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Matti Kankainen
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Journal Articles

Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses

Jana von Jan, Sanna Timonen, Till Braun, Qu Jiang, Aleksandr Ianevski, Yayi Peng, Kathleen McConnell, Paola Sindaco, Tony Andreas Müller, Sabine Pützer, Hanna Klepzig, Dennis Jungherz, Annika Dechow, Linus Wahnschaffe, Anil K. Giri, Matti Kankainen, Heikki Kuusanmäki, Heidi A. Neubauer, Richard Moriggl, Paolo Mazzeo, Nicole Schmidt, Raphael Koch, Michael Hallek, Amel Chebel, David Armisen, Laurent Genestier, Emmanuel Bachy, Anjali Mishra, Alexandra Schrader, Tero Aittokallio, Satu Mustjoki, Marco Herling
Journal: Blood
Blood (2024) 144 (15): 1595–1610.
https://doi.org/10.1182/blood.2023022884
Published: 2024
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis Associated with Rheumatoid Arthritis

Emil Hiitola, Juuso Korhonen, Jukka Koskela, Matti Kankainen, Milla Alakuijala, Heidi Kokkonen, Aoxing Liu, Paavo Häppölä, Paula Savola, Tiina Kelkka, Marjatta Leirisalo-Repo, Ritva Peltomaa, Laura Pirilä, Pia Isomäki, Markku Kauppi, Oili Kaipiainen-Seppänen, FinnGen Consortium, Giulio Genovese, Andrea Ganna, Solbritt Rantapää-Dahlqvist, Satu Mustjoki, Mikko Myllymäki
Journal: Blood
Blood (2023) 142 (Supplement 1): 2698.
https://doi.org/10.1182/blood-2023-173664
Published: 2023
Journal Articles

Natural Killer Cells Are Active Against Myeloma, Leukemia or Lymphoma Cells with Loss of Tumor Suppressor Genes

Olga Dashevsky, Sara Gandolfi, Olli Dufva, Ricardo De Matos Simoes, Jani Huuhtanen, Benjamin G. Barwick, Ryosuke Shirasaki, Michal Sheffer, Aidan Culhane, Jonathan D. Licht, Christine-Ivy Liacos, Evangelos Terpos, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Lawrence H. Boise, Francisca Vazquez, Matti Kankainen, Satu Mustjoki, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 6842.
https://doi.org/10.1182/blood-2023-189570
Published: 2023
Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Johanna Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Aino Häkkinen, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer A. Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean Anthony Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S. Mitsiades, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 8343–8344.
https://doi.org/10.1182/blood-2022-167535
Published: 2022
Journal Articles

A Comprehensive, Multiomics Analysis of Natural Killer-Cell Malignancies

Petra Johanna Nygren, Aino Häkkinen, Daehong Kim, Timo Jarvinen, Fumihiro Ishida, Stefania Bortoluzzi, Andrea Binatti, Vanessa Rebecca Gasparini, Renato Zambello, Mikko Myllymäki, Seishi Ogawa, Yusuke Okuno, Hiroshi Kimura, John Chan, Olli Dufva, Satu Mustjoki, Matti Kankainen
Journal: Blood
Blood (2022) 140 (Supplement 1): 6390–6391.
https://doi.org/10.1182/blood-2022-162285
Published: 2022
Journal Articles

Somatic Mutations in T Cells in Patients with Hematological Diseases

Sofie Lundgren, Timo Järvinen, Mikko A Keränen, Jason Theodoropoulos, Daehong Kim, Urpu Salmenniemi, Gunilla Walldin, Paula Savola, Tiina Kelkka, Hanna Rajala, Pekka Ellonen, Eva Hellström-Lindberg, Maija Itälä-Remes, Mikko Myllymäki, Matti Kankainen, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 5496–5497.
https://doi.org/10.1182/blood-2022-163112
Published: 2022
Journal Articles

Synergistic Role of Leukemic and Non-Leukemic Immune Repertoires in CD8+ T-Cell Large Granular Lymphocytic Leukemia As Identified By Single-Cell Transcriptomics

