1-20 of 84
Caroline A. Heckman
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Investigating the Role of Neutrophil Extracellular Traps (NETs) in Multiple Myeloma Pathogenesis and Disease Evolution

Paul Dowling, Katie Dunphy, Despina Bazou, Juho J. Miettinen, Caroline A. Heckman, Peter O'Gorman
Journal: Blood
Blood (2024) 144 (Supplement 1): 6928.
https://doi.org/10.1182/blood-2024-205586
Published: 2024
Journal Articles

Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia

Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh B. Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2024-207199
Published: 2024
Journal Articles

Efficacy of the Peptide Drug Conjugates Melflufen and OPDC3 in Venetoclax Resistant Acute Myeloid Leukemia

Romika Kumari, Juho J. Miettinen, Mahesh B. Tambe, June Olgac, Tanja Ruokoranta, Nemo Ikonen, Minna H. Suvela, Maiju-Emilia Huppunen, Stefan Svensson Gelius, Klara Acs, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1548.
https://doi.org/10.1182/blood-2024-194582
Published: 2024
Journal Articles

Deciphering Variability in Light Chain Amyloidosis and Amyloidosis with Co-Occurring Multiple Myeloma By Single-Cell RNA Sequencing

Ankita Srivastava, Romika Kumari, Juho J. Miettinen, Minna H. Suvela, Klara Acs, Sini Luoma, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 4648.
https://doi.org/10.1182/blood-2024-209791
Published: 2024
Journal Articles

Integrative Analysis of Transcriptomic and Proteomic Data Identifies Patterns of Primary Resistance to Venetoclax-Azacitidine and Reveals Targetable Vulnerabilities in Acute Myeloid Leukemia (AML)

Ida Vänttinen, Joseph Saad, Tanja Ruokoranta, Sari Kytölä, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Caroline A. Heckman, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2024) 144 (Supplement 1): 2757.
https://doi.org/10.1182/blood-2024-209429
Published: 2024
Journal Articles

Ex Vivo Venetoclax Sensitivity Predicts Clinical Response in Acute Myeloid Leukemia in the Prospective VenEx Trial

Clinical Trials & Observations
Sari Kytölä, Ida Maria Vänttinen, Tanja Ruokoranta, Anu Partanen, Annasofia Holopainen, Joseph Saad, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Katariina Räty, Maija Itälä-Remes, Imre Västrik, Minna Suvela, Alun Owen Parsons, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Tero Jalkanen, Teppo Huttunen, Pia Ettala, MD, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood blood.2024024968.
https://doi.org/10.1182/blood.2024024968
Published: 2024
Includes: Supplemental data
Journal Articles

A menin-KMT2A inhibitor to overcome resistance

Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (11): 1139–1140.
https://doi.org/10.1182/blood.2024025760
Published: 2024
Journal Articles

Targeting Venetoclax Resistance in TP53 -Mutated Acute Myeloid Leukemia

Ida Vänttinen, Tanja Ruokoranta, Joseph J Saad, Sari Kytölä, Monica Hellesøy, Stein-Erik Gullaksen, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Krister Wennerberg, Bjorn T. Gjertsen, Caroline A. Heckman, Mika Kontro, Heikki Kuusanmäki
Journal: Blood
Blood (2023) 142 (Supplement 1): 2927.
https://doi.org/10.1182/blood-2023-189340
Published: 2023
Journal Articles

Indicators of Response to the Wee1 Inhibitor Adavosertib in Acute Myeloid Leukemia

Ankita Srivastava, Caroline A. Heckman, Juho Jalmari Miettinen, Olivier Harismendy
Journal: Blood
Blood (2023) 142 (Supplement 1): 5007.
https://doi.org/10.1182/blood-2023-188608
Published: 2023
Journal Articles

Combined Single Cell Flow Cytometry and Imaging Analyses Reveal Immunomodulatory Effects Exerted By Targeted Phospho-SYK Inhibitors with Elevated Sensitivity in NPM1 Mutated AML

