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Juho J. Miettinen
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Journal Articles

Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia

Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh B. Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2024-207199
Published: 2024
Journal Articles

Efficacy of the Peptide Drug Conjugates Melflufen and OPDC3 in Venetoclax Resistant Acute Myeloid Leukemia

Romika Kumari, Juho J. Miettinen, Mahesh B. Tambe, June Olgac, Tanja Ruokoranta, Nemo Ikonen, Minna H. Suvela, Maiju-Emilia Huppunen, Stefan Svensson Gelius, Klara Acs, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1548.
https://doi.org/10.1182/blood-2024-194582
Published: 2024
Journal Articles

Deciphering Variability in Light Chain Amyloidosis and Amyloidosis with Co-Occurring Multiple Myeloma By Single-Cell RNA Sequencing

Ankita Srivastava, Romika Kumari, Juho J. Miettinen, Minna H. Suvela, Klara Acs, Sini Luoma, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 4648.
https://doi.org/10.1182/blood-2024-209791
Published: 2024
Journal Articles

Investigating the Role of Neutrophil Extracellular Traps (NETs) in Multiple Myeloma Pathogenesis and Disease Evolution

Paul Dowling, Katie Dunphy, Despina Bazou, Juho J. Miettinen, Caroline A. Heckman, Peter O'Gorman
Journal: Blood
Blood (2024) 144 (Supplement 1): 6928.
https://doi.org/10.1182/blood-2024-205586
Published: 2024
Journal Articles

A Potential Role of NK Cells and ABCB9 in Modulating the Response to Melflufen in Multiple Myeloma

Philipp Sergeev, Sadiksha Adhikari, Juho J. Miettinen, Maiju-Emilia Huppunen, Minna Suvela, Ana Slipicevic, Nina N. Nupponen, Klara Acs, Fredrik Lehmann, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 6000–6001.
https://doi.org/10.1182/blood-2022-162182
Published: 2022
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML

Ana Rio-Machin, Findlay Bewicke-Copley, Jiexin Zheng, Pedro Casado Izquierdo, Juho J. Miettinen, Naeem Khan, Jonas Demeulemeester, Szilvia Krizsán, Christopher Middleton, Sam Benkwitz-Bedford, Joseph Saad, Amaia Vilas-Zornoza, Teresa Ezponda, William Grey, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Ryan J Colm, Jonathan Bond, Doriana Di Bella, Krister Wennerberg, Alun Parsons, Andy G.X. Zeng, Hannah Armes, Karina Close, Fadimana Kaya, Kevin Rouault-Pierre, John G. Gribben, Felipe Prosper, James Cavenagh, John E. Dick, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, Guy Sauvageau, Kimmo Porkka, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro Cutillas, Jude Fitzgibbon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1030–1032.
https://doi.org/10.1182/blood-2022-159069
Published: 2022
Journal Articles

The Novel Peptide Drug Conjugate OPDC3 Is Highly Active in Different Hematological Malignancies

Juho J. Miettinen, Tanja Ruokoranta, Vilma Ikonen, Maiju-Emilia Huppunen, Klara Acs, Fredrik Lehmann, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10697–10698.
https://doi.org/10.1182/blood-2022-166090
Published: 2022
Journal Articles

Phosphoproteomic Analysis of Primary Myeloma Patient Samples Identifies Distinct Phosphorylation Signatures Correlating with Chemo-Sensitivity Profiles in an Ex Vivo Drug Sensitivity Testing Platform

Katie Dunphy, Paul Dowling, Juho J. Miettinen, Caroline A. Heckman, Paula Meleady, Michael Henry, Despina Bazou, Peter O'Gorman
Journal: Blood
Blood (2021) 138 (Supplement 1): 2666.
https://doi.org/10.1182/blood-2021-148382
Published: 2021
Journal Articles

Single Cell RNA Sequencing Identifies Potential Molecular Indicators of Response to Melflufen in Multiple Myeloma

Philipp Sergeev, Sadiksha Adhikari, Juho J. Miettinen, Maiju-Emilia Huppunen, Minna Suvela, Ana Slipicevic, Nina N. Nupponen, Fredrik Lehmann, Caroline A. Heckman
Journal: Blood
Blood (2021) 138 (Supplement 1): 1194.
https://doi.org/10.1182/blood-2021-147191
Published: 2021