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Journal Articles

Pre-CAR-T GTE Scoring of Electroencephalogram Abnormalities As Predictive Biomarkers for Icans

Blood (2024) 144 (Supplement 1): 2081.

https://doi.org/10.1182/blood-2024-199102

Published: 2024

Journal Articles

Suppressed Expression of ASCT1 Contributes to the Maintenance of Leukemia Stemness Via the Enhancement of Antioxidant Capacity

Yu Kochi, Yoshikane Kikushige, Toshihiro Miyamoto, Koichi Akashi

Blood (2022) 140 (Supplement 1): 2992.

https://doi.org/10.1182/blood-2022-170782

Published: 2022

Journal Articles

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia

Taro Tochigi, Toshihiro Miyamoto, Kiwamu Hatakeyama, Teppei Sakoda, Daisuke Ishihara, Hidetoshi Irifune, Takahiro Shima, Koji Kato, Takahiro Maeda, Takumi Ito, Hiroshi Handa, Koichi Akashi, Yoshikane Kikushige

Blood (2020) 135 (24): 2146–2158.

https://doi.org/10.1182/blood.2019003749

Published: 2020

Includes: Supplemental data

Journal Articles

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells

Fumiaki Jinnouchi, Takuji Yamauchi, Ayano Yurino, Takuya Nunomura, Michitaka Nakano, Chika Iwamoto, Teppei Obara, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Eishi Baba, Koichi Akashi, Katsuto Takenaka

Blood (2020) 135 (19): 1661–1672.

https://doi.org/10.1182/blood.2019002194

Published: 2020

Includes: Supplemental data

Journal Articles

Somatic Mutations Potentiating RAS-MAPK Signaling Confer Resistant Potential Against FLT3-Inhibitors to Acute Myelogenous Leukemia

Masayasu Hayashi, MD PhD, Yoshikane Kikushige, MD PhD, Takuya Harada, MD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 910.

https://doi.org/10.1182/blood-2019-130694

Published: 2019

Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2516.

https://doi.org/10.1182/blood-2019-129372

Published: 2019

Journal Articles

Identification of Thrombospondin-1 As a Novel Substrate of Cereblon Responsible for IMiDs-Induced Venous Thromboembolism

Kiwamu Hatakeyama, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 631.

https://doi.org/10.1182/blood-2019-125670

Published: 2019

Journal Articles

Evaluation of TIM-3-Positive LSCs Post Allo-SCT Is a Highly Sensitive Strategy to Predict AML Relapses

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Takuya Harada, MD, Hidetoshi Irifune, MD, Masayasu Hayashi, MD PhD, Goichi Yoshimoto, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2702.

https://doi.org/10.1182/blood-2019-127779

Published: 2019

Journal Articles

Identification of GPAT1 As a Novel Therapeutic Target for Acute Leukemia By Inhibiting Leukemia Specific Metabolism

Hidetoshi Irifune, MD, Yu Kochi, MD, Masayasu Hayashi, MD PhD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 1384.

https://doi.org/10.1182/blood-2019-125661

Published: 2019

Journal Articles

Evaluation of TIM-3+ LSCs Is a Highly Sensitive MRD Monitoring Strategy to Predict AML Relapse after Allogenic Stem Cell Transplantation

Masayasu Hayashi, MD PhD, Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Hidetoshi Irifune, MD, Goichi Yoshimoto, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2018) 132 (Supplement 1): 1390.

https://doi.org/10.1182/blood-2018-99-116640

Published: 2018

Journal Articles

Identification of TIM-3/Gal-9 Autocrine Loop As a Novel Wnt-Ligands Independent Machinery for the Constitutive Activation of Canonical Wnt Pathway in AML-LSCs

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2018) 132 (Supplement 1): 1460.

https://doi.org/10.1182/blood-2018-99-116897

Published: 2018

Journal Articles

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 3919.

https://doi.org/10.1182/blood.V130.Suppl_1.3919.3919

Published: 2017

Journal Articles

PML-RARa of the Short but Not the Long/Variant Isoform Initiate from CD34 + TIM-3 + LSCs with Hierarchical Leukemic Organization

Mariko Minami, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 3967.

https://doi.org/10.1182/blood.V130.Suppl_1.3967.3967

Published: 2017

Journal Articles

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Blood (2017) 129 (25): 3332–3343.

https://doi.org/10.1182/blood-2016-09-741611

Published: 2017

Includes: Supplemental data

Journal Articles

Introduction of Macrophage Tolerance By Human SIRPA Knock-in Enhances Peripheral Reconstitution of Human Hematopoiesis in Xenotransplantation Model

Fumiaki Jinnouchi, MD, Katsuto Takenaka, MD PhD, Chika Iwamoto, PhD, Takuji Yamauchi, MD PhD, Ayano Yurino, MD, Takuya Nunomura, MD, Yoshikane Kikushige, MD PhD, Koji Kato, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 29.

