) 146 (Supplement 1): 2357.

https://doi.org/10.1182/blood-2025-2357

Published: 2025

Journal Articles

Impact of prior B-cell-directed immunotherapy on the outcome of CD19 CAR T-cell therapy in aggressive B-cell lymphoma - an analysis of the EBMT and the GoCART coalition

Blood (2025) 146 (Supplement 1): 1937.

https://doi.org/10.1182/blood-2025-1937

Published: 2025

Journal Articles

In Vivo modeling of leukemic evolution in ELANE-associated severe congenital neutropenia

Jeremy Haaf, Malte Ritter, Sergey Kandabarau, Maksim Klimiankou, Amy Schmidt, Claudia Lengerke, Daniel Link, Karl Welte, Patricia Arreba-Tutusaus, Julia Skokowa

Blood (2025) 146 (Supplement 1): 750.

https://doi.org/10.1182/blood-2025-750

Published: 2025

Journal Articles

Immune recovery and immunologic remodeling after CD19-directed chimeric antigen receptor T cell therapy in autoimmune diseases

Andreas Riedel, Ann-Christin Pecher, Lucca Kimmich, Dennis Usow, Luca Hensen, Jan Christian Schroeder, Saskia Rudat, Hildegard Keppeler, Jianfeng Liu, Christoph Faul, Anna Stanger, Wolfgang Bethge, Joerg Henes, Claudia Lengerke

Blood (2025) 146 (Supplement 1): 2335.

https://doi.org/10.1182/blood-2025-2335

Published: 2025

Journal Articles

The addition of a tyrosine kinase inhibitor to intensive chemotherapy significantly improves outcome in de novo BCR::ABL1+ acute myeloid leukemia treated with intensive chemotherapy

Sarah Bertoli, Niklas Landberg, Emilie Bérard, Camille Gondran, Laetitia Largeaud, Véronique De Mas, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Sylvain Garciaz, Ludovic Gabellier, Gabrielle Roth-Guepin, Corentin Orvain, Pierre Peterlin, Rudy Birsen, Magda Alexis, Martin Carre, Emmanuelle Tavernier, Marion Boissard Simonet, Chantal Himberlin, Marc Maynadié, Kamel Laribi, Cécile Moluçon-Chabrot, Amine Belhabri, Samy Chraibi, Quentin Cabrera, Delphine Lebon, Emmanuel Raffoux, Thomas Cluzeau, Jean-Baptiste Micol, Mathieu Leclerc, Céline Berthon, Herve Dombret, Gunnar Juliusson, Anna Robelius, Sören Lehmann, Martin Jädersten, Lovisa Wennström, Pau Montesinos, Carmen Botella, Juan Miguel Bergua Burgues, Raimundo Garcia, Josefina Serrano, Mariluz Amigo, Patricia Garcia Ramirez, Claudia Sossa, Juan Manuel Alonso-Dominguez, Hartmut Döhner, Konstanze Döhner, Daniela Späth, Michael Kühn, Claudia Lengerke, Hans-Jörg Tischler, Christoph Röllig, Leo Ruhnke, Christian Thiede, Andreas Burchert, Hubert Serve, Carsten Mueller-Tidow, Claudia Baldus, Jurjen Versluis, Peter Valk, Daniel Kristensen, Anne Stidsholt Roug, Jiri Mayer, Mika Kontro, Pia Ettala, Vladimir Lazarevic, Christian Recher

Blood (2025) 146 (Supplement 1): 991.

https://doi.org/10.1182/blood-2025-991

Published: 2025

Journal Articles

The laminin receptor integrin α7β1 marks a highly migratory cell population and correlates with poor prognosis in Acute Myeloid Leukemia.

