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Journal Articles

Next-Generation Sequencing Analysis of Clonal Hierarchy and Dynamics in T-Large Granular Lymphocyte Leukemia Suggests Emergence of STAT3 Clones within Pre-Existing Dominant T-Cell Repertoire Responses Otherwise Silenced in Normal Individuals

Peter W Chomczynski, Michael J. Clemente, M.S., Srinivasa Reddy Sanikommu, MD, Alek d Nielsen, B.S., Cassandra M. Hirsch, BSc, Hanna Rajala, MD, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Satu Mustjoki, MD PhD, Alan E. Lichtin, MD, Jaroslaw P Maciejewski, MD PhD FACP

Blood (2016) 128 (22): 2731.

https://doi.org/10.1182/blood.V128.22.2731.2731

Published: 2016

Journal Articles

Somatic Mutations in Splicing Factor 3b, Subunit 1 (SF3B1) Are a Useful Biomarker to Differentiate Between Clonal and Non-Clonal Causes of Sideroblastic Anemia

Valeria Visconte, PhD, Ali Tabarroki, MD, Christopher Gerace, Karam Al-Issa, MD, Eric D. Hsi, MD, Heesun J. Rogers, MD PhD, Mikkael A. Sekeres, MD MS, Bernard J. Silver, MD, Alan E. Lichtin, MD, Sudipto Mukherjee, MD MPH, Ramon V. Tiu, MD

Blood (2014) 124 (21): 5597.

https://doi.org/10.1182/blood.V124.21.5597.5597

Published: 2014

Journal Articles

Burden of Disease and Clinical Responses in Low and Intermediate-1 Risk Myelofibrosis Patients Treated with Ruxolitinib

Ahmad Zarzour, MD, Ali Tabarroki, MD, Valeria Visconte, PhD, Rokana Taftaf, MD, Heesun J. Rogers, MD PhD, Jing Ai, MD PhD, Nikolaos Papadantonakis, MD PhD, Alan E. Lichtin, Yogen Saunthararajah, MD, Brady L Stein, MDMHS, Ramon V. Tiu, MD

Blood (2014) 124 (21): 1834.

https://doi.org/10.1182/blood.V124.21.1834.1834

Published: 2014

Journal Articles

Rates of Infection in Myelofibrosis Patients Treated with Ruxolitinib

Ahmad Zarzour, MD, Ali Tabarroki, MD, Rokana Taftaf, MD, Valeria Visconte, PhD, Jing Ai, MD PhD, Betty K. Hamilton, MD, Nikolaos Papadantonakis, MD PhD, Alan E. Lichtin, Leonard J. Horwitz, MD, Anjali S. Advani, MD, Mikkael A. Sekeres, MD MS, Ramon V. Tiu, MD

Blood (2014) 124 (21): 1835.

https://doi.org/10.1182/blood.V124.21.1835.1835

Published: 2014

Journal Articles

Inhibition Of The JAK/STAT Signaling Pathway As a Novel Therapy In CD8+ T-Large Granular Lymphocyte Leukemia

Michael J. Clemente, Bilori Bilori, Swapna Thota, MD, Manuel G. Afable, II, Holleh D. Husseinzadeh, Alan E. Lichtin, Jaroslaw P. Maciejewski, MD, PhD

Blood (2013) 122 (21): 3902.

https://doi.org/10.1182/blood.V122.21.3902.3902

Published: 2013

Journal Articles

Association Of Large Granular Lymphocytic Leukemia (LGL) With B-Cell Lymphoproliferative Disorders

Alan P. Z. Skarbnik, MD, Craig A. Portell, MD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Ramon V. Tiu, MD, Brad Pohlman, MD, Manuel G. Afable, II, Anjali S. Advani, MD, Robert M Dean, MD, Brian T. Hill, MD, PhD, Leonard J. Horwitz, MD, Deepa Jagadeesh, MD, MPH, Alan E. Lichtin, Christy Samaras, DO, Mikkael A. Sekeres, MD, MS, Michael Millenson, MD, Mitchell R Smith, MD, PhD

Blood (2013) 122 (21): 1387.

https://doi.org/10.1182/blood.V122.21.1387.1387

Published: 2013

Journal Articles

Inhibition Of JAK-STAT Pathway As a Therapeutic Option For Myelofibrosis Associated Pulmonary Hypertension

Blood (2013) 122 (21): 1585.

https://doi.org/10.1182/blood.V122.21.1585.1585

Published: 2013

Journal Articles

Triple Negative (J AK2 exon 12 /14 and MPL wild type) Myelofibrosis Have Higher Expression Of CDC25A and Greater Sensitivity To CDC25A Inhibition Compared To JAK2 Mutant Cases

Ali Tabarroki, MD, Valeria Visconte, PhD, Heesun J. Rogers, MD, PhD, Juraj Bodo, PhD, Li Zhang, Felicitas Lacbawan, Edy Hasrouni, John Barnard, Alan E. Lichtin, Daniel Lindner, Mikkael A. Sekeres, MD, MS, Ramon V. Tiu, MD

