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Journal Articles

Advances in CD137-Enriched Adoptive T Cell Therapy for Acute Myeloid Leukemia Via Ex Vivo Immune Cell Priming with DC/AML Fusion Vaccine

Kathrine S Rallis, Jessica Liegel, Giulia Cheloni, Poorva Bindal, Isabella Saldarriaga, Junyan Zhang, Georges Chedid, Joseph Abirached, Jonah Lee, John G. Clohessy, Samprity Ankita, Rajeev Relangi, Lina Bisharat, Hazal Toros, Sophia Adamia, Jasper B Lee, Donald Kufe, Kai W Wucherpfennig, Jacalyn Rosenblatt, David Avigan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4817.
https://doi.org/10.1182/blood-2024-208563
Published: 2024
Journal Articles

Randomized Phase II Trial of Dendritic Cell/AML Fusion Cell Vaccination Compared to Standard of Care Therapy in AML CR1

Prateek Pophali, Giulia Cheloni, Richard M. Stone, Kai W Wucherpfennig, Aric C. Hall, Amir T. Fathi, Lina Bisharat, Emma K Logan, Yiwen Liu, Donna S. Neuberg, Malgorzata McMasters, Jessica Liegel, Jacqueline S. Garcia, Daniel J. DeAngelo, Michele Narcis, Dina Stroopinsky, Pavania Elavalakanar, Ioannis S Vlachos, Ilene A. Galinsky, Jason Pyrdol, Georges Chedid, Dimitra Karagkouni, Shivani Nanda, Kathrine S Rallis, Isabella Saldarriaga, Hazal Toros, Haitham Abdelhakim, Amelia Langston, Joseph P. McGuirk, Donald Kufe, David Avigan, Jacalyn Rosenblatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4256.
https://doi.org/10.1182/blood-2024-200876
Published: 2024
Journal Articles

Phase 1 Trial of Dendritic Cell/AML Fusion Cell Vaccine after Allogeneic Stem Cell Transplant in Acute Myeloid Leukemia

Jessica Liegel, Giulia Cheloni, Georges Chedid, Genevieve Gerhard, Dimitra Karagkouni, Richard Stone, Robert J. Soiffer, Lina Bisharat, Samprity Ankita, Isabella Saldarriaga, Emma K Logan, Michele Narcis, Jennifer Tichon, Yiwen Liu, Malgorzata McMasters, Juan Carlos Varela, Hassan El Banna, Vincent T. Ho, Rizwan Romee, Donna S. Neuberg, Kathrine S Rallis, Sophia Adamia, Benjamin L. Ebert, Donald Kufe, Ioannis Vlachos, David Avigan, Jacalyn Rosenblatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 772.
https://doi.org/10.1182/blood-2023-190832
Published: 2023
Journal Articles

Treatment with DC/AML Fusion Vaccine and CD3xCD123 Bi-Specific T-Cell Engager (CD123-CODV-TCE) for Treatment of Acute Myeloid Leukemia

Dina Stroopinsky, Anita G. Koshy, Jessica J. Liegel, Myrna Nahas, Giulia Cheloni, Joshua Hauser, Daniela Torres, Poorva Bindal, Maryam Rahimian, Lina Bisharat, Paula Fraenkel, Ozlem Yildirim, Helene Bonnevaux, Stephane Guerif, Donald Kufe, Jacalyn Rosenblatt, David Avigan
Journal: Blood
Blood (2021) 138 (Supplement 1): 904.
https://doi.org/10.1182/blood-2021-148219
Published: 2021
Journal Articles

Impact of Autologous Hematopoietic Cell Transplant (HCT) Followed By Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance in Increasing Multiple Myeloma (MM) Immunity (BMT CTN 1401)