Saskia Rudat, Elsa Görsch, Marlon Arnone, Hildegard Keppeler, Nandini Asokan, Jan Christian Schroeder, Taylor Mills, Lea Kramer, Jan Pauluschke-Fröhlich, Maksim Klimiankou, Jan Weller, Gerd Klein, Claudia Lengerke

Blood (2025) 146 (Supplement 1): 3491.

https://doi.org/10.1182/blood-2025-3491

Published: 2025

Journal Articles

Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia

Jan Christian Schroeder, Patrice Zeis, Borhan R. Saeed, Lanzhu Li, Christine Beschorner, Claudia Lengerke, Christian Schuerch

Blood (2025) 146 (Supplement 1): 2572.

https://doi.org/10.1182/blood-2025-2572

Published: 2025

Journal Articles

CD19/CD22 CAR-T cells in adult patients with relapsed/refractory B-cell malignancies

Laurent Phely, Stefan Hug, Luca Hensen, Elena Mirovic, Christoph Faul, Wichard Vogel, Claudia Lengerke, Wolfgang Bethge

Blood (2025) 146 (Supplement 1): 4142.

https://doi.org/10.1182/blood-2025-4142

Published: 2025

Journal Articles

Phenotypic evolution of circulating tumor plasma cells across MGUS, SMM and multiple myeloma

Martin Pietzsch, Sina Beer, Lucca Kimmich, Chiara Windsor, Britta Besemer, Claudia Lengerke, Anna Stanger

Blood (2025) 146 (Supplement 1): 3914.

https://doi.org/10.1182/blood-2025-3914

Published: 2025

Journal Articles

Defining a high-risk population for CAR-T-cell therapy: The impact of clonal hematopoiesis and pre-existing neutropenia on severe outcomes in patients treated for malignant and non-malignant conditions

Alisha Weiss-Haug, Reka Haraszti, Jan Christian Schroeder, Kristina Reuß, Britta Merz, Saskia Rudat, Hildegard Keppeler, Lea Kramer, Elena Mirovic, Christoph Faul, Ann-Christin Pecher, Joerg Henes, Katrin Lutz, Luca Hensen, Wolfgang Bethge, Friederike Schwartz, Claudia Lengerke

Blood (2025) 146 (Supplement 1): 5942.

https://doi.org/10.1182/blood-2025-5942

Published: 2025

Journal Articles

Trial in progress: Safety and feasibility of a venetoclax-augmented treosulfan-based reduced intensity conditioning before allogeneic stem cell transplantation in AML, MDS/AML and higher risk MDS (VeStAL)

Lucas Mix, Wichard Vogel, Britta Besemer, Peter Martus, Claudia Lengerke, Wolfgang Bethge, Christoph Faul

Blood (2025) 146 (Supplement 1): 6001.

https://doi.org/10.1182/blood-2025-6001

Published: 2025

Journal Articles

Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization

Blood (2025) 146 (16): 1964–1978.

https://doi.org/10.1182/blood.2025028460

Published: 2025

Includes: Multimedia, Supplemental data

Journal Articles

A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations

Blood (2025) 145 (20): 2317–2335.

https://doi.org/10.1182/blood.2023022576

Published: 2025

Includes: Supplemental data

Journal Articles

Impact of Allogeneic Hematopoietic Cell Transplantation Post-Sars-Cov-2 Infection: A Retrospective Analysis By the German Cooperative Transplant Study Group

Blood (2024) 144 (Supplement 1): 3554.

https://doi.org/10.1182/blood-2024-204560

Published: 2024

Journal Articles

Characterization of a Human Bone Marrow-Derived CRISPR/Cas9 Cell Model for Chronic Myeloid Leukemia

Pia Christin Radszuweit, Barbara Mankel, Fulya Korkmaz, Hildegard Keppeler, Claudia Lengerke, Dominik Schneidawind, Corina Schneidawind

Blood (2024) 144 (Supplement 1): 1353.

https://doi.org/10.1182/blood-2024-209947

Published: 2024

Journal Articles

Primary Vitreoretinal Lymphoma: A Comprehensive Retrospective Analysis of 65 Cases at Two European Centers

Sina Alexandra Beer, Carola Huber, Michael Sommer, Stefan Wirths, Daniela Süsskind, Claudia Lengerke, David Adrian Merle