Blood (2013) 122 (21): 5259.

https://doi.org/10.1182/blood.V122.21.5259.5259

Published: 2013

Journal Articles

Spliceosome Gene Mutations Are Frequently Found In JAK2 Negative Myelofibrosis and Associated With Worse Clinical Outcomes

Ali Tabarroki, MD, Valeria Visconte, PhD, Heesun J. Rogers, MD, PhD, Juraj Bodo, PhD, Li Zhang, Edy Hasrouni, John Barnard, Alan E. Lichtin, Mikkael A. Sekeres, MD, MS, Ramon V. Tiu, MD

Blood (2013) 122 (21): 4063.

https://doi.org/10.1182/blood.V122.21.4063.4063

Published: 2013

Journal Articles

Modified Dose Escalation Of Ruxolitinib: A Feasible Therapeutic Approach In The Management Of Myelofibrosis

Ali Tabarroki, MD, Daniel Lindner, Valeria Visconte, PhD, Heesun J. Rogers, MD, PhD, John Desamito, Hien K. Duong, MD, Alan E. Lichtin, Anjali S. Advani, MD, Ronald M. Sobecks, MD, Tracy Cinalli, RN, Kristin Dodd, RN, Jing Ai, MD, PhD, Yogen Saunthararajah, M.D., Matt Kalaycio, MD, Brady L. Stein, MD, Mikkael A. Sekeres, MD, MS, Ramon V. Tiu, MD

Blood (2013) 122 (21): 1586.

https://doi.org/10.1182/blood.V122.21.1586.1586

Published: 2013

Journal Articles

Splicing Factor 3b Subunit 1 ( SF3B1) mediates Mitochondrial Iron Overload In Myelodysplastic Syndromes With Ring Sideroblasts By Alternative Splicing Of Mitoferrin-1 ( SLC25A37 )

Blood (2013) 122 (21): 1555.

https://doi.org/10.1182/blood.V122.21.1555.1555

Published: 2013

Journal Articles

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

Blood (2013) 122 (14): 2453–2459.

https://doi.org/10.1182/blood-2013-04-494930

Published: 2013

Includes: Supplemental data

Journal Articles

Identification and Monitoring of Pathogenic T Cell Clones Using Deep TCR Sequencing in T-Large Granular Lymphocyte Leukemia and Aplastic Anemia

Michael J. Clemente, Bartlomiej Przychodzen, BS, Hideki Makishima, Manuel G. Afable, II, MD, Marcin W Wlodarski, Alan E. Lichtin, MD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2012) 120 (21): 3477.

https://doi.org/10.1182/blood.V120.21.3477.3477

Published: 2012

Journal Articles

Identifying Immunogenetic Features That Distinguish Immune Mediated, Immunosuppression-Sensitive Disease in Aplastic Anemia (AA)

Manuel G. Afable, II, MD, Theresa Guo, MD, Bartlomiej P Przychodzen, Lisa Rybicki, MS, Michael J. Clemente, Andres Jerez, MD, PhD, Holleh D Husseinzadeh, MD;, Edward P Evans, Alan E. Lichtin, MD, Aleksandra Wodnar-Filipowicz, PhD, Mikkael A. Sekeres, MD, MS, Jaroslaw P. Maciejewski, MD, PhD

Blood (2012) 120 (21): 3481.

https://doi.org/10.1182/blood.V120.21.3481.3481

Published: 2012

Journal Articles

STAT3-Mutations Indicate the Presence of Subclinical Self-Reactive Cytotoxic T Cell Clones in Aplastic Anemia and Myelodysplastic Syndromes

Blood (2012) 120 (21): 646.

https://doi.org/10.1182/blood.V120.21.646.646

Published: 2012

Journal Articles

Anemia Associated with Increased IL-6 and IL-8 Levels Predicts for Worse Progression-Free Survival in T-Cell and NK-Cell Large Granular Lymphocyte (LGL) Leukemia but Is Improved by Treatment with Cyclophosphamide

Craig A. Portell, MD, Valeria Visconte, PhD, Michael J. Clemente, Manuel G. Afable, II, MD, Ali Tabarroki, MD, Fabiola Traina, MD, PhD, Yang Liu, Betty K. Hamilton, MD, Andres Jarez, Manoj Bupathi, MD, Leonard J. Horwitz, MD, Alan E. Lichtin, MD, Anjali Advani, MD, Mikkael A. Sekeres, MD, MS, Jaroslaw P. Maciejewski, MD, PhD, Ramon V. Tiu, MD

Blood (2012) 120 (21): 1261.

https://doi.org/10.1182/blood.V120.21.1261.1261

Published: 2012

Journal Articles

T Cell Receptor Repertoire Landscape Mapping: A Novel Paradigm for T Cell Mediated Autoimmune Disorders Based on Deep Vβ Chain Sequencing

Michael J Clemente, Bartlomiej Przychodzen, Hideki Makishima, MD, PhD, Manuel G Afable, II, MD, Alan E. Lichtin, MD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2011) 118 (21): 1341.