David J. Chung, Nina Shah, Dina Stroopinsky, Juan WU, Lina Bisharat, Natalie S. Callander, Brent R. Logan, Kenneth C. Anderson, Thinle Chodon, Meera Mohan, Steven Devine, Yvonne A. Efebera, Nancy Geller, Peiman Hematti, Leona A. Holmberg, Alan Howard, Bryon Johnson, Hillard M Lazarus, Ehsan Malek, Philip L. McCarthy, David H. McKenna, Adam M. Mendizabal, Nikhil C. Munshi, Lynn O'Donnell, Aaron P. Rapoport, Ajay K. Nooka, Jane Reese, Robert J. Soiffer, Lynne Uhl, Giulia Cheloni, Dimitra Karagkouni, Ioannis Vlachos, James W. Young, Jacalyn Rosenblatt, Edmund K. Waller, Marcelo C Pasquini, David Avigan
Journal: Blood
Blood (2021) 138 (Supplement 1): 899.
https://doi.org/10.1182/blood-2021-149659
Published: 2021
Journal Articles

Post-Transplant Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine for Prevention of Relapse

Jessica J. Liegel, Poorva Bindal, Richard M. Stone, Robert J. Soiffer, Dina Stroopinsky, Giulia Cheloni, Lina Bisharat, Daniela Torres, Maryam Rahimian, Seo Yeon Yoo, Emma K. Logan, Pavania Elavalakanar, Hassan El Banna, Joshua Hauser, Anita G. Koshy, Rizwan Romee, Vincent T. Ho, Donna S. Neuberg, Yiwen Liu, Lourdes M. Mendez, Ajoy L. Dias, Benjamin L. Ebert, Donald Kufe, David Avigan, Jacalyn Rosenblatt
Journal: Blood
Blood (2021) 138 (Supplement 1): 2830.
https://doi.org/10.1182/blood-2021-154166
Published: 2021
Journal Articles

Synergism between CAR-T Cells and a Personalized Tumor Vaccine in Hematological Malignances

Giulia Cheloni, Marzia Capelletti, Daniela Torres, Poorva Bindal, Jessica J. Liegel, Dina Stroopinsky, Lina Bisharat, Maryam Rahimian, Seo Yeon Yoo, Joshua Hauser, Anita G. Koshy, Kenel Dufort, John G. Clohessy, Donald Kufe, Maria Themeli, Jacalyn Rosenblatt, Michel Sadelain, David Avigan
Journal: Blood
Blood (2021) 138 (Supplement 1): 737.
https://doi.org/10.1182/blood-2021-150307
Published: 2021
Journal Articles

Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine Following Allogeneic Transplantation in a Phase 1 Clinical Trial

Jessica Liegel, MD, Richard M. Stone, MD, Robert J. Soiffer, MD, Dina Stroopinsky, PhD, Lina Bisharat, Maryam Rahimian, Emma Logan, Pavania Elavalakanar, MSc, BSc, Vincent T. Ho, MD, Rizwan Romee, MD, Donna S. Neuberg, ScD, Yiwen Liu, Lourdes M. Mendez, MD PhD, Ajoy L. Dias, MD, Poorva Bindal, MD, Anita Koshy, MD, Shira Orr, PhD, Daniela Torres, Giulia Cheloni, PhD, Benjamin L. Ebert, MDPhD, Donald Kufe, MD, David E. Avigan, MD, Jacalyn Rosenblatt, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10.
https://doi.org/10.1182/blood-2020-141634
Published: 2020
Journal Articles

Development of Novel Second Generation DC/Tumor Fusion Vaccine in Lymphoma

Shira Orr, PhD, Marzia Capelletti, PhD MBBS, Haider Ghiasuddin, Dina Stroopinsky, PhD, Jessica Liegel, MD, Myrna Nahas, MD, Matthew Weinstock, MD, Adam Morin, Robin M. Joyce, MD, Salvia Jain, MD, Jon E. Arnason, MD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 392.
https://doi.org/10.1182/blood-2019-124768
Published: 2019
Journal Articles

Transcriptome Sequencing Demonstrates Unique Signature Associated with Durable Clinical Response to DC/AML Fusion Vaccine

Jessica Liegel, MD, Manoj Bhasin, PhD, German A. Pihan, MD, Dina Stroopinsky, PhD, Beena Thomas, PhD, Shreya Sindhu, Haider Ghiasuddin, Emma Logan, Adam Morin, Marzia Capelletti, PhD MMSc, Shira Orr, PhD, Myrna Nahas, MD, Matthew Weinstock, MD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Richard M. Stone, MD, Donald Kufe, MD, David E. Avigan, MD, Jacalyn Rosenblatt, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3832.
https://doi.org/10.1182/blood-2019-129451
Published: 2019
Journal Articles

