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Takahiro Shima
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Journal Articles

Pre-CAR-T GTE Scoring of Electroencephalogram Abnormalities As Predictive Biomarkers for Icans

Hidetaka Nakagaki, Takuji Yamauchi, Takahiko Mukaino, Ayumi Sakata, Eriko Watanabe, Mitsuru Watanabe, Daisuke Ishihara, Hiroshi Imanaga, Kensuke Sasaki, Teppei Sakoda, Fumiaki Jinnouchi, Kohta Miyawaki, Takahiro Shima, Yoshikane Kikushige, Yasuo Mori, Yuya Kunisaki, Taeko Hotta, Hiroshi Shigeto, Noriko Isobe, Koichi Akashi, Koji Kato
Journal: Blood
Blood (2024) 144 (Supplement 1): 2081.
https://doi.org/10.1182/blood-2024-199102
Published: 2024
Journal Articles

Phase 1 Results: First-in-Human Phase 1/2 Study of the Menin-MLL Inhibitor Enzomenib (DSP-5336) in Patients with Relapsed or Refractory Acute Leukemia

Joshua F Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Harry P. Erba, Kentaro Fukushima, Takahiro Shima, Neil D. Palmisiano, Eunice S. Wang, Uma Borate, Joseph Brandwein, Cristina Papayannidis, Pau Montesinos, Gina Keiffer, Yasushi Miyazaki, Naoko Hosono, Takayuki Ikezoe, Yoshiaki Ogawa, Timothy S Pardee, Stephen Anthony Strickland, Koichi Onodera, Shang-Ju Wu, Melissa G Ooi, Emmanuel Raffoux, Susana Vives, Alireza Eghtedar, Hongliang Cai, Curtis Allred, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 213.
https://doi.org/10.1182/blood-2024-194827
Published: 2024
Journal Articles

Impact of Anti-Thymocyte Globulin on Procalcitonin Levels Comparison during Fever in Allogeneic Stem Cell Transplantation Conditioning

Takahiro Shima, Mariko Minami, Yasuo Mori, Shin-ichi Mizuno, Toshihiro Miyamoto, Koji Kato, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6985.
https://doi.org/10.1182/blood-2023-174235
Published: 2023
Journal Articles

Interleukin-18 and Soluble Interleukin-2 Receptor Are Useful Markers for Enhanced Diagnosis of Intravascular Lymphoma

Takahiro Shima, Yusuke Yamauchi, Masahiro Ohtsu, Hiroki Mitoma, Koji Kato, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6117.
https://doi.org/10.1182/blood-2023-181258
Published: 2023
Journal Articles

Fever with Significant Procalcitonin Increase Following Gemtuzumab Ozogamicin Infusion in Hematologic Malignancy Patients without Evidence of Infection

Chiaki Kubara, Takahiro Shima, Yasuo Mori, Koji Kato, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 7281.
https://doi.org/10.1182/blood-2023-180039
Published: 2023
Journal Articles

Phase 1/2 First-in-Human Study of the Menin-MLL Inhibitor DSP-5336 in Patients with Relapsed or Refractory Acute Leukemia

Naval Daver, Joshua F. Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Kentaro Fukushima, Takayuki Ikezoe, Yoshiaki Ogawa, Joseph Brandwein, Eunice S. Wang, Yasushi Miyazaki, Timothy Pardee, Naoko Hosono, Takahiro Shima, Hisayuki Yokoyama, Noboru Asada, Joseph Jurcic, Hongliang Cai, Akinobu Watanabe, Matthew Hitron, Emily Brooks, Bo Xu, Jatin Shah, Hagop M. Kantarjian, Harry P. Erba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2911.
https://doi.org/10.1182/blood-2023-179252
Published: 2023
Journal Articles

Platelet Decrease and Efficacy of Platelet-Rich Plasma Return for Peripheral Blood Stem Cell Apheresis

Takahiro Shima, MD PhD, Teppei Sakoda, MD, Tomoko Henzan, MD, Yuya Kunisaki, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD, Toshihiro Miyamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-142316
Published: 2020
Journal Articles

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia

Taro Tochigi, Toshihiro Miyamoto, Kiwamu Hatakeyama, Teppei Sakoda, Daisuke Ishihara, Hidetoshi Irifune, Takahiro Shima, Koji Kato, Takahiro Maeda, Takumi Ito, Hiroshi Handa, Koichi Akashi, Yoshikane Kikushige
Journal: Blood
Blood (2020) 135 (24): 2146–2158.
https://doi.org/10.1182/blood.2019003749
Published: 2020
Includes: Supplemental data
Journal Articles

Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation

Samuel A. Stoner, Ming Yan, Katherine Tin Heng Liu, Kei-Ichiro Arimoto, Takahiro Shima, Huan-You Wang, Daniel T. Johnson, Rafael Bejar, Catriona Jamieson, Kun-Liang Guan, Dong-Er Zhang
Journal: Blood
Blood (2019) 134 (20): 1730–1744.
https://doi.org/10.1182/blood.2019000170
Published: 2019
Includes: Supplemental data
Journal Articles

RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models

Yi-Jou Huang, BS, Ming Yan, PhD, Jia-Yu Chen, PhD, Liang Chen, PhD, Eunhee Kim, PhD, Takahiro Shima, MD PhD, Amanda G Davis, BS, Sayuri Miyauchi, DDS, PhD, Samuel A Stoner, Xiang-Dong Fu, PhD, Omar I Abdel-Wahab, MD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1796.
https://doi.org/10.1182/blood-2018-99-119104
Published: 2018
Journal Articles

