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Journal Articles

Dual Split-Signaling TIM3+CLEC12a Targeting CAR T-Cells with Optimized Signaling As a Safe Potential Therapy for Acute Myeloid Leukemia

Jort J Van Der Schans, Paresh Vishwasrao, Noortje Van Gils, Mashhour Hosny, Ziyu Wang, Jennemiek Van Arkel, Sonja Zweegman, Maria Themeli, Gert Ossenkoppele, Niels W.C.J. van de Donk, Arjan A. Van de Loosdrecht, Linda Smit, Tuna Mutis
Journal: Blood
Blood (2023) 142 (Supplement 1): 883.
https://doi.org/10.1182/blood-2023-180799
Published: 2023
Journal Articles

Targeting miRNA-551b, a "Stemness"-like microRNA, to Eradicate AML (Stem) Cells

Tània Martiáñez, PhD, Noortje Van Gils, MSc, David Christian De Leeuw, MD PhD, Eline Vermue, Arjo Rutten, Fedor Denkers, Han J.M.P. Verhagen, MSc, Jeroen J. W. M. Janssen, MD PhD, Gert J. Ossenkoppele, MD PhD, Connie Jimenez, PhD, Linda Smit, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1494.
https://doi.org/10.1182/blood-2018-99-116024
Published: 2018
Journal Articles

Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells

Noortje Van Gils, MSc, Han J.M.P. Verhagen, MSc, Arjo Rutten, Renee X. Menezes, Mei-Ling Tsui, Esmee Dekens, Fedor Denkers, E Vermue, Jeroen J. W. M. Janssen, MD PhD, Gert J. Ossenkoppele, MD PhD, Linda Smit, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3937.
https://doi.org/10.1182/blood-2018-99-115858
Published: 2018
Journal Articles

Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all- trans retinoic acid

Brief Report
Han J. M. P. Verhagen, Marjon A. Smit, Arjo Rutten, Fedor Denkers, Pino J. Poddighe, Pauline A. Merle, Gert J. Ossenkoppele, Linda Smit
Journal: Blood
Blood (2016) 127 (4): 458–463.
https://doi.org/10.1182/blood-2015-07-653840
Published: 2016
Includes: Supplemental data
Journal Articles

Microrna-551b Is Preferentially Expressed In Hematopoietic Stem and Multipotent Progenitor Cells and High Expression In Acute Myeloid Leukemia Is An Independent Prognostic Factor For Relapse and Poor Survival

David C. de Leeuw, MD, Fedor Denkers, Peter J. Valk, PhD, Gerrit Jan Schuurhuis, PhD, Gert J. Ossenkoppele, MD PhD, Linda Smit, PhD
Journal: Blood
Blood (2013) 122 (21): 1322.
https://doi.org/10.1182/blood.V122.21.1322.1322
Published: 2013
Journal Articles

Microrna Profiling Classifies Acute Leukemias of Ambiguous Lineage As Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia

David C. de Leeuw, MD, Willemijn de van den Ancker, Fedor Denkers, Renee X. de Menezes, PhD, Theresia M. Westers, PhD, Gert J. Ossenkoppele, MD, PhD, Arjan A. Van de Loosdrecht, MD, PhD, Linda Smit, PhD
Journal: Blood
Blood (2012) 120 (21): 1443.
https://doi.org/10.1182/blood.V120.21.1443.1443
Published: 2012
Journal Articles

MicroRNA Expression Profiling of Hematopoietic and Leukemic Stem Cells in Acute Myeloid Leukemia,

David C. de Leeuw, MD, Fedor Denkers, Gerrit J. Schuurhuis, PhD, Gert J Ossenkoppele, MD, PhD, Linda Smit, PhD
Journal: Blood
Blood (2011) 118 (21): 3999.
https://doi.org/10.1182/blood.V118.21.3999.3999
Published: 2011
Journal Articles

Application of Kinase Activity Profiles to Predict Upcoming TKI Resistance In CML-Patients.

Piet Boender, PhD, Jeroen Janssen, MD., PhD, Linda Smit, PhD, Rob Ruijtenbeek, PhD, Adrienne van den Berg, BSc, Rik de Wijn, PhD, Gert J. Ossenkoppele, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3425.
https://doi.org/10.1182/blood.V116.21.3425.3425
Published: 2010
Journal Articles

Targeting of CLEC12A In Acute Myeloid Leukemia by Antibody-Drug-Conjugates and Bispecific CLL-1×CD3 BiTE Antibody

Paul Noordhuis, PhD, Monique Terwijn, Arjo P Rutten, Linda Smit, PhD, Gert J. Ossenkoppele, MD, PhD, Gerrit J. Schuurhuis, PhD
Journal: Blood
Blood (2010) 116 (21): 2890.
https://doi.org/10.1182/blood.V116.21.2890.2890
Published: 2010
Journal Articles

The Prognostic Value of CD34 Expression In Acute Myeloid Leukemia. A Mystery Solved

Gerrit J. Schuurhuis, PhD, Angèle Kelder, Monique Terwijn, Arjo P Rutten, Linda Smit, PhD, Sonja Zweegman, MD, PhD, Gert Ossenkoppele, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2725.
https://doi.org/10.1182/blood.V116.21.2725.2725
Published: 2010
Journal Articles

High Aldehyde Dehydrogenase Activity (ALDH) Is a General Marker for Normal Hematopoietic Stem Cells but Not Leukemic Stem Cells in Acute Myeloid Leukemia (AML). .

Linda Smit, PhD, Lisa A Min, Monique Terwijn, Angele Kelder, Alexander N Snel, Gert J Ossenkoppele, MD, PhD, Gerrit J. Schuurhuis, PhD
Journal: Blood
Blood (2009) 114 (22): 4035.
https://doi.org/10.1182/blood.V114.22.4035.4035
Published: 2009