T Cells Educated By DC/AML Fusions in the Context of 4-1BB Costimulation As a Potent Strategy for Adoptive Cellular Therapy

Jessica Liegel, MD, Dina Stroopinsky, PhD, Haider Ghiasuddin, Adam Morin, Marzia Capelletti, PhD MMSc, Shira Orr, PhD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Myrna Nahas, MD, Matthew Weinstock, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2673.
https://doi.org/10.1182/blood-2019-131491
Published: 2019
Journal Articles

Potent Synergy between Combination of Chimeric Antigen Receptor (CAR) Therapy Targeting CD19 in Conjunction with Dendritic Cell (DC)/Tumor Fusion Vaccine in Hematological Malignancies

Marzia Capelletti, PhD MMSc, Jessica Liegel, MD, Maria Themeli, MD PhD, Tuna Mutis, Dina Stroopinsky, PhD, Shira Orr, PhD, Daniela Torres, Adam Morin, Gertrude Gunset, BA, Haider Ghiasuddin, Maryam Rahimian, MD, Myrna Nahas, MD, Lina Bisharat, Shufen Meng, MD, Nikhil C. Munshi, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, Michel Sadelain, MD PhD, David E. Avigan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3227.
https://doi.org/10.1182/blood-2019-124944
Published: 2019
Journal Articles

Ex-Vivo Stimulation with DC/AML Fusion Vaccine in the Presence of Cytokines Leads to an Activated T Cell Memory Phenotype and Enhanced Cytotoxicity with Potential for Use As an Adoptive Cellular Therapy

Jessica Liegel, MD, Dina Stroopinsky, PhD, Lourdes M. Mendez, MD PhD, Malgorzata McMasters, MD, Haider Ghiasuddin, BA, Maryam Rahimian, MD, Myrna Nahas, MD, Matthew Weinstock, MD, Salvia Jain, MD, Marzia Capelletti, PhD MMSc, Lina Bisharat, MA, Adam Morin, BA, Shira Orr, PhD, Jacalyn Rosenblatt, MD, Donald Kufe, MD, David E. Avigan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2728.
https://doi.org/10.1182/blood-2018-99-119996
Published: 2018
Journal Articles

A Novel Monoclonal Antibody Combination Plus DC/AML Fusion Vaccine Eradicates AML in an Immunocompetent Murine Model

Dina Stroopinsky, PhD, Jessica Liegel, MD, Kathleen M. Mahoney, MD PhD, Jacalyn Rosenblatt, MD, Benjamin L. Ebert, MD PhD, Richard M. Stone, MD, Maryam Rahimian, MD, Myrna Nahas, MD, Shira Orr, PhD, Marzia Capelletti, PhD MMSc, Matthew Weinstock, MD, Salvia Jain, MD, Lina Bisharat, MA, Haider Ghiasuddin, BA, Adam Morin, BA, Donald Kufe, MD, Gordon J Freeman, PhD, David E. Avigan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1446.
https://doi.org/10.1182/blood-2018-99-120259
Published: 2018
Journal Articles

The Effect of Lenalidomide on Multiple Myeloma Associated Macrophages

Noam Benyamini, MD, Samah Waked, BS.c., Lina Bisharat, MSc, Noam Bettman, PhD, Tami Katz, PhD
Journal: Blood
Blood (2016) 128 (22): 3689.
https://doi.org/10.1182/blood.V128.22.3689.3689
Published: 2016
Journal Articles

Different Sources of Stromal Cells Diversely Affect Survival and Trafficking of Mantle Cell Lymphoma Cells

Tami Katz, PhD, Shoham Shivtiel-Arad, PhD, Hitam Saadi, Noam Bettman, PhD, Lina Bisharat, MSc, Irit Avivi, MD, Netanel A Horowitz, MD
Journal: Blood
Blood (2015) 126 (23): 2670.
https://doi.org/10.1182/blood.V126.23.2670.2670
Published: 2015
Journal Articles

