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Joseph Brandwein
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Journal Articles

Phase 1 Results: First-in-Human Phase 1/2 Study of the Menin-MLL Inhibitor Enzomenib (DSP-5336) in Patients with Relapsed or Refractory Acute Leukemia

Joshua F Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Harry P. Erba, Kentaro Fukushima, Takahiro Shima, Neil D. Palmisiano, Eunice S. Wang, Uma Borate, Joseph Brandwein, Cristina Papayannidis, Pau Montesinos, Gina Keiffer, Yasushi Miyazaki, Naoko Hosono, Takayuki Ikezoe, Yoshiaki Ogawa, Timothy S Pardee, Stephen Anthony Strickland, Koichi Onodera, Shang-Ju Wu, Melissa G Ooi, Emmanuel Raffoux, Susana Vives, Alireza Eghtedar, Hongliang Cai, Curtis Allred, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 213.
https://doi.org/10.1182/blood-2024-194827
Published: 2024
Journal Articles

10 Year Follow-up of CALGB 10603/Ratify: Midostaurin Versus Placebo Plus Intensive Chemotherapy in Newly Diagnosed FLT3 Mutant Acute Myeloid Leukemia Patients Aged 18-60 Years

Richard M Stone, Jun Yin, Sumithra J Mandrekar, Axel Benner, Maral Saadati, Ilene A. Galinsky, Ben L. Sanford, Rebecca Teske, Susan M. Geyer, Thomas Prior, Sergio Amadori, Frederick R. Appelbaum, Joseph Brandwein, Konstanze Döhner, Gerhard Ehninger, Arnold Ganser, Rebecca B. Klisovic, Jürgen Krauter, Guido Marcucci, Bruno Medeiros, Dietger W. Niederwieser, Miguel A. Sanz, Richard F. Schlenk, Hubert Serve, Jorge Sierra, Martin S. Tallman, Andrew H Wei, Theo J.M. de Witte, Christian Thiede, Hartmut Döhner, Richard A. Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 218.
https://doi.org/10.1182/blood-2024-201058
Published: 2024
Journal Articles

Infectious Complications and Antibiotic Prophylaxis during Induction Therapy with Venetoclax Plus Azacitidine for Previously Untreated AML: A Real-World Experience

Joseph Brandwein, Elena Liew, David Page, Peng Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 5971.
https://doi.org/10.1182/blood-2024-199315
Published: 2024
Journal Articles

Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis

Maria Agustina Perusini, Claire Andrews, Eshetu G Atenafu, Sarit E. Assouline, Joseph Brandwein, Mohammad Jarrar, Steven M. Chan, Signy Chow, Dina Khalaf, Vikas Gupta, Dawn C. Maze, Mark D. Minden, Gizelle Popradi, Waleed Sabry, Lalit Saini, David Sanford, Lynn Savoie, Aaron Schimmer, Andre C. Schuh, Karen Yee, Hassan Sibai
Journal: Blood
Blood (2024) 144 (Supplement 1): 1506.
https://doi.org/10.1182/blood-2024-204004
Published: 2024
Journal Articles

Preliminary Results from a Phase 1b/2 Open-Label, Multicenter, Dose Optimization Clinical Study of the Safety, Tolerability, and Pharmacokinetic (PK) and Pharmacodynamic (PD) Profiles of Cfi-400945 As a Single Agent or in Combination with Azacitidine in Patients (Pts) with Acute Myeloid Leukemia, Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia (TWT-202)

Brian A. Jonas, Karen Yee, Alice Mims, Paul B. Koller, Joseph Brandwein, Gail J. Roboz, Glenn Michelson, Linh Nguyen, Mark R Bray, Emily Roberts-Thomson, Roger Sidhu, Gautam Borthakur
Journal: Blood
Blood (2023) 142 (Supplement 1): 4294.
https://doi.org/10.1182/blood-2023-182027
Published: 2023
Journal Articles

Final Results of the Phase Ib/II Study Evaluating Enasidenib in Combination with Venetoclax in Patients with IDH2 -Mutated Relapsed/Refractory Myeloid Malignancies

Guillaume Richard-Carpentier, Gopila Gupta, Charina Cameron, Severine Cathelin, Aniket Bankar, Marta Beata Davidson, Vikas Gupta, Dawn C. Maze, Mark D. Minden, Tracy Murphy, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Courtney D. DiNardo, Joseph Brandwein, Caroline Jane McNamara, Steven M. Chan
Journal: Blood
Blood (2023) 142 (Supplement 1): 159.
https://doi.org/10.1182/blood-2023-188341
Published: 2023
Journal Articles