Dipabarna Bhattacharya, Jani Huuhtanen, Matti Kankainen, Tapio Lönnberg, Cassandra M Kerr, Jason Theodoropoulos, Hanna Rajala, Tiina Kasanen, Till Braun, Antonella Teramo, Renato Zambello, Marco Herling, Fumihiro Ishida, Toru Kawakami, Marko Salmi, Thomas P. Loughran, Jr., Jaroslaw P. Maciejewski, Harri Lähdesmäki, Tiina Kelkka, Satu Mustjoki
Journal: Blood
Blood (2021) 138 (Supplement 1): 1318.
https://doi.org/10.1182/blood-2021-146539
Published: 2021
Journal Articles

Somatic STAT3 Mutations in CD8+ T Cells of HTLV-2 Positive Blood Donors

Daehong Kim, Mikko Myllymäki, Matti Kankainen, Timo Jarvinen, Giljun Park, Roberta Bruhn, Edward L Murphy, Satu Mustjoki
Journal: Blood
Blood (2021) 138 (Supplement 1): 3133.
https://doi.org/10.1182/blood-2021-146326
Published: 2021
Journal Articles

Functional Genomic Landscape of Natural Killer Cell Evasion in Multiple Myeloma

Sara Gandolfi, Olli Dufva, Jani Huuhtanen, Olga Dashevsky, Jay Klievink, Jonas Bouhlal, Michal Sheffer, Matti Kankainen, Ricardo De Matos Simoes, Satu Mustjoki, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 732.
https://doi.org/10.1182/blood-2021-153925
Published: 2021
Journal Articles

Single-Cell Characterization of the Immune and Leukemic Cells Following Anti-TIM3 and Hypomethylating Agent Combination Therapy in Patients with AML or MDS

Jani Huuhtanen, Oscar Brück, Karita Peltonen, Anna Kreutzman, Olli Dufva, Matti Kankainen, Mette Ilander, Hanna Lähteenmäki, Tiina Kasanen, Jay Klievink, Mika Kontro, Elena J Orlando, Viviana Cremasco, Joel Wagner, Marc Pelletier, Harri Lähdesmäki, Catherine A. Sabatos-Peyton, Mikael L. Rinne, Kimmo Porkka, Satu Mustjoki
Journal: Blood
Blood (2021) 138 (Supplement 1): 801.
https://doi.org/10.1182/blood-2021-147150
Published: 2021
Journal Articles

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Olli Dufva, Jan Koski, Pilvi Maliniemi, Aleksandr Ianevski, Jay Klievink, Judith Leitner, Petri Pölönen, Helena Hohtari, Khalid Saeed, Tiina Hannunen, Pekka Ellonen, Peter Steinberger, Matti Kankainen, Tero Aittokallio, Mikko A. I. Keränen, Matti Korhonen, Satu Mustjoki
Journal: Blood
Blood (2020) 135 (9): 597–609.
https://doi.org/10.1182/blood.2019002121
Published: 2020
Includes: Supplemental data
Journal Articles

CRISPR Screens Identify Mechanisms of Natural Killer Cell Evasion across Blood Cancers

Olli Dufva, Khalid Saeed, Sara Gandolfi, MD, Michal Sheffer, PhD, Jay Klievink, Petri Pölönen, MSc, Tiina Hannunen, Mette Ilander, PhD, Pekka Ellonen, BSc, Matti Kankainen, PhD, Dean Anthony Lee, MD PhD, Constantine S. Mitsiades, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3597.
https://doi.org/10.1182/blood-2019-129837
Published: 2019
Journal Articles

BCR-ABL1 p190 in CML: A Minor Breakpoint with a Major Impact

Shady Adnan Awad, MD, Helena Hohtari, MD, Komal Kumar Javarappa, PhD, Tania Brandstoetter, Daehong Kim, Swapnil Potdar, MSc, Caroline A Heckman, PhD, Soili Kytölä, PhD, Kimmo Porkka, Eszter Doma, PhD, Veronika Sexl, MD PhD, Matti Kankainen, PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 190.
https://doi.org/10.1182/blood-2019-126584
Published: 2019
Journal Articles

