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Journal Articles

CTLA-4-Based Activation Inducible Costimulatory Receptors Endow CAR-T Cells with Safe, Tumor-Restricted, Multi-Targeting and Increased Persistence

Afroditi Katsarou, Georgios Kladis, Alexandros Nianias, Jiaxian Wang, Thomas Baardemans, Ruud Ruiter, Marie José Kersten, Sonja Zweegman, Tuna Mutis, Richard Groen, Maria Themeli

Blood (2024) 144 (Supplement 1): 2042.

https://doi.org/10.1182/blood-2024-208274

Published: 2024

Journal Articles

Dual Split-Signaling TIM3+CLEC12a Targeting CAR T-Cells with Optimized Signaling As a Safe Potential Therapy for Acute Myeloid Leukemia

Jort J Van Der Schans, Paresh Vishwasrao, Noortje Van Gils, Mashhour Hosny, Ziyu Wang, Jennemiek Van Arkel, Sonja Zweegman, Maria Themeli, Gert Ossenkoppele, Niels W.C.J. van de Donk, Arjan A. Van de Loosdrecht, Linda Smit, Tuna Mutis

Blood (2023) 142 (Supplement 1): 883.

https://doi.org/10.1182/blood-2023-180799

Published: 2023

Journal Articles

Heterogeneity in Access and Toxicity Management of Commercially Available BCMA-Directed CAR-T and Bispecific T-Cell Engager Therapy Among the International Myeloma Community

Blood (2023) 142 (Supplement 1): 7248.

https://doi.org/10.1182/blood-2023-184710

Published: 2023

Journal Articles

Selecting CD7 − T cells for CAR T-cell therapy

Maria Themeli

Blood (2022) 140 (25): 2652–2653.

https://doi.org/10.1182/blood.2022017935

Published: 2022

Journal Articles

Synergism between CAR-T Cells and a Personalized Tumor Vaccine in Hematological Malignances

Giulia Cheloni, Marzia Capelletti, Daniela Torres, Poorva Bindal, Jessica J. Liegel, Dina Stroopinsky, Lina Bisharat, Maryam Rahimian, Seo Yeon Yoo, Joshua Hauser, Anita G. Koshy, Kenel Dufort, John G. Clohessy, Donald Kufe, Maria Themeli, Jacalyn Rosenblatt, Michel Sadelain, David Avigan

Blood (2021) 138 (Supplement 1): 737.

https://doi.org/10.1182/blood-2021-150307

Published: 2021

Journal Articles

Interactions with a "Humanized" Mesenchymal Bone Marrow Stromal Niche In Vivo Modify the Patterns of Essential Genes for Myeloma Cells: Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Olga Dashevsky, Sara Gandolfi, MD, Megan Bariteau, BSc, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Maria Themeli, MD PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Richard W.J. Groen, PhD, Constantine S. Mitsiades, MD PhD

Blood (2020) 136 (Supplement 1): 40.

https://doi.org/10.1182/blood-2020-143151

Published: 2020

Journal Articles

The Impact and Modulation of Microenvironment-Induced Immune Resistance Against CAR T Cell and Antibody Treatments in Multiple Myeloma

Lisa C. Holthof, MSc, Hilma J. Van Der Horst, MSc, Renée Poels, Jort T. van der Schans, MSc, Anne T. Gelderloos, MSc, Fengzhi Li, Henk Lokhorst, MD PhD, Sonja Zweegman, MD PhD, Maria Themeli, MD PhD, Niels W. C. J. Van De Donk, Richard W.J. Groen, PhD, Tuna Mutis, MD PhD

Blood (2019) 134 (Supplement_1): 137.

https://doi.org/10.1182/blood-2019-125818

Published: 2019

Journal Articles

Potent Synergy between Combination of Chimeric Antigen Receptor (CAR) Therapy Targeting CD19 in Conjunction with Dendritic Cell (DC)/Tumor Fusion Vaccine in Hematological Malignancies

Marzia Capelletti, PhD MMSc, Jessica Liegel, MD, Maria Themeli, MD PhD, Tuna Mutis, Dina Stroopinsky, PhD, Shira Orr, PhD, Daniela Torres, Adam Morin, Gertrude Gunset, BA, Haider Ghiasuddin, Maryam Rahimian, MD, Myrna Nahas, MD, Lina Bisharat, Shufen Meng, MD, Nikhil C. Munshi, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, Michel Sadelain, MD PhD, David E. Avigan, MD

Blood (2019) 134 (Supplement_1): 3227.

https://doi.org/10.1182/blood-2019-124944

Published: 2019

Journal Articles

The Combination of 41BB and CD28 Costimulatory Signals Endows Lower Affinity CAR T Cells with the Most Optimal Properties for Selective Targeting of the Tumor Associated Antigen CD38

Esther Drent, MSc, Renée Poels, BSc, Niels WCJ Van De Donk, Sonja Zweegman, MD PhD, Henk M Lokhorst, Richard WJ Groen, PhD, Tuna Mutis, PhD, Maria Themeli, MD PhD

Blood (2017) 130 (Supplement 1): 3183.

https://doi.org/10.1182/blood.V130.Suppl_1.3183.3183

Published: 2017

Journal Articles

Reducing on-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors By Affinity Optimization

Esther Drent, MSc, Maria Themeli, MD PhD, Renée Poels, Niels W.C.J. van de Donk, MD PhD, Henk M. Lokhorst, MD PhD, Tuna Mutis, MD PhD

Blood (2016) 128 (22): 2170.

https://doi.org/10.1182/blood.V128.22.2170.2170

Published: 2016

Journal Articles

L3MBTL1: A Polycomb Protein At the Node of Crosstalk Between the BMP4 and Hippo Signaling Pathways in Erythropoiesis.

