1-20 of 24
Simon Raffel
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Outcome of Patients with Hematologic or Molecular Relapsed/Refractory (R/R) Acute T- Lymphoblastic Leukemia - Data from the GMALL Study Group

Anjali Cremer, Maher Hanoun, Ralph Wäsch, Simon Raffel, Klaus Wethmar, Andreas Viardot, Walter Fiedler, Knut Wendelin, Lore Marretta, Wolfram Jung, Roland Schroers, Vladan Vucinic, Monika Brüggemann, Stefan Schwartz, Hubert Serve, Nicola Goekbuget
Journal: Blood
Blood (2024) 144 (Supplement 1): 1436.
https://doi.org/10.1182/blood-2024-202270
Published: 2024
Journal Articles

Mutant Idh1 Blocks Neutrophil Maturation By Repressing Myeloid Progenitor Programs

Mariam Hakobyan, Jens Langstein, Emely Kleinert, Maximilian Schoenung, Mark Hartmann, Hannah Rohdjess, Jessica Wojtarowicz, Sina Staeble, Rainer Claus, Lars Bullinger, Christopher C. Oakes, Katharina Zoldan, Michael Cross, Uwe Platzbecker, Niclas Kneisel, Simon Raffel, Ulrich Germing, Gregor Hoermann, Karsten Rippe, Stefan Fröhling, Stefan Pusch, Christoph Plass, Michael Milsom, Daniel Lipka
Journal: Blood
Blood (2024) 144 (Supplement 1): 1341.
https://doi.org/10.1182/blood-2024-210352
Published: 2024
Journal Articles

A Senescent Subset in Human Hematopoietic Stem Cell (HSC) Compartment As Target for Senotherapy

Laura Poisa-Beiro, Jonathan JM Landry, Bowen Yan, Michael Kardorff, Volker Eckstein, Laura Villacorta, Anne-Claude Gavin, Judith Zaugg, Vladimir Benes, Simon Raffel, Daohong Zhou, Anthony D Ho
Journal: Blood
Blood (2024) 144 (Supplement 1): 1282.
https://doi.org/10.1182/blood-2024-194004
Published: 2024
Journal Articles

The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis

Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann, Claas Reimer, Anna Dietterle, Dorothee Winterberg, Caroline Mary, Frédérique Corallo, Julien Taurelle, Emma Narbeburu, Stéphanie Neyton, Mylène Déramé, Sabrina Pengam, Fotini Vogiatzi, Beat Bornhauser, Jean-Pierre Bourquin, Simon Raffel, Vladyslava Dovhan, Thomas Schüler, Gabriele Escherich, Monique L. den Boer, Judith M. Boer, Wiebke Wessels, Matthias Peipp, Julia Alten, Željko Antić, Anke K. Bergmann, Martin Schrappe, Gunnar Cario, Monika Brüggemann, Nicolas Poirier, Denis M. Schewe
Journal: Blood
Blood (2024) 143 (26): 2735–2748.
https://doi.org/10.1182/blood.2023021088
Published: 2024
Includes: Supplemental data
Journal Articles

Dose Reduced Chemotherapy in Sequence with Blinatumomab for Newly Diagnosed Older Patients with Ph/BCR::ABL Negative B-Precursor Adult Lymphoblastic Leukemia (ALL): Preliminary Results of the GMALL Bold Trial

Nicola Goekbuget, Stefan Schwartz, Christoph Faul, Max S. Topp, Marion Subklewe, Andrea Renzelmann, Andrea Stoltefuss, Bernd Hertenstein, Anne Wilke, Simon Raffel, Nadja Jäkel, Vladan Vucinic, Dirk Markus Niemann, Lena Reiser, Hubert Serve, Monika Brüggemann, Andreas Viardot
Journal: Blood
Blood (2023) 142 (Supplement 1): 964.
https://doi.org/10.1182/blood-2023-180472
Published: 2023
Journal Articles

Venetoclax and Blinatumomab for Adult Patients with Relapsed/Refractory or MRD Positive Ph-Negative B-Precursor ALL: First Results of the GMALL-Bliven Trial

Lars Fransecky, Walter Fiedler, Christoph Röllig, Tim Sauer, Simon Raffel, Winfried Alsdorf, Lisa Heberling, Kumaran Nagarajan, Britta Steer, Philipp Nakov, Björn Steffen, Dorothee Deckbar, Sonja Bendig, Lorenz Bastian, Martin Neumann, Monika Brueggemann, Nicola Goekbuget, Claudia D Baldus
Journal: Blood
Blood (2023) 142 (Supplement 1): 1502.
https://doi.org/10.1182/blood-2023-173937
Published: 2023
Journal Articles

Improving Anti-Tumor Efficacy of CAR T-Cell Therapy for Acute Myeloid Leukemia (AML): Results from a Multi-Drug Interaction Screening Approach