https://doi.org/10.1182/blood.V118.21.1341.1341

Published: 2011

Journal Articles

Low Incidence of Thrombosis in Hemophilic Patients Undergoing Surgeries or Invasive Procedures,

Yan Feng, MD, PhD, Desiree Carcioppolo, Alan E. Lichtin, MD

Blood (2011) 118 (21): 4221.

https://doi.org/10.1182/blood.V118.21.4221.4221

Published: 2011

Journal Articles

Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

Michael J. Clemente, Marcin W. Wlodarski, Hideki Makishima, Aaron D. Viny, Isabell Bretschneider, Mohammad Shaik, Nelli Bejanyan, Alan E. Lichtin, Eric D. Hsi, Ronald L. Paquette, Thomas P. Loughran, Jr, Jaroslaw P. Maciejewski

Blood (2011) 118 (16): 4384–4393.

https://doi.org/10.1182/blood-2011-02-338517

Published: 2011

Includes: Supplemental data

Journal Articles

New TET2 , ASXL1 and CBL Mutations Have Poor Prognostic Impact In Systemic Mastocytosis and Related Disorders

Fabiola Traina, MD, PhD, Ania Jankowska, MSC, Hideki Makishima, MD, PhD, Fred H. Hsieh, MD, Yingchun Han, PhD, Christine O'Keefe, PhD, Yuka Sugimoto, MD, PhD, Sanjay R. Mohan, MD, Hadrian Szpurka, PhD, Courtney Prince, Kathryn Guinta, MSC, Mikkael A. Sekeres, MD, MS, Matt Kalaycio, MD, Alan E. Lichtin, MD, Anjali S. Advani, MD, Edward Copelan, MD, Ronald Sobecks, MD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Ramon V. Tiu, MD

Blood (2010) 116 (21): 3076.

https://doi.org/10.1182/blood.V116.21.3076.3076

Published: 2010

NARROW

Next-Generation Sequencing Analysis of Clonal Hierarchy and Dynamics in T-Large Granular Lymphocyte Leukemia Suggests Emergence of STAT3 Clones within Pre-Existing Dominant T-Cell Repertoire Responses Otherwise Silenced in Normal Individuals

Somatic Mutations in Splicing Factor 3b, Subunit 1 (SF3B1) Are a Useful Biomarker to Differentiate Between Clonal and Non-Clonal Causes of Sideroblastic Anemia

Burden of Disease and Clinical Responses in Low and Intermediate-1 Risk Myelofibrosis Patients Treated with Ruxolitinib

Rates of Infection in Myelofibrosis Patients Treated with Ruxolitinib

Inhibition Of The JAK/STAT Signaling Pathway As a Novel Therapy In CD8+ T-Large Granular Lymphocyte Leukemia

Association Of Large Granular Lymphocytic Leukemia (LGL) With B-Cell Lymphoproliferative Disorders

Inhibition Of JAK-STAT Pathway As a Therapeutic Option For Myelofibrosis Associated Pulmonary Hypertension

Triple Negative (J AK2 exon 12 /14 and MPL wild type) Myelofibrosis Have Higher Expression Of CDC25A and Greater Sensitivity To CDC25A Inhibition Compared To JAK2 Mutant Cases

Spliceosome Gene Mutations Are Frequently Found In JAK2 Negative Myelofibrosis and Associated With Worse Clinical Outcomes

Modified Dose Escalation Of Ruxolitinib: A Feasible Therapeutic Approach In The Management Of Myelofibrosis

Splicing Factor 3b Subunit 1 ( SF3B1) mediates Mitochondrial Iron Overload In Myelodysplastic Syndromes With Ring Sideroblasts By Alternative Splicing Of Mitoferrin-1 ( SLC25A37 )

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

Identification and Monitoring of Pathogenic T Cell Clones Using Deep TCR Sequencing in T-Large Granular Lymphocyte Leukemia and Aplastic Anemia

Identifying Immunogenetic Features That Distinguish Immune Mediated, Immunosuppression-Sensitive Disease in Aplastic Anemia (AA)

STAT3-Mutations Indicate the Presence of Subclinical Self-Reactive Cytotoxic T Cell Clones in Aplastic Anemia and Myelodysplastic Syndromes

Anemia Associated with Increased IL-6 and IL-8 Levels Predicts for Worse Progression-Free Survival in T-Cell and NK-Cell Large Granular Lymphocyte (LGL) Leukemia but Is Improved by Treatment with Cyclophosphamide

T Cell Receptor Repertoire Landscape Mapping: A Novel Paradigm for T Cell Mediated Autoimmune Disorders Based on Deep Vβ Chain Sequencing

Low Incidence of Thrombosis in Hemophilic Patients Undergoing Surgeries or Invasive Procedures,

Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

New TET2 , ASXL1 and CBL Mutations Have Poor Prognostic Impact In Systemic Mastocytosis and Related Disorders

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American Society of Hematology

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ASH Publications

American Society of Hematology

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