Bridget A Robinson, Philipp Sergeev, Yoko Kosaka, Thomas Jacob, Andy Kaempf, Evan F. Lind, Cristina Tognon, Luis A. Carvajal, Jorge F. DiMartino, Caroline A. Heckman, Tania Q Vu
Journal: Blood
Blood (2023) 142 (Supplement 1): 5037.
https://doi.org/10.1182/blood-2023-186506
Published: 2023
Journal Articles

Label-Free High Dimensional Single Cell Morphological Profiling of Different Hematological Malignancies By Ghost Cytometry

Asako Tsubouchi, Juho Jalmari Miettinen, Keisuke Wagatsuma, Satoru Akai, Yuri An, Mika Uematsu, Philipp Sergeev, Dimitrios Tsallos, Markus Vaha-Koskela, Sadao Ota, Caroline A. Heckman
Journal: Blood
Blood (2023) 142 (Supplement 1): 5347.
https://doi.org/10.1182/blood-2023-188393
Published: 2023
Journal Articles

The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients

Fadimana Kaya, Findlay Bewicke-Copley, Pedro Casado Izquierdo, Jiexin Zheng, Juho Jalmari Miettinen, Naeem Khan, Szilvia Krizsán, Joseph J Saad, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Josée Hébert, Janet Matthews, Marianne Grantham, Doriana Di Bella, Krister Wennerberg, Alun Parsons, John G. Gribben, James D. Cavenagh, Sylvie D Freeman, Csaba Bödör, Guy Sauvageau, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro R Cutillas, Kevin Rouault-Pierre, Jude Fitzgibbon, Ana Rio-Machin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4302.
https://doi.org/10.1182/blood-2023-174891
Published: 2023
Journal Articles

The Impact of the Peptide Drug Conjugate Melflufen on the Myeloma Tumour Microenvironment

Philipp Sergeev, Juho Jalmari Miettinen, Stefan Svensson Gelius, Klara Acs, Caroline A. Heckman
Journal: Blood
Blood (2023) 142 (Supplement 1): 5781.
https://doi.org/10.1182/blood-2023-188603
Published: 2023
Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho Miettinen, Komal K. Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2023) 141 (13): 1610–1625.
https://doi.org/10.1182/blood.2021011094
Published: 2023
Includes: Supplemental data
Journal Articles

The Novel Peptide Drug Conjugate OPDC3 Is Highly Active in Different Hematological Malignancies

Juho J. Miettinen, Tanja Ruokoranta, Vilma Ikonen, Maiju-Emilia Huppunen, Klara Acs, Fredrik Lehmann, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10697–10698.
https://doi.org/10.1182/blood-2022-166090
Published: 2022
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Enabling the Implementation of Next-Generation Sequencing into Clinical Diagnosis: Nemhesys Project

Jesús María Hernández-Rivas, Inmaculada Serramito-Gómez, Saara Kallio, Amparo Cantalejo, Jana Kotaskova, Ana E. Rodriguez, María Abáigar, Rocio Benito, Anna Dolnik, Mark Catherwood, Jaine Blayney, Boris Tichý, Ivana Chalupová, Philippe Dubois, Roberto Lopez, Carlos Barranquero, María Díaz Lorenzo, Mylène Leitzelman, Sadiksha Adhikari, Šárka Pospíšilová, Lars Bullinger, Ken I Mills, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 13122–13124.
https://doi.org/10.1182/blood-2022-163285
Published: 2022
Journal Articles

A Potential Role of NK Cells and ABCB9 in Modulating the Response to Melflufen in Multiple Myeloma

Philipp Sergeev, Sadiksha Adhikari, Juho J. Miettinen, Maiju-Emilia Huppunen, Minna Suvela, Ana Slipicevic, Nina N. Nupponen, Klara Acs, Fredrik Lehmann, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 6000–6001.
https://doi.org/10.1182/blood-2022-162182
Published: 2022
Journal Articles

Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax

Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Amanda Ranta, Minna Suvela, Alun Parsons, Imre Västrik, Sanna M. Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2022) 140 (Supplement 1): 2020–2022.
https://doi.org/10.1182/blood-2022-159391
Published: 2022
Journal Articles

Monosomy 7 and Del(7q) Cause Selective Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia

Joseph Saad, Samuli Eldfors, Vilma Ikonen, Bjørn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 1033–1035.
https://doi.org/10.1182/blood-2022-163242
Published: 2022