Julia M. Unglaub, Berit Brinkmann, Qian Chen, David Sedloev, Peter-Martin Bruch, Carolin Kolb, Volker Eckstein, Yi Liu, Anita Schmitt, Simon Raffel, Michael Schmitt, Carsten Müller-Tidow, Junyan Lu, Sascha Dietrich, Tim Sauer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5969.
https://doi.org/10.1182/blood-2023-181251
Published: 2023
Journal Articles

Mechanisms of Aging Vary with Developmental Stages in the Human Hematopoietic Trajectory

Laura Poisa-Beiro, Jonathan JM Landry, Michael Kardorff, Volker Eckstein, Laura Villacorta, Anne-Claude Gavin, Vladimir Benes, Simon Raffel, Anthony D Ho
Journal: Blood
Blood (2023) 142 (Supplement 1): 1323.
https://doi.org/10.1182/blood-2023-180830
Published: 2023
Journal Articles

Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1

Maike Janssen, Christina Schmidt, Peter-Martin Bruch, Maximilian F. Blank, Christian Rohde, Alexander Waclawiczek, Daniel Heid, Simon Renders, Stefanie Göllner, Lisa Vierbaum, Birgit Besenbeck, Sophie A. Herbst, Mareike Knoll, Carolin Kolb, Adriana Przybylla, Katharina Weidenauer, Anne Kathrin Ludwig, Margarete Fabre, Muxin Gu, Richard F. Schlenk, Friedrich Stölzel, Martin Bornhäuser, Christoph Röllig, Uwe Platzbecker, Claudia Baldus, Hubert Serve, Tim Sauer, Simon Raffel, Caroline Pabst, George Vassiliou, Binje Vick, Irmela Jeremias, Andreas Trumpp, Jeroen Krijgsveld, Carsten Müller-Tidow, Sascha Dietrich
Journal: Blood
Blood (2022) 140 (24): 2594–2610.
https://doi.org/10.1182/blood.2021014241
Published: 2022
Includes: Supplemental data
Journal Articles

Inotuzumab Ozogamicin Induction Followed By Standard Chemotherapy Yields High Remission Rates and Promising Survival in Older (>55 Years) Patients with De Novo B-Lymphoblastic Leukemia (GMALL-Initial1 Trial)

Matthias Stelljes, Nael Alakel, Ralph Wäsch, Sebastian Scholl, Kathrin Nachtkamp, Andreas Rank, Mathias Haenel, Bernd Spriewald, Maher Hanoun, Sonja Martin, Katjana Schwab, Julian Knaden, Lena Reiser, Julia Marx, Klaus Wethmar, Tim Sauer, Wolfgang E. Berdel, Georg Lenz, Monika Brüggemann, Simon Raffel, Nicola Goekbuget
Journal: Blood
Blood (2022) 140 (Supplement 1): 510–512.
https://doi.org/10.1182/blood-2022-162235
Published: 2022
Journal Articles

Cell Cycle and Differentiation Arrest in Senescent Population of Human Hematopoietic Stem and Progenitor Cell Compartment

Laura Poisa-Beiro, Jonathan JM Landry, Simon Raffel, Volker Eckstein, Laura Villacorta, Anne-Claude Gavin, Vladimir Benes, Anthony D Ho
Journal: Blood
Blood (2022) 140 (Supplement 1): 5751–5752.
https://doi.org/10.1182/blood-2022-164547
Published: 2022
Journal Articles

Macs - a Leukemic Stem Cell- Based Predictor of Clinical Response to Venetoclax and Other BH3 Mimetics for Acute Myeloid Leukemia

Simon Renders, Alexander Waclawiczek, Aino-Maija Leppä, Cecilia Reyneri, Barbara Betz, Karolin Stumpf, Maike Janssen, Julia M. Unglaub, Elisa Donato, Rabia Shahswar, Simon Raffel, Michael Heuser, Richard F. Schlenk, Michael Hundemer, Tim Sauer, Carsten Müller-Tidow, Andreas Trumpp
Journal: Blood
Blood (2022) 140 (Supplement 1): 2023–2024.
https://doi.org/10.1182/blood-2022-164831
Published: 2022
Journal Articles

Outcome of 841 Older Patients (>55 yrs) with Newly Diagnosed Ph/BCR-ABL Negative ALL Prospectively Treated According to Pediatric-Based, Age-Adapted GMALL Protocols

Nicola Goekbuget, Andreas Viardot, Björn Steffen, Joachim Hahn, Bernd Spriewald, Sonja Martin, Simon Raffel, Lino L. Teichmann, Arne Trummer, Winfried Alsdorf, Anke Morgner, Stefan Schwartz, Matthias Stelljes, Vladan Vucinic, Nael Alakel, Andrea Stoltefuß, Claudia D. Baldus, Monika Brüggemann, Hubert Serve, Dieter Hoelzer
Journal: Blood
Blood (2022) 140 (Supplement 1): 121–123.
https://doi.org/10.1182/blood-2022-158934
Published: 2022
Journal Articles

