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Klaus H. Metzeler
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Journal Articles

A Phase 1, Open-Label, Dose Escalation and Dose Expansion Study of Cln-049 for the Treatment of Acute Myeloid Leukemia Patients with Measurable Residual Disease

Jonas S. Heitmann, Juliane S. Walz, Helmut R. Salih, Klaus H Metzeler, Daniel Heudobler, Felicitas R Thol, Hermann Einsele, Veit L. Buecklein, Pau Montesinos, Ana Alfonso Pierola, Gala Vega, Eduardo Rodriguez Arboli, Juan Miguel Bergua Burgues, Suhail Chaudhry, Judith Inumerable, Todd Shearer, Laura Liu, Sandeep Kaur, Kaida Wu, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.1.
https://doi.org/10.1182/blood-2024-201478
Published: 2024
Journal Articles

The Differential Impact of Secondary-Type Mutations in a Multinational Cohort of 5311 Intensively Treated Acute Myeloid Leukemia Patients

Jan-Niklas Eckardt, Marius Bill, Konstanze Döhner, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. H. Brummendorf, Utz Krug, Bernhard Wörmann, Hermann Einsele, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Johannes Schetelig, Jan Moritz Middeke, Lars Bullinger, Michael Heuser, Felicitas R Thol, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Mueller-Tidow, Barbora Weinbergerova, Jiri Mayer, Pierre-Yves Dumas, Sarah Bertoli, Eric Delabesse, Christian Récher, Arnaud Pigneux, Tobias Herold, Arnold Ganser, Hartmut Döhner, Martin Bornhäuser, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 2934.
https://doi.org/10.1182/blood-2024-201945
Published: 2024
Journal Articles

Targeting of Various Inflammatory Circuits Does Not Ameliorate Ineffective Hematopoiesis: Results of the Lucas and Canfire Studies Investigating IRAK4 or IL-1β Blockade to Target Anemia in Lower-Risk MDS

Anne Sophie Kubasch, Katharina Zoldan, Michael Cross, Marie Schneider, Jens Przybilla, Dirk Hasenclever, Klaus H Metzeler, Uwe Platzbecker
Journal: Blood
Blood (2024) 144 (Supplement 1): 3221.
https://doi.org/10.1182/blood-2024-199032
Published: 2024
Journal Articles

The Differences between Ide-Cel and Cilta-Cel in Relapsed Myeloma at Single Cell Resolution

David Fandrei, Michael Rade, Markus Kreuz, Luise Fischer, Patrick Born, Sabine Seiffert, Andreas Boldt, Jonathan Scolnick, Lakshmi Venkatraman, Stacy Xu, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Klaus H Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrike Köhl, Uwe Platzbecker, Vladan Vucinic, Kristin Reiche, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1877.
https://doi.org/10.1182/blood-2024-210746
Published: 2024
Journal Articles

Measurable Residual Disease Detection of IDH1 or IDH2 Mutations Post but Not Prior to Allogeneic Hematopoietic Stem Cell Transplantation Show High Prognostic Relevance in Patients with Acute Myeloid Leukemia

Jacob Jendro, Lara Bischof, Jule Ussmann, Tung Pham Thanh, Donata Backhaus, Dominic Brauer, Vladan Vucinic, Carmen Herling, Marco Herling, Georg-Nikolaus Franke, Maximilian Merz, Klaus H Metzeler, Uwe Platzbecker, Sebastian Schwind, Madlen Jentzsch
Journal: Blood
Blood (2024) 144 (Supplement 1): 4334.
https://doi.org/10.1182/blood-2024-207490
Published: 2024
Journal Articles

The Presence of SH2B3 mutations Identifies a Distinct Subtype of Myelodysplastic Neoplasms

