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Luis A. Carvajal
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Journal Articles

Combined Single Cell Flow Cytometry and Imaging Analyses Reveal Immunomodulatory Effects Exerted By Targeted Phospho-SYK Inhibitors with Elevated Sensitivity in NPM1 Mutated AML

Bridget A Robinson, Philipp Sergeev, Yoko Kosaka, Thomas Jacob, Andy Kaempf, Evan F. Lind, Cristina Tognon, Luis A. Carvajal, Jorge F. DiMartino, Caroline A. Heckman, Tania Q Vu
Journal: Blood
Blood (2023) 142 (Supplement 1): 5037.
https://doi.org/10.1182/blood-2023-186506
Published: 2023
Journal Articles

The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies

Akanksha Pandey, Luis A. Carvajal, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Tressa Hood, Linlin Guo, Tamara D Hopkins, Nikolaus Obholzer, Michael R. McKeown, Jorge F. DiMartino, Charles Y. Lin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2259.
https://doi.org/10.1182/blood-2023-174114
Published: 2023
Journal Articles

KB-Lanra 1001: A Phase 1b/2 Study of Safety, PK, PD, and Preliminary Efficacy of the Selective SYK Inhibitor Lanraplenib in Combination with the FLT3 Inhibitor Gilteritinib in FLT3-Mutated R/R AML

Monteserrat Arnan, Anand Ashwin Patel, Jordi Esteve, Lawrence Morris, Gary J. Schiller, Ronan T. Swords, Juan M. Alonso-Dominguez, Laura C. Michaelis, Naval Daver, Luis A. Carvajal, Gordon Bray, Elizabeth Olek, Richard E. Cutler, Jorge F. DiMartino, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 5973.
https://doi.org/10.1182/blood-2023-178804
Published: 2023
Journal Articles

The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia

Luis A. Carvajal, Michael R. McKeown, Tressa Hood, Linlin Guo, Charles Y. Lin, Jorge F. DiMartino
Journal: Blood
Blood (2023) 142 (Supplement 1): 5951.
https://doi.org/10.1182/blood-2023-186605
Published: 2023
Journal Articles

Analysis of Patient-Level Data from 3 Cooperative Group Trials Confirms a Survival Advantage for NPM1 m Patients Achieving MRD-Negative CR after Intensive Induction

Konstanze Döhner, Hartmut Döhner, Daniela Weber, Silke Kapp-Schwoerer, Amanda Gilkes, Ian Thomas, Sean Johnson, Nicola Potter, Yana Bevan, Jad Othman, Nigel H. Russell, Christoph Röllig, Christian Thiede, Martin Bornhaeuser, Thomas Oellerich, Jenna Elder, Luis A. Carvajal, Zung To, Jorge DiMartino, Richard Dillon
Journal: Blood
Blood (2022) 140 (Supplement 1): 6293–6294.
https://doi.org/10.1182/blood-2022-159212
Published: 2022
Journal Articles

SYK Inhibitors, Entospletinib and Lanraplenib, Show Potent Anti-Leukemic Activity in Combination with Targeted Agents

Luis A. Carvajal, Michael McKeown, Tressa Hood, Pavan Kumar, Douglas C. Saffran, Jorge DiMartino
Journal: Blood
Blood (2022) 140 (Supplement 1): 5932–5933.
https://doi.org/10.1182/blood-2022-159087
Published: 2022
Journal Articles

Development of a Standardized, DNA-Based Next Generation Sequencing Assay for Assessment of Measurable Residual Disease (MRD) in Acute Myeloid Leukemia (AML) As the Primary Endpoint in the Agility Study

Luis A. Carvajal, Tressa Hood, Yana Bevan, Richard Dillon, Nicola Potter, Ian Thomas, Sean Johnson, Jad Othman, Amanda Gilkes, Nigel H. Russell, Adam Sikorski, Pete Ellis, Giovanni Marsico, Greg Jones, Crystal MacKenzie, Zung To, Jorge DiMartino, Pavan Kumar
Journal: Blood
Blood (2022) 140 (Supplement 1): 3377–3378.
https://doi.org/10.1182/blood-2022-159154
Published: 2022
Journal Articles

Pseudoprogression (PsP) in Patients with Peripheral T-Cell Lymphoma (PTCL) Treated with the Novel Stapled Peptide ALRN-6924, a Dual Inhibitor of MDMX and MDM2

Andrei R. Shustov, MD, Amitkumar Mehta, MD, Lubomir Sokol, MD PhD, Luis A. Carvajal, PhD, Vincent Guerlavais, PhD, Manoj Samant, PhD, Narayana Narasimhan, PhD, David Sutton, BSc, D. Allen Annis, PhD, Dawn Pinchasik, MD, Manuel Aivado, MD PhD, Ronald Korn, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5348.
https://doi.org/10.1182/blood-2018-99-119489
Published: 2018
Journal Articles

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Ileana Antony-Debre, PhD, Ananya Paul, Joana Leite, Kelly Mitchell, Hye Mi Kim, Luis A. Carvajal, PhD, Tihomira Tidorova, Samuel Taylor, Kenneth Huang, Arvind Kumar, Abdelbasset A Farahat, Boris Bartholdy, PhD, Swathi-Rao Narayanagari, M.S, Jiahao Chen, Alberto Ambesi-Impiombato, Adolfo A. Ferrando, MD PhD, Ioannis Mantzaris, MD, Evripidis Gavathiotis, CPA, PhD BSc, Amit Verma, MD, Britta Will, PhD, David W Boykin, W David Wilson, Gregory MK Poon, Ulrich G. Steidl, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 858.
https://doi.org/10.1182/blood.V130.Suppl_1.858.858
Published: 2017
Journal Articles

Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia

Luis A. Carvajal, PhD, Daniela Ben-Neriah, B.S, Adrien Senecal, PhD, Lumie Bernard, M.S, Swathi-Rao Narayanagari, M.S, Charles Kenworthy, B.S, Victor Thiruthuvanathan, M.S, Vincent Guerlavais, PhD, D. Allen Annis, PhD, Boris Bartholdy, PhD, Britta Will, PhD, Jesus Anampa, MD, Ioannis Mantzaris, MD, Manuel A. Aivado, MD PhD, Robert H Singer, PhD, Robert Coleman, PhD, Amit Verma, MD, Ulrich G. Steidl, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 795.
https://doi.org/10.1182/blood.V130.Suppl_1.795.795
Published: 2017
Journal Articles

Pre-Clinical Modeling of Concomitant Therapy with Azacytidine and Eltrombopag in MDS/AML

Sally Cole, Lumie Benard, Luis A. Carvajal, PhD, Amit Verma, MD, Ulrich G. Steidl, MDPhD, Pedro Marques Ramos, PhD, Celine Pallaud, PhD, Britta Will, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2950.
https://doi.org/10.1182/blood.V130.Suppl_1.2950.2950
Published: 2017