Phase 1/2 First-in-Human Study of the Menin-MLL Inhibitor DSP-5336 in Patients with Relapsed or Refractory Acute Leukemia

Naval Daver, Joshua F. Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Kentaro Fukushima, Takayuki Ikezoe, Yoshiaki Ogawa, Joseph Brandwein, Eunice S. Wang, Yasushi Miyazaki, Timothy Pardee, Naoko Hosono, Takahiro Shima, Hisayuki Yokoyama, Noboru Asada, Joseph Jurcic, Hongliang Cai, Akinobu Watanabe, Matthew Hitron, Emily Brooks, Bo Xu, Jatin Shah, Hagop M. Kantarjian, Harry P. Erba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2911.
https://doi.org/10.1182/blood-2023-179252
Published: 2023
Journal Articles

The Application of the SORE6 Reporter in the Studies of Acute Myeloid Leukemia - a Novel Model for Disease Relapses

Justine Lai, Joseph Brandwein, Chuquan Shang, Will Chen, Michael P. Chu, Irwindeep Sandhu, Raymond Lai, Peng Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9155.
https://doi.org/10.1182/blood-2022-159216
Published: 2022
Journal Articles

Implementing RNAi Therapy Targeting FLT3 in Acute Myeloid Leukemia (AML)

Aysha Ansari, Remant Bahadur KC, Mohammad Nasrullah, Daniel NM Sundaram, Luis Morales Burbano, Joseph Brandwein, Xiaoyan Jiang, Hasan Uludag
Journal: Blood
Blood (2022) 140 (Supplement 1): 7791–7792.
https://doi.org/10.1182/blood-2022-169187
Published: 2022
Journal Articles

Preliminary Results from a Phase 2 Open-Label, Multicenter, Dose Optimization Clinical Study of the Safety, Tolerability, and Pharmacokinetic (PK) and Pharmacodynamic (PD) Profiles of Cfi-400945 As a Single Agent or in Combination with Azacitidine or Decitabine in Patients with Acute Myeloid Leukemia, Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia (TWT-202)

Brian A. Jonas, Karen Yee, Paul B. Koller, Joseph Brandwein, Alice S. Mims, Glenn C. Michelson, Linh Nguyen, Mark R Bray, Emily L Roberts-Thomson, Gautam Borthakur
Journal: Blood
Blood (2022) 140 (Supplement 1): 9076–9077.
https://doi.org/10.1182/blood-2022-158370
Published: 2022
Journal Articles

Targeting N-Myristoylation for Adult Acute Myeloid Leukemia Therapy

Jay Gamma, Erwan Beauchamp, Qiang Liu, Aishwarya Iyer, Megan Yap, Zoulika Zak, Cassidy Ekstrom, Krista Vincent, Joseph Brandwein, Jean C.Y. Wang, Naveen Pemmaraju, Gautam Borthakur, John R. Mackey, Luc G. Berthiaume
Journal: Blood
Blood (2022) 140 (Supplement 1): 3088–3089.
https://doi.org/10.1182/blood-2022-170544
Published: 2022
Journal Articles

Changing Frontline AML Treatment Patterns in Alberta, Canada from 2013 - 2022

Kurt Ebeling, Peng Wang, Elena Liew, Nancy Zhu, Mark Hnatiuk, Minakshi S. Taparia, Marlene Hamilton, Joseph Brandwein
Journal: Blood
Blood (2022) 140 (Supplement 1): 11636–11637.
https://doi.org/10.1182/blood-2022-159231
Published: 2022
Journal Articles

Alberta Cellular and Immunotherapy (ACIT) 001, Results of Decentralized Production of Second Generation, Anti-CD19/41BB/CD3z Chimeric Antigen Receptor (CAR) T-Cells in Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL)

Michael P. Chu, Zack M. Breckenridge, Andrew Daly, Mona Shafey, Victor A. Lewis, Sunil J. Desai, Peng Wang, Joseph Brandwein, Peter Duggan, Beverly Wilson, Bindu Thapa, Carina Debes-Marun, Irwindeep Sandhu
Journal: Blood
Blood (2022) 140 (Supplement 1): 7466–7467.
https://doi.org/10.1182/blood-2022-165887
Published: 2022
Journal Articles

Validation of NMT1 and NMT2 As Novel Drug Targets in Adult Acute Myeloid Leukemia: Rationale for N-Myristoyltransferase Inhibition with Pclx-001 for Clinical Trials