https://doi.org/10.1182/blood.V128.22.29.29

Published: 2016

Journal Articles

TIM-3/Gal-9 Signaling Enhances Self-Renewal Capacity of AML-LSCs through Mimicking Canonical Wnt Signaling

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 1673.

https://doi.org/10.1182/blood.V128.22.1673.1673

Published: 2016

Journal Articles

Identification of ASCT1 As a Candidate Molecule Enhancing Antioxidant Activity in Primary Human AML Cells

Yu Kochi, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 1674.

https://doi.org/10.1182/blood.V128.22.1674.1674

Published: 2016

Journal Articles

IMiDs Cause Thrombocytopenia By the Inhibition of Proplatelet Formation, through Blocking Estradiol Autocrine Loop in Human Megakaryocytes

Taro Tochigi, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 894.

https://doi.org/10.1182/blood.V128.22.894.894

Published: 2016

Journal Articles

First Preclinical Report of the Efficacy and PD Results of KHK2823, a Non-Fucosylated Fully Human Monoclonal Antibody Against IL-3Rα

Tadakazu Akiyama, PhD, Shin-ichiro Takayanagi, PhD, Yoshimi Maekawa, Kohta Miyawaki, MD, Fumiaki Jinnouchi, MD, Takashi Jiromaru, MD, Takeshi Sugio, MD, Shinya Daitoku, MD, Hirotake Kusumoto, MD, Munetake Shimabe, PhD, Satoshi Nishikawa, Kengo Yamawaki, Kousuke Iijima, Masanori Hiura, Takeshi Takahashi, PhD, Yoshikane Kikushige, MD PhD, Hiromi Iwasaki, MD PhD, Koichi Akashi, MD PhD, Tomonori Tawara, PhD

Blood (2015) 126 (23): 1349.

https://doi.org/10.1182/blood.V126.23.1349.1349

Published: 2015

Journal Articles

Mobilization of Human Immature Hematopoietic Progenitors after Combinatory Use of Bortezomib and Immunomodulatory Drugs

Taro Tochigi, Takatoshi Aoki, MD, Yoshikane Kikushige, MD PhD, Tomohiko Kamimura, MD PhD, Takuji Yamauchi, MD PhD, Koji Kato, MD PhD, Katsuto Takenaka, MDPhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2015) 126 (23): 316.

https://doi.org/10.1182/blood.V126.23.316.316

Published: 2015

NARROW

Pre-CAR-T GTE Scoring of Electroencephalogram Abnormalities As Predictive Biomarkers for Icans

Suppressed Expression of ASCT1 Contributes to the Maintenance of Leukemia Stemness Via the Enhancement of Antioxidant Capacity

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug–induced thrombocytopenia

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells

Somatic Mutations Potentiating RAS-MAPK Signaling Confer Resistant Potential Against FLT3-Inhibitors to Acute Myelogenous Leukemia

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Identification of Thrombospondin-1 As a Novel Substrate of Cereblon Responsible for IMiDs-Induced Venous Thromboembolism

Evaluation of TIM-3-Positive LSCs Post Allo-SCT Is a Highly Sensitive Strategy to Predict AML Relapses

Identification of GPAT1 As a Novel Therapeutic Target for Acute Leukemia By Inhibiting Leukemia Specific Metabolism

Evaluation of TIM-3+ LSCs Is a Highly Sensitive MRD Monitoring Strategy to Predict AML Relapse after Allogenic Stem Cell Transplantation

Identification of TIM-3/Gal-9 Autocrine Loop As a Novel Wnt-Ligands Independent Machinery for the Constitutive Activation of Canonical Wnt Pathway in AML-LSCs

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

PML-RARa of the Short but Not the Long/Variant Isoform Initiate from CD34 + TIM-3 + LSCs with Hierarchical Leukemic Organization

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Introduction of Macrophage Tolerance By Human SIRPA Knock-in Enhances Peripheral Reconstitution of Human Hematopoiesis in Xenotransplantation Model

TIM-3/Gal-9 Signaling Enhances Self-Renewal Capacity of AML-LSCs through Mimicking Canonical Wnt Signaling

Identification of ASCT1 As a Candidate Molecule Enhancing Antioxidant Activity in Primary Human AML Cells

IMiDs Cause Thrombocytopenia By the Inhibition of Proplatelet Formation, through Blocking Estradiol Autocrine Loop in Human Megakaryocytes

First Preclinical Report of the Efficacy and PD Results of KHK2823, a Non-Fucosylated Fully Human Monoclonal Antibody Against IL-3Rα

Mobilization of Human Immature Hematopoietic Progenitors after Combinatory Use of Bortezomib and Immunomodulatory Drugs

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American Society of Hematology

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ASH Publications

American Society of Hematology

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