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Journal Articles

Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations

Hartmut Döhner, Courtney D. DiNardo, Frederick R. Appelbaum, Charles Craddock, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Andrew H. Wei, Bob Löwenberg
Journal: Blood
Blood (2024) 144 (21): 2169–2173.
https://doi.org/10.1182/blood.2024025409
Published: 2024
Journal Articles

The Prognostic Impact of Myelodysplasia-Related Gene Mutations in Acute Myeloid Leukemia with FLT3 -ITD Mutations

Rabea Mecklenbrauck, Angela Villaverde Ramiro, Eric Sträng, Razif Gabdoulline, Javier Martínez Elicegui, Marta Sobas, Lisa Pleyer, Maria Teresa Voso, Axel Benner, Alberto Hernández Sánchez, Jesse M. Tettero, Laura Tur, Klaus H Metzeler, Guadalupe Onate, Soren Lehmann, Brian J P Huntly, Ian Thomas, Felicitas R Thol, Florian Heidel, Peter J. M. Valk, Konstanze Döhner, Torsten Haferlach, Ken I Mills, Hartmut Döhner, Gastone Castellani, Gert Ossenkoppele, Jesus Maria Hernandez Rivas, Lars Bullinger, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 844.
https://doi.org/10.1182/blood-2024-202362
Published: 2024
Journal Articles

Long-Term Outcome of 1296 Patients with Newly Diagnosed with APL: A Harmony Alliance Study

Luca Guarnera, Soren Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel H. Russell, Richard Dillon, Ian Thomas, Gert Ossenkoppele, Marco Vignetti, Edoardo la Sala, Alfonso Piciocchi, Angela Villaverde Ramiro, Laura Tur, Carmelo Gurnari, Lars Bullinger, Jesús María Hernández-Rivas, Maria Teresa Voso
Journal: Blood
Blood (2023) 142 (Supplement 1): 727.
https://doi.org/10.1182/blood-2023-185121
Published: 2023
Journal Articles

Dual Split-Signaling TIM3+CLEC12a Targeting CAR T-Cells with Optimized Signaling As a Safe Potential Therapy for Acute Myeloid Leukemia

Jort J Van Der Schans, Paresh Vishwasrao, Noortje Van Gils, Mashhour Hosny, Ziyu Wang, Jennemiek Van Arkel, Sonja Zweegman, Maria Themeli, Gert Ossenkoppele, Niels W.C.J. van de Donk, Arjan A. Van de Loosdrecht, Linda Smit, Tuna Mutis
Journal: Blood
Blood (2023) 142 (Supplement 1): 883.
https://doi.org/10.1182/blood-2023-180799
Published: 2023
Journal Articles

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Lok Lam Ngai, Coen R. Veenstra, Patrycja Gradowska, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Jesse M. Tettero, Costa Bachas, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Canan Alhan, Theresia M. Westers, Peter J. M. Valk, David C. de Leeuw, Bob Lowenberg, Gert Ossenkoppele, Jacqueline Cloos, Arjan A. van de Loosdrecht
Journal: Blood
Blood (2023) 142 (Supplement 1): 323.
https://doi.org/10.1182/blood-2023-184703
Published: 2023
Journal Articles

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Lok Lam Ngai, Diana Hanekamp, Angèle Kelder, Willemijn Scholten, Jannemieke Carbaat-Ham, Mona M.H.E Fayed, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Tim R. Mocking, Vincent H.J. Van Der Velden, Jennichjen Slomp, Willemijn Hobo, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Arjan A. van de Loosdrecht, Gert Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2023-181709
Published: 2023
Journal Articles

Impact of Hemodilution on Measurable Residual Disease Measured Via Flow-Cytometry in Acute Myeloid Leukemia Analyzed Using Subsequent Pulls

Jesse M. Tettero, Maaike Heidinga, Tim R. Mocking, Glenn Fransen, Ezra S Beerman, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Lok Lam Ngai, Costa Bachas, Arjan A. Van de Loosdrecht, Gert Ossenkoppele, David C. de Leeuw, Jeroen J.W.M. Janssen, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1559.
https://doi.org/10.1182/blood-2023-179242
Published: 2023
Journal Articles

Machine Learning Provides Individualized Prediction of Outcomes after First Complete Remission in Adult AML Patients - Results from the Harmony Platform

Alberto Hernández Sánchez, Javier Martínez Elicegui, Marta Sobas, Eric Sträng, Axel Benner, María Abáigar, Gastone Castellani, Laura Tur, Peter J. M. Valk, Angela Villaverde Ramiro, Klaus H Metzeler, Raúl Azibeiro Melchor, Jurjen Versluis, Daniele Dall'Olio, Teresa González, Jesse M. Tettero, Joaquin Martinez-Lopez, Helena Fidalgo, Jorge Sierra, Frederik Damm, Ken I Mills, Soren Lehmann, Ian Thomas, Jiří Mayer, Christian Thiede, Maria Teresa Voso, Guillermo Sanz, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk Reinhardt, Michel van Speybroeck, Renate Schulze-Rath, Martje Barbus, John E Butler, Jesús María Hernández-Rivas, Brian Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger
Journal: Blood
Blood (2023) 142 (Supplement 1): 62.
https://doi.org/10.1182/blood-2023-183029
Published: 2023
Journal Articles