Blood (2024) 144 (Supplement 1): 4464.

https://doi.org/10.1182/blood-2024-203779

Published: 2024

Journal Articles

Long-Term Immunological Consequences of CD19 CAR T Cell Therapy: Analysis of Infectious Complications and Immune Reconstitution

Andreas Riedel, Jan Frederic Weller, Laurent Phely, Stefan Hug, Christoph Faul, Claudia Lengerke, Wolfgang Andreas Bethge

Blood (2024) 144 (Supplement 1): 7248.

https://doi.org/10.1182/blood-2024-210536

Published: 2024

Journal Articles

Dual CD19/CD22-Targeting CAR-T Cells for Richter Transformation: A Case Series

Stefan Hug, Laurent Phely, Andreas Riedel, Simon Killinger, Luca Hensen, Christoph Faul, Wolfgang Andreas Bethge, Claudia Lengerke

Blood (2024) 144 (Supplement 1): 6544.

https://doi.org/10.1182/blood-2024-200768

Published: 2024

Journal Articles

Modulating G-CSFR Signaling Using De Novo Designed Cytokines

Timo Ullrich, Birte Hernandez Alvarez, Christoph Pollmann, Malte Ulrich Ritter, Jérémy Haaf, Narges Aghaallaei, Jacob Piehler, Ivan Tesakov, Maya El-Riz, Kateryna Maksymenko, Valeriia Hatskovska, Sergey Kandabarau, Maksim Klimiankou, Claudia Lengerke, Karl Welte, Andrei Lupas, Julia Skokowa, Mohammad ElGamacy

Blood (2024) 144 (Supplement 1): 4967.

https://doi.org/10.1182/blood-2024-209668

Published: 2024

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Trial in progress: Phase II Study of (early) combination salvage therapy with venetoclax and intensified decitabine in relapsed/refractory AML (VenSwitch)

PARP1 inhibition sensitizes AML to CD123 CAR-NK cells via immunophenotypic remodeling

Impact of prior B-cell-directed immunotherapy on the outcome of CD19 CAR T-cell therapy in aggressive B-cell lymphoma - an analysis of the EBMT and the GoCART coalition

In Vivo modeling of leukemic evolution in ELANE-associated severe congenital neutropenia

Immune recovery and immunologic remodeling after CD19-directed chimeric antigen receptor T cell therapy in autoimmune diseases

The addition of a tyrosine kinase inhibitor to intensive chemotherapy significantly improves outcome in de novo BCR::ABL1+ acute myeloid leukemia treated with intensive chemotherapy

The laminin receptor integrin α7β1 marks a highly migratory cell population and correlates with poor prognosis in Acute Myeloid Leukemia.

Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia

CD19/CD22 CAR-T cells in adult patients with relapsed/refractory B-cell malignancies

Phenotypic evolution of circulating tumor plasma cells across MGUS, SMM and multiple myeloma

Defining a high-risk population for CAR-T-cell therapy: The impact of clonal hematopoiesis and pre-existing neutropenia on severe outcomes in patients treated for malignant and non-malignant conditions

Trial in progress: Safety and feasibility of a venetoclax-augmented treosulfan-based reduced intensity conditioning before allogeneic stem cell transplantation in AML, MDS/AML and higher risk MDS (VeStAL)

Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization

A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations

Impact of Allogeneic Hematopoietic Cell Transplantation Post-Sars-Cov-2 Infection: A Retrospective Analysis By the German Cooperative Transplant Study Group

Characterization of a Human Bone Marrow-Derived CRISPR/Cas9 Cell Model for Chronic Myeloid Leukemia

Primary Vitreoretinal Lymphoma: A Comprehensive Retrospective Analysis of 65 Cases at Two European Centers

Long-Term Immunological Consequences of CD19 CAR T Cell Therapy: Analysis of Infectious Complications and Immune Reconstitution

Dual CD19/CD22-Targeting CAR-T Cells for Richter Transformation: A Case Series

Modulating G-CSFR Signaling Using De Novo Designed Cytokines

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