Leukemic Stem Cells of Monocytic AMLs Are Not-Resistant to BCL-2 Inhibition

Simon Renders, Aino-Maija Leppä, Alexander Waclawiczek, Maike Janssen, Elisa Donato, Cecilia Reyneri, Julia M. Unglaub, Michael Hundemer, Richard F. Schlenk, Simon Raffel, Carsten Müller-Tidow, Tim Sauer, Andreas Trumpp
Journal: Blood
Blood (2021) 138 (Supplement 1): 3469.
https://doi.org/10.1182/blood-2021-149781
Published: 2021
Journal Articles

Elevated Central Carbon Metabolism - a Hallmark for Senescent Cells in Aging Human Hematopoietic Stem Cell Compartment

Laura Poisa-Beiro, Jonathan Landry, Simon Raffel, Volker Eckstein, Anne-Claude Gavin, Motomu Tanaka, Vladimir Benes, Anthony D. Ho
Journal: Blood
Blood (2021) 138 (Supplement 1): 1088.
https://doi.org/10.1182/blood-2021-150761
Published: 2021
Journal Articles

Final Induction Therapy Results of an Open Label Phase II Study Using Inotuzumab Ozogamicin for Induction Therapy, Followed By a Conventional Chemotherapy Based Consolidation and Maintenance Therapy in Patients Aged 56 Years and Older with Acute B-Lymphoblastic Leukemia (INITIAL-1 trial)

Matthias Stelljes, Nael Alakel, Ralph Wäsch, Sebastian Scholl, Kathrin Nachtkamp, Andreas Rank, Mathias Haenel, Bernd Spriewald, Maher Hanoun, Sonja Martin, Katjana Schwab, Julian Knaden, Julia Marx, Klaus Wethmar, Tim Sauer, Wolfgang E. Berdel, Georg Lenz, Martin Dugas, Nicola Goekbuget, Monika Brueggemann, Simon Raffel
Journal: Blood
Blood (2021) 138 (Supplement 1): 2300.
https://doi.org/10.1182/blood-2021-145553
Published: 2021
Journal Articles

Interim Results of a Multicenter, Single-Arm Study to Assess Blinatumomab in Adult Patients (pts) with Minimal Residual Disease (MRD) of B-Precursor (BCP) Acute Lymphoblastic Leukemia (GMALL-MOLACT1-BLINA)

Nicola Goekbuget, MD, Wiba Keke Wermann, Stefan Schwartz, MD PhD, Andreas Hüttmann, MD, Christoph Faul, MD, Simon Raffel, MD, Andreas Viardot, Professor Dr, Walter Fiedler, MD, Nael Alakel, MD, Matthias Stelljes, MD, Marion Subklewe, MD, Ralph Wäsch, Sonja Martin, MD, Wolfram Jung, MD, Vladan Vucinic, MD, Mustafa Kondakci, MD, Lars R. Fransecky, MD, Daniela Heidenreich, MD, Knut Wendelin, MD, Julian Hermann, Hubert Serve, MD PhD, Ralf C Bargou, MD PhD, Max S. Topp, MD, Monika Brüggemann, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-137350
Published: 2020
Journal Articles

First Results of an Open Label Phase II Study to Evaluate the Efficacy and Safety of Inotuzumab Ozogamicin for Induction Therapy Followed By a Conventional Chemotherapy Based Consolidation and Maintenance Therapy in Patients Aged 56 Years and Older with Acute Lymphoblastic Leukemia (INITIAL-1 trial)

Matthias Stelljes, MD, Simon Raffel, MD, Ralph Wäsch, Sebastian Scholl, Mustafa Kondakci, MD, Andreas Rank, PD Dr, Mathias Haenel, MD, Sonja Martin, MD, Katjana Schwab, MD, Julian Knaden, Klaus Wethmar, MD, Tim Sauer, MD, Wolfgang E. Berdel, Prof., MD, Georg Lenz, Martin Dugas, Monika Brüggemann, MD, Nicola Goekbuget, MD, Nael Alakel, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-136920
Published: 2020
Journal Articles

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells

Simon Raffel, Daniel Klimmeck, Mattia Falcone, Aykut Demir, Alireza Pouya, Petra Zeisberger, Christoph Lutz, Marco Tinelli, Oliver Bischel, Lars Bullinger, Christian Thiede, Anne Flörcken, Jörg Westermann, Gerhard Ehninger, Anthony D. Ho, Carsten Müller-Tidow, Zuguang Gu, Carl Herrmann, Jeroen Krijgsveld, Andreas Trumpp, Jenny Hansson
Journal: Blood
Blood (2020) 136 (13): 1507–1519.
https://doi.org/10.1182/blood.2019003654
Published: 2020
Includes: Supplemental data
Journal Articles

Characteristic Amino Acid and Energy Metabolism in AML Stem Cells As Revealed By Quantitative Multiplex Proteomics

Simon Raffel, MD, Jenny Hansson, Mattia Falcone, Christoph Lutz, Oliver Bischel, MD, Anthony D Ho, Jeroen Krijgsveld, Andreas Trumpp, Prof, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2780.
https://doi.org/10.1182/blood-2018-99-117046
Published: 2018