Machine Learning Allows the Identification of New Co-Mutational Patterns with Prognostic Implications in NPM1 Mutated AML - Results of the European Harmony Alliance

Alberto Hernández Sánchez, Angela Villaverde Ramiro, Eric Sträng, Castellani Gastone, Caroline A. Heckman, Jurjen Versluis, María Abáigar, Marta Anna Sobas, Raúl Azibeiro Melchor, Axel Benner, Peter JM Valk, Klaus H. Metzeler, Teresa González, Daniele Dall'Olio, Jesse M. Tettero, Javier Martinez Elicegui, Joaquín Martínez-López, Marta Pratcorona, Frederik Damm, Ken I Mills, Christian Thiede, Maria Teresa Voso, Guillermo Sanz, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Amin T. Turki, Rubén Villoria Medina, Michel van Speybroeck, Renate Schulze-Rath, Martje Barbus, John E Butler, Jesús María Hernández-Rivas, Brian James Patrick Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger
Journal: Blood
Blood (2022) 140 (Supplement 1): 739–742.
https://doi.org/10.1182/blood-2022-167138
Published: 2022
Journal Articles

Long-Term Follow-up of AML Patients Treated Intensively before the Era of Targeted Agents. a Big Data Analysis from the Harmony Collaboration

Marta Anna Sobas, Angela Villaverde Ramiro, Alberto Hernández Sánchez, Javier Martinez Elicegui, Teresa González, Raúl Azibeiro Melchor, María Abáigar, Laura Tur, Daniele Dall'Olio, Eric Sträng, Jesse M. Tettero, Castellani Gastone, Axel Benner, Konstanze Döhner, Christian Thiede, Amin T. Turki, Klaus H. Metzeler, Torsten Haferlach, Frederick Damm, Rosa Ayala, Joaquín Martínez-López, Ken I Mills, Jorge Sierra, Sören Lehmann, Matteo G. Della Porta, Jiri Mayer, Dirk Reinhardt, Rubén Villoria Medina, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian James Patrick Huntly, Gert Ossenkoppele, Hartmut Dohner, Lars Bullinger
Journal: Blood
Blood (2022) 140 (Supplement 1): 6053–6055.
https://doi.org/10.1182/blood-2022-165088
Published: 2022
Journal Articles

Increased LFS Following Hematopoietic Cell Transplantation As Compared to Conventional Consolidation Therapy in Patients >60 Years with AML in First Complete Remission and a Matched Donor: Results of a Randomized Phase III Study

Dietger Niederwieser, Dirk Hasenclever, Wolfgang E. Berdel, Bart J. Biemond, Haifa Kathrin Al-Ali, Yves Chalandon, Michel Van Gelder, Christian Junghanss, Goesta Gahrton, Mathias Haenel, Rüdiger Hehlmann, Thomas Heinicke, Andreas Hochhaus, Simona Iacobelli, Rien van Marwijk Kooy, Nicolaus Kröger, Jeroen J.W.M. Janssen, Madlen Jentzsch, Frank Breywisch, Mohamad Mohty, Stavroula Masouridi-Levrat, Gert Ossenkoppele, Jakob Passweg, Wolfram Pönisch, Johannes Schetelig, Christoph Schliemann, Sebastian Schwind, Matthias Stelljes, Peter JM Valk, Bob Lowenberg, Jan J. Cornelissen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2126–2129.
https://doi.org/10.1182/blood-2022-157684
Published: 2022
Journal Articles

Rearrangements Involving 11q23/ KMT2A : Mutational Landscape and Prognostic Implications - Results of the Harmony Alliance AML Database

Alberto Hernández Sánchez, Teresa González, Marta Anna Sobas, Eric Sträng, Castellani Gastone, María Abáigar, Peter JM Valk, Angela Villaverde Ramiro, Axel Benner, Klaus H. Metzeler, Jesse M. Tettero, Joaquín Martínez-López, Marta Pratcorona, Javier Martinez Elicegui, Ken I Mills, Christian Thiede, Guillermo Sanz, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk Reinhardt, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian James Patrick Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger
Journal: Blood
Blood (2022) 140 (Supplement 1): 551–554.
https://doi.org/10.1182/blood-2022-167480
Published: 2022
Journal Articles

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

Hartmut Döhner, Andrew H. Wei, Frederick R. Appelbaum, Charles Craddock, Courtney D. DiNardo, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Bob Löwenberg
Journal: Blood
Blood (2022) 140 (12): 1345–1377.
https://doi.org/10.1182/blood.2022016867
Published: 2022
Journal Articles