Maria Julia Montoro, Pamela Acha, Manja Meggendorfer, Najla H Al Ali, Víctor Navarro, Sherry Pierce, Carlos Bravo-Perez, Marie Adeline Migeon, Mestre Julia, Klaus H Metzeler, Michael Wulfert, Andres Jerez, Marina Díaz-Beyá, Beate Betz, Emmanuelle Clappier, Mar Tormo, Helena Pomares, Mónica Del Rey, Silvia Saumell, Laura Barbero, María Eugenia Rivero, Maria Diez-Campelo, David Sallman, Teresa Ezponda, Weina Chen, Zhuoer Xie, Francesc Bosch, Ulrich Germing, Uwe Platzbecker, Francesc Sole, Pierre Fenaux, Jaroslaw Maciejewski, Guillermo Garcia-Manero, Rami S. Komrokji, Torsten Haferlach, David Valcarcel
Journal: Blood
Blood (2024) 144 (Supplement 1): 3214.
https://doi.org/10.1182/blood-2024-194488
Published: 2024
Journal Articles

Preliminary Safety and Efficacy of Luspatercept Initiated at Maximum Approved Dose in Patients with Transfusion Dependent Anemia Due to Very Low, Low and Intermediate Risk MDS with Ring Sideroblasts: First Results of the Lusplus Trial

Katharina S. S. Götze, Anna Hecht, Anne Sophie Kubasch, Maria Diez-Campelo, Georg Stüssi, David Valcarcel, Patricia Font Lopez, Elvira Mora Castera, Blanca Xicoy, Teresa Bernal Del Castillo, Dominik Wolf, Nicola Andina, Nicolas Bonadies, Gregor Stehle, Karoline V. Gleixner, Klaus H Metzeler, Arnold Schröder, Dorothea Schipp, Maria Tormo, Ana Alfonso Pierola, Aristoteles Giagounidis, Martin Puttrich, Uwe Platzbecker
Journal: Blood
Blood (2024) 144 (Supplement 1): 3207.
https://doi.org/10.1182/blood-2024-208432
Published: 2024
Journal Articles

Trial in Progress: A Randomized-Controlled Phase 2 Study Evaluating Venetoclax Plus Azacitidine Versus Intensive Chemotherapy in Adult Patients with Newly Diagnosed, NPM1 -Mutated AML - the SAL/AMLCG Vincent Trial

Lydia Kretschmer, Leo Ruhnke, Christoph Schliemann, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Christoph Schmid, Maher Hanoun, Tim Sauer, Klaus H Metzeler, Kerstin Schäfer-Eckart, Mathias Hänel, Martina Crysandt, Paul Jäger, Stefan W. Krause, Christine Dierks, Stefan Klein, Nadia Maguire, Lukas Peter Frenzel, Veit L. Buecklein, Frank Fiebig, Anna Harig, Christian Thiede, Moritz Middeke, Richard Dillon, Claudia D Baldus, Hubert Serve, Uwe Platzbecker, Karsten Spiekermann, Wolfgang Hiddemann, Martin Bornhäuser, Richard F. Schlenk, Carsten Müller-Tidow, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 1527.1.
https://doi.org/10.1182/blood-2024-198164
Published: 2024
Journal Articles

Prognostic Value of Baseline and Early Response FDG-PET/CT Combined with Cellular Dynamics in Patients with Refractory and Relapsed Mantle Cell Lymphoma (MCL) Undergoing Chimeric Antigen Receptor (CAR)-T Cell Therapy

Simon M Krauß, Sabine Seiffert, Carmen Perez Fernandez, Thomas Walter Georgi, Janine Kirchberg, Enrica Bach, Mandy Brueckner, Madlen Jentzsch, Carmen Herling, Maximilian Merz, Klaus H Metzeler, Marco Herling, Georg-Nikolaus Franke, Andreas Boldt, Solveig Tiepolt, Regine Kluge, Ulrike Koehl, Timm Denecke, Osama Sabri, Ulrich Sack, Uwe Platzbecker, Lars Kurch, Vladan Vucinic
Journal: Blood
Blood (2024) 144 (Supplement 1): 6343.
https://doi.org/10.1182/blood-2024-206686
Published: 2024
Journal Articles

Persistent Thrombocytopenia and Neutropenia Are Associated with Increased Mortality in Patients Treated with Anti-BCMA CAR T Cells for Relapsed/Refractory Multiple Myeloma

Thomas C Wiemers, David Fandrei, Sabine Seiffert, Michael Rade, Susanne Rieprecht, Patrick Born, Markus Kreuz, Luise Fischer, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Klaus H Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrike Köhl, Maik Friedrich, Andreas Boldt, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 7095.
https://doi.org/10.1182/blood-2024-202101
Published: 2024
Journal Articles

