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Journal Articles

Comprehensive Drug Profiling and CRISPR Screening Reveal Essential Pathways for NK Cell Cytotoxicity

Jonas Bouhlal, Emmi Jokinen, Petra Nygren, Diogo Dias, Aleksandr Ianevski, Jay Klievink, Hanna Lähteenmäki, Essi Laajala, Hanna Duàn, Emmi Järvelä, Helka Göös, Matti Korhonen, Salomé Decombis, Konstantin Matjusinski, Mikko Myllymäki, Maija Hollmén, Khalid Saeed, Dean Anthony Lee, Tero Aittokallio, Sara Gandolfi, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 913.
https://doi.org/10.1182/blood-2024-202448
Published: 2024
Journal Articles

High-Throughput Screens Identify NEDD8 Inhibition As a Strategy to Augment Natural Killer Cell Cytotoxicity Against Blood Cancers

Jonas Bouhlal, Petra Nygren, Emmi Jokinen, Essi Laajala, Aleksandr Ianevski, Diogo Dias, Jay Klievink, Hanna Lähteenmäki, Hanna Duàn, Khalid Saeed, Dean Anthony Lee, Tero Aittokallio, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2023) 142 (Supplement 1): 3634.
https://doi.org/10.1182/blood-2023-174386
Published: 2023
Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Johanna Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Aino Häkkinen, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer A. Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean Anthony Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S. Mitsiades, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 8343–8344.
https://doi.org/10.1182/blood-2022-167535
Published: 2022
Journal Articles

Outcomes Following Acute Pulmonary Embolism in an Irish Population of over 1 Million Individuals: Opportunities for Quality Improvement and More Effective Resource Utilisation

Alexandra Tierney, Fionnuala Ni Ainle, Declan Lyons, Osasere Edebiri, Khalid Saeed, Sarah Kelliher, Kiran Saif, Rehman Faryal, Su Wai Maung, Howard Johnson, Michael Fitzpatrick, Roseann O' Doherty, Jillian Coll, Sara Mohamed, Mohamed Ali, Noirin Bannon, Annemarie O'Neill, Tomas Breslin, Karen Murphy, Barry Kevane
Journal: Blood
Blood (2021) 138 (Supplement 1): 2979.
https://doi.org/10.1182/blood-2021-148491
Published: 2021
Journal Articles

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Olli Dufva, Jan Koski, Pilvi Maliniemi, Aleksandr Ianevski, Jay Klievink, Judith Leitner, Petri Pölönen, Helena Hohtari, Khalid Saeed, Tiina Hannunen, Pekka Ellonen, Peter Steinberger, Matti Kankainen, Tero Aittokallio, Mikko A. I. Keränen, Matti Korhonen, Satu Mustjoki
Journal: Blood
Blood (2020) 135 (9): 597–609.
https://doi.org/10.1182/blood.2019002121
Published: 2020
Includes: Supplemental data
Journal Articles

Heterogeneity of Molecular Mechanisms Determining Blood Cancer Cell Lines Resistance to Natural Killer Cells in the Context of Tumor-Stromal Interactions: Insights from Studies of Pooled "DNA-Barcoded" Cell Line Panels

Sara Gandolfi, MD, Michal Sheffer, PhD, Olli Dufva, Khalid Saeed, Emily Lowry, Olga Dashevsky, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Jennifer Roth, Rizwan Romee, MD PhD, Satu Mustjoki, MD PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 620.
https://doi.org/10.1182/blood-2019-130793
Published: 2019
Journal Articles

CRISPR Screens Identify Mechanisms of Natural Killer Cell Evasion across Blood Cancers

Olli Dufva, Khalid Saeed, Sara Gandolfi, MD, Michal Sheffer, PhD, Jay Klievink, Petri Pölönen, MSc, Tiina Hannunen, Mette Ilander, PhD, Pekka Ellonen, BSc, Matti Kankainen, PhD, Dean Anthony Lee, MD PhD, Constantine S. Mitsiades, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3597.
https://doi.org/10.1182/blood-2019-129837
Published: 2019
Journal Articles

Genome-Scale CRISPR Screens Identify Essential Genes for Sensitivity to Natural Killer Cells in Hematological Malignancies

Olli Dufva, Jay Klievink, Khalid Saeed, Matti Kankainen, PhD, Mette Ilander, PhD, Tiina Hannunen, Sonja Lagström, Pekka Ellonen, BSc, Dean Anthony Lee, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 732.
https://doi.org/10.1182/blood-2018-99-117985
Published: 2018