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Journal Articles

Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia

Hannah J Uckelmann, Elena L Haarer, Reina Takeda, Eric Wong, Christian Marinaccio, Charles Hatton, Yanhe Wen, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Chun-Wei David Chen, Lorenzo Brunetti, Scott A. Armstrong

Blood (2022) 140 (Supplement 1): 5835–5836.

https://doi.org/10.1182/blood-2022-166630

Published: 2022

Journal Articles

The menin-MLL1 interaction is a molecular dependency in NUP98 -rearranged AML

Emily B. Heikamp, Jill A. Henrich, Florian Perner, Eric M. Wong, Charles Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann, Sumiko Takao, Yaniv Kazansky, Yana Pikman, Gerard M. McGeehan, Edward A. Kolb, Alex Kentsis, Scott A. Armstrong

Blood (2022) 139 (6): 894–906.

https://doi.org/10.1182/blood.2021012806

Published: 2022

Includes: Supplemental data

Journal Articles

Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1 -Rearranged and NPM1 -Mutant AML

Wallace Bourgeois, Brandon J. Aubrey, Jevon A. Cutler, Katherine A. Donovan, Charles Hatton, Alexandra C. P. Theall, Radoslaw P. Nowak, Gerard M. McGeehan, Eric S. Fischer, Scott A. Armstrong

Blood (2021) 138 (Supplement 1): 208.

https://doi.org/10.1182/blood-2021-150971

Published: 2021

Journal Articles

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts

Florian Perner, Jayant Y. Gadrey, Yijun Xiong, Charles Hatton, Benjamin K. Eschle, Andreas Weiss, Frédéric Stauffer, Christoph Gaul, Ralph Tiedt, Jennifer A. Perry, Scott A. Armstrong, Andrei V. Krivtsov

Blood (2020) 136 (17): 1983–1988.

https://doi.org/10.1182/blood.2020006113

Published: 2020

Includes: Supplemental data

Journal Articles

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

Hannah J. Uckelmann, PhD, Stephanie M. Kim, BA, Noa J. C. Antonissen, Andrei V. Krivtsov, PhD, Charles Hatton, Gerard M. McGeehan, PhD, Ross L. Levine, MD, George S. Vassiliou, Scott A. Armstrong, MD PhD

Blood (2018) 132 (Supplement 1): 546.

https://doi.org/10.1182/blood-2018-99-110851

Published: 2018

NARROW

Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia

The menin-MLL1 interaction is a molecular dependency in NUP98 -rearranged AML

Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1 -Rearranged and NPM1 -Mutant AML

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

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ASH Publications

American Society of Hematology

Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia

The menin-MLL1 interaction is a molecular dependency in NUP98 -rearranged AML

Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1 -Rearranged and NPM1 -Mutant AML

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

Email alerts

ASH Publications

American Society of Hematology

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