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Journal Articles

Somatic Mutations in T Cells in Patients with Hematological Diseases

Sofie Lundgren, Timo Järvinen, Mikko A Keränen, Jason Theodoropoulos, Daehong Kim, Urpu Salmenniemi, Gunilla Walldin, Paula Savola, Tiina Kelkka, Hanna Rajala, Pekka Ellonen, Eva Hellström-Lindberg, Maija Itälä-Remes, Mikko Myllymäki, Matti Kankainen, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 5496–5497.
https://doi.org/10.1182/blood-2022-163112
Published: 2022
Journal Articles

Synergistic Role of Leukemic and Non-Leukemic Immune Repertoires in CD8+ T-Cell Large Granular Lymphocytic Leukemia As Identified By Single-Cell Transcriptomics

Dipabarna Bhattacharya, Jani Huuhtanen, Matti Kankainen, Tapio Lönnberg, Cassandra M Kerr, Jason Theodoropoulos, Hanna Rajala, Tiina Kasanen, Till Braun, Antonella Teramo, Renato Zambello, Marco Herling, Fumihiro Ishida, Toru Kawakami, Marko Salmi, Thomas P. Loughran, Jr., Jaroslaw P. Maciejewski, Harri Lähdesmäki, Tiina Kelkka, Satu Mustjoki
Journal: Blood
Blood (2021) 138 (Supplement 1): 1318.
https://doi.org/10.1182/blood-2021-146539
Published: 2021
Journal Articles

Somatic Mutations in CD8+ T Cells in Patients with Chronic Immune Thrombocytopenia Are Associated with Increased Clonality and Cytotoxic Phenotype of CD8+ T Cells

Hanna Rajala, MD PhD, Paula Savola, MD, Sofie Lundgren, BMed, Samuli Eldfors, PhD, Tiina Kelkka, PhD, Freja Ebeling, MD PhD, Satu Mustjoki, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 131.
https://doi.org/10.1182/blood-2018-99-113373
Published: 2018
Journal Articles

Acquired Somatic Mutations in T Cells in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndromes

Sofie Lundgren, Mikko Keränen, MD PhD, Kari Nousiainen, Samuli Eldfors, Sari Hannula, Tiina Hannunen, Pekka Ellonen, Gunilla Walldin, Michael Clemente, Freja Ebeling, MD PhD, Hanna Rajala, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP, Harri Lähdesmäki, PhD, Eva Hellstrom-Lindberg, MD PhD, Satu Mustjoki, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1169.
https://doi.org/10.1182/blood.V130.Suppl_1.1169.1169
Published: 2017
Journal Articles

Next-Generation Sequencing Analysis of Clonal Hierarchy and Dynamics in T-Large Granular Lymphocyte Leukemia Suggests Emergence of STAT3 Clones within Pre-Existing Dominant T-Cell Repertoire Responses Otherwise Silenced in Normal Individuals

Peter W Chomczynski, Michael J. Clemente, M.S., Srinivasa Reddy Sanikommu, MD, Alek d Nielsen, B.S., Cassandra M. Hirsch, BSc, Hanna Rajala, MD, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Satu Mustjoki, MD PhD, Alan E. Lichtin, MD, Jaroslaw P Maciejewski, MD PhD FACP
Journal: Blood
Blood (2016) 128 (22): 2731.
https://doi.org/10.1182/blood.V128.22.2731.2731
Published: 2016
Journal Articles

Bone Marrow Lymphocytic Status during Tyrosine Kinase Inhibitor Therapy and Its Relation to Therapy Response in Chronic Phase Chronic Myeloid Leukemia Patients

Mohamed El Missiry, MD MSc, Shady Adnan, MD MSc, Hanna Rajala, MD PhD, Ahmed Al-Samadi, DDS, PhD, Marja Ekblom, Berit Markevän, MD PhD, Ingbritt Åstrand-Grundström, Maren Wold, Birgitte Ravn Juhl, MD dr.MDsci, Ole Weis Bjerrum, MD DMSc, Inger Haulin, Kimmo Porkka, MD PhD, Ulla Olsson-Strömberg, Henrik Hjorth-Hansen, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4027.
https://doi.org/10.1182/blood.V126.23.4027.4027
Published: 2015
Journal Articles

Drug Sensitivity Profiling Identifies Drugs for Targeting Constitutively Active Mutant STAT3 and Mutant STAT5B Positive Malignancies

Heikki Kuusanmäki, MSc, Hanna Rajala, MD PhD, Arjan van Adrichem, Muntasir Mamun Majumder, MSc,BPharm, Emma I Andersson, MSc, Krister Wennerberg, PhD, Satu Mustjoki, MDPhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2014) 124 (21): 1771.
https://doi.org/10.1182/blood.V124.21.1771.1771
Published: 2014
Journal Articles

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

Andres Jerez, Michael J. Clemente, Hideki Makishima, Hanna Rajala, Ines Gómez-Seguí, Thomas Olson, Kathy McGraw, Bartlomiej Przychodzen, Austin Kulasekararaj, Manuel Afable, Holleh D. Husseinzadeh, Naoko Hosono, Francis LeBlanc, Sonja Lagström, Dan Zhang, Pekka Ellonen, André Tichelli, Catherine Nissen, Alan E. Lichtin, Aleksandra Wodnar-Filipowicz, Ghulam J. Mufti, Alan F. List, Satu Mustjoki, Thomas P. Loughran, Jr, Jaroslaw P. Maciejewski
Journal: Blood
Blood (2013) 122 (14): 2453–2459.
https://doi.org/10.1182/blood-2013-04-494930
Published: 2013
Includes: Supplemental data