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Ensar Halilovic
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Journal Articles

A First in Human Study of VOB560 in Combination with MIK665 in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma, Acute Myeloid Leukemia, or Multiple Myeloma

Harinder Gill, Ine Moors, Kimmo Porkka, Yakir Moshe, Sung Soo Yoon, Naval Daver, Enrique M Ocio, Masafumi Fukaya, Tim Sauer, Maria-Victoria Mateos, Frank Stegelmann, Marta Ubezio, Alessia Campagna, Massimo Magagnoli, Heiko Maacke, Laurent Susini, Kae Ishihara, Ines Cordeiro Filipe, Xiaozhou Zhang, Richard Ducray, Lidiya Bebrevska, Ensar Halilovic, Amy Luyt, Armando Santoro
Journal: Blood
Blood (2024) 144 (Supplement 1): 5997.
https://doi.org/10.1182/blood-2024-199074
Published: 2024
Journal Articles

Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia

Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh B. Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2024-207199
Published: 2024
Journal Articles

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Clinical Trials & Observations
Donia M. Moujalled, Fiona C. Brown, Chong Chyn Chua, Michael A. Dengler, Giovanna Pomilio, Natasha S. Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S. Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J. Herold, Guillaume Lessene, Jerry M. Adams, David C. S. Huang, Andrew W. Roberts, Piers Blombery, Andrew H. Wei
Journal: Blood
Blood (2023) 141 (6): 634–644.
https://doi.org/10.1182/blood.2022016090
Published: 2023
Includes: Supplemental data
Journal Articles

Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo

Anna Skwarska, Donia M Moujalled, Paul F Panis, Shraddha Patel, Qi Zhang, Shelley Herbrich, Vinitha Kurvilla, Natalia Baran, Giovanna Pomilio, Ensar Halilovic, Prakash Mistry, Vivian Ruvolo, Peter P. Ruvolo, Alix Derréal, Sebastien Banquet, Magdalena Niemira, Adam Kretowski, Naval Daver, Michael Andreeff, Andrew H. Wei, Marina Konopleva
Journal: Blood
Blood (2021) 138 (Supplement 1): 2248.
https://doi.org/10.1182/blood-2021-151042
Published: 2021
Journal Articles

Preliminary Results from a Phase Ib Study Exploring MDM2 Inhibitor Siremadlin (HDM201) in Combination with B-Cell Lymphoma-2 (BCL-2) Inhibitor Venetoclax in Patients with Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (HR-MDS)

Andrew H. Wei, Massimo Breccia, Melissa Ooi, Maria Teresa Cedena Romero, Fabio Ciceri, Harry P. Erba, Anil Gaur, Romain Sechaud, Ensar Halilovic, Brigitte Kuenzle, Claire Fabre, Kimmo Porkka
Journal: Blood
Blood (2021) 138 (Supplement 1): 1283.
https://doi.org/10.1182/blood-2021-144650
Published: 2021
Journal Articles

Dynamic BH3 Profiling As Pharmacodynamic Biomarker for the Activity of BH3 Mimetics

Rongqing Pan, PhD, Youzhen Wang, Shumei Qiu, Jeremy Ryan, Ensar Halilovic
Journal: Blood
Blood (2020) 136 (Supplement 1): 6.
https://doi.org/10.1182/blood-2020-138916
Published: 2020
Journal Articles

Individualized Mitochondrial Functional Approach to Combination of BCL-2 and MCL-1 Antagonism in Acute Myeloid Leukemia

Shruti Bhatt, PhD, Marissa Pioso, Elyse Ann Olesinski, Binyam Yilma, Leutz Buon, Sophia Adamia, PhD, Holly Zhu, Jeremy Ryan, Youzhen Wang, Morris Erick, Ensar Halilovic, David M. Weinstock, MD, Jacqueline S Garcia, MD, Anthony Letai
Journal: Blood
Blood (2019) 134 (Supplement_1): 2551.
https://doi.org/10.1182/blood-2019-131101
Published: 2019
Journal Articles

Antimyeloma Effect of the Simultaneous Inhibition of MCL-1 (with S63845) and BCL-2 (with Venetoclax) in the Presence of the Microenvironment

Esperanza M Algarín, MSc, Andrea Díaz-Tejedor, Pedro Mogollón, Susana Hernández-García, Luis Corchete, Laura San-Segundo, Montserrat Martín-Sánchez, Lorena González-Méndez, Marie Schoumacher, Sébastien Banquet, Laurence Kraus-Berthier, Ioana Kloos, Ensar Halilovic, Heiko Maacke, Norma C. Gutierrez, MD PhD, Maria-Victoria Mateos, MD PhD, Teresa Paíno, Mercedes Garayoa, Enrique M. Ocio, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 954.
https://doi.org/10.1182/blood-2018-99-116075
Published: 2018
Journal Articles

The MDM2 Inhibitor NVP-CGM097 Is Highly Active in a Randomized Preclinical Trial of B-Cell Acute Lymphoblastic Leukemia Patient Derived Xenografts

Elizabeth C Townsend, PhD, Tiffany DeSouza, B.S., Mark A. Murakami, MD MA, Joan Montero, PhD, Kristen Stevenson, MS, Amanda L Christie, B.S., Alexandra N Christodolou, M.Sc., Una Vojinovic, B.S., Nadja Kopp, M.S., Patrizia Barzaghi-Rinaudo, Masato Murakami, MD, PhD, Anthony Letai, MD PhD, Sebastien Jeay, Jens Wuerthner, Ensar Halilovic, David M. Weinstock
Journal: Blood
Blood (2015) 126 (23): 797.
https://doi.org/10.1182/blood.V126.23.797.797
Published: 2015