Fabiana Perna, MD, Ly P. Vu, Maria Themeli, MD, PhD, Ruben Hoya-Arias, PhD, Fan Liu, MD, PhD, Lan Wang, PhD, Nadia Gurvich, PhD, Todd Hricik, BS, Eirini P. Papapetrou, MD, PhD, Malcolm A.S. AS Moore, Ross L. Levine, Michel Sadelain, MD, PhD, Stephen Nimer, MD

Blood (2012) 120 (21): 2296.

https://doi.org/10.1182/blood.V120.21.2296.2296

Published: 2012

Journal Articles

Targeting a Novel Epigenetic Silencing Mechanism to Efficiently Upregulate Fetal Globin Gene Expression

Fabiana Perna, MD, Ly P. Vu, Maria Themeli, MD, Ruben Hoya-Arias, PhD, Xinyang Zhao, PhD, Eirini P. Papapetrou, MD, PhD, Michel Sadelain, MD, PhD, Stephen D. Nimer, MD

Blood (2011) 118 (21): 352.

https://doi.org/10.1182/blood.V118.21.352.352

Published: 2011

Journal Articles

Comparative Blood Group Profiling of Human Erythroid Cells (EBs) Generated from Adult Blood (AB), Cord Blood (CB), Human Embryonic Stem Cells (hESC) and Induced Pluripotent Stem Cells (iPS)

Barbara Ghinassi, Maria Themeli, MD, Kai-Hsin Chang, Gregory Halverson, Ghazala Hashmi, Michel Sadelain, MD, PhD, Thalia Papayannopoulou, Anna Rita F Migliaccio, PhD, Carolyn Whitsett

Blood (2011) 118 (21): 1027.

https://doi.org/10.1182/blood.V118.21.1027.1027

Published: 2011

Journal Articles

Pharmacokinetics and Clinical Activity of Very Low Dose (10mg) Alemtuzumab In Transplantation for Acute Leukemia.

Alexandros Spyridonidis, MD, PhD, Maria Liga, Evangelia Triantafyllou, Maria Themeli, Marina Karakantza, Nicholas Zoumbos

Blood (2010) 116 (21): 1275.

https://doi.org/10.1182/blood.V116.21.1275.1275

Published: 2010

Journal Articles

Alloantigeneic Reactions after Human Hematopoietic Cell Transplantation Induce Genomic Alterations in Epithelium: A Confirmation in Vivo and in Vitro Study and Implications to Secondary Neoplasia

Maria Themeli, Loizos Petrikkos, Miguel Waterhouse, Hartmut Bertz, Eleni Lagadinou, Nicholas Zoumbos, Jürgen Finke, Alexandros Spyridonidis

Blood (2008) 112 (11): 452.

https://doi.org/10.1182/blood.V112.11.452.452

Published: 2008

Journal Articles

Horizontal Gene Transfer through Apoptotic Bodies Confers a Possible Mechanism of Epithelial Chimerism after Allogeneic Hematopoietic Cell Transplantation.

Miguel Waterhouse, Maria Themeli, Jurgen Finke, Alexandros Spyridonidis

Blood (2008) 112 (11): 2320.

https://doi.org/10.1182/blood.V112.11.2320.2320

Published: 2008

NARROW

CTLA-4-Based Activation Inducible Costimulatory Receptors Endow CAR-T Cells with Safe, Tumor-Restricted, Multi-Targeting and Increased Persistence

Dual Split-Signaling TIM3+CLEC12a Targeting CAR T-Cells with Optimized Signaling As a Safe Potential Therapy for Acute Myeloid Leukemia

Heterogeneity in Access and Toxicity Management of Commercially Available BCMA-Directed CAR-T and Bispecific T-Cell Engager Therapy Among the International Myeloma Community

Selecting CD7 − T cells for CAR T-cell therapy

Synergism between CAR-T Cells and a Personalized Tumor Vaccine in Hematological Malignances

Interactions with a "Humanized" Mesenchymal Bone Marrow Stromal Niche In Vivo Modify the Patterns of Essential Genes for Myeloma Cells: Therapeutic Implications

The Impact and Modulation of Microenvironment-Induced Immune Resistance Against CAR T Cell and Antibody Treatments in Multiple Myeloma

Potent Synergy between Combination of Chimeric Antigen Receptor (CAR) Therapy Targeting CD19 in Conjunction with Dendritic Cell (DC)/Tumor Fusion Vaccine in Hematological Malignancies

The Combination of 41BB and CD28 Costimulatory Signals Endows Lower Affinity CAR T Cells with the Most Optimal Properties for Selective Targeting of the Tumor Associated Antigen CD38

Reducing on-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors By Affinity Optimization

L3MBTL1: A Polycomb Protein At the Node of Crosstalk Between the BMP4 and Hippo Signaling Pathways in Erythropoiesis.

Targeting a Novel Epigenetic Silencing Mechanism to Efficiently Upregulate Fetal Globin Gene Expression

Comparative Blood Group Profiling of Human Erythroid Cells (EBs) Generated from Adult Blood (AB), Cord Blood (CB), Human Embryonic Stem Cells (hESC) and Induced Pluripotent Stem Cells (iPS)

Pharmacokinetics and Clinical Activity of Very Low Dose (10mg) Alemtuzumab In Transplantation for Acute Leukemia.

Alloantigeneic Reactions after Human Hematopoietic Cell Transplantation Induce Genomic Alterations in Epithelium: A Confirmation in Vivo and in Vitro Study and Implications to Secondary Neoplasia

Horizontal Gene Transfer through Apoptotic Bodies Confers a Possible Mechanism of Epithelial Chimerism after Allogeneic Hematopoietic Cell Transplantation.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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