Oral azacitidine prolongs survival of patients with AML in remission independently of measurable residual disease status

Clinical Trials & Observations
Gail J. Roboz, Farhad Ravandi, Andrew H. Wei, Hervé Dombret, Felicitas Thol, Maria Teresa Voso, Andre C. Schuh, Kimmo Porkka, Ignazia La Torre, Barry Skikne, Jianhua Zhong, C. L. Beach, Alberto Risueño, Daniel L. Menezes, Gert Ossenkoppele, Hartmut Döhner
Journal: Blood
Blood (2022) 139 (14): 2145–2155.
https://doi.org/10.1182/blood.2021013404
Published: 2022
Includes: Supplemental data
Journal Articles

CC-486 Prolongs Survival for Patients with Acute Myeloid Leukemia (AML) in Remission after Intensive Chemotherapy (IC) Independent of the Presence of Measurable Residual Disease (MRD) at Study Entry: Results from the QUAZAR AML-001 Maintenance Trial

Gail J. Roboz, MD, Farhad Ravandi, MBBS, Andrew H Wei, MBBS, PhD, Hervé Dombret, MD, Hartmut Döhner, Felicitas Thol, Maria Teresa Voso, MD, Andre C. Schuh, Kimmo Porkka, Ignazia La Torre, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, C.L. Beach, PharmD, Alberto Risueño, Daniel Lopes de Menezes, PhD, Gert Ossenkoppele, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-140837
Published: 2020
Journal Articles

Lenalidomide with or without Erythropoietin and Granulocyte-Colony Stimulating Factor Shows Efficacy in Patients with Low and Intermediate-1 Risk Myelodysplastic Syndrome with or without Del 5q, Refractory or Unlikely to Respond to Erythropoietin. Results of a HOVON89 Phase II Randomized Multicenter Study. (EudraCT 2008-002195-10)

Arjan A. van de Loosdrecht, MD PhD, Dana A Chitu, PhD, Eline MP Cremers, MD, Theresia M Westers, PhD, Canan Alhan, MD, Heleen Visser-Wisselaar, PhD, Annelies Verbrugge, Petra Muus, MD PhD, Inge de Greef, MD PhD, Pierre W Wijermans, MD, Joop H. Jansen, PhD, Saskia K. Klein, MD PhD, Edo Vellenga, MD PhD, Marie-Cecile Legdeur, MD PhD, Wendy Deenik, MD PhD, Mojca jongen-Lavrencic, MD PhD, Rien van Marwijk-Kooy, Bea Tanis, MD PhD, Jurgen Wegman, Tanja van Maanen, Gert Ossenkoppele, MD PhD
Journal: Blood
Blood (2016) 128 (22): 224.
https://doi.org/10.1182/blood.V128.22.224.224
Published: 2016
Journal Articles

Early Post-Transplant Epigenetic Therapy By Panobinostat and Decitabine Followed By Donor Lymphocyte Infusion (DLI): Interim Results of the HOVON-116 Phase I/II Feasibility Study in Poor-Risk AML Recipients of Allogeneic Stem Cell Transplantation (alloHSCT)

Jan J. Cornelissen, MD PhD, Yvette van Norden, MD PhD MSc., Michel van Gelder, MD PhD, Dimitri A. Breems, MD PhD, Johan Maertens, MD PhD, Mojca Jongen-Lavrencic, MD PhD, Annoek Broers, MD PhD, Sacha S. Zeerleder, MD PhD, Lucien Noens, MD PhD, Gert Ossenkoppele, MD PhD, Ellen Meijer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 832.
https://doi.org/10.1182/blood.V128.22.832.832
Published: 2016
Journal Articles

How I treat the older patient with acute myeloid leukemia

Clinical Trials & Observations
Gert Ossenkoppele, Bob Löwenberg
Journal: Blood
Blood (2015) 125 (5): 767–774.
https://doi.org/10.1182/blood-2014-08-551499
Published: 2015
Journal Articles

MRD in AML: time for redefinition of CR?

Clinical Trials & Observations
Gert Ossenkoppele, Gerrit Jan Schuurhuis
Journal: Blood
Blood (2013) 121 (12): 2166–2168.
https://doi.org/10.1182/blood-2013-01-480590
Published: 2013
Journal Articles

The EUTOS CML score aims to support clinical decision-making

Verena Hoffmann, Michele Baccarani, Joerg Hasford, Joelle Guilhot, Susanne Saussele, Gianantonio Rosti, François Guilhot, Kimmo Porkka, Gert Ossenkoppele, Doris Lindoerfer, Bengt Simonsson, Markus Pfirrmann, Rüdiger Hehlmann
Journal: Blood
Blood (2012) 119 (12): 2966–2967.
https://doi.org/10.1182/blood-2012-01-402511
Published: 2012