CT-Based Muscle Quality and Visceral Obesity Prior to Allogeneic Hematopoietic Stem Cell Transplantation Is of Prognostic Relevance in Patients with Acute Myeloid Leukemia

Jule Ussmann, Clara Wall, Lara Bischof, Jacob Jendro, Dominic Brauer, Donata Backhaus, Klaus H Metzeler, Marco Herling, Carmen Herling, Vladan Vucinic, Georg-Nikolaus Franke, Maximilian Merz, Timm Denecke, Uwe Platzbecker, Sebastian Schwind, Hans-Jonas Meyer, Madlen Jentzsch
Journal: Blood
Blood (2024) 144 (Supplement 1): 2158.
https://doi.org/10.1182/blood-2024-199943
Published: 2024
Journal Articles

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Binje Vick, Vindi Jurinovic, Lena Lagally, Kristina Kuhbandner, Lisa Latzko, Chiara Arnreich, Maja Rothenberg-Thurley, Gerulf Hänel, Amelie Muth, Annika Maria Dufour, Stephanie Schneider, Maya C. Andre, Claudia D Baldus, Martin P Carroll, Martin Ebinger, Katharina S. S. Götze, Pablo Menéndez, Jean-Emmanuel Sarry, Talía Velasco-Hernández, Michael von Bergwelt-Baildon, Klaus H Metzeler, Philipp A. Greif, Marion Subklewe, Sebastian Vosberg, Tobias Herold, Karsten Spiekermann, Irmela Jeremias
Journal: Blood
Blood (2024) 144 (Supplement 1): 6085.
https://doi.org/10.1182/blood-2024-198652
Published: 2024
Journal Articles

The Prognostic Impact of Myelodysplasia-Related Gene Mutations in Acute Myeloid Leukemia with FLT3 -ITD Mutations

Rabea Mecklenbrauck, Angela Villaverde Ramiro, Eric Sträng, Razif Gabdoulline, Javier Martínez Elicegui, Marta Sobas, Lisa Pleyer, Maria Teresa Voso, Axel Benner, Alberto Hernández Sánchez, Jesse M. Tettero, Laura Tur, Klaus H Metzeler, Guadalupe Onate, Soren Lehmann, Brian J P Huntly, Ian Thomas, Felicitas R Thol, Florian Heidel, Peter J. M. Valk, Konstanze Döhner, Torsten Haferlach, Ken I Mills, Hartmut Döhner, Gastone Castellani, Gert Ossenkoppele, Jesus Maria Hernandez Rivas, Lars Bullinger, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 844.
https://doi.org/10.1182/blood-2024-202362
Published: 2024
Journal Articles

Prevalence and Mutational Make-up of Secondary Hematologic Neoplasms in Multiple Myeloma Patients after CAR-T Cell Therapy

Johannes Waldschmidt, Maximilian Merz, Judith S. Hecker, Franz Reinhard, Benjamin GT Shibru, Marion Hoegner, Anna Gebauer, David Fandrei, Manja Meggendorfer, Marietta Truger, Johannes Jung, Daniel Teschner, Max S. Topp, Anna Purcarea, Vladan Vucinic, Martin K. Kortüm, Torsten Haferlach, Florian Bassermann, Uwe Platzbecker, Hermann Einsele, Claudia Haferlach, Klaus H Metzeler, Katharina S. S. Götze, Leo Rasche
Journal: Blood
Blood (2024) 144 (Supplement 1): 4688.
https://doi.org/10.1182/blood-2024-210233
Published: 2024
Journal Articles

Secondary-Type Mutations Do Not Impact the Favorable Outcome of NPM1 -Mutated Acute Myeloid Leukemia Patients - Results from a Large Cohort of Intensively Treated Patients

Marius Bill, Jan-Niklas Eckardt, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Utz Krug, Bernhard Wörmann, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Hermann Einsele, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hanel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Leo Ruhnke, Johannes Schetelig, Jan Moritz Middeke, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Müller-Tidow, Martin Bornhäuser, Tobias Herold, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2023) 142 (Supplement 1): 721.
https://doi.org/10.1182/blood-2023-186160
Published: 2023
Journal Articles