Genome-Scale CRISPR Screens Identify Essential Genes for Sensitivity to Natural Killer Cells in Hematological Malignancies

Olli Dufva, Jay Klievink, Khalid Saeed, Matti Kankainen, PhD, Mette Ilander, PhD, Tiina Hannunen, Sonja Lagström, Pekka Ellonen, BSc, Dean Anthony Lee, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 732.
https://doi.org/10.1182/blood-2018-99-117985
Published: 2018
Journal Articles

RUNX1 Mutations Identify an Entity of Blast Phase Chronic Myeloid Leukemia (BP-CML) Patients with Distinct Phenotype, Transcriptional Profile and Drug Vulnerabilities

Shady Awad, MD, Matti Kankainen, PhD, Olli Dufva, Caroline A Heckman, PhD, Kimmo Porkka, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4257.
https://doi.org/10.1182/blood-2018-99-111602
Published: 2018
Journal Articles

Somatic Mutations in T Cells As Possible Regulators of Immunodeficiency

Paula Savola, MD, Timi Martelius, MD PhD, Matti Kankainen, PhD, Yrjö Koski, BTech, Samuli Eldfors, PhD, Jani Huuhtanen, BMed, Tiina Kelkka, PhD, Sofie Lundgren, BMed, Pekka Ellonen, BSc, Panu Kovanen, MD PhD, Soili Kytölä, PhD, Mikko Seppänen, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 515.
https://doi.org/10.1182/blood-2018-99-110757
Published: 2018
Journal Articles

Gene-Drug Interactions in AML Patients Identified By RNA Sequencing and Comprehensive Ex Vivo Drug Sensitivity and Resistance Testing

Ashwini Kumar, MRes, Dishaben Rameshbhai Malani, MSc, Bhagwan Yadav, PhD, Matti Kankainen, PhD, Swapnil Potdar, MSc, Mika Kontro, MD, Kimmo Porkka, MD PhD, Olli Kallioniemi, MD PhD, Simon Anders, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1398.
https://doi.org/10.1182/blood.V130.Suppl_1.1398.1398
Published: 2017
Journal Articles

Identification of Progression-Associated Mutations in Chronic Myeloid Leukemia (CML) By Comparative Genomic Analysis

Shady Adnan Awad, MD, Matti Kankainen, PhD, Samuli Eldfors, Bhagwan Yadav, PhD, Soili Kytölä, Pekka Ellonen, Mahmoud Kamel, MD PhD, Caroline A Heckman, PhD, Kimmo Porkka, MD PhD, Satu Mustjoki, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 250.
https://doi.org/10.1182/blood.V130.Suppl_1.250.250
Published: 2017
Journal Articles

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Olli Dufva, Matti Kankainen, PhD, Tiina Kelkka, PhD, Shady Adnan Awad, MD, Nodoka Sekiguchi, MD, Bhagwan Yadav, MSc, Samuli Eldfors, MSc, Heikki Kuusanmäki, MSc, Emma I Andersson, MSc, Disha Malani, MSc, Paavo Pietarinen, MSc, Leena Saikko, Panu E Kovanen, MD PhD, Junji Suzumiya, MD PhD, Ritsuro Suzuki, MD PhD, Young Hyeh Ko, MD, Won Seog Kim, MD PhD, Shih-Sung Chuang, MD, Thomas P. Loughran, Jr., MD, Wing Chung Chan, MD, Koichi Ohshima, MD PhD, Tero Aittokallio, Fumihiro Ishida, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2921.
https://doi.org/10.1182/blood.V128.22.2921.2921
Published: 2016
Journal Articles

Novel Mutations in Patients with Blast Crisis or Accelerated Phase Chronic Myeloid Leukemia

Shady Adnan Awad, MD, Matti Kankainen, PhD, Samuli Eldfors, MSc, Soili Kytölä, PhD, Pekka Ellonen, Mahmoud Kamel, MD PhD, Caroline A Heckman, PhD, Kimmo Porkka, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1924.
https://doi.org/10.1182/blood.V128.22.1924.1924
Published: 2016