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Luc G. Berthiaume
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Journal Articles

Zelenirstat Nmt Inhibitor in Patients with Relapsed/Refractory B-Cell Lymphoma and Acute Myelogenous Leukemia: Mechanistic Insights and Clinical Outcomes

Randeep Sangha, John Kuruvilla, Laurie H. Sehn, Michael Weickert, Erwan Beauchamp, Jay M. Gamma, Naveen Pemmaraju, Gautam Borthakur, Luc G. Berthiaume, John R. Mackey
Journal: Blood
Blood (2024) 144 (Supplement 1): 5791.
https://doi.org/10.1182/blood-2024-208480
Published: 2024
Journal Articles

Targeting N-Myristoylation for Adult Acute Myeloid Leukemia Therapy

Jay Gamma, Erwan Beauchamp, Qiang Liu, Aishwarya Iyer, Megan Yap, Zoulika Zak, Cassidy Ekstrom, Krista Vincent, Joseph Brandwein, Jean C.Y. Wang, Naveen Pemmaraju, Gautam Borthakur, John R. Mackey, Luc G. Berthiaume
Journal: Blood
Blood (2022) 140 (Supplement 1): 3088–3089.
https://doi.org/10.1182/blood-2022-170544
Published: 2022
Journal Articles

A First in Class, Open-Label, First-in-Human, Phase I Trial of Daily Oral Pclx-001

Randeep Sangha, Laurie H. Sehn, Rahima Jamal, Jennifer Spratlin, John Kuruvilla, Michael J. Weickert, Luc G. Berthiaume, John R. Mackey
Journal: Blood
Blood (2022) 140 (Supplement 1): 12057–12058.
https://doi.org/10.1182/blood-2022-168140
Published: 2022
Journal Articles

Validation of NMT1 and NMT2 As Novel Drug Targets in Adult Acute Myeloid Leukemia: Rationale for N-Myristoyltransferase Inhibition with Pclx-001 for Clinical Trials

Jay Gamma, Aishwarya Iyer, Megan Yap, Zoulika Zak, Krista Vincent, Cassidy Ekstrom, Erwan Beauchamp, Lynne Postovit, John R. Mackey, Naveen Pemmaraju, Gautam Borthakur, Joseph Brandwein, Luc G. Berthiaume
Journal: Blood
Blood (2021) 138 (Supplement 1): 4344.
https://doi.org/10.1182/blood-2021-154000
Published: 2021
Journal Articles

An Open-Label, First-in-Human, Phase I Trial of Daily Pclx-001

Randeep Sangha, John R. Mackey, Laurie H. Sehn, John Kuruvilla, Michael J. Weickert, Luc G. Berthiaume
Journal: Blood
Blood (2021) 138 (Supplement 1): 1364.
https://doi.org/10.1182/blood-2021-153613
Published: 2021
Journal Articles

Nonclinical Efficacy and Toxicity and Selection of a Safe Clinical Starting Dose for an NMT Inhibitor in Development for Hematological Malignancies

Michael J. Weickert, PhD, John Dillberger, DVM, PhD, Caren Brown, Francis Phaneuf, John R. Mackey, MD, Randeep Sangha, MD, Luc G. Berthiaume, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-141910
Published: 2020
Journal Articles

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

Michael Weickert, John Dillberger, John R. Mackey, Paul Wyatt, David Gray, Kevin Read, Christian Li, Audrey Parenteau, Luc G. Berthiaume
Journal: Blood
Blood (2019) 134 (Supplement_1): 3362.
https://doi.org/10.1182/blood-2019-124934
Published: 2019
Journal Articles

N-Myristoyltransferase 2 (NMT2) Protein Levels Predict Survival in Acute Myeloid Leukemia (AML): A Novel Prognostic Biomarker

Ryan J Stubbins, MDMSc, Zoulika Zak, Aishwarya Iyer, Megan Yap, Krista Vincent, Lynne M Postovit, MD, John R Mackey, MD, Artur J Szkotak, MD PhD, Lalit Saini, MD, Luc G Berthiaume, PhD, Joseph M. Brandwein, MD FRCPC
Journal: Blood
Blood (2017) 130 (Supplement 1): 3914.
https://doi.org/10.1182/blood.V130.Suppl_1.3914.3914
Published: 2017