Single Cell Multi-Omic Dissection of Response and Resistance to Chimeric Antigen Receptor T Cells Against BCMA in Relapsed Multiple Myeloma

Maximilian Merz, Luise Fischer, Jaren Sia, Patrick Born, Ronald Weiss, Nora Grieb, Michael Rade, Andreas Boldt, Stephan Fricke, Paul Franz, Jonathan Scolnick, Lakshmi Venkatraman, Stacy Xu, Christina Kloetzer, Simone Heyn, Anne Sophie Kubasch, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jule Ussmann, Klaus H Metzeler, Marco Herling, Carmen Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrich Sack, Ulrike Koehl, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic
Journal: Blood
Blood (2023) 142 (Supplement 1): 453.
https://doi.org/10.1182/blood-2023-187371
Published: 2023
Journal Articles

Apheresis for Production of Chimeric Antigen Receptor (CAR) T Cells in Patients with Multiple Myeloma - Clinical Factors, Cell Composition and T Cell Senescence

Vladan Vucinic, Janine Kirchberg, Mandy Brueckner, Patrick Born, Luise Fischer, Enrica Bach, Nora Grieb, Simone Heyn, Christina Kloetzer, Klaus H Metzeler, Sandra Hoffmann, Carmen Herling, Marco Herling, Georg-Nikolaus Franke, Sebastian Schwind, Song-Yau Wang, Madlen Jentzsch, Uwe Platzbecker, Maximilian Merz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3521.
https://doi.org/10.1182/blood-2023-182222
Published: 2023
Journal Articles

Outcome of Intensively Treated Elderly AML Patients Reported to the Harmony Alliance Compares Well to Outcome of Control Patients of the Prospective Randomized HOVON 103 Study in Elderly AML

Sjoerd J.F. Hermans, Jurjen Versluis, Yvette van Norden, Erik D. van Werkhoven, Jeroen J.W.M. Janssen, Gerwin A. Huls, Bob Lowenberg, Thomas Pabst, Dimitri A. Breems, Elizabeth Berkx, Avinash G. Dinmohamed, Peter C. Huijgens, Eric Sträng, Jesús María Hernández-Rivas, Hartmut Döhner, Marta Sobas, Lars Bullinger, Rosa Ayala, Joaquin Martinez-Lopez, Klaus H Metzeler, Torsten Haferlach, Christian Thiede, Carin A. Uyl-De Groot, Gert J. Ossenkoppele, Francesco Pignatti, Jan J. Cornelissen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2023-186277
Published: 2023
Journal Articles

D DX41 -Low Expression Mimics Germline DDX41 -Phenotype in Acute Myeloid Leukemia

Wajma Shahbaz, Vindi Jurinovic, Aarif M. N. Batcha, Christian Rausch, Maja Rothenberg-Thurley, Annika Maria Dufour, Bianka Ksienzyk, Stephanie Schneider, Michaela Neusser, Maria Cristina Sauerland, Dennis Görlich, Wolfgang E. Berdel, Bernhard J. Woermann, Utz Krug, Jan Braess, Wolfgang Hiddemann, Ulrich Mansmann, Sebastian Vosberg, Philipp A. Greif, Karsten Spiekermann, Klaus H Metzeler, Tobias Herold
Journal: Blood
Blood (2023) 142 (Supplement 1): 820.
https://doi.org/10.1182/blood-2023-187419
Published: 2023
Journal Articles

Impact of KMT2A -PTD Mutational Subgroups on Outcome of AML Patients after Induction Therapy and Allogeneic Hematopoietic Cell Transplantation

Desiree Kunadt, Sven Zukunft, Klaus H Metzeler, Christoph Röllig, Christoph Schliemann, Jan Braess, Carsten Müller-Tidow, Alwin Kraemer, Sebastian Scholl, Inken Hilgendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Thomas Schroeder, Martin Kaufmann, Jan Moritz Middeke, Katja Sockel, Leo Ruhnke, Uwe Platzbecker, Hubert Serve, Matthias Stelljes, Claudia D Baldus, Andreas Neubauer, Johannes Schetelig, David Poitz, Christian Thiede, Martin Bornhäuser, Friedrich Stölzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 2236.
https://doi.org/10.1182/blood-2023-187273
Published: 2023