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Timo Siitonen
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Journal Articles

Integrating Computational Cytomorphological Analysis of Bone Marrow Smears and Clinical Data for Predicting Response to Venetoclax and Hypomethylating Agents in AML

Henri Sundquist, Mikael Tatun, Mikko Purhonen, Laura Toivanen, Johanna Rimpiläinen, Samuli Rounioja, Timo Siitonen, Marja Pyörälä, Pentti Mäntymaa, Sari Kytölä, Kimmo Porkka, Sanna Siitonen, Heikki Kuusanmäki, Mika Kontro, Oscar E. Brück
Journal: Blood
Blood (2024) 144 (Supplement 1): 4320.
https://doi.org/10.1182/blood-2024-206949
Published: 2024
Journal Articles

Integrative Analysis of Transcriptomic and Proteomic Data Identifies Patterns of Primary Resistance to Venetoclax-Azacitidine and Reveals Targetable Vulnerabilities in Acute Myeloid Leukemia (AML)

Ida Vänttinen, Joseph Saad, Tanja Ruokoranta, Sari Kytölä, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Caroline A. Heckman, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2024) 144 (Supplement 1): 2757.
https://doi.org/10.1182/blood-2024-209429
Published: 2024
Journal Articles

Encouraging Efficacy of Bexmarilimab with Azacitidine in Relapsed or Refractory MDS in Bexmab Ph1/2 Study

Mika Kontro, Anthony S. Stein, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Jenna H Rannikko, Jesper Mickos, Rita Turpin, Milja Hakoniemi, Birge Berns, Sofia Aakko, Inka Pawlitzky, Maija Hollmén, Amer M. Zeidan, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.
https://doi.org/10.1182/blood-2024-206804
Published: 2024
Journal Articles

Ex Vivo Venetoclax Sensitivity Predicts Clinical Response in Acute Myeloid Leukemia in the Prospective VenEx Trial

Clinical Trials & Observations
Sari Kytölä, Ida Maria Vänttinen, Tanja Ruokoranta, Anu Partanen, Annasofia Holopainen, Joseph Saad, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Katariina Räty, Maija Itälä-Remes, Imre Västrik, Minna Suvela, Alun Owen Parsons, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Tero Jalkanen, Teppo Huttunen, Pia Ettala, MD, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood blood.2024024968.
https://doi.org/10.1182/blood.2024024968
Published: 2024
Includes: Supplemental data
Journal Articles

Encouraging Efficacy Observed in Bexmab Study: A Phase 1/2 Study to Assess Safety and Efficacy of Bexmarilimab in Combination with Standard of Care in Myeloid Malignancies

Mika Kontro, Anthony Selwyn Stein, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Maija Hollmén, Marie-Louise Fjaellskog, Inka Pawlitzky, Amer M. Zeidan, Naval Daver
Journal: Blood
Blood (2023) 142 (Supplement 1): 2915.
https://doi.org/10.1182/blood-2023-174912
Published: 2023
Journal Articles

Targeting Venetoclax Resistance in TP53 -Mutated Acute Myeloid Leukemia

Ida Vänttinen, Tanja Ruokoranta, Joseph J Saad, Sari Kytölä, Monica Hellesøy, Stein-Erik Gullaksen, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Krister Wennerberg, Bjorn T. Gjertsen, Caroline A. Heckman, Mika Kontro, Heikki Kuusanmäki
Journal: Blood
Blood (2023) 142 (Supplement 1): 2927.
https://doi.org/10.1182/blood-2023-189340
Published: 2023
Journal Articles

The clinical picture of ERCC6L2 disease: from bone marrow failure to acute leukemia

Clinical Trials & Observations
Marja Hakkarainen, Ilse Kaaja, Suvi P. M. Douglas, Tom Vulliamy, Inderjeet Dokal, Jean Soulier, Lise Larcher, Régis Peffault de Latour, Thierry Leblanc, Flore Sicre de Fontbrune, Timo Siitonen, Olli Lohi, Eva Hellström-Lindberg, Gisela Barbany, Bianca Tesi, Akiko Shimamura, Fabian Beier, Sharon Jackson, Amir Asher Kuperman, Tzipora Falik Zaccai, Hannah Tamary, Cristina Mecucci, Ilaria Capolsini, Kirsi Jahnukainen, Urpu Salmenniemi, Riitta Niinimäki, Teppo Varilo, Outi Kilpivaara, Ulla Wartiovaara-Kautto
Journal: Blood
Blood (2023) 141 (23): 2853–2866.
https://doi.org/10.1182/blood.2022019425
Published: 2023
Includes: Supplemental data
Journal Articles

Trial in Progress: A Phase I/II Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination with Standard of Care in Patients with Hematological Malignancies (BEXMAB)

Inka Pawlitzky, Timo Siitonen, Naval Daver, Juho Jalkanen, Sofia Aako, Marie-Louise Fjällskog, Mika Kontro
Journal: Blood
Blood (2022) 140 (Supplement 1): 11751–11752.
https://doi.org/10.1182/blood-2022-156786
Published: 2022
Journal Articles

Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax

Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Amanda Ranta, Minna Suvela, Alun Parsons, Imre Västrik, Sanna M. Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2022) 140 (Supplement 1): 2020–2022.
https://doi.org/10.1182/blood-2022-159391
Published: 2022
Journal Articles

