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Jonas Bouhlal
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Journal Articles

Bone Marrow Stromal Cells Hamper Leukemia Cell Induced NK Cell Activation and Cytotoxicity

Salomé Decombis, Johannes Smolander, Jonas Bouhlal, Jay Klievink, Hanna Lähteenmäki, Emmi Jokinen, Linh Lin, Hanna Laitinen, Konstantin Matjusinski, Eveliina Holappa, Mikko Myllymäki, Heidi Haikala, Sara Gandolfi, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 4814.
https://doi.org/10.1182/blood-2024-202959
Published: 2024
Journal Articles

Genomic Subtypes of AML Define Sensitivity to NK Cell Cytotoxicity

Hanna Duàn, Emmi Jokinen, Hanna Lähteenmäki, Jay Klievink, Jonas Bouhlal, Essi Laajala, Jason Theodoropoulos, Heikki Kuusanmäki, Tanja Ruokoranta, Pauliina Rumm, Dean Anthony Lee, Esa Pitkänen, Tomi P Mäkelä, Kimmo Porkka, Oscar E. Brück, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 329.
https://doi.org/10.1182/blood-2024-199448
Published: 2024
Journal Articles

Comprehensive Drug Profiling and CRISPR Screening Reveal Essential Pathways for NK Cell Cytotoxicity

Jonas Bouhlal, Emmi Jokinen, Petra Nygren, Diogo Dias, Aleksandr Ianevski, Jay Klievink, Hanna Lähteenmäki, Essi Laajala, Hanna Duàn, Emmi Järvelä, Helka Göös, Matti Korhonen, Salomé Decombis, Konstantin Matjusinski, Mikko Myllymäki, Maija Hollmén, Khalid Saeed, Dean Anthony Lee, Tero Aittokallio, Sara Gandolfi, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 913.
https://doi.org/10.1182/blood-2024-202448
Published: 2024
Journal Articles

Primary Acute Myeloid Leukemia Cells Trigger Distinct Activation Patterns in Expanded NK Cells

Hanna Duàn, Olli Dufva, Emmi Jokinen, Hanna Lähteenmäki, Jay Klievink, Jonas Bouhlal, Jason Theodoropoulos, Heikki Kuusanmäki, Tanja Ruokoranta, Pauliina Rumm, Dean Anthony Lee, Esa Pitkänen, Tomi P Mäkelä, Kimmo Porkka, Oscar Brück, Satu Mustjoki
Journal: Blood
Blood (2023) 142 (Supplement 1): 66.
https://doi.org/10.1182/blood-2023-174037
Published: 2023
Journal Articles

High-Throughput Screens Identify NEDD8 Inhibition As a Strategy to Augment Natural Killer Cell Cytotoxicity Against Blood Cancers

Jonas Bouhlal, Petra Nygren, Emmi Jokinen, Essi Laajala, Aleksandr Ianevski, Diogo Dias, Jay Klievink, Hanna Lähteenmäki, Hanna Duàn, Khalid Saeed, Dean Anthony Lee, Tero Aittokallio, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2023) 142 (Supplement 1): 3634.
https://doi.org/10.1182/blood-2023-174386
Published: 2023
Journal Articles

Single-Cell Analysis of Immune Recognition in Chronic Myeloid Leukemia Patients Following Tyrosine Kinase Inhibitor Discontinuation

Jani Huuhtanen, Shady Adnan-Awad, Jason Theodoropoulos, Sofia Forstén, Rebecca Warfvinge, Olli Dufva, Jonas Bouhlal, Parashar Dhapola, Hanna Duàn, Essi Laajala, Tiina Kasanen, Jay Klievink, Mette Ilander, Taina Jaatinen, Ulla Olsson-Strömberg, Henrik Hjorth-Hansen, Andreas Burchert, Göran Karlsson, Anna Kreutzman, Harri Lähdesmäki, Satu Mustjoki
Journal: Blood
Blood (2023) 142 (Supplement 1): 3146.
https://doi.org/10.1182/blood-2023-185630
Published: 2023
Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho Miettinen, Komal K. Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2023) 141 (13): 1610–1625.
https://doi.org/10.1182/blood.2021011094
Published: 2023
Includes: Supplemental data
Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Johanna Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Aino Häkkinen, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer A. Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean Anthony Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S. Mitsiades, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 8343–8344.
https://doi.org/10.1182/blood-2022-167535
Published: 2022
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Functional Genomic Landscape of Natural Killer Cell Evasion in Multiple Myeloma

Sara Gandolfi, Olli Dufva, Jani Huuhtanen, Olga Dashevsky, Jay Klievink, Jonas Bouhlal, Michal Sheffer, Matti Kankainen, Ricardo De Matos Simoes, Satu Mustjoki, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 732.
https://doi.org/10.1182/blood-2021-153925
Published: 2021