Jay Gamma, Aishwarya Iyer, Megan Yap, Zoulika Zak, Krista Vincent, Cassidy Ekstrom, Erwan Beauchamp, Lynne Postovit, John R. Mackey, Naveen Pemmaraju, Gautam Borthakur, Joseph Brandwein, Luc G. Berthiaume
Journal: Blood
Blood (2021) 138 (Supplement 1): 4344.
https://doi.org/10.1182/blood-2021-154000
Published: 2021
Journal Articles

Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study

Clinical Trials & Observations
Guillermo Garcia-Manero, Elizabeth A. Griffiths, David P. Steensma, Gail J. Roboz, Richard Wells, James McCloskey, II, Olatoyosi Odenike, Amy E. DeZern, Karen Yee, Lambert Busque, Casey O’Connell, Laura C. Michaelis, Joseph Brandwein, Hagop Kantarjian, Aram Oganesian, Mohammad Azab, Michael R. Savona
Journal: Blood
Blood (2020) 136 (6): 674–683.
https://doi.org/10.1182/blood.2019004143
Published: 2020
Journal Articles

Discordance Between Morphologic and Cytogenetic Findings Following Induction Chemotherapy for Acute Myeloid Leukemia Is Prevalent in Patients with Bone Marrow Blasts >2% and Is Associated with Poor Clinical Outcomes

Lalit Saini, MD, Joseph Brandwein, MD FRCPC, Irwindeep Sandhu, MD
Journal: Blood
Blood (2015) 126 (23): 4978.
https://doi.org/10.1182/blood.V126.23.4978.4978
Published: 2015
Journal Articles

Outcomes of Down-Syndrome Associated Acute Lymphoblastic Leukemia in Adults: A Single Center Retrospective Review

Sita D. Bhella, MD, Eshetu G Atenafu, M.Sc., P.Stat., Joseph Brandwein, MD FRCPC, Vikas Gupta, MD FRCP, FRCPath, Johann Hitzler, MD FRCP (C), FAAP, Dina Khalaf, BSc, MSc, MD, Andrzej Lutynski, MD, Aaron D. Schimmer, MD PhD, Andre C Schuh, MD FRCPC, Amr Rostom, MD, Anna Rydlewski, MD, Karen W.L. Yee, MD, Mark D. Minden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3717.
https://doi.org/10.1182/blood.V126.23.3717.3717
Published: 2015
Journal Articles

Incidence of Catheter-Related Venous Thromboembolism Events in Acute Leukemia patients ; A Comparative, Retrospective Study of the Safety of Peripherally-Inserted Vs Centrally-Inserted Central Venous Catheters

Mohammad Refaei, MD BSc, MSc, Bruna Fernandes, Joseph Brandwein, MD FRCPC, M. Dawn Goodyear, MD, Cynthia M Wu, MD FRCPC
Journal: Blood
Blood (2015) 126 (23): 3546.
https://doi.org/10.1182/blood.V126.23.3546.3546
Published: 2015
Journal Articles

Antithymocyte Globulin at Clinically Relevant Concentration Kills Leukemic Blasts

Rosy Dabas, Rachelle Lee, Maria Theresa Servito, Poonam Dharmani Khan, Monica Modi, MD, Tiffany Van Slyke, Joanne Luider, Caylib Durand, Loree Larratt, MD, Joseph Brandwein, MD FRCPC, Andrew Daly, MD FRCPC, Faisal M Khan, PhD D (ABHI), Jan Storek, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5481.
https://doi.org/10.1182/blood.V126.23.5481.5481
Published: 2015
Journal Articles

Bone Marrow Aspirates Alone without a Trephine Biopsy May be Insufficient for the Detection of Residual Leukemia Following Intensive Chemotherapy for the Treatment of Acute Myeloid Leukemia

Lalit Saini, MD, Robert Turner, MD, Loree Larratt, MD, Joseph Brandwein, MD, Marlene Ann Hamilton, MD, Anthea Peters, MD MSc, FRCPC, Cynthia M Wu, MD FRCPC, Nancy Zhu, MD, Jeffery M. Patterson, MD, Lauren Bolster, MD, Michael Mant, MD, Bruce Ritchie, MD, Elena Liew, MD, Imran Mirza, MD FRCPC, Graeme R. Quest, MDMSc, Susan Nahirniak, Sunita Gosh, PhD, P.Stat., P.Stat, Irwindeep Sandhu, MD FRCPC
Journal: Blood
Blood (2014) 124 (21): 2336.
https://doi.org/10.1182/blood.V124.21.2336.2336
Published: 2014