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Alexander N. Snel
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Journal Articles

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Lok Lam Ngai, Coen R. Veenstra, Patrycja Gradowska, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Jesse M. Tettero, Costa Bachas, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Canan Alhan, Theresia M. Westers, Peter J. M. Valk, David C. de Leeuw, Bob Lowenberg, Gert Ossenkoppele, Jacqueline Cloos, Arjan A. van de Loosdrecht
Journal: Blood
Blood (2023) 142 (Supplement 1): 323.
https://doi.org/10.1182/blood-2023-184703
Published: 2023
Journal Articles

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Lok Lam Ngai, Diana Hanekamp, Angèle Kelder, Willemijn Scholten, Jannemieke Carbaat-Ham, Mona M.H.E Fayed, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Tim R. Mocking, Vincent H.J. Van Der Velden, Jennichjen Slomp, Willemijn Hobo, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Arjan A. van de Loosdrecht, Gert Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2023-181709
Published: 2023
Journal Articles

Impact of Hemodilution on Measurable Residual Disease Measured Via Flow-Cytometry in Acute Myeloid Leukemia Analyzed Using Subsequent Pulls

Jesse M. Tettero, Maaike Heidinga, Tim R. Mocking, Glenn Fransen, Ezra S Beerman, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Lok Lam Ngai, Costa Bachas, Arjan A. Van de Loosdrecht, Gert Ossenkoppele, David C. de Leeuw, Jeroen J.W.M. Janssen, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1559.
https://doi.org/10.1182/blood-2023-179242
Published: 2023
Journal Articles

Prospective validation of the prognostic relevance of CD34 + CD38 – AML stem cell frequency in the HOVON-SAKK132 trial

Clinical Trials & Observations
Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A. M. A. Hofland, Mona M. H. E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Arjan A. van de Loosdrecht, Johan A. Maertens, Markus G. Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Jeroen J. W. M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 141 (21): 2657–2661.
https://doi.org/10.1182/blood.2022019160
Published: 2023
Includes: Supplemental data
Journal Articles

Prospective Validation of CD34+CD38- Leukemic Stem Cell Frequency in the HOVON-SAKK 132 Trial: Perspectives for Future Improvements

Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A.M. Hofland, Mona M.H.E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Patrycja Gradowska, Bob Lowenberg, David C. de Leeuw, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2022) 140 (Supplement 1): 9125–9127.
https://doi.org/10.1182/blood-2022-157753
Published: 2022
Journal Articles

Relapsed AML Patients with Mutational Shifts Harbor An Oligoclonal Primitive Cell Compartment at Presentation; Evidence for Clonal Selection towards Relapse

Costa Bachas, Gerrit Jan Schuurhuis, PhD, Zinia J. Kwidama, Angèle Kelder, Alexander N. Snel, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2010) 116 (21): 751.
https://doi.org/10.1182/blood.V116.21.751.751
Published: 2010
Journal Articles

Accurate Detection of Residual Leukemic Stem Cells In Remission Bone Marrow Predicts Relapse In Acute Myeloid Leukemia Patients

Monique Terwijn, Arjo P Rutten, Angèle Kelder, Alexander N Snel, Willemijn J Scholten, Sonja Zweegman, Gert J Ossenkoppele, Gerrit J Schuurhuis
Journal: Blood
Blood (2010) 116 (21): 759.
https://doi.org/10.1182/blood.V116.21.759.759
Published: 2010
Journal Articles

High Prognostic Impact of Flowcytometric Minimal Residual Disease Detection In Acute Myeloid Leukemia: Prospective Data From the HOVON/SAKK 42a Study

Monique Terwijn, Angèle Kelder, Wim L.J. van Putten, Alexander N. Snel, Vincent H.J. van der elden, PhD, Rik A. Brooimans, PhD, Nancy Boeckx, MD, PhD, Frank W.M.B. Preijers, PhD, Bob Löwenberg, MD, PhD, Angelika M. Dräger, PhD, Peter C. Huijgens, MD, PhD, Peter J.M Valk, PhD, Johan Maertens, MD, Thomas Pabst, MD, PhD, Gert J. Ossenkoppele, MD, PhD, Gerrit J. Schuurhuis, PhD
Journal: Blood
Blood (2010) 116 (21): 760.
https://doi.org/10.1182/blood.V116.21.760.760
Published: 2010
Journal Articles

Combination of CD34/CD38 Immunophenotypes and Side Population (SP) Reveals the Putative Leukemia Stem Cell/Leukemia Initiating Cell In Acute Myeloid Leukemia.

Gerrit J Schuurhuis, PhD, Bijan Moshaver, Alexander N Snel, Gert J. Ossenkoppele, MD, PhD, Sonja Zweegman, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1582.
https://doi.org/10.1182/blood.V116.21.1582.1582
Published: 2010
Journal Articles

Specificity of Markers of Leukemia Initiating Cells with a New Multiparameter Flow Cytometry Based Appraoch; Impact for Prognostic and Therapeutic Applications

Gerrit J. Schuurhuis, PhD, Rolf Wouters, Angèle Kelder, Arjo P Rutten, Alexander N Snel, Monique Terwijn, Paul Noordhuis, PhD, Sonja Zweegman, MD, PhD, Gert J. Ossenkoppele, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1834.
https://doi.org/10.1182/blood.V116.21.1834.1834
Published: 2010
Journal Articles

Leukemic Stem Cell Assessment in Remission Bone Marrow of Acute Myeloid Leukemia Patients Is a New Prognostic Parameter.

Monique Terwijn, Angèle Kelder, Arjo P Rutten, Alexander N Snel, Willemijn Scholten, Sonja Zweegman, MD, PhD, Gert Ossenkoppele, MD, PhD, Gerrit Jan Schuurhuis, PhD
Journal: Blood
Blood (2009) 114 (22): 399.
https://doi.org/10.1182/blood.V114.22.399.399
Published: 2009
Journal Articles

High Aldehyde Dehydrogenase Activity (ALDH) Is a General Marker for Normal Hematopoietic Stem Cells but Not Leukemic Stem Cells in Acute Myeloid Leukemia (AML). .

Linda Smit, PhD, Lisa A Min, Monique Terwijn, Angele Kelder, Alexander N Snel, Gert J Ossenkoppele, MD, PhD, Gerrit J. Schuurhuis, PhD
Journal: Blood
Blood (2009) 114 (22): 4035.
https://doi.org/10.1182/blood.V114.22.4035.4035
Published: 2009