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Michael R. McKeown
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Journal Articles

Multi-Omic Transcription Regulatory Network Mapping Identifies Targetable Oncogenic TF-Cofactor Relationship between IRF4 and p300 in Multiple Myeloma, and Is Used to Improve TF Protein-Protein Interaction Methodology

Yupeng Zheng, Walter F Lenoir, Marek J Kobylarz, Jun Li, Tamara D Hopkins, Michael R McKeown, Michelle G. Shum, Kameron R Mori, Elizabeth C Townsend, Benjamin W Trotter, Peter B Rahl, Nikolaus D Obholzer, Charles Y Lin
Journal: Blood
Blood (2024) 144 (Supplement 1): 4970.
https://doi.org/10.1182/blood-2024-210684
Published: 2024
Journal Articles

The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies

Akanksha Pandey, Luis A. Carvajal, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Tressa Hood, Linlin Guo, Tamara D Hopkins, Nikolaus Obholzer, Michael R. McKeown, Jorge F. DiMartino, Charles Y. Lin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2259.
https://doi.org/10.1182/blood-2023-174114
Published: 2023
Journal Articles

The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia

Luis A. Carvajal, Michael R. McKeown, Tressa Hood, Linlin Guo, Charles Y. Lin, Jorge F. DiMartino
Journal: Blood
Blood (2023) 142 (Supplement 1): 5951.
https://doi.org/10.1182/blood-2023-186605
Published: 2023
Journal Articles

Clinical Pharmacodynamic Markers and Combinations with SY1425 (tamibarotene) in a Genomically-Defined Subset of Non-APL AML

Michael R McKeown, PhD, Christopher Fiore, PhD, Emily Lee, BS, Matthew L Eaton, PhD, Christian C. Fritz, PhD
Journal: Blood
Blood (2016) 128 (22): 2898.
https://doi.org/10.1182/blood.V128.22.2898.2898
Published: 2016
Journal Articles

SY1425 (tamibarotene) Induces Profound Transcriptional Changes in AML Tumors with High Retinoic Acid Receptor Alpha

Christopher Fiore, PhD, Michael R McKeown, PhD, Emily Lee, BS, Matthew L Eaton, PhD, Christian C. Fritz, PhD
Journal: Blood
Blood (2016) 128 (22): 1523.
https://doi.org/10.1182/blood.V128.22.1523.1523
Published: 2016
Journal Articles

Inhibition of c-Myc Expression and Function in Hematologic Malignancies

Ghayas C Issa, MD, Jake E Delmore, Michael R McKeown, Madeleine E Lemieux, Peter B Rahl, Hannah M. Jacobs, Efstathios Kastritis, MD, Timothy Gilpatrick, Ronald M Paranal, Jun Qi, Junwei Shi, Marta Chesi, Anna C. Schinzel, PhD, Christopher R. Vakoc, M.D., Ph.D., P.Leif Bergsagel, MD, Paul G. Richardson, MD, Richard Young, PhD, William C. Hahn, MD, PhD, Irene M. Ghobrial, MD, Kenneth C Anderson, MD, Andrew L. Kung, MD, PhD, Constantine S. Mitsiades, MD, PhD, James E Bradner, MD
Journal: Blood
Blood (2011) 118 (21): 1409.
https://doi.org/10.1182/blood.V118.21.1409.1409
Published: 2011