CPSF1-Mediated Acute Myeloid Leukemia Fusion 3'UTR Alternation Is a Potential Therapeutic Target

Takahiro Shima, MD PhD, Amanda G Davis, Daniel T Johnson, Yu Kochi, MD, Sayuri Miyauchi, DDS, PhD, Samuel A Stoner, Junichiro Yuda, MD, Toshihiro Miyamoto, MD PhD, Jie-Hua Zhou, MD, Edward D. Ball, MD, Koichi Akashi, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 885.
https://doi.org/10.1182/blood-2018-99-119199
Published: 2018
Journal Articles

FIP1L1 Regulates Alternative Polyadenylation of Leukemia-Associated Genes in Acute Myeloid Leukemia

Amanda G Davis, BS, Takahiro Shima, MD PhD, Ruijia Wang, PhD, Dinghai Zheng, PhD, Bin Tian, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3882.
https://doi.org/10.1182/blood-2018-99-119582
Published: 2018
Journal Articles

Hippo Kinase Inactivation Contributes to Del(20q) Malignancies and Cooperates with JAK2-V617F to Promote Myelofibrosis in Mice

Samuel A Stoner, Ming Yan, PhD, Katherine Liu, Takahiro Shima, MD PhD, Huan-You Wang, MD PhD, Kei-Ichiro Arimoto, PhD, Rafael Bejar, MD PhD, Catriona Jamieson, MD PhD, Kun-Liang Guan, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 99.
https://doi.org/10.1182/blood-2018-99-115591
Published: 2018
Journal Articles

RUNX1 Deficiency and SRSF2 Mutation Cooperate to Promote Myelodysplastic Syndrome Development

Yi-Jou Huang, BS, Ming Yan, PhD, Eunhee Kim, PhD, Amanda G Davis, BS, Takahiro Shima, MD PhD, Sayuri Miyauchi, DDS, PhD, Xiang-Dong Fu, PhD, Omar Abdel-Wahab, MD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 119.
https://doi.org/10.1182/blood.V130.Suppl_1.119.119
Published: 2017
Journal Articles

Characterization of the Post-Transcriptional Regulation of AML1-ETO Expression in t(8;21) Leukemia Cells

Daniel T Johnson, BS, Takahiro Shima, MD PhD, Amanda G Davis, BS, Dong-Er Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3790.
https://doi.org/10.1182/blood.V130.Suppl_1.3790.3790
Published: 2017
Journal Articles

CPSF1 Regulates AML1-ETO Fusion Gene Polyadenylation and Stability in t(8;21) Acute Myelogenous Leukemia

Takahiro Shima, MD PhD, Amanda G Davis, Sayuri Miyauchi, DDS, PhD, Yu Kochi, MD, Daniel T Johnson, Samuel A Stoner, BS, Yuda Junichiro, MD, Toshihiro Miyamoto, MD PhD, Jie-Hua Zhou, MD, Edward D Ball, MD, Koichi Akashi, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2498.
https://doi.org/10.1182/blood.V130.Suppl_1.2498.2498
Published: 2017
Journal Articles

Usp18 Is Required for Normal Stem Cell Maintenance

Kei-ichiro Arimoto, PhD, Yue Zhang, Ming Yan, PhD, Sayuri Miyauchi, DDS, PhD, Stephanie Weng, PhD, Samuel A. Stoner, Takahiro Shima, MD PhD, Yukiko Komeno, MD PhD, Kentson Lam, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2016) 128 (22): 3863.
https://doi.org/10.1182/blood.V128.22.3863.3863
Published: 2016
Journal Articles

Prior Use of Mogamulizumab to Allogenic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-Versus-Host Disease

Takeshi Sugio, MD, Koji Kato, MD PhD, Takatoshi Aoki, MD, Takanori Ota, MD, Noriyuki Saito, MD, Shuro Yoshida, MD, Ichiro Kawano, MD, Hideho Henzan, MD, Ken Takase, MD, Tsuyoshi Muta, MD PhD, Kohta Miyawaki, MD, Takahiro Shima, MD PhD, Shuichiro Takashima, MD PhD, Takuji Yamauchi, MD PhD, Yasuo Mori, MDPhD, Goichi Yoshimoto, MD PhD, Kenjiro Kamezaki, MD PhD, Katsuto Takenaka, MD PhD, Tomohiko Kamimura, MD PhD, Yuju Ohno, MD PhD, Tetsuya Eto, MD PhD, Ryosuke Ogawa, MD PhD, Hiromi Iwasaki, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1940.
https://doi.org/10.1182/blood.V126.23.1940.1940
Published: 2015
Journal Articles

TIM-3 and Its Ligand, Galectin-9 Constitute a Pan-Myeloid Autocrine Loop to Develop and Maintain Malignant Stem Cells in Most Human Myeloid Leukemia

Yoshikane Kikushige, MD PhD, Junichiro Yuda, MD, Takahiro Shima, MD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 835.
https://doi.org/10.1182/blood.V124.21.835.835
Published: 2014
Journal Articles

TIM-3, a Leukemia Stem Cell Marker, Plays a Role In Leukemic Transformation Through Autocrine Stimulatory Signaling By Its Ligand, Galectin-9

Yoshikane Kikushige, MD PhD, Junichiro Yuda, MD, Takahiro Shima, MD, Toshihiro Miyamoto, MD, Koichi Akashi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4196.
https://doi.org/10.1182/blood.V122.21.4196.4196
Published: 2013