Blockade of PD-1 in Combination with Dendritic Cell/Myeloma Fusion Cell Vaccination Following Autologous Stem Cell Transplantation Is Well Tolerated, Induces Anti-Tumor Immunity and May Lead to Eradication of Measureable Disease

Jacalyn Rosenblatt, MD, Irit Avivi, MD, Noam Binyamini, MD, Lynne Uhl, MD, Poorvi Somaiya, Dina Stroopinsky, PhD, Kristen Anna Palmer, Maxwell Douglas Coll, Tami Katz, PhD, Lina Bisharat, MSc, Robin Joyce, MD, James D. Levine, MD, Jon E. Arnason, MD, Katarina Luptakova, MD, Malgorzata McMasters, MD, Salvia Jain, MD, Merav Leiba, MD, Aya Sato-Dilorenzo, RN, BSN, OCN, Emma Logan, Mary Paty Bryant, Viki Held, Paul G. Richardson, MD, Jacob P. Laubach, MD, Arnon Nagler, MD MSc, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD, Jacob M. Rowe, MD, Donald Kufe, MD, David Avigan, MD
Journal: Blood
Blood (2015) 126 (23): 4218.
https://doi.org/10.1182/blood.V126.23.4218.4218
Published: 2015
Journal Articles

Blockade of PD-1 in Combination with Dendritic Cell/Myeloma Fusion Cell Vaccination Following Autologous Stem Cell Transplantation

Jacalyn Rosenblatt, MD, Irit Avivi, MD, Baldev Vasir, PhD, Lynne Uhl, MD, Tami Katz, PhD, Poorvi Somaiya, Heidi Mills, Robin Joyce, MD, James D. Levine, MD, Dimitrios Tzachanis, MD, PhD, Vassiliki A. Boussiotis, MD, PhD, Katarina Luptakova, MD, Jon E. Arnason, MD, Natalie Drummy, RN, Carol Delaney, RN, Emma Breault, Vicki Held, Lina Bisharat, Nancy Giallombardo, NP, Katharine Conway, NP, Jamie Mortellite, NP, Judith Wagoner, NP, Michael Schickler, PhD, Rinat Rotem-Yehudar, PhD, Paul G. Richardson, MD, Jacob P. Laubach, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Jacob M Rowe, MD, Donald Kufe, MD, David Avigan, MD
Journal: Blood
Blood (2012) 120 (21): 578.
https://doi.org/10.1182/blood.V120.21.578.578
Published: 2012
Journal Articles

Chronic Lymphocytic Leukemia Cells Exhibit Inhibitory Properties of Regulatory B Cells

Shimrit Ringelstein-Harlev, MD, Irit Avivi, MD, Lina Bisharat, Tamar Katz, Ph.D
Journal: Blood
Blood (2012) 120 (21): 3874.
https://doi.org/10.1182/blood.V120.21.3874.3874
Published: 2012
Journal Articles

Clinical Trial Evaluating DC/AML Fusion Cell Vaccination Alone and in Conjunction with PD-1 Blockade in AML Patients Who Achieve a Chemotherapy-Induced Remission

Jacalyn Rosenblatt, MD, Richard M. Stone, MD, Irit Avivi, MD, Lynne Uhl, MD, Donna Neuberg, ScD, Robin Joyce, MD, Dimitrios Tzachanis, MD, PhD, James D. Levine, MD, Vassiliki A Boussiotis, MD, PhD, Jeffrey Zwicker, MD, Jon E. Arnason, MD, Katarina Luptakova, MD, David P. Steensma, MD, Daniel J DeAngelo, MD, PhD, Ilene Galinsky, ANP, Baldev Vasir, PhD, Poorvi Somaiya, Heidi Mills, BA, Yan Emily Yuan, Jessica Bonhoff, BA, Carol Delaney, RN, Natalie Drummy, Lowell Nicholson, Dina Stroopinsky, PhD, Vicki Held, Tami Katz, PhD, Lina Bisharat, Jacob M. Rowe, MD, Donald Kufe, MD, David Avigan, MD
Journal: Blood
Blood (2011) 118 (21): 948.
https://doi.org/10.1182/blood.V118.21.948.948
Published: 2011