Multinational Study on the Clinical and Genetic Features of the ERCC6L2-Disease

Marja Hakkarainen, Suvi P. M. Douglas, Tom Vulliamy, Inderjeet Dokal, Jean Soulier, Lise Larcher, Riitta Niinimäki, Timo Siitonen, Eva Hellstrom Lindberg, Gisela Barbany, Bianca Tesi, Amir Asher Kuperman, Hannah Tamary, Sharon Jackson, Outi Kilpivaara, Ulla Wartiovaara-Kautto
Journal: Blood
Blood (2021) 138 (Supplement 1): 864.
https://doi.org/10.1182/blood-2021-145039
Published: 2021
Journal Articles

Ex Vivo Drug Sensitivity Testing to Predict Response to Venetoclax + Azacitidine in Acute Myeloid Leukemia: Interim Results of the Prospective Multicenter Phase II Venex Trial

Heikki Kuusanmäki, Sari Kytölä, Ida Vänttinen, Amanda Ranta, Tanja Ruokoranta, Annasofia Holopainen, Sirpa Koskela, Milla E.L. Kuusisto, Kimmo Porkka, Riikka Räty, Imre Västrik, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mika Kontro
Journal: Blood
Blood (2021) 138 (Supplement 1): 228.
https://doi.org/10.1182/blood-2021-147691
Published: 2021
Journal Articles

RVD + ASCT + Lenalidomide Maintenance Benefits Patients without High-Risk Cytogenetics and Results in Recovery of the Normal Plasma Cell Composition in Bone Marrow

Raija Silvennoinen, MD, Pekka Anttila, MD, Marjaana Säily, MD PhD, Tuija Lundan, PhD, Jouni Heiskanen, MD, Timo Siitonen, MD PhD, Sakari Kakko, MD PhD, Mervi Putkonen, MDPhD, Hanna Ollikainen, MD, Venla Terävä, MD, Anu Partanen, MD, Kirsi Launonen, MD, Anu Räsänen, MD, Anu Sikiö, MD, Merja Suominen, MD, Piotr Bazia, MD, Kristiina Kananen, MD PhD, Juha Lievonen, MD, Tuomas Selander, MSc, Imre Västrik, Dr, PhD, Tarja-Terttu Pelliniemi, MD PhD, Kimmo Porkka, MD PhD, Kari Remes, MD PhD, Esa Jantunen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 676.
https://doi.org/10.1182/blood.V128.22.676.676
Published: 2016
Journal Articles

Large Granular Lymphocyte Infiltration in the Bone Marrow in Children and Young Adults May Suggest Primary Immune Deficiency

Mervi H Taskinen, MD PhD, Satu Mustjoki, MD PhD, Kirsi Jahnukainen, MD PhD, Luca Trotta, MSc, Timo Siitonen, MD PhD, Timo Hautala, MD PhD, Andrey Zavialov, PhD, Kaarina Heiskanen, MD PhD, Emma M Haapaniemi, MD PhD, Janna Saarela, MD PhD, Mikko Seppänen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1024.
https://doi.org/10.1182/blood.V126.23.1024.1024
Published: 2015
Journal Articles

A Prospective Phase 2 Study to Assess Immunophenotypic Remission after Lenalidomide-Based Induction Followed By ASCT and Lenalidomide Maintenance in Patients with Newly Diagnosed Multiple Myeloma

Raija Silvennoinen, MD, Pekka Anttila, MD, Marjaana Säily, MD PhD, Tuija Lundan, PhD, Jouni Heiskanen, MD, Timo Siitonen, MD PhD, Sakari Kakko, MD PhD, Mervi Putkonen, MDPhD, Hanna Ollikainen, MD, Venla Terävä, MD, Anu Partanen, MD, Kirsi Launonen, MD, Anu Räsänen, MD, Anu Sikiö, MD, Merja Suominen, MD, Piotr Bazia, MD, Kristiina Kananen, MD PhD, Tuomas Selander, MSc, Taru Kuittinen, MD PhD, Kimmo Porkka, MD PhD, Kari Remes, MDPhD, Esa Jantunen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1977.
https://doi.org/10.1182/blood.V126.23.1977.1977
Published: 2015
Journal Articles

A Randomized Comparison of Low-Dose Cyclophosphamide + G-CSF Versus G-CSF Alone Mobilization after Lenalidomide-Bortezomib-Dexamethasone (RVD) Induction in Multiple Myeloma

Raija Silvennoinen, MD, Tuija Lundan, PhD, Pekka Anttila, MD, Jouni Heiskanen, MD, Marjaana Säily, MDPhD, Timo Siitonen, MDPhD, Sakari Kakko, MDPhD, Hanna Ollikainen, MD, Seppo Vanhatalo, MD, Mervi Putkonen, MDPhD, Venla Terävä, MD, Anu Kutila, MD, Mari Partio, MD, Kirsi Launonen, MD, Anu Räsänen, MD, Anu Sikiö, MD, Merja Suominen, MD, Piotr Bazia, MD, Kristiina Kananen, MDPhD, Taru Kuittinen, MD PhD, Kimmo Porkka, MD PhD, Kari Remes, MD PhD, Esa Jantunen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 847.
https://doi.org/10.1182/blood.V